{"id":"https://openalex.org/W2008687986","doi":"https://doi.org/10.1016/j.bbapap.2004.11.009","title":"ADAM-mediated ectodomain shedding of HB-EGF in receptor cross-talk","display_name":"ADAM-mediated ectodomain shedding of HB-EGF in receptor cross-talk","publication_year":2004,"publication_date":"2004-12-16","ids":{"openalex":"https://openalex.org/W2008687986","doi":"https://doi.org/10.1016/j.bbapap.2004.11.009","mag":"2008687986","pmid":"https://pubmed.ncbi.nlm.nih.gov/16054021"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbapap.2004.11.009","doi":"https://doi.org/10.1016/j.bbapap.2004.11.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbapap.2004.11.009","pdf_url":null,"source":{"id":"https://openalex.org/S4210222880","display_name":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","issn_l":"1570-9639","issn":["1570-9639","1878-1454"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102915092","display_name":"Shigeki Higashiyama","orcid":"https://orcid.org/0000-0002-2417-3921","observed_orcids":["https://orcid.org/0000-0002-2417-3921"]},"institutions":[{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I43545212","display_name":"Ehime University","ror":"https://ror.org/017hkng22","country_code":"JP","type":"education","lineage":["https://openalex.org/I43545212"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shigeki Higashiyama","raw_affiliation_strings":["Division of Biochemistry and Molecular Genetics, Department of Molecular and Cellular Biology, Ehime University School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan. shigeki@m.ehime-u.ac.jp","Division of Biochemistry and Molecular Genetics, Department of Molecular and Cellular Biology, Ehime University School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan","PRESTO, JST, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry and Molecular Genetics, Department of Molecular and Cellular Biology, Ehime University School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan. shigeki@m.ehime-u.ac.jp","institution_ids":["https://openalex.org/I43545212"]},{"raw_affiliation_string":"Division of Biochemistry and Molecular Genetics, Department of Molecular and Cellular Biology, Ehime University School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan","institution_ids":["https://openalex.org/I43545212"]},{"raw_affiliation_string":"PRESTO, JST, Japan","institution_ids":["https://openalex.org/I4210086780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083111745","display_name":"Daisuke Nanba","orcid":"https://orcid.org/0000-0002-9765-9113","observed_orcids":["https://orcid.org/0000-0002-9765-9113"]},"institutions":[{"id":"https://openalex.org/I43545212","display_name":"Ehime University","ror":"https://ror.org/017hkng22","country_code":"JP","type":"education","lineage":["https://openalex.org/I43545212"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daisuke Nanba","raw_affiliation_strings":["Division of Biochemistry and Molecular Genetics, Department of Molecular and Cellular Biology, Ehime University School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry and Molecular Genetics, Department of Molecular and Cellular Biology, Ehime University School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan","institution_ids":["https://openalex.org/I43545212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5102915092"],"corresponding_institution_ids":["https://openalex.org/I4210086780","https://openalex.org/I43545212"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":null,"fwci":0.8695,"has_fulltext":false,"cited_by_count":162,"citation_normalized_percentile":{"value":0.70659722,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"1751","issue":"1","first_page":"110","last_page":"117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.7865999937057495,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.7865999937057495,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.1981000006198883,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hb-egf","display_name":"HB-EGF","score":0.8820000290870667},{"id":"https://openalex.org/keywords/ectodomain-shedding","display_name":"ectodomain shedding","score":0.8529999852180481},{"id":"https://openalex.org/keywords/adam-metalloproteases","display_name":"ADAM metalloproteases","score":0.8569999933242798},{"id":"https://openalex.org/keywords/adam10","display_name":"ADAM10","score":0.9900000095367432},{"id":"https://openalex.org/keywords/adam12","display_name":"ADAM12","score":0.9990000128746033},{"id":"https://openalex.org/keywords/adam17","display_name":"ADAM17","score":1.0},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.8320000171661377},{"id":"https://openalex.org/keywords/receptor-crosstalk","display_name":"receptor cross-talk","score":0.7910000085830688},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.7950000166893005},{"id":"https://openalex.org/keywords/gpcr-agonists","display_name":"GPCR agonists","score":0.6470000147819519},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.5320000052452087},{"id":"https://openalex.org/keywords/heart-disease","display_name":"heart disease","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C1009742","wikidata":"https://www.wikidata.org/wiki/Q5333998","display_name":"Ectodomain","level":3,"score":0.9902368783950806},{"id":"https://openalex.org/C2778715156","wikidata":"https://www.wikidata.org/wiki/Q17709536","display_name":"ADAM10","level":5,"score":0.845235288143158},{"id":"https://openalex.org/C2778259572","wikidata":"https://www.wikidata.org/wiki/Q407908","display_name":"Disintegrin","level":4,"score":0.7351996302604675},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6378431916236877},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.5788897275924683},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5308875441551208},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.49466392397880554},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.48198050260543823},{"id":"https://openalex.org/C159048773","wikidata":"https://www.wikidata.org/wiki/Q14914537","display_name":"Heparin-binding EGF-like growth factor","level":4,"score":0.44635096192359924},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43849048018455505},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39556893706321716},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.22372367978096008},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18376919627189636}],"mesh":[{"descriptor_ui":"D000072198","descriptor_name":"ADAM17 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072199","descriptor_name":"ADAM12 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016282","descriptor_name":"Aspartic Acid Endopeptidases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020239","descriptor_name":"Receptor Cross-Talk","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051722","descriptor_name":"ADAM Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066257","descriptor_name":"Heparin-binding EGF-like Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbapap.2004.11.009","doi":"https://doi.org/10.1016/j.bbapap.2004.11.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbapap.2004.11.009","pdf_url":null,"source":{"id":"https://openalex.org/S4210222880","display_name":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","issn_l":"1570-9639","issn":["1570-9639","1878-1454"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","raw_type":"journal-article"},{"id":"pmid:16054021","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16054021","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":105,"referenced_works":["https://openalex.org/W156564485","https://openalex.org/W188006079","https://openalex.org/W308204182","https://openalex.org/W1483862258","https://openalex.org/W1485965660","https://openalex.org/W1486948598","https://openalex.org/W1514034386","https://openalex.org/W1550565578","https://openalex.org/W1557197358","https://openalex.org/W1595716544","https://openalex.org/W1598192021","https://openalex.org/W1665534178","https://openalex.org/W1804521283","https://openalex.org/W1963690717","https://openalex.org/W1964493811","https://openalex.org/W1968656665","https://openalex.org/W1971988944","https://openalex.org/W1977545091","https://openalex.org/W1977993125","https://openalex.org/W1979566289","https://openalex.org/W1981148940","https://openalex.org/W1981493299","https://openalex.org/W1981859725","https://openalex.org/W1982342754","https://openalex.org/W1983530651","https://openalex.org/W1983829588","https://openalex.org/W1983883945","https://openalex.org/W1986041519","https://openalex.org/W1989021197","https://openalex.org/W1989355270","https://openalex.org/W1990198117","https://openalex.org/W1991888662","https://openalex.org/W1996433668","https://openalex.org/W1999805805","https://openalex.org/W2000517557","https://openalex.org/W2003610823","https://openalex.org/W2006881752","https://openalex.org/W2006985579","https://openalex.org/W2010806829","https://openalex.org/W2012289375","https://openalex.org/W2017080249","https://openalex.org/W2017353498","https://openalex.org/W2019994988","https://openalex.org/W2022685199","https://openalex.org/W2026038159","https://openalex.org/W2030789072","https://openalex.org/W2033771299","https://openalex.org/W2035090185","https://openalex.org/W2037143824","https://openalex.org/W2037369692","https://openalex.org/W2037790468","https://openalex.org/W2037821855","https://openalex.org/W2038086562","https://openalex.org/W2038499121","https://openalex.org/W2041058556","https://openalex.org/W2050674912","https://openalex.org/W2051444637","https://openalex.org/W2052167720","https://openalex.org/W2054012934","https://openalex.org/W2056263610","https://openalex.org/W2057044649","https://openalex.org/W2067188105","https://openalex.org/W2067450274","https://openalex.org/W2068280585","https://openalex.org/W2072219853","https://openalex.org/W2074511614","https://openalex.org/W2074623822","https://openalex.org/W2079825774","https://openalex.org/W2080414061","https://openalex.org/W2081399863","https://openalex.org/W2083456571","https://openalex.org/W2084339088","https://openalex.org/W2086041680","https://openalex.org/W2086324825","https://openalex.org/W2089480351","https://openalex.org/W2089523316","https://openalex.org/W2095796144","https://openalex.org/W2096478205","https://openalex.org/W2097432825","https://openalex.org/W2097805597","https://openalex.org/W2106004899","https://openalex.org/W2108685802","https://openalex.org/W2109815943","https://openalex.org/W2116027412","https://openalex.org/W2121076016","https://openalex.org/W2124806986","https://openalex.org/W2126514623","https://openalex.org/W2127150853","https://openalex.org/W2127730758","https://openalex.org/W2131104865","https://openalex.org/W2132475459","https://openalex.org/W2134533989","https://openalex.org/W2136144485","https://openalex.org/W2137033699","https://openalex.org/W2137396410","https://openalex.org/W2138642580","https://openalex.org/W2139688694","https://openalex.org/W2140486223","https://openalex.org/W2141838148","https://openalex.org/W2150861078","https://openalex.org/W2155508906","https://openalex.org/W2162827558","https://openalex.org/W2167955976","https://openalex.org/W2334499091","https://openalex.org/W4232995978"],"related_works":["https://openalex.org/W2072219853","https://openalex.org/W1990198117","https://openalex.org/W1997005830","https://openalex.org/W1973250026","https://openalex.org/W1982796291","https://openalex.org/W2129033989","https://openalex.org/W2951386479","https://openalex.org/W2079913429","https://openalex.org/W2794422249","https://openalex.org/W7095657528"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}