{"id":"https://openalex.org/W2008667231","doi":"https://doi.org/10.3181/00379727-156-39971","title":"Effects on Temperature of Morphine Injected into the Preoptic/Anterior Hypothalamus, Medulla Oblongata, and Peripherally in Unrestrained and Restrained Rats","display_name":"Effects on Temperature of Morphine Injected into the Preoptic/Anterior Hypothalamus, Medulla Oblongata, and Peripherally in Unrestrained and Restrained Rats","publication_year":1977,"publication_date":"1977-12-01","ids":{"openalex":"https://openalex.org/W2008667231","doi":"https://doi.org/10.3181/00379727-156-39971","mag":"2008667231","pmid":"https://pubmed.ncbi.nlm.nih.gov/594082"},"language":"en","primary_location":{"id":"doi:10.3181/00379727-156-39971","doi":"https://doi.org/10.3181/00379727-156-39971","is_oa":false,"landing_page_url":"https://doi.org/10.3181/00379727-156-39971","pdf_url":null,"source":{"id":"https://openalex.org/S67514239","display_name":"Experimental Biology and Medicine","issn_l":"0071-3384","issn":["0071-3384","1535-3699","1535-3702"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011940125","display_name":"GP Trzcinka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094379","display_name":"University of Texas Health Science Center at Dallas","ror":"https://ror.org/00q16t150","country_code":"US","type":"education","lineage":["https://openalex.org/I4210094379"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. P. Trzcinka","raw_affiliation_strings":["Departments of Psychiatry, Physiology, Neurology, and Pharmacology, The University of Texas Health Science Center at Dallas, Dallas, Texas 75235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychiatry, Physiology, Neurology, and Pharmacology, The University of Texas Health Science Center at Dallas, Dallas, Texas 75235","institution_ids":["https://openalex.org/I4210094379"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109964033","display_name":"James M. Lipton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094379","display_name":"University of Texas Health Science Center at Dallas","ror":"https://ror.org/00q16t150","country_code":"US","type":"education","lineage":["https://openalex.org/I4210094379"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. M. Lipton","raw_affiliation_strings":["Departments of Psychiatry, Physiology, Neurology, and Pharmacology, The University of Texas Health Science Center at Dallas, Dallas, Texas 75235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychiatry, Physiology, Neurology, and Pharmacology, The University of Texas Health Science Center at Dallas, Dallas, Texas 75235","institution_ids":["https://openalex.org/I4210094379"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024481284","display_name":"Mike F. Hawkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094379","display_name":"University of Texas Health Science Center at Dallas","ror":"https://ror.org/00q16t150","country_code":"US","type":"education","lineage":["https://openalex.org/I4210094379"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Hawkins","raw_affiliation_strings":["Departments of Psychiatry, Physiology, Neurology, and Pharmacology, The University of Texas Health Science Center at Dallas, Dallas, Texas 75235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychiatry, Physiology, Neurology, and Pharmacology, The University of Texas Health Science Center at Dallas, Dallas, Texas 75235","institution_ids":["https://openalex.org/I4210094379"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111679567","display_name":"Wesley G. Clark","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094379","display_name":"University of Texas Health Science Center at Dallas","ror":"https://ror.org/00q16t150","country_code":"US","type":"education","lineage":["https://openalex.org/I4210094379"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. G. Clark","raw_affiliation_strings":["Departments of Psychiatry, Physiology, Neurology, and Pharmacology, The University of Texas Health Science Center at Dallas, Dallas, Texas 75235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychiatry, Physiology, Neurology, and Pharmacology, The University of Texas Health Science Center at Dallas, Dallas, Texas 75235","institution_ids":["https://openalex.org/I4210094379"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210094379"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":null,"fwci":2.4017,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.85041551,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"156","issue":"3","first_page":"523","last_page":"526"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.49880000948905945,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.49880000948905945,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.20319999754428864,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11109","display_name":"Thermoregulation and physiological responses","score":0.07029999792575836,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/morphine","display_name":"morphine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/preoptic-anterior-hypothalamus","display_name":"preoptic anterior hypothalamus","score":0.7820000052452087},{"id":"https://openalex.org/keywords/medulla-oblongata","display_name":"medulla oblongata","score":0.9980000257492065},{"id":"https://openalex.org/keywords/body-temperature","display_name":"body temperature","score":0.7080000042915344},{"id":"https://openalex.org/keywords/hyperthermia","display_name":"hyperthermia","score":0.8769999742507935},{"id":"https://openalex.org/keywords/hypothermia","display_name":"hypothermia","score":0.996999979019165},{"id":"https://openalex.org/keywords/restraint","display_name":"restraint","score":0.7279999852180481},{"id":"https://openalex.org/keywords/intracerebral-injection","display_name":"intracerebral injection","score":0.6460000276565552},{"id":"https://openalex.org/keywords/intraperitoneal-administration","display_name":"intraperitoneal administration","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C2778110749","wikidata":"https://www.wikidata.org/wiki/Q189033","display_name":"Medulla oblongata","level":3,"score":0.9028706550598145},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.6957530379295349},{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.6879791617393494},{"id":"https://openalex.org/C2993719464","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Anterior hypothalamus","level":3,"score":0.6227423548698425},{"id":"https://openalex.org/C2776451244","wikidata":"https://www.wikidata.org/wiki/Q7240592","display_name":"Preoptic area","level":3,"score":0.4908226430416107},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4352438747882843},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4294959604740143},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38333916664123535},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.36902034282684326},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35319703817367554},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.16535985469818115}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001831","descriptor_name":"Body Temperature","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007032","descriptor_name":"Hypothalamus, Anterior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007032","descriptor_name":"Hypothalamus, Anterior","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008526","descriptor_name":"Medulla Oblongata","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009020","descriptor_name":"Morphine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011301","descriptor_name":"Preoptic Area","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011301","descriptor_name":"Preoptic Area","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012149","descriptor_name":"Restraint, Physical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3181/00379727-156-39971","doi":"https://doi.org/10.3181/00379727-156-39971","is_oa":false,"landing_page_url":"https://doi.org/10.3181/00379727-156-39971","pdf_url":null,"source":{"id":"https://openalex.org/S67514239","display_name":"Experimental Biology and Medicine","issn_l":"0071-3384","issn":["0071-3384","1535-3699","1535-3702"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:594082","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/594082","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1971402676","https://openalex.org/W2415289635","https://openalex.org/W1965268655","https://openalex.org/W2290649233","https://openalex.org/W1968376366","https://openalex.org/W2059137324","https://openalex.org/W1995326450","https://openalex.org/W2067597030","https://openalex.org/W2043232551","https://openalex.org/W2079678326"],"abstract_inverted_index":{"SummaryChanges":[0],"in":[1,5,60,76,89],"Tre":[2],"were":[3],"determined":[4],"unrestrained":[6],"rats":[7],"after":[8],"injections":[9,28,46],"of":[10,35,47,57,70],"morphine":[11],"into":[12,19],"the":[13,20,36,42,68,77,90],"PO/AH":[14,37,53,78],"and":[15,54,80],"MED":[16],"regions.":[17],"Injections":[18],"former":[21],"site":[22],"consistently":[23],"caused":[24,29],"hyperthermia,":[25],"while":[26],"medullary":[27,45],"only":[30],"inconsistent":[31],"small":[32],"responses.":[33],"Destruction":[34],"region":[38,79],"did":[39],"not":[40],"enhance":[41],"response":[43],"to":[44,52,87],"morphine.":[48],"Restraint":[49],"reversed":[50],"responses":[51],"ip":[55],"administration":[56],"morphine,":[58],"resulting":[59],"hypothermia.":[61],"These":[62],"results":[63],"provide":[64],"additional":[65],"evidence":[66],"for":[67],"concept":[69],"a":[71,81],"sensitive":[72],"primary":[73],"temperature":[74],"control":[75],"secondary":[82],"control,":[83],"which":[84],"responds":[85],"minimally":[86],"drugs,":[88],"medulla.":[91]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
