{"id":"https://openalex.org/W2008666476","doi":"https://doi.org/10.1002/bdrc.21016","title":"Elastin signaling in wound repair","display_name":"Elastin signaling in wound repair","publication_year":2012,"publication_date":"2012-09-01","ids":{"openalex":"https://openalex.org/W2008666476","doi":"https://doi.org/10.1002/bdrc.21016","mag":"2008666476","pmid":"https://pubmed.ncbi.nlm.nih.gov/23109320"},"language":"en","primary_location":{"id":"doi:10.1002/bdrc.21016","doi":"https://doi.org/10.1002/bdrc.21016","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bdrc.21016","pdf_url":null,"source":{"id":"https://openalex.org/S4394736884","display_name":"Birth Defects Research Part C Embryo Today Reviews","issn_l":"1542-975X","issn":["1542-975X","1542-9768"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","poland-100"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth Defects Research Part C: Embryo Today: Reviews","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060609198","display_name":"Jessica F. Almine","orcid":"https://orcid.org/0000-0003-2260-0560","observed_orcids":["https://orcid.org/0000-0003-2260-0560"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jessica F. Almine","raw_affiliation_strings":["School of Molecular Bioscience, University of Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular Bioscience, University of Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069501501","display_name":"Steven G. Wise","orcid":"https://orcid.org/0000-0001-7964-819X","observed_orcids":["https://orcid.org/0000-0001-7964-819X"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2801241159","display_name":"The Heart Research Institute","ror":"https://ror.org/046fa4y88","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801241159"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Steven G. Wise","raw_affiliation_strings":["School of Molecular Bioscience, University of Sydney, New South Wales, Australia","The Heart Research Institute, Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular Bioscience, University of Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"The Heart Research Institute, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I2801241159"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007081664","display_name":"Anthony S. Weiss","orcid":"https://orcid.org/0000-0002-8106-4836","observed_orcids":["https://orcid.org/0000-0002-8106-4836"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Anthony S. Weiss","raw_affiliation_strings":["School of Molecular Bioscience, University of Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular Bioscience, University of Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007081664"],"corresponding_institution_ids":["https://openalex.org/I129604602"],"apc_list":null,"apc_paid":null,"fwci":1.2769,"has_fulltext":false,"cited_by_count":163,"citation_normalized_percentile":{"value":0.74543644,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"96","issue":"3","first_page":"248","last_page":"257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/elastin","display_name":"elastin","score":0.8970000147819519},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.9800000190734863},{"id":"https://openalex.org/keywords/scar-formation","display_name":"scar formation","score":0.875},{"id":"https://openalex.org/keywords/scarless-wound-healing","display_name":"scarless wound healing","score":0.7379999756813049},{"id":"https://openalex.org/keywords/fetal-skin-development","display_name":"fetal skin development","score":0.7139999866485596},{"id":"https://openalex.org/keywords/elastic-fibers","display_name":"elastic fibers","score":0.7689999938011169},{"id":"https://openalex.org/keywords/skin-barrier-function","display_name":"skin barrier function","score":0.5450000166893005},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.6029999852180481},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7559999823570251},{"id":"https://openalex.org/keywords/extracellular-matrix-production","display_name":"extracellular matrix synthesis","score":0.8040000200271606},{"id":"https://openalex.org/keywords/protease-production","display_name":"protease production","score":0.9070000052452087},{"id":"https://openalex.org/keywords/skin-wounds","display_name":"skin wounds","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C2779869378","wikidata":"https://www.wikidata.org/wiki/Q409747","display_name":"Elastin","level":2,"score":0.9683368802070618},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.7792500257492065},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5264276266098022},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4698796570301056},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.41281238198280334},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37505778670310974},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31504082679748535},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.31001731753349304},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24383461475372314},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002921","descriptor_name":"Cicatrix","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004549","descriptor_name":"Elastin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012879","descriptor_name":"Skin Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/bdrc.21016","doi":"https://doi.org/10.1002/bdrc.21016","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bdrc.21016","pdf_url":null,"source":{"id":"https://openalex.org/S4394736884","display_name":"Birth Defects Research Part C Embryo Today Reviews","issn_l":"1542-975X","issn":["1542-975X","1542-9768"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","poland-100"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth Defects Research Part C: Embryo Today: Reviews","raw_type":"journal-article"},{"id":"pmid:23109320","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23109320","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth defects research. Part C, Embryo today : reviews","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":95,"referenced_works":["https://openalex.org/W28584108","https://openalex.org/W113046667","https://openalex.org/W148753544","https://openalex.org/W1487383944","https://openalex.org/W1488709028","https://openalex.org/W1555202207","https://openalex.org/W1565388169","https://openalex.org/W1576773659","https://openalex.org/W1751758267","https://openalex.org/W1963816691","https://openalex.org/W1967823590","https://openalex.org/W1968384520","https://openalex.org/W1969749903","https://openalex.org/W1974088650","https://openalex.org/W1978307806","https://openalex.org/W1990365437","https://openalex.org/W1991890343","https://openalex.org/W1992864703","https://openalex.org/W1993829402","https://openalex.org/W1994472758","https://openalex.org/W1997629297","https://openalex.org/W1998776491","https://openalex.org/W1999034868","https://openalex.org/W2000209705","https://openalex.org/W2000856419","https://openalex.org/W2004600332","https://openalex.org/W2006816193","https://openalex.org/W2007441851","https://openalex.org/W2007732720","https://openalex.org/W2008591577","https://openalex.org/W2012654176","https://openalex.org/W2013381560","https://openalex.org/W2013571306","https://openalex.org/W2023336969","https://openalex.org/W2024335985","https://openalex.org/W2029132765","https://openalex.org/W2030635244","https://openalex.org/W2031304251","https://openalex.org/W2034863072","https://openalex.org/W2039914635","https://openalex.org/W2043733449","https://openalex.org/W2043916833","https://openalex.org/W2045751204","https://openalex.org/W2050198557","https://openalex.org/W2054594987","https://openalex.org/W2055701307","https://openalex.org/W2055779465","https://openalex.org/W2055870465","https://openalex.org/W2057733376","https://openalex.org/W2060700926","https://openalex.org/W2062712176","https://openalex.org/W2067241864","https://openalex.org/W2067245236","https://openalex.org/W2067914624","https://openalex.org/W2068943878","https://openalex.org/W2069760696","https://openalex.org/W2070644273","https://openalex.org/W2071092166","https://openalex.org/W2072640657","https://openalex.org/W2075112237","https://openalex.org/W2078410720","https://openalex.org/W2083252148","https://openalex.org/W2085293124","https://openalex.org/W2085320561","https://openalex.org/W2085875208","https://openalex.org/W2092896554","https://openalex.org/W2093985540","https://openalex.org/W2094546356","https://openalex.org/W2094747108","https://openalex.org/W2103984819","https://openalex.org/W2115328944","https://openalex.org/W2116717938","https://openalex.org/W2117201968","https://openalex.org/W2122628729","https://openalex.org/W2123550509","https://openalex.org/W2133265542","https://openalex.org/W2134652066","https://openalex.org/W2136772857","https://openalex.org/W2140273413","https://openalex.org/W2147838279","https://openalex.org/W2153170434","https://openalex.org/W2155784353","https://openalex.org/W2159193579","https://openalex.org/W2161106805","https://openalex.org/W2161561755","https://openalex.org/W2164692123","https://openalex.org/W2317167426","https://openalex.org/W2325727928","https://openalex.org/W3113164427","https://openalex.org/W3189920043","https://openalex.org/W3203480729","https://openalex.org/W4210961984","https://openalex.org/W4211100021","https://openalex.org/W4250359445","https://openalex.org/W6844102523"],"related_works":["https://openalex.org/W1555202207","https://openalex.org/W1542918066","https://openalex.org/W2991159015","https://openalex.org/W2014906392","https://openalex.org/W100055208","https://openalex.org/W2011904016","https://openalex.org/W2046875468","https://openalex.org/W7098083405","https://openalex.org/W1592253612","https://openalex.org/W2478502943"],"abstract_inverted_index":{"Skin":[0],"is":[1,29,54,64,68,103,113,169],"an":[2,13,30,48,71],"important":[3],"organ":[4],"to":[5,96,128,178],"the":[6,16,41,160,200],"human":[7],"body":[8,17],"as":[9,12],"it":[10,124],"functions":[11],"interface":[14],"between":[15],"and":[18,36,80,92,106,135,137,147,151,176,185],"environment.":[19],"Cutaneous":[20],"injury":[21],"elicits":[22],"a":[23,88,108,125,139,179,192,197],"complex":[24],"wound":[25,52,62,100,130,165,193],"healing":[26,53,63,194],"process,":[27],"which":[28],"orchestration":[31],"of":[32,44,51,77,82,90,121,141,156,162,189,203],"cells,":[33],"matrix":[34,149],"components,":[35],"signaling":[37,78,187],"factors":[38],"that":[39,206],"re-establishes":[40],"barrier":[42],"function":[43],"skin.":[45,97],"In":[46,98],"adults,":[47],"unavoidable":[49],"consequence":[50],"scar":[55,116],"formation.":[56,117],"However,":[57],"in":[58,171,174,181,191],"early":[59],"fetal":[60,163,204],"development,":[61],"scarless.":[65],"This":[66],"phenomenon":[67],"characterized":[69],"by":[70],"attenuated":[72],"inflammatory":[73],"response,":[74],"differential":[75],"expression":[76],"factors,":[79],"regeneration":[81],"normal":[83],"skin":[84,205],"architecture.":[85],"Elastin":[86,132,167],"endows":[87],"range":[89,140],"mechanical":[91],"cell":[93,142,145,186],"interactive":[94],"properties":[95,120],"adult":[99,129],"healing,":[101],"elastin":[102,122,157,190],"severely":[104],"lacking":[105],"only":[107],"disorganized":[109],"elastic":[110],"fiber":[111],"network":[112],"present":[114],"after":[115],"The":[118,154,183],"inherent":[119],"make":[123],"desirable":[126],"inclusion":[127],"healing.":[131,166,211],"imparts":[133],"recoil":[134],"resistance":[136],"induces":[138],"activities,":[143],"including":[144],"migration":[146],"proliferation,":[148],"synthesis,":[150],"protease":[152],"production.":[153],"effects":[155],"align":[158],"with":[159,199],"hallmarks":[161],"scarless":[164,210],"synthesis":[168],"substantial":[170],"late":[172],"stage":[173],"utero":[175],"drops":[177],"trickle":[180],"adults.":[182],"physical":[184],"advantages":[188],"context":[195],"creates":[196],"parallel":[198],"innate":[201],"features":[202],"can":[207],"allow":[208],"for":[209]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":26},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}