{"id":"https://openalex.org/W2008666148","doi":"https://doi.org/10.1111/jvh.12387","title":"Definition of an HB sAg to DNA international unit conversion factor by enrichment of circulating hepatitis B virus forms","display_name":"Definition of an HB sAg to DNA international unit conversion factor by enrichment of circulating hepatitis B virus forms","publication_year":2015,"publication_date":"2015-01-29","ids":{"openalex":"https://openalex.org/W2008666148","doi":"https://doi.org/10.1111/jvh.12387","mag":"2008666148","pmid":"https://pubmed.ncbi.nlm.nih.gov/25644062"},"language":"en","primary_location":{"id":"doi:10.1111/jvh.12387","doi":"https://doi.org/10.1111/jvh.12387","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jvh.12387","pdf_url":null,"source":{"id":"https://openalex.org/S164225461","display_name":"Journal of Viral Hepatitis","issn_l":"1352-0504","issn":["1352-0504","1365-2893"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Viral Hepatitis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024418361","display_name":"Nathalie D\u00e9sir\u00e9","orcid":"https://orcid.org/0000-0002-3129-4342","observed_orcids":["https://orcid.org/0000-0002-3129-4342"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"N. D\u00e9sir\u00e9","raw_affiliation_strings":["Inserm U1135 Paris France","Virology Department Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital AP\u2010HP Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1135 Paris France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Virology Department Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital AP\u2010HP Paris France","institution_ids":["https://openalex.org/I4210121705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047242678","display_name":"Yen Ngo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Y. Ngo","raw_affiliation_strings":["Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital Service d'H\u00e9pato\u2010Gastro\u2010Ent\u00e9rologie Universit\u00e9 Paris 6 CNRS UMR 8149 AP\u2010HP Paris France","UMR 8149 UPMC Univ Paris 06 Sorbonne Universit\u00e9s Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital Service d'H\u00e9pato\u2010Gastro\u2010Ent\u00e9rologie Universit\u00e9 Paris 6 CNRS UMR 8149 AP\u2010HP Paris France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210121705","https://openalex.org/I4405264447"]},{"raw_affiliation_string":"UMR 8149 UPMC Univ Paris 06 Sorbonne Universit\u00e9s Paris France","institution_ids":["https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020848386","display_name":"Jean\u2010Fran\u00e7ois Franetich","orcid":"https://orcid.org/0000-0002-3308-8550","observed_orcids":["https://orcid.org/0000-0002-3308-8550"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J.\u2010F. Franetich","raw_affiliation_strings":["Inserm U1135, Paris, France","UMR S945 UPMC Univ Paris 06 Sorbonne Universit\u00e9s Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1135, Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"UMR S945 UPMC Univ Paris 06 Sorbonne Universit\u00e9s Paris France","institution_ids":["https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072378304","display_name":"Laurent Demb\u00e9l\u00e9","orcid":"https://orcid.org/0000-0001-9087-8439","observed_orcids":["https://orcid.org/0000-0001-9087-8439"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"L. Dembele","raw_affiliation_strings":["Inserm U1135, Paris, France","UMR S945 UPMC Univ Paris 06 Sorbonne Universit\u00e9s Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1135, Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"UMR S945 UPMC Univ Paris 06 Sorbonne Universit\u00e9s Paris France","institution_ids":["https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077020153","display_name":"Dominique Mazier","orcid":"https://orcid.org/0000-0002-8059-1810","observed_orcids":["https://orcid.org/0000-0002-8059-1810"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"D. Mazier","raw_affiliation_strings":["Inserm U1135, Paris, France","UMR S945 UPMC Univ Paris 06 Sorbonne Universit\u00e9s Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1135, Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"UMR S945 UPMC Univ Paris 06 Sorbonne Universit\u00e9s Paris France","institution_ids":["https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110959160","display_name":"Jean\u2010Christophe Vaillant","orcid":"https://orcid.org/0000-0003-0563-120X","observed_orcids":["https://orcid.org/0000-0003-0563-120X"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J.\u2010C. Vaillant","raw_affiliation_strings":["Service de Chirurgie Digestive H\u00e9pato\u2010Bilio\u2010Pancr\u00e9atique et Transplantation H\u00e9patique Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital AP\u2010HP Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Chirurgie Digestive H\u00e9pato\u2010Bilio\u2010Pancr\u00e9atique et Transplantation H\u00e9patique Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital AP\u2010HP Paris France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000462944","display_name":"Thierry Poynard","orcid":"https://orcid.org/0000-0002-3726-7230","observed_orcids":["https://orcid.org/0000-0002-3726-7230"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"T. Poynard","raw_affiliation_strings":["Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital Service d'H\u00e9pato\u2010Gastro\u2010Ent\u00e9rologie Universit\u00e9 Paris 6 CNRS UMR 8149 AP\u2010HP Paris France","UMR 8149 UPMC Univ Paris 06 Sorbonne Universit\u00e9s Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital Service d'H\u00e9pato\u2010Gastro\u2010Ent\u00e9rologie Universit\u00e9 Paris 6 CNRS UMR 8149 AP\u2010HP Paris France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210121705","https://openalex.org/I4405264447"]},{"raw_affiliation_string":"UMR 8149 UPMC Univ Paris 06 Sorbonne Universit\u00e9s Paris France","institution_ids":["https://openalex.org/I4405264447"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067253433","display_name":"Vincent Thibault","orcid":"https://orcid.org/0000-0001-6517-2901","observed_orcids":["https://orcid.org/0000-0001-6517-2901"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"V. Thibault","raw_affiliation_strings":["Inserm U1135 Paris France","Virology Department Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital AP\u2010HP Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1135 Paris France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Virology Department Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital AP\u2010HP Paris France","institution_ids":["https://openalex.org/I4210121705"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5067253433"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210121705"],"apc_list":{"value":4610,"currency":"USD","value_usd":4610},"apc_paid":null,"fwci":1.5062,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.80730181,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"22","issue":"9","first_page":"718","last_page":"726"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.9879999756813049},{"id":"https://openalex.org/keywords/hepatitis-b-surface-antigen","display_name":"hepatitis B surface antigen","score":0.6650000214576721},{"id":"https://openalex.org/keywords/hbv-dna","display_name":"HBV DNA","score":0.8740000128746033},{"id":"https://openalex.org/keywords/subviral-particles","display_name":"subviral particles","score":0.9279999732971191},{"id":"https://openalex.org/keywords/dane-particles","display_name":"Dane particles","score":0.8500000238418579},{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":0.875},{"id":"https://openalex.org/keywords/primary-human-hepatocytes","display_name":"primary human hepatocytes","score":0.8370000123977661},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.39100000262260437},{"id":"https://openalex.org/keywords/hbsag-quantification","display_name":"HBsAg quantification","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C2777410769","wikidata":"https://www.wikidata.org/wiki/Q2282887","display_name":"HBsAg","level":4,"score":0.8980539441108704},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.7550656199455261},{"id":"https://openalex.org/C2775940106","wikidata":"https://www.wikidata.org/wiki/Q10478733","display_name":"HBeAg","level":5,"score":0.6325042843818665},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5345415472984314},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5342822074890137},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5006768703460693},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.45820167660713196},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38442230224609375},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3556824326515198},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3522992730140686},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34430092573165894},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22165408730506897},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08540147542953491}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003955","descriptor_name":"Diagnostic Tests, Routine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006514","descriptor_name":"Hepatitis B Surface Antigens","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/jvh.12387","doi":"https://doi.org/10.1111/jvh.12387","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jvh.12387","pdf_url":null,"source":{"id":"https://openalex.org/S164225461","display_name":"Journal of Viral Hepatitis","issn_l":"1352-0504","issn":["1352-0504","1365-2893"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Viral Hepatitis","raw_type":"journal-article"},{"id":"pmid:25644062","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25644062","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of viral hepatitis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320321445","display_name":"Assistance Publique - H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14"},{"id":"https://openalex.org/F4320321833","display_name":"Agence Nationale de Recherches sur le Sida et les H\u00e9patites Virales","ror":"https://ror.org/01kv58h76"},{"id":"https://openalex.org/F4320323400","display_name":"Universit\u00e9 Pierre et Marie Curie","ror":"https://ror.org/02en5vm52"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W39008639","https://openalex.org/W175109609","https://openalex.org/W253357658","https://openalex.org/W1481674391","https://openalex.org/W1642879362","https://openalex.org/W1751218746","https://openalex.org/W1970934632","https://openalex.org/W1997681955","https://openalex.org/W2009631075","https://openalex.org/W2010266469","https://openalex.org/W2012414573","https://openalex.org/W2022627036","https://openalex.org/W2026179924","https://openalex.org/W2033837061","https://openalex.org/W2035857574","https://openalex.org/W2038334617","https://openalex.org/W2043987692","https://openalex.org/W2050571266","https://openalex.org/W2061171442","https://openalex.org/W2072159851","https://openalex.org/W2089908069","https://openalex.org/W2094798000","https://openalex.org/W2103169204","https://openalex.org/W2103776714","https://openalex.org/W2107057287","https://openalex.org/W2116951262","https://openalex.org/W2120426460","https://openalex.org/W2123335423","https://openalex.org/W2132760779","https://openalex.org/W2143130283","https://openalex.org/W2143853300","https://openalex.org/W2157039129","https://openalex.org/W2330570786","https://openalex.org/W2417372645"],"related_works":["https://openalex.org/W4309138762","https://openalex.org/W2519905611","https://openalex.org/W2040490434","https://openalex.org/W2568316277","https://openalex.org/W4414119795","https://openalex.org/W2900868509","https://openalex.org/W4411488067","https://openalex.org/W2343361526","https://openalex.org/W7120307824","https://openalex.org/W7044670295"],"abstract_inverted_index":{"Hepatitis":[0],"B":[1],"(HBV)":[2],"virus":[3,142],"infection":[4,209],"is":[5,27],"characterized":[6,120],"by":[7,121,127],"the":[8,22,44,55,110,158,187,198,202,218,235],"overproduction":[9],"of":[10,21,57,96,109,131,141,163,171,189,201,221,238,246],"subviral":[11],"particles":[12,17],"(SVP)":[13],"over":[14,241],"infectious":[15],"Dane":[16],"(VP).":[18],"Precise":[19],"regulation":[20,237],"ratio":[23,46,149],"between":[24],"these":[25],"forms":[26],"unknown,":[28],"but":[29],"its":[30],"fluctuation":[31],"may":[32],"have":[33],"a":[34,115,122,147,183,228],"clinical":[35],"impact.":[36],"An":[37],"enrichment":[38],"method":[39],"was":[40,101],"applied":[41,178],"to":[42,53,138,151,166,206,217,233],"assess":[43],"SVP/VP":[45,148],"in":[47,85,93,143,154,191,225],"chronically":[48],"infected":[49],"patients":[50,71],"(CHB)":[51],"and":[52,61,77,81,210],"compare":[54],"sensitivity":[56,199],"HBs":[58],"antigen":[59],"(HBsAg)":[60],"DNA":[62,80],"detection":[63],"methods.":[64],"Plasmas":[65],"from":[66],"9":[67],"genotype":[68],"A-D":[69],"CHB":[70,193],"were":[72,83],"fractionated":[73,106],"on":[74,179],"Nycodenz(\u00ae)":[75],"gradients,":[76],"both":[78],"HBV":[79,172,208],"HBsAg":[82,164,214,224,239],"quantified":[84],"each":[86],"collected":[87],"fraction":[88],"using":[89],"standardized":[90],"techniques":[91,203],"expressed":[92],"IU/mL.":[94],"Infection":[95],"primary":[97],"human":[98],"hepatocytes":[99],"(PHHs)":[100],"performed":[102],"with":[103,133,146],"crude":[104],"or":[105],"plasma.":[107],"Independently":[108],"genotype,":[111],"all":[112],"plasmas":[113],"showed":[114],"similar":[116,150],"rate-zonal":[117],"separation":[118,176],"profile":[119],"bottom":[123],"DNA-enriched":[124],"peak":[125],"surmounted":[126],"HBsAg-enriched":[128],"fractions.":[129],"Inoculation":[130],"PHH":[132],"plasma-derived":[134],"VP-enriched":[135],"fractions":[136],"led":[137],"long-lasting":[139],"production":[140,240],"cell":[144],"supernatants":[145],"that":[152,212],"observed":[153],"patient":[155,180],"plasmas.":[156],"In":[157],"VP":[159,190],"fraction,":[160],"one":[161],"IU":[162,170],"corresponded":[165],"approximately":[167],"5":[168],"million":[169],"DNA.":[173],"Rate-zonal":[174],"gradient":[175],"directly":[177],"plasma":[181],"allows":[182],"better":[184],"insight":[185],"into":[186],"distribution":[188],"HBeAg-positive":[192],"carriers.":[194],"This":[195],"study":[196],"highlights":[197],"difference":[200],"classically":[204],"used":[205],"monitor":[207],"indicates":[211],"VP-associated":[213],"contributes":[215],"modestly":[216],"overall":[219],"amount":[220],"total":[222],"circulating":[223],"CHB.":[226,247],"Such":[227],"fractionation":[229],"approach":[230],"should":[231],"help":[232],"understand":[234],"fine":[236],"replication":[242],"at":[243],"different":[244],"stages":[245]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
