{"id":"https://openalex.org/W2008657247","doi":"https://doi.org/10.3389/fnagi.2013.00029","title":"Molecular mechanisms of cognitive dysfunction following traumatic brain injury","display_name":"Molecular mechanisms of cognitive dysfunction following traumatic brain injury","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2008657247","doi":"https://doi.org/10.3389/fnagi.2013.00029","mag":"2008657247","pmid":"https://pubmed.ncbi.nlm.nih.gov/23847533","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3705200"},"language":"en","primary_location":{"id":"doi:10.3389/fnagi.2013.00029","doi":"https://doi.org/10.3389/fnagi.2013.00029","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnagi.2013.00029","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnagi.2013.00029/pdf","source":{"id":"https://openalex.org/S118428158","display_name":"Frontiers in Aging Neuroscience","issn_l":"1663-4365","issn":["1663-4365"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fnagi.2013.00029/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Kendall R. Walker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kendall R. Walker","raw_affiliation_strings":["Alzheimer\u2019s Disease Research Laboratory, Department of Neuroscience, Tufts University School of Medicine, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Research Laboratory, Department of Neuroscience, Tufts University School of Medicine, Boston, MA, USA","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025046197","display_name":"Giuseppina Tesco","orcid":"https://orcid.org/0000-0002-3336-7488","observed_orcids":["https://orcid.org/0000-0002-3336-7488"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Giuseppina Tesco","raw_affiliation_strings":["Tufts University, Neuroscience, 136 Harrison Ave, ST 328A, Boston, 02111, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tufts University, Neuroscience, 136 Harrison Ave, ST 328A, Boston, 02111, Massachusetts, United States","institution_ids":["https://openalex.org/I121934306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025046197"],"corresponding_institution_ids":["https://openalex.org/I121934306"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":11.2732,"has_fulltext":true,"cited_by_count":281,"citation_normalized_percentile":{"value":0.99115273,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"5","issue":null,"first_page":"29","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.5859000086784363,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.5859000086784363,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.37299999594688416,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.02930000051856041,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":1.0},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.8040000200271606},{"id":"https://openalex.org/keywords/secondary-injury-mechanisms","display_name":"secondary injury mechanisms","score":0.7850000262260437},{"id":"https://openalex.org/keywords/chronic-traumatic-encephalopathy","display_name":"chronic traumatic encephalopathy","score":0.847000002861023},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8569999933242798},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.8270000219345093},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8830000162124634},{"id":"https://openalex.org/keywords/axonal-injury","display_name":"axonal injury","score":0.8080000281333923},{"id":"https://openalex.org/keywords/synaptic-dysfunction","display_name":"synaptic dysfunction","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neuronal-loss","display_name":"neuronal loss","score":0.7900000214576721},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.43799999356269836}],"concepts":[{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.7646284103393555},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.6292621493339539},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5679702758789062},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4608663022518158},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4300847053527832},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2673179507255554}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fnagi.2013.00029","doi":"https://doi.org/10.3389/fnagi.2013.00029","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnagi.2013.00029","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnagi.2013.00029/pdf","source":{"id":"https://openalex.org/S118428158","display_name":"Frontiers in Aging Neuroscience","issn_l":"1663-4365","issn":["1663-4365"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2703457","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3705200","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3705200","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3705200","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Aging Neurosci","raw_type":"Text"},{"id":"pmid:23847533","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23847533","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in aging neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:494ad9f017e54f75824568881e542f05","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/494ad9f017e54f75824568881e542f05","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Aging Neuroscience, Vol 5 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnagi.2013.00029","doi":"https://doi.org/10.3389/fnagi.2013.00029","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnagi.2013.00029","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnagi.2013.00029/pdf","source":{"id":"https://openalex.org/S118428158","display_name":"Frontiers in Aging Neuroscience","issn_l":"1663-4365","issn":["1663-4365"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4821014688","display_name":"Role of BACE in the pathogenesis of Alzheimer's disease after head trauma","funder_award_id":"R01AG033016","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6734258643","display_name":"Role of BACE stabilization in Alzheimer's disease","funder_award_id":"R01AG025952","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320309944","display_name":"Cure Alzheimer's Fund","ror":"https://ror.org/05ewr7t48"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2008657247.pdf","grobid_xml":"https://content.openalex.org/works/W2008657247.grobid-xml"},"referenced_works_count":275,"referenced_works":["https://openalex.org/W52983112","https://openalex.org/W1461993479","https://openalex.org/W1490397100","https://openalex.org/W1497928508","https://openalex.org/W1516718221","https://openalex.org/W1535134773","https://openalex.org/W1553957684","https://openalex.org/W1559324825","https://openalex.org/W1578695981","https://openalex.org/W1580550354","https://openalex.org/W1600183911","https://openalex.org/W1743419595","https://openalex.org/W1857364306","https://openalex.org/W1860908381","https://openalex.org/W1862284587","https://openalex.org/W1894924936","https://openalex.org/W1905311838","https://openalex.org/W1926095516","https://openalex.org/W1939082208","https://openalex.org/W1963667121","https://openalex.org/W1964169664","https://openalex.org/W1964574311","https://openalex.org/W1965918817","https://openalex.org/W1966558330","https://openalex.org/W1967157227","https://openalex.org/W1967464880","https://openalex.org/W1968155219","https://openalex.org/W1970892028","https://openalex.org/W1973418455","https://openalex.org/W1975656204","https://openalex.org/W1976696624","https://openalex.org/W1977232716","https://openalex.org/W1983078635","https://openalex.org/W1983759041","https://openalex.org/W1984028460","https://openalex.org/W1986301740","https://openalex.org/W1988278010","https://openalex.org/W1989349429","https://openalex.org/W1989824843","https://openalex.org/W1990065094","https://openalex.org/W1990111821","https://openalex.org/W1990994673","https://openalex.org/W1991787085","https://openalex.org/W1993124121","https://openalex.org/W1994278260","https://openalex.org/W1994807972","https://openalex.org/W1994819066","https://openalex.org/W1996422388","https://openalex.org/W1998383478","https://openalex.org/W1998919607","https://openalex.org/W1999082266","https://openalex.org/W1999721410","https://openalex.org/W2001402586","https://openalex.org/W2001594475","https://openalex.org/W2003855031","https://openalex.org/W2004349171","https://openalex.org/W2005795337","https://openalex.org/W2007047564","https://openalex.org/W2008030217","https://openalex.org/W2008219426","https://openalex.org/W2008757745","https://openalex.org/W2009382150","https://openalex.org/W2010527958","https://openalex.org/W2010766264","https://openalex.org/W2011348649","https://openalex.org/W2011815976","https://openalex.org/W2011845342","https://openalex.org/W2011892319","https://openalex.org/W2011949052","https://openalex.org/W2012543913","https://openalex.org/W2012620766","https://openalex.org/W2013111251","https://openalex.org/W2013583419","https://openalex.org/W2014567150","https://openalex.org/W2015786514","https://openalex.org/W2016097648","https://openalex.org/W2017471497","https://openalex.org/W2017956681","https://openalex.org/W2018661667","https://openalex.org/W2019544787","https://openalex.org/W2019608814","https://openalex.org/W2020019327","https://openalex.org/W2021742640","https://openalex.org/W2022647670","https://openalex.org/W2023136593","https://openalex.org/W2023757933","https://openalex.org/W2023819682","https://openalex.org/W2024382752","https://openalex.org/W2025275866","https://openalex.org/W2026206739","https://openalex.org/W2028174194","https://openalex.org/W2028265367","https://openalex.org/W2029904352","https://openalex.org/W2030011352","https://openalex.org/W2030787334","https://openalex.org/W2031762170","https://openalex.org/W2032080482","https://openalex.org/W2032951220","https://openalex.org/W2033283296","https://openalex.org/W2035382111","https://openalex.org/W2035398481","https://openalex.org/W2035709128","https://openalex.org/W2036162274","https://openalex.org/W2036712372","https://openalex.org/W2037440669","https://openalex.org/W2037616499","https://openalex.org/W2038003980","https://openalex.org/W2040232914","https://openalex.org/W2040808375","https://openalex.org/W2041802741","https://openalex.org/W2044097582","https://openalex.org/W2044626031","https://openalex.org/W2044904524","https://openalex.org/W2045732157","https://openalex.org/W2046802002","https://openalex.org/W2046952010","https://openalex.org/W2047198245","https://openalex.org/W2049017493","https://openalex.org/W2049481822","https://openalex.org/W2050523782","https://openalex.org/W2050800676","https://openalex.org/W2051513829","https://openalex.org/W2052036530","https://openalex.org/W2053103401","https://openalex.org/W2054384828","https://openalex.org/W2054640009","https://openalex.org/W2054835198","https://openalex.org/W2056143628","https://openalex.org/W2057252927","https://openalex.org/W2057766834","https://openalex.org/W2057774514","https://openalex.org/W2057795759","https://openalex.org/W2058333671","https://openalex.org/W2058371877","https://openalex.org/W2058830580","https://openalex.org/W2059182725","https://openalex.org/W2059517195","https://openalex.org/W2059709590","https://openalex.org/W2060286035","https://openalex.org/W2060351135","https://openalex.org/W2060911909","https://openalex.org/W2061466239","https://openalex.org/W2062399102","https://openalex.org/W2063065406","https://openalex.org/W2063486140","https://openalex.org/W2064470441","https://openalex.org/W2064958479","https://openalex.org/W2065904280","https://openalex.org/W2066376812","https://openalex.org/W2066442550","https://openalex.org/W2067106012","https://openalex.org/W2067324713","https://openalex.org/W2068330750","https://openalex.org/W2070448139","https://openalex.org/W2071425128","https://openalex.org/W2072625029","https://openalex.org/W2072840073","https://openalex.org/W2073009405","https://openalex.org/W2073589898","https://openalex.org/W2073595496","https://openalex.org/W2074571304","https://openalex.org/W2075604126","https://openalex.org/W2075770826","https://openalex.org/W2076807570","https://openalex.org/W2077024919","https://openalex.org/W2078039302","https://openalex.org/W2078597721","https://openalex.org/W2078661875","https://openalex.org/W2079185455","https://openalex.org/W2079235734","https://openalex.org/W2081070804","https://openalex.org/W2081207317","https://openalex.org/W2081282178","https://openalex.org/W2081525217","https://openalex.org/W2083267691","https://openalex.org/W2084625947","https://openalex.org/W2088411318","https://openalex.org/W2088637934","https://openalex.org/W2089391594","https://openalex.org/W2090751165","https://openalex.org/W2091021351","https://openalex.org/W2092044187","https://openalex.org/W2092223649","https://openalex.org/W2092281175","https://openalex.org/W2092580775","https://openalex.org/W2092814867","https://openalex.org/W2093426751","https://openalex.org/W2094188444","https://openalex.org/W2094848718","https://openalex.org/W2095136054","https://openalex.org/W2095367777","https://openalex.org/W2096019298","https://openalex.org/W2099157718","https://openalex.org/W2099390250","https://openalex.org/W2100026237","https://openalex.org/W2100359094","https://openalex.org/W2103428562","https://openalex.org/W2103860290","https://openalex.org/W2105012205","https://openalex.org/W2105515629","https://openalex.org/W2105910930","https://openalex.org/W2106726179","https://openalex.org/W2106729121","https://openalex.org/W2106733186","https://openalex.org/W2106837589","https://openalex.org/W2109837753","https://openalex.org/W2110498232","https://openalex.org/W2115953703","https://openalex.org/W2116016048","https://openalex.org/W2117983251","https://openalex.org/W2120307371","https://openalex.org/W2120802597","https://openalex.org/W2122046606","https://openalex.org/W2123974942","https://openalex.org/W2124054037","https://openalex.org/W2124127229","https://openalex.org/W2124245455","https://openalex.org/W2124443688","https://openalex.org/W2124478244","https://openalex.org/W2124541280","https://openalex.org/W2124729399","https://openalex.org/W2124894530","https://openalex.org/W2125405084","https://openalex.org/W2125948731","https://openalex.org/W2126340923","https://openalex.org/W2128960489","https://openalex.org/W2129285116","https://openalex.org/W2129985526","https://openalex.org/W2130473558","https://openalex.org/W2132018272","https://openalex.org/W2132066310","https://openalex.org/W2132397828","https://openalex.org/W2135380777","https://openalex.org/W2136321913","https://openalex.org/W2136942291","https://openalex.org/W2137832426","https://openalex.org/W2137938185","https://openalex.org/W2138577197","https://openalex.org/W2139552156","https://openalex.org/W2140432027","https://openalex.org/W2140655858","https://openalex.org/W2141166280","https://openalex.org/W2141655042","https://openalex.org/W2142046013","https://openalex.org/W2142851017","https://openalex.org/W2146373526","https://openalex.org/W2147435466","https://openalex.org/W2148508813","https://openalex.org/W2149954869","https://openalex.org/W2151373091","https://openalex.org/W2153438315","https://openalex.org/W2153885285","https://openalex.org/W2153966730","https://openalex.org/W2155075190","https://openalex.org/W2155971051","https://openalex.org/W2157743819","https://openalex.org/W2158592797","https://openalex.org/W2160220922","https://openalex.org/W2161919187","https://openalex.org/W2165557965","https://openalex.org/W2169908210","https://openalex.org/W2170725855","https://openalex.org/W2170921124","https://openalex.org/W2185009194","https://openalex.org/W2206023631","https://openalex.org/W2296293854","https://openalex.org/W2319236841","https://openalex.org/W2338817593","https://openalex.org/W2402602414","https://openalex.org/W2405229097","https://openalex.org/W2548000951","https://openalex.org/W2736091234","https://openalex.org/W4241684762","https://openalex.org/W4249688612","https://openalex.org/W4297069145"],"related_works":["https://openalex.org/W3034508140","https://openalex.org/W4285106147","https://openalex.org/W4396831234","https://openalex.org/W2999135873","https://openalex.org/W7128002657","https://openalex.org/W3097826984","https://openalex.org/W7212906126","https://openalex.org/W2961425819","https://openalex.org/W6907405355","https://openalex.org/W2069802231"],"abstract_inverted_index":{"Traumatic":[0],"brain":[1],"injury":[2,85,175],"(TBI)":[3],"results":[4],"in":[5,13,26,136,152],"significant":[6,59],"disability":[7],"due":[8],"to":[9,66,89,117,184],"cognitive":[10,70,100],"deficits":[11],"particularly":[12],"attention,":[14],"learning":[15],"and":[16,18,29,46,95,98,104,126,139,143],"memory,":[17],"higher-order":[19],"executive":[20],"functions.":[21],"The":[22],"role":[23,148],"of":[24,32,54,81,120,123,131,146,149,168,172],"TBI":[25,116,142,169],"chronic":[27,49,185],"neurodegeneration":[28],"the":[30,82,113,118,147],"development":[31,119],"neurodegenerative":[33],"diseases":[34],"including":[35],"Alzheimer's":[36],"disease":[37,40],"(AD),":[38],"Parkinson's":[39],"(PD),":[41],"Amyotrophic":[42],"Lateral":[43],"Sclerosis":[44],"(ALS)":[45],"most":[47],"recently":[48],"traumatic":[50],"encephalopathy":[51],"(CTE)":[52],"is":[53,170],"particular":[55,109],"importance.":[56],"However,":[57],"despite":[58],"effort":[60],"very":[61],"few":[62],"therapeutic":[63],"options":[64],"exist":[65],"prevent":[67],"or":[68],"reverse":[69],"impairment":[71,101],"following":[72,106,141],"TBI.":[73,107],"In":[74,108],"this":[75],"review,":[76],"we":[77,110,156],"present":[78],"experimental":[79],"evidence":[80,130,145],"known":[83],"secondary":[84,174],"mechanisms":[86,114,134,151,176],"which":[87,161],"contribute":[88],"neuronal":[90],"cell":[91],"loss,":[92],"axonal":[93],"injury,":[94],"synaptic":[96],"dysfunction":[97],"hence":[99],"both":[102],"acutely":[103],"chronically":[105],"focus":[111],"on":[112],"linking":[115],"two":[121],"forms":[122],"dementia:":[124],"AD":[125,153],"CTE.":[127],"We":[128],"provide":[129,144],"potential":[132],"molecular":[133],"involved":[135],"modulating":[137],"A\u03b2":[138,162],"Tau":[140],"these":[150],"pathology.":[154],"Additionally":[155],"propose":[157],"a":[158,165,179],"mechanism":[159],"by":[160],"generated":[163],"as":[164],"direct":[166],"result":[167],"capable":[171],"exacerbating":[173],"thereby":[177],"establishing":[178],"neurotoxic":[180],"cascade":[181],"that":[182],"leads":[183],"neurodegeneration.":[186]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":24},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":39},{"year":2019,"cited_by_count":32},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":27},{"year":2016,"cited_by_count":21},{"year":2015,"cited_by_count":19},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}