{"id":"https://openalex.org/W2008654233","doi":"https://doi.org/10.1034/j.1600-0404.2003.00166.x","title":"Impact of recently diagnosed multiple sclerosis on quality of life, anxiety, depression and distress of patients and partners","display_name":"Impact of recently diagnosed multiple sclerosis on quality of life, anxiety, depression and distress of patients and partners","publication_year":2003,"publication_date":"2003-09-12","ids":{"openalex":"https://openalex.org/W2008654233","doi":"https://doi.org/10.1034/j.1600-0404.2003.00166.x","mag":"2008654233","pmid":"https://pubmed.ncbi.nlm.nih.gov/14616290"},"language":"en","primary_location":{"id":"doi:10.1034/j.1600-0404.2003.00166.x","doi":"https://doi.org/10.1034/j.1600-0404.2003.00166.x","is_oa":false,"landing_page_url":"https://doi.org/10.1034/j.1600-0404.2003.00166.x","pdf_url":null,"source":{"id":"https://openalex.org/S66034498","display_name":"Acta Neurologica Scandinavica","issn_l":"0001-6314","issn":["0001-6314","1600-0404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neurologica Scandinavica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026632683","display_name":"A. Cecile J.W. Janssens","orcid":"https://orcid.org/0000-0002-6153-4976","observed_orcids":["https://orcid.org/0000-0002-6153-4976"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A. C. J. W. Janssens","raw_affiliation_strings":["Department of Neurology, Erasmus MC, Rotterdam, The Netherlands","Department of Medical Psychology and Psychotherapy, Erasmus MC, Rotterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Erasmus MC, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686"]},{"raw_affiliation_string":"Department of Medical Psychology and Psychotherapy, Erasmus MC, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037368893","display_name":"Pieter A. van Doorn","orcid":"https://orcid.org/0000-0003-2584-3357","observed_orcids":["https://orcid.org/0000-0003-2584-3357","https://orcid.org/0000-0002-3208-3475"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"P. A. van Doorn","raw_affiliation_strings":["Department of Neurology, Erasmus MC, Rotterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Erasmus MC, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022140613","display_name":"Josien B. de Boer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J. B. de Boer","raw_affiliation_strings":["Department of Medical Psychology and Psychotherapy, Erasmus MC, Rotterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Psychology and Psychotherapy, Erasmus MC, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111951366","display_name":"F.G.A. van der Mech\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"F. G. A. van der Mech\u00e9","raw_affiliation_strings":["Department of Neurology, Erasmus MC, Rotterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Erasmus MC, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026470404","display_name":"Jan Passchier","orcid":"https://orcid.org/0000-0002-7319-7188","observed_orcids":["https://orcid.org/0000-0002-7319-7188"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J. Passchier","raw_affiliation_strings":["Department of Medical Psychology and Psychotherapy, Erasmus MC, Rotterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Psychology and Psychotherapy, Erasmus MC, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103531311","display_name":"Rogier Q. Hintzen","orcid":"https://orcid.org/0000-0003-2585-3643","observed_orcids":["https://orcid.org/0000-0003-2585-3643"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"R. Q. Hintzen","raw_affiliation_strings":["Department of Neurology, Erasmus MC, Rotterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Erasmus MC, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2801952686"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":null,"fwci":3.9889,"has_fulltext":false,"cited_by_count":295,"citation_normalized_percentile":{"value":0.93345196,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"108","issue":"6","first_page":"389","last_page":"395"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":1.0},{"id":"https://openalex.org/keywords/newly-diagnosed-patients","display_name":"newly diagnosed patients","score":0.7229999899864197},{"id":"https://openalex.org/keywords/partners-of-patients","display_name":"partners of patients","score":0.6959999799728394},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8880000114440918},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.9760000109672546},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":1.0},{"id":"https://openalex.org/keywords/psychological-distress","display_name":"psychological distress","score":0.7490000128746033},{"id":"https://openalex.org/keywords/emotional-burden","display_name":"emotional burden","score":0.7950000166893005},{"id":"https://openalex.org/keywords/disability-severity","display_name":"disability severity","score":0.6259999871253967},{"id":"https://openalex.org/keywords/functional-limitations","display_name":"functional limitations","score":0.5929999947547913},{"id":"https://openalex.org/keywords/psychological-support","display_name":"psychological support","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.8406791687011719},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.7611312866210938},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.7423932552337646},{"id":"https://openalex.org/C139265228","wikidata":"https://www.wikidata.org/wiki/Q5283089","display_name":"Distress","level":2,"score":0.7198436856269836},{"id":"https://openalex.org/C2778739829","wikidata":"https://www.wikidata.org/wiki/Q17027611","display_name":"Hospital Anxiety and Depression Scale","level":3,"score":0.6184879541397095},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.5630218386650085},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5501155257225037},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.508396327495575},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5019731521606445},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.4371471107006073},{"id":"https://openalex.org/C3020031316","wikidata":"https://www.wikidata.org/wiki/Q6817452","display_name":"Psychological distress","level":3,"score":0.43231379985809326},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3715416193008423},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17341655492782593},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D003625","descriptor_name":"Data Collection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018454","descriptor_name":"Spouses","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1034/j.1600-0404.2003.00166.x","doi":"https://doi.org/10.1034/j.1600-0404.2003.00166.x","is_oa":false,"landing_page_url":"https://doi.org/10.1034/j.1600-0404.2003.00166.x","pdf_url":null,"source":{"id":"https://openalex.org/S66034498","display_name":"Acta Neurologica Scandinavica","issn_l":"0001-6314","issn":["0001-6314","1600-0404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neurologica Scandinavica","raw_type":"journal-article"},{"id":"pmid:14616290","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14616290","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta neurologica Scandinavica","raw_type":"Comparative Study"},{"id":"pmh:oai:pure.eur.nl:openaire_cris_publications/8b302c88-9be7-4c24-ac9f-377902ee0f59","doi":null,"is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/8b302c88-9be7-4c24-ac9f-377902ee0f59","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Janssens, C, van Doorn, P, de Boer, JB, Meche, F, Passchier, J & Hintzen, R 2003, 'Impact of recently diagnosed multiple sclerosis on quality of life, anxiety, depression and distress of patients and partners', Acta Neurologica Scandinavica, vol. 108, pp. 389-395. https://doi.org/10.1034/j.1600-0404.2003.00166.x","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:pure.eur.nl:publications/8b302c88-9be7-4c24-ac9f-377902ee0f59","doi":null,"is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/8b302c88-9be7-4c24-ac9f-377902ee0f59","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Neurologica Scandinavica, 108, 389 - 395. Wiley-Blackwell Publishing Ltd","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W89624907","https://openalex.org/W1810877555","https://openalex.org/W1968978629","https://openalex.org/W1978542069","https://openalex.org/W2004721338","https://openalex.org/W2009268161","https://openalex.org/W2017170615","https://openalex.org/W2034417379","https://openalex.org/W2037377025","https://openalex.org/W2050271629","https://openalex.org/W2051439236","https://openalex.org/W2055574804","https://openalex.org/W2061343308","https://openalex.org/W2066358461","https://openalex.org/W2076989760","https://openalex.org/W2086826898","https://openalex.org/W2097735742","https://openalex.org/W2098147922","https://openalex.org/W2102471539","https://openalex.org/W2106866241","https://openalex.org/W2112165124","https://openalex.org/W2130355701","https://openalex.org/W2131630839","https://openalex.org/W2135934250","https://openalex.org/W2138123424","https://openalex.org/W2163790711","https://openalex.org/W2166281097","https://openalex.org/W2418942173","https://openalex.org/W4230030041","https://openalex.org/W4292806894"],"related_works":["https://openalex.org/W2162191903","https://openalex.org/W2090042313","https://openalex.org/W1998137645","https://openalex.org/W2568652617","https://openalex.org/W4378234845","https://openalex.org/W1997479346","https://openalex.org/W7010700054","https://openalex.org/W2372142080","https://openalex.org/W7097948049","https://openalex.org/W1983380774"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Studies":[1],"demonstrating":[2],"reduced":[3],"quality":[4,37,52],"of":[5,22,26,38,40,53,68,91,96,103,107,112,117,121,139,164],"life":[6,39,54,140],"and":[7,36,45,57,61,64,76,94,105,110,124,158,166],"psychological":[8,192],"well-being":[9],"in":[10,73,128,144,168],"multiple":[11],"sclerosis":[12],"(MS)":[13],"have":[14],"typically":[15],"investigated":[16],"patients":[17,44,75,93,109,129,145,157],"within":[18],"more":[19,131],"advanced":[20],"stages":[21],"disease.":[23],"The":[24],"aim":[25],"the":[27,33,92,97,108,113,169,173],"present":[28],"paper":[29],"was":[30,141],"to":[31,184],"evaluate":[32],"emotional":[34],"burden":[35],"recently":[41],"diagnosed":[42],"MS":[43],"their":[46,77,159],"partners.":[47],"METHODS:":[48],"Data":[49],"on":[50],"health-related":[51],"(SF-36),":[55],"anxiety":[56,165],"depression":[58,123],"(Hospital":[59],"Anxiety":[60],"Depression":[62],"Scale)":[63,70],"disease-related":[65],"distress":[66,125,167],"(Impact":[67],"Event":[69],"were":[71,126],"obtained":[72],"101":[74],"partners":[78,98,114,160],"(n=78).":[79],"RESULTS:":[80],"On":[81],"average":[82],"8":[83],"months":[84],"after":[85,172],"diagnosis":[86],"(range":[87],"0-24":[88],"months),":[89],"34%":[90],"40%":[95],"had":[99,115],"clinically":[100],"high":[101,162],"levels":[102,116,163],"anxiety,":[104,122],"36%":[106],"24%":[111],"severe":[118],"distress.":[119],"Scores":[120],"higher":[127,153],"with":[130,147,152],"functional":[132],"limitations":[133],"(Expanded":[134],"Disability":[135],"Status":[136],"Scale=3.0).":[137],"Quality":[138],"significantly":[142],"poorer":[143],"compared":[146],"controls,":[148],"particularly":[149],"among":[150],"those":[151,186],"disability.":[154],"CONCLUSIONS:":[155],"Both":[156],"demonstrated":[161],"early":[170],"period":[171],"diagnosis.":[174],"These":[175],"findings":[176],"indicate":[177],"careful":[178],"attention":[179],"by":[180],"health":[181],"care":[182],"professionals":[183],"identify":[185],"who":[187],"may":[188],"benefit":[189],"from":[190],"further":[191],"support.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":18}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}