{"id":"https://openalex.org/W2008649974","doi":"https://doi.org/10.1002/ptr.1527","title":"The antimycobacterial components of hops (Humulus lupulus) and their dereplication","display_name":"The antimycobacterial components of hops (Humulus lupulus) and their dereplication","publication_year":2004,"publication_date":"2004-09-01","ids":{"openalex":"https://openalex.org/W2008649974","doi":"https://doi.org/10.1002/ptr.1527","mag":"2008649974","pmid":"https://pubmed.ncbi.nlm.nih.gov/15478197"},"language":"en","primary_location":{"id":"doi:10.1002/ptr.1527","doi":"https://doi.org/10.1002/ptr.1527","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ptr.1527","pdf_url":null,"source":{"id":"https://openalex.org/S206789554","display_name":"Phytotherapy Research","issn_l":"0951-418X","issn":["0951-418X","1099-1573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050948974","display_name":"Michael Stavri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124357947","display_name":"University of London","ror":"https://ror.org/04cw6st05","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947"]},{"id":"https://openalex.org/I4405283614","display_name":"UCL School of Pharmacy","ror":"https://ror.org/01zna6t55","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405283614","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael Stavri","raw_affiliation_strings":["Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, UK","institution_ids":["https://openalex.org/I124357947","https://openalex.org/I4405283614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102261831","display_name":"Ruth Schneider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124357947","display_name":"University of London","ror":"https://ror.org/04cw6st05","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947"]},{"id":"https://openalex.org/I4405283614","display_name":"UCL School of Pharmacy","ror":"https://ror.org/01zna6t55","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405283614","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ruth Schneider","raw_affiliation_strings":["Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, London, UK","institution_ids":["https://openalex.org/I124357947","https://openalex.org/I4405283614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044509696","display_name":"Gemma O\u2019Donnell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124357947","display_name":"University of London","ror":"https://ror.org/04cw6st05","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947"]},{"id":"https://openalex.org/I4405283614","display_name":"UCL School of Pharmacy","ror":"https://ror.org/01zna6t55","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405283614","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gemma O'Donnell","raw_affiliation_strings":["Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, London, UK","institution_ids":["https://openalex.org/I124357947","https://openalex.org/I4405283614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072255597","display_name":"Doris Lechner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124357947","display_name":"University of London","ror":"https://ror.org/04cw6st05","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947"]},{"id":"https://openalex.org/I4405283614","display_name":"UCL School of Pharmacy","ror":"https://ror.org/01zna6t55","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405283614","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Doris Lechner","raw_affiliation_strings":["Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, London, UK","institution_ids":["https://openalex.org/I124357947","https://openalex.org/I4405283614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012672741","display_name":"Franz Bu\u010dar","orcid":"https://orcid.org/0000-0002-7417-616X","observed_orcids":["https://orcid.org/0000-0002-7417-616X"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Franz Bucar","raw_affiliation_strings":["Institute for Pharmacognosy, University of Graz, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Pharmacognosy, University of Graz, Graz, Austria","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087444768","display_name":"Simon Gibbons","orcid":"https://orcid.org/0000-0003-1587-6809","observed_orcids":["https://orcid.org/0000-0003-1587-6809","https://orcid.org/0000-0001-6366-0215"]},"institutions":[{"id":"https://openalex.org/I124357947","display_name":"University of London","ror":"https://ror.org/04cw6st05","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947"]},{"id":"https://openalex.org/I4405283614","display_name":"UCL School of Pharmacy","ror":"https://ror.org/01zna6t55","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405283614","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Simon Gibbons","raw_affiliation_strings":["Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, London, UK","institution_ids":["https://openalex.org/I124357947","https://openalex.org/I4405283614"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5087444768"],"corresponding_institution_ids":["https://openalex.org/I124357947","https://openalex.org/I4405283614"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":2.7067,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.87806013,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"18","issue":"9","first_page":"774","last_page":"776"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13798","display_name":"Hops Chemistry and Applications","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13798","display_name":"Hops Chemistry and Applications","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hop","display_name":"Humulus lupulus","score":0.9670000076293945},{"id":"https://openalex.org/keywords/antimycobacterial-activity","display_name":"antimycobacterial activity","score":0.9330000281333923},{"id":"https://openalex.org/keywords/dereplication","display_name":"dereplication","score":0.8370000123977661},{"id":"https://openalex.org/keywords/mycobacterium-fortuitum","display_name":"Mycobacterium fortuitum","score":0.9089999794960022},{"id":"https://openalex.org/keywords/fatty-acids","display_name":"fatty acids","score":0.8410000205039978},{"id":"https://openalex.org/keywords/oleic-acid","display_name":"oleic acid","score":0.9390000104904175},{"id":"https://openalex.org/keywords/linoleic-acid","display_name":"linoleic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/unsaturated-fatty-acids","display_name":"unsaturated fatty acids","score":0.9750000238418579},{"id":"https://openalex.org/keywords/bioassay-guided-fractionation","display_name":"bioassay-guided fractionation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/natural-product-screening","display_name":"natural product screening","score":0.5709999799728394},{"id":"https://openalex.org/keywords/lipophilic-extracts","display_name":"lipophilic extracts","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C2779421835","wikidata":"https://www.wikidata.org/wiki/Q104212","display_name":"Humulus lupulus","level":3,"score":0.9274116158485413},{"id":"https://openalex.org/C2779685592","wikidata":"https://www.wikidata.org/wiki/Q2853298","display_name":"Antimycobacterial","level":4,"score":0.9264881014823914},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6252593398094177},{"id":"https://openalex.org/C2780809830","wikidata":"https://www.wikidata.org/wiki/Q407426","display_name":"Linoleic acid","level":3,"score":0.546844482421875},{"id":"https://openalex.org/C2781403372","wikidata":"https://www.wikidata.org/wiki/Q207688","display_name":"Oleic acid","level":2,"score":0.4741727113723755},{"id":"https://openalex.org/C2779936771","wikidata":"https://www.wikidata.org/wiki/Q209727","display_name":"Palmitic acid","level":3,"score":0.4523232877254486},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.37397316098213196},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.3359718322753906},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.2988157868385315},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2841672897338867},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21347886323928833},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.055757492780685425},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C2776242653","wikidata":"https://www.wikidata.org/wiki/Q22907699","display_name":"Pepper","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009161","descriptor_name":"Mycobacterium","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009161","descriptor_name":"Mycobacterium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D027582","descriptor_name":"Humulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/ptr.1527","doi":"https://doi.org/10.1002/ptr.1527","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ptr.1527","pdf_url":null,"source":{"id":"https://openalex.org/S206789554","display_name":"Phytotherapy Research","issn_l":"0951-418X","issn":["0951-418X","1099-1573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy Research","raw_type":"journal-article"},{"id":"pmid:15478197","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15478197","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy research : PTR","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1351776","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1351776/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PHYTOTHERAPY RESEARCH , 18 (9) pp. 774-776. (2004)","raw_type":"Article"},{"id":"pmh:oai:ueaeprints.uea.ac.uk:75852","doi":null,"is_oa":false,"landing_page_url":"https://ueaeprints.uea.ac.uk/id/eprint/75852/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400384","display_name":"UEA Digital Repository (University of East Anglia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1118541","host_organization_name":"University of East Anglia","host_organization_lineage":["https://openalex.org/I1118541"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W607878787","https://openalex.org/W1608503145","https://openalex.org/W1848640367","https://openalex.org/W1979438375","https://openalex.org/W1989038565","https://openalex.org/W2015770292","https://openalex.org/W2037672318","https://openalex.org/W2039187492","https://openalex.org/W2051961864","https://openalex.org/W2080655099","https://openalex.org/W2086670976","https://openalex.org/W2113678087","https://openalex.org/W2125400249","https://openalex.org/W2148346877","https://openalex.org/W2165330946","https://openalex.org/W2170176073"],"related_works":["https://openalex.org/W4385543606","https://openalex.org/W4312201846","https://openalex.org/W1788270159","https://openalex.org/W2015770292","https://openalex.org/W2595045039","https://openalex.org/W2415286712","https://openalex.org/W4287833879","https://openalex.org/W4366165130","https://openalex.org/W2565480599","https://openalex.org/W1970740201"],"abstract_inverted_index":{"Bioassay-guided":[0],"fractionation":[1],"of":[2,6,42,51,57,66,105,119,139,142,160,164],"a":[3,31,43,146],"hexane":[4],"extract":[5],"strobile":[7],"hops":[8],"(Humulus":[9],"lupulus)":[10],"was":[11,28],"undertaken":[12],"to":[13],"isolate":[14],"and":[15,35,60,70,80,98,108],"characterize":[16],"the":[17,21,40,52,55,94,112,158],"antimycobacterial":[18,151],"constituents":[19],"using":[20],"fast-growing":[22,113],"mycobacterial":[23],"species":[24,114],"Mycobacterium":[25],"fortuitum.":[26],"Activity":[27],"associated":[29],"with":[30,47,63],"low":[32],"polarity":[33],"fraction":[34],"1H":[36],"NMR":[37],"spectra":[38],"indicated":[39,54],"presence":[41,56],"fatty":[44,83,165],"acid":[45],"mixture":[46],"unsaturated":[48,95],"components.":[49],"GC-MS":[50,138],"derivatives":[53],"palmitic,":[58],"stearic":[59],"oleic":[61,97],"acids":[62,84,100],"small":[64],"quantities":[65],"lignoceric,":[67],"arachidic,":[68],"behenic":[69],"linoleic":[71,99],"acids.":[72,166],"These":[73],"compounds":[74],"were":[75,85],"assessed":[76],"against":[77,111],"M.":[78],"fortuitum":[79],"all":[81],"saturated":[82],"inactive":[86],"at":[87],"concentrations":[88,104],"greater":[89],"than":[90],"256":[91],"microg/ml,":[92],"whereas":[93],"fats":[96],"displayed":[101],"minimum":[102],"inhibitory":[103],"between":[106],"4":[107],"16":[109],"microg/ml":[110],"tested.":[115],"The":[116],"widespread":[117],"occurrence":[118],"these":[120],"components":[121,141],"could":[122],"render":[123],"screening":[124],"for":[125,162],"antimycobacterials":[126],"from":[127],"natural":[128],"sources":[129],"highly":[130],"problematic":[131],"without":[132],"adequate":[133],"dereplication.":[134],"We":[135],"propose":[136],"that":[137],"derivatised":[140],"lipophilic":[143],"extracts":[144],"be":[145],"first":[147],"step":[148],"before":[149],"any":[150],"bioassay-guided":[152],"study,":[153],"as":[154],"this":[155],"technique":[156],"is":[157],"method":[159],"choice":[161],"dereplication":[163]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}