{"id":"https://openalex.org/W2008579577","doi":"https://doi.org/10.1155/2012/472751","title":"Air Pollution, Oxidative Stress, and Alzheimer's Disease","display_name":"Air Pollution, Oxidative Stress, and Alzheimer's Disease","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2008579577","doi":"https://doi.org/10.1155/2012/472751","mag":"2008579577","pmid":"https://pubmed.ncbi.nlm.nih.gov/22523504","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3317180"},"language":"en","primary_location":{"id":"doi:10.1155/2012/472751","doi":"https://doi.org/10.1155/2012/472751","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/472751","pdf_url":"https://downloads.hindawi.com/journals/jeph/2012/472751.pdf","source":{"id":"https://openalex.org/S11392764","display_name":"Journal of Environmental and Public Health","issn_l":"1687-9805","issn":["1687-9805","1687-9813"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Environmental and Public Health","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/jeph/2012/472751.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015905180","display_name":"Paula Valencia Moulton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134113660","display_name":"University of Nevada, Reno","ror":"https://ror.org/01keh0577","country_code":"US","type":"education","lineage":["https://openalex.org/I134113660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paula Valencia Moulton","raw_affiliation_strings":["The Environmental Sciences and Health Graduate Program, University of Nevada, Reno, NV 89557-0186, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Environmental Sciences and Health Graduate Program, University of Nevada, Reno, NV 89557-0186, USA","institution_ids":["https://openalex.org/I134113660"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041364260","display_name":"Wei Yang","orcid":"https://orcid.org/0000-0002-7490-4710","observed_orcids":["https://orcid.org/0000-0002-7490-4710"]},"institutions":[{"id":"https://openalex.org/I134113660","display_name":"University of Nevada, Reno","ror":"https://ror.org/01keh0577","country_code":"US","type":"education","lineage":["https://openalex.org/I134113660"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wei Yang","raw_affiliation_strings":["School of Community Health Sciences, University of Nevada, Reno, NV 89557-0274, USA","The Environmental Sciences and Health Graduate Program, University of Nevada, Reno, NV 89557-0186, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Community Health Sciences, University of Nevada, Reno, NV 89557-0274, USA","institution_ids":["https://openalex.org/I134113660"]},{"raw_affiliation_string":"The Environmental Sciences and Health Graduate Program, University of Nevada, Reno, NV 89557-0186, USA","institution_ids":["https://openalex.org/I134113660"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041364260"],"corresponding_institution_ids":["https://openalex.org/I134113660"],"apc_list":{"value":1450,"currency":"USD","value_usd":1450},"apc_paid":{"value":1450,"currency":"USD","value_usd":1450},"fwci":1.4228,"has_fulltext":true,"cited_by_count":281,"citation_normalized_percentile":{"value":0.78453039,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"2012","issue":null,"first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.8169000148773193,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.8169000148773193,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.09030000120401382,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.06750000268220901,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9070000052452087},{"id":"https://openalex.org/keywords/air-pollution","display_name":"air pollution","score":1.0},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":1.0},{"id":"https://openalex.org/keywords/environmental-toxicants","display_name":"environmental toxins","score":0.8230000138282776},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.7599999904632568},{"id":"https://openalex.org/keywords/population-aging","display_name":"population aging","score":0.5699999928474426},{"id":"https://openalex.org/keywords/epidemiological-evidence","display_name":"epidemiological evidence","score":0.6430000066757202},{"id":"https://openalex.org/keywords/public-health-interventions","display_name":"public health interventions","score":0.8930000066757202}],"concepts":[{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.6682532429695129},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.638491690158844},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6273353695869446},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6249723434448242},{"id":"https://openalex.org/C64357122","wikidata":"https://www.wikidata.org/wiki/Q1149766","display_name":"Causality (physics)","level":2,"score":0.5844782590866089},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.5592992305755615},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.556398868560791},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5137215852737427},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.4738907217979431},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.47002267837524414},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4334949851036072},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.42813533544540405},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18936365842819214},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06495210528373718},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000393","descriptor_name":"Air Pollutants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000397","descriptor_name":"Air Pollution","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010126","descriptor_name":"Ozone","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D052638","descriptor_name":"Particulate Matter","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1155/2012/472751","doi":"https://doi.org/10.1155/2012/472751","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/472751","pdf_url":"https://downloads.hindawi.com/journals/jeph/2012/472751.pdf","source":{"id":"https://openalex.org/S11392764","display_name":"Journal of Environmental and Public Health","issn_l":"1687-9805","issn":["1687-9805","1687-9813"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Environmental and Public Health","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2335575","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3317180","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3317180","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3317180","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Environ Public Health","raw_type":"Text"},{"id":"pmid:22523504","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22523504","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of environmental and public health","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.271.470","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.271.470","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/76/7e/J_Environ_Public_Health_2012_Mar_15_2012_472751.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:fda7b19c82b6487e8dcadfb7b54b0955","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/fda7b19c82b6487e8dcadfb7b54b0955","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Environmental and Public Health, Vol 2012 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2012/472751","doi":"https://doi.org/10.1155/2012/472751","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/472751","pdf_url":"https://downloads.hindawi.com/journals/jeph/2012/472751.pdf","source":{"id":"https://openalex.org/S11392764","display_name":"Journal of Environmental and Public Health","issn_l":"1687-9805","issn":["1687-9805","1687-9813"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Environmental and Public Health","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320312725","display_name":"University of Nevada, Reno","ror":"https://ror.org/01keh0577"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2008579577.pdf","grobid_xml":"https://content.openalex.org/works/W2008579577.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W137912862","https://openalex.org/W161194141","https://openalex.org/W271555730","https://openalex.org/W1225974061","https://openalex.org/W1503895697","https://openalex.org/W1506998763","https://openalex.org/W1533541108","https://openalex.org/W1536018957","https://openalex.org/W1571725385","https://openalex.org/W1586118170","https://openalex.org/W1601731633","https://openalex.org/W1668274355","https://openalex.org/W1911339081","https://openalex.org/W1969330570","https://openalex.org/W1970033499","https://openalex.org/W1981076200","https://openalex.org/W1987408858","https://openalex.org/W1987478403","https://openalex.org/W1995100225","https://openalex.org/W1999631936","https://openalex.org/W2003366520","https://openalex.org/W2003933765","https://openalex.org/W2008649582","https://openalex.org/W2011072792","https://openalex.org/W2017581860","https://openalex.org/W2022392583","https://openalex.org/W2022523548","https://openalex.org/W2027189256","https://openalex.org/W2030135352","https://openalex.org/W2031253610","https://openalex.org/W2031654442","https://openalex.org/W2034224707","https://openalex.org/W2034707849","https://openalex.org/W2035170352","https://openalex.org/W2036566995","https://openalex.org/W2037707616","https://openalex.org/W2038484930","https://openalex.org/W2038769845","https://openalex.org/W2039705617","https://openalex.org/W2043090378","https://openalex.org/W2048807516","https://openalex.org/W2049192526","https://openalex.org/W2053247751","https://openalex.org/W2053379890","https://openalex.org/W2054384828","https://openalex.org/W2067623278","https://openalex.org/W2068609215","https://openalex.org/W2070046033","https://openalex.org/W2090858520","https://openalex.org/W2091387609","https://openalex.org/W2093767464","https://openalex.org/W2101861123","https://openalex.org/W2102768232","https://openalex.org/W2113007696","https://openalex.org/W2115251260","https://openalex.org/W2116237065","https://openalex.org/W2116334261","https://openalex.org/W2128903550","https://openalex.org/W2128969673","https://openalex.org/W2129270004","https://openalex.org/W2129852583","https://openalex.org/W2130261616","https://openalex.org/W2134787735","https://openalex.org/W2139826497","https://openalex.org/W2140282454","https://openalex.org/W2146141276","https://openalex.org/W2147243248","https://openalex.org/W2154812708","https://openalex.org/W2157359173","https://openalex.org/W2157713029","https://openalex.org/W2158822760","https://openalex.org/W2159200188","https://openalex.org/W2161093330","https://openalex.org/W2161576159","https://openalex.org/W2165462380","https://openalex.org/W2166551135","https://openalex.org/W2315512556","https://openalex.org/W2332175236","https://openalex.org/W2407546311","https://openalex.org/W4245099342"],"related_works":["https://openalex.org/W7097000963","https://openalex.org/W4414976299","https://openalex.org/W7163899692","https://openalex.org/W2995944111","https://openalex.org/W4240092866","https://openalex.org/W2788689682","https://openalex.org/W7222178750","https://openalex.org/W4379619201","https://openalex.org/W4253899426","https://openalex.org/W6884751384"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1],"(AD)":[2],"is":[3,30,66,87,106],"the":[4,26,69,81,90,115,119,133],"most":[5],"common":[6],"form":[7],"of":[8,12,71,93,142],"dementia":[9],"affecting":[10],"millions":[11,20],"people":[13],"worldwide":[14],"and":[15,39,124,126],"will":[16,137],"continue":[17],"to":[18,56,60,108],"affect":[19],"more":[21],"with":[22,97],"population":[23,99,134],"aging":[24],"on":[25,132],"rise.":[27],"AD":[28,53,79,125],"causality":[29],"multifactorial.":[31],"Known":[32],"causal":[33],"factors":[34],"include":[35],"genetic":[36],"predisposition,":[37],"age,":[38],"sex.":[40],"Environmental":[41],"toxins":[42],"such":[43],"as":[44],"air":[45],"pollution":[46],"(AP)":[47],"have":[48],"also":[49],"been":[50],"implicated":[51],"in":[52,68,78,140],"causation.":[54],"Exposure":[55],"AP":[57,74,94],"can":[58],"lead":[59],"chronic":[61],"oxidative":[62],"stress":[63],"(OS),":[64],"which":[65,136],"involved":[67],"pathogenesis":[70],"AD.":[72],"Whereas":[73],"plays":[75],"a":[76],"role":[77],"pathology,":[80],"epidemiological":[82,101],"evidence":[83,102,117,139],"for":[84,103,129],"this":[85,104,111],"association":[86],"limited.":[88],"Given":[89],"significant":[91],"prevalence":[92],"exposure":[95],"combined":[96],"increased":[98],"aging,":[100],"link":[105],"important":[107],"consider.":[109],"In":[110],"paper,":[112],"we":[113],"examine":[114],"existing":[116],"supporting":[118],"relationship":[120],"between":[121],"AP,":[122],"OS,":[123],"provide":[127,138],"recommendations":[128],"future":[130],"research":[131],"level,":[135],"support":[141],"public":[143],"health":[144],"interventions.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":26},{"year":2023,"cited_by_count":27},{"year":2022,"cited_by_count":30},{"year":2021,"cited_by_count":28},{"year":2020,"cited_by_count":33},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":21},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}