{"id":"https://openalex.org/W2008564385","doi":"https://doi.org/10.1091/mbc.e14-01-0683","title":"Reciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2","display_name":"Reciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2","publication_year":2014,"publication_date":"2014-03-26","ids":{"openalex":"https://openalex.org/W2008564385","doi":"https://doi.org/10.1091/mbc.e14-01-0683","mag":"2008564385","pmid":"https://pubmed.ncbi.nlm.nih.gov/24672053","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4019497"},"language":"en","primary_location":{"id":"doi:10.1091/mbc.e14-01-0683","doi":"https://doi.org/10.1091/mbc.e14-01-0683","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.e14-01-0683","pdf_url":null,"source":{"id":"https://openalex.org/S188085164","display_name":"Molecular Biology of the Cell","issn_l":"1059-1524","issn":["1059-1524","1939-4586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of the Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4019497","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000331309","display_name":"John Michael Lee","orcid":"https://orcid.org/0000-0001-8473-4674","observed_orcids":["https://orcid.org/0000-0001-8473-4674"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M. Lee","raw_affiliation_strings":["Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017708813","display_name":"Yiping Tu","orcid":"https://orcid.org/0000-0002-4630-9113","observed_orcids":["https://orcid.org/0000-0002-4630-9113"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yiping Tu","raw_affiliation_strings":["Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055875192","display_name":"Angelica Tatar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angelica Tatar","raw_affiliation_strings":["Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034606058","display_name":"Daniel Y. Wu","orcid":"https://orcid.org/0000-0002-3242-5172","observed_orcids":["https://orcid.org/0000-0002-3242-5172"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Wu","raw_affiliation_strings":["Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008166631","display_name":"Chika Nobumori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chika Nobumori","raw_affiliation_strings":["Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037537612","display_name":"Hea-Jin Jung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hea-Jin Jung","raw_affiliation_strings":["Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057960297","display_name":"Yuko Yoshinaga","orcid":"https://orcid.org/0000-0002-4978-9394","observed_orcids":["https://orcid.org/0000-0002-4978-9394"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuko Yoshinaga","raw_affiliation_strings":["Children's Hospital, Oakland Research Institute, Oakland, CA 94609"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital, Oakland Research Institute, Oakland, CA 94609","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039907737","display_name":"Catherine Coffinier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Coffinier","raw_affiliation_strings":["Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101563372","display_name":"Pieter J. de Jong","orcid":"https://orcid.org/0000-0002-7972-5260","observed_orcids":["https://orcid.org/0000-0002-7972-5260"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pieter J. de Jong","raw_affiliation_strings":["Children's Hospital, Oakland Research Institute, Oakland, CA 94609"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital, Oakland Research Institute, Oakland, CA 94609","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068606823","display_name":"Loren G. Fong","orcid":"https://orcid.org/0000-0002-4465-5290","observed_orcids":["https://orcid.org/0000-0002-4465-5290"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Loren G. Fong","raw_affiliation_strings":["Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085755071","display_name":"Stephen G. Young","orcid":"https://orcid.org/0000-0001-7270-3176","observed_orcids":["https://orcid.org/0000-0001-7270-3176"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen G. Young","raw_affiliation_strings":["Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095","Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095","Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095","dDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"dDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5068606823","https://openalex.org/A5085755071"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":null,"apc_paid":null,"fwci":1.5027,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.81019072,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"25","issue":"10","first_page":"1666","last_page":"1675"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lamin-b1","display_name":"lamin B1","score":0.9629999995231628},{"id":"https://openalex.org/keywords/lamin-b2","display_name":"lamin B2","score":1.0},{"id":"https://openalex.org/keywords/b-type-lamins","display_name":"B-type lamins","score":0.984000027179718},{"id":"https://openalex.org/keywords/functional-redundancy","display_name":"functional redundancy","score":0.7960000038146973},{"id":"https://openalex.org/keywords/neuronal-migration","display_name":"neuronal migration","score":0.722000002861023},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.7329999804496765},{"id":"https://openalex.org/keywords/complementation","display_name":"complementation","score":0.37299999594688416}],"concepts":[{"id":"https://openalex.org/C179093185","wikidata":"https://www.wikidata.org/wiki/Q424506","display_name":"Lamin","level":3,"score":0.976489782333374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7729038000106812},{"id":"https://openalex.org/C94912109","wikidata":"https://www.wikidata.org/wiki/Q687194","display_name":"Nuclear lamina","level":5,"score":0.6482275724411011},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.5280804634094238},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.43124544620513916},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.419107586145401},{"id":"https://openalex.org/C2796436","wikidata":"https://www.wikidata.org/wiki/Q3109064","display_name":"Gene knockin","level":3,"score":0.4111662805080414},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3823085427284241},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.28065410256385803},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.2508837580680847},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1881735622882843},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.13502147793769836},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.09457501769065857}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009436","descriptor_name":"Neural Tube Defects","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034881","descriptor_name":"Nuclear Lamina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034921","descriptor_name":"Lamin Type B","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D034921","descriptor_name":"Lamin Type B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055879","descriptor_name":"Gene Knock-In Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1091/mbc.e14-01-0683","doi":"https://doi.org/10.1091/mbc.e14-01-0683","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.e14-01-0683","pdf_url":null,"source":{"id":"https://openalex.org/S188085164","display_name":"Molecular Biology of the Cell","issn_l":"1059-1524","issn":["1059-1524","1939-4586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of the Cell","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4019497","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4019497","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Biol Cell","raw_type":"Text"},{"id":"pmid:24672053","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24672053","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology of the cell","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt4xs335c7","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/4xs335c7","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular biology of the cell, vol 25, iss 10","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt4xs335c7","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/4xs335c7","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Biology of the Cell, vol 25, iss 10","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4019497","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4019497","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Biol Cell","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.428600013256073,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G178143519","display_name":"New Therapeutic Approaches for Hutchinson-Gilford Progeria Syndrome","funder_award_id":"R01HL086683","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3278763530","display_name":null,"funder_award_id":"HL-089781","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3410830270","display_name":null,"funder_award_id":"HL-86683","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4522303692","display_name":"CaaX Protein Processing and Human Disease","funder_award_id":"R01AG035626","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5506362793","display_name":null,"funder_award_id":"AG035626","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5703994739","display_name":"Development of a New Therapeutic Approach for Prelamin A Diseases","funder_award_id":"R01AG047192","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6346852583","display_name":"Cardiovascular Scientist Training Program","funder_award_id":"T32HL007895","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8940860874","display_name":"Protein Prenylation and Progeria","funder_award_id":"R01HL089781","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1589817092","https://openalex.org/W1665551917","https://openalex.org/W1822464658","https://openalex.org/W1978257498","https://openalex.org/W1978390749","https://openalex.org/W1981648832","https://openalex.org/W1996899853","https://openalex.org/W2007107824","https://openalex.org/W2017985097","https://openalex.org/W2042168939","https://openalex.org/W2050505892","https://openalex.org/W2050680464","https://openalex.org/W2056074681","https://openalex.org/W2057329292","https://openalex.org/W2064005074","https://openalex.org/W2065776621","https://openalex.org/W2070067710","https://openalex.org/W2072236644","https://openalex.org/W2072308003","https://openalex.org/W2073786590","https://openalex.org/W2088969742","https://openalex.org/W2098100188","https://openalex.org/W2099925982","https://openalex.org/W2101083045","https://openalex.org/W2102613320","https://openalex.org/W2119932131","https://openalex.org/W2120207407","https://openalex.org/W2136490523","https://openalex.org/W2139797302","https://openalex.org/W2140358769","https://openalex.org/W2149467639","https://openalex.org/W2150148408","https://openalex.org/W2151614224","https://openalex.org/W2152506916","https://openalex.org/W2156426014","https://openalex.org/W2172254982","https://openalex.org/W2395929971"],"related_works":["https://openalex.org/W2000466664","https://openalex.org/W1978257498","https://openalex.org/W1978390749","https://openalex.org/W2070067710","https://openalex.org/W1991120047","https://openalex.org/W2042979866","https://openalex.org/W2042168939","https://openalex.org/W2337304908","https://openalex.org/W2140358769","https://openalex.org/W4407953719"],"abstract_inverted_index":{"Lamins":[0],"B1":[1,84,143,150,169],"and":[2,10,18,47,79,170,179],"B2":[3,73,97,135,163,171],"(B-type":[4],"lamins)":[5],"have":[6,58,172],"very":[7],"similar":[8],"sequences":[9],"are":[11],"expressed":[12],"ubiquitously.":[13],"In":[14],"addition,":[15],"both":[16],"Lmnb1-":[17],"Lmnb2-deficient":[19],"mice":[20,80,91,120,153],"die":[21],"soon":[22,104],"after":[23,105],"birth":[24,106],"with":[25,107,141],"neuronal":[26,37,108],"layering":[27,109],"abnormalities":[28,110,139],"in":[29,41,111,118,126,151,175],"the":[30,51,55,75,86,112,116,138,157,176,193],"cerebral":[31,113],"cortex,":[32],"a":[33],"consequence":[34],"of":[35,53,95,133,148,183,192],"defective":[36],"migration.":[38],"The":[39],"similarities":[40],"amino":[42],"acid":[43],"sequences,":[44],"expression":[45],"patterns,":[46],"knockout":[48],"phenotypes":[49],"raise":[50],"question":[52],"whether":[54],"two":[56],"proteins":[57],"redundant":[59],"functions.":[60],"To":[61],"investigate":[62],"this":[63],"topic,":[64],"we":[65],"generated":[66],"\"reciprocal":[67],"knock-in":[68],"mice\"-mice":[69],"that":[70,81,130,167,180],"make":[71,82],"lamin":[72,83,96,100,134,142,149,162,186],"from":[74,85],"Lmnb1":[76],"locus":[77,88],"(Lmnb1(B2/B2))":[78],"Lmnb2":[87],"(Lmnb2(B1/B1)).":[89],"Lmnb1(B2/B2)":[90,119],"produced":[92],"increased":[93,131,146,181],"amounts":[94,132,147],"but":[98],"no":[99],"B1;":[101],"they":[102],"died":[103],"cortex.":[114],"However,":[115],"defects":[117,159],"were":[121],"less":[122],"severe":[123],"than":[124],"those":[125],"Lmnb1-knockout":[127],"mice,":[128],"indicating":[129],"partially":[136],"ameliorate":[137],"associated":[140],"deficiency.":[144,164],"Similarly,":[145],"Lmnb2(B1/B1)":[152],"did":[154],"not":[155,188],"prevent":[156],"neurodevelopmental":[158],"elicited":[160],"by":[161],"We":[165],"conclude":[166],"lamins":[168],"unique":[173],"roles":[174],"developing":[177],"brain":[178],"production":[182],"one":[184],"B-type":[185],"does":[187],"fully":[189],"complement":[190],"loss":[191],"other.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
