{"id":"https://openalex.org/W2008559677","doi":"https://doi.org/10.1073/pnas.89.16.7796","title":"Role of rap1B and p21ras GTPase-activating protein in the regulation of phospholipase C-gamma 1 in human platelets.","display_name":"Role of rap1B and p21ras GTPase-activating protein in the regulation of phospholipase C-gamma 1 in human platelets.","publication_year":1992,"publication_date":"1992-08-15","ids":{"openalex":"https://openalex.org/W2008559677","doi":"https://doi.org/10.1073/pnas.89.16.7796","mag":"2008559677","pmid":"https://pubmed.ncbi.nlm.nih.gov/1323853","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/49798"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.89.16.7796","doi":"https://doi.org/10.1073/pnas.89.16.7796","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.89.16.7796","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC49798","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107839089","display_name":"Mauro Torti","orcid":"https://orcid.org/0000-0002-8607-2835","observed_orcids":["https://orcid.org/0000-0002-8607-2835"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Torti","raw_affiliation_strings":["Division of Cell Biology, Burroughs Wellcome Co., Research Triangle Park, NC 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Biology, Burroughs Wellcome Co., Research Triangle Park, NC 27709","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111851285","display_name":"Eduardo G. Lapetina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E G Lapetina","raw_affiliation_strings":["Division of Cell Biology, Burroughs Wellcome Co., Research Triangle Park, NC 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Biology, Burroughs Wellcome Co., Research Triangle Park, NC 27709","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7936,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.9185616,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"89","issue":"16","first_page":"7796","last_page":"7800"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phospholipase-c-gamma1","display_name":"phospholipase C-gamma1","score":0.9190000295639038},{"id":"https://openalex.org/keywords/rap1b","display_name":"Rap1b","score":0.9380000233650208},{"id":"https://openalex.org/keywords/human-platelets","display_name":"human platelets","score":0.9039999842643738},{"id":"https://openalex.org/keywords/thrombin","display_name":"thrombin","score":0.7540000081062317},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.824999988079071},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.8500000238418579},{"id":"https://openalex.org/keywords/protein-protein-complex-formation","display_name":"protein-protein complex formation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/signaling-complexes","display_name":"signaling complexes","score":0.6000000238418579},{"id":"https://openalex.org/keywords/ras-signaling","display_name":"Ras signaling","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C2778597717","wikidata":"https://www.wikidata.org/wiki/Q420248","display_name":"Phospholipase C","level":3,"score":0.7732740640640259},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6567485332489014},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.6549636721611023},{"id":"https://openalex.org/C6182249","wikidata":"https://www.wikidata.org/wiki/Q700007","display_name":"Phospholipase D","level":3,"score":0.6097878813743591},{"id":"https://openalex.org/C12927208","wikidata":"https://www.wikidata.org/wiki/Q210430","display_name":"Phospholipase","level":3,"score":0.5304977893829346},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4871041774749756},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4750939607620239},{"id":"https://openalex.org/C78297661","wikidata":"https://www.wikidata.org/wiki/Q10760862","display_name":"Phosphoinositide phospholipase C","level":4,"score":0.45952850580215454},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.4189884662628174},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40245887637138367},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.320515513420105},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26361310482025146},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15830034017562866}],"mesh":[{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010716","descriptor_name":"Phosphatidylinositols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019269","descriptor_name":"Phosphatidylinositol 4,5-Diphosphate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020668","descriptor_name":"rap GTP-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020690","descriptor_name":"GTPase-Activating Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020703","descriptor_name":"ras GTPase-Activating Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043265","descriptor_name":"Phosphatidylinositol Diacylglycerol-Lyase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.89.16.7796","doi":"https://doi.org/10.1073/pnas.89.16.7796","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.89.16.7796","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:93381","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC49798","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:1323853","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1323853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:49798","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC49798/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:93381","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC49798","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.428600013256073,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W35037724","https://openalex.org/W207951093","https://openalex.org/W240647565","https://openalex.org/W1480553100","https://openalex.org/W1481167131","https://openalex.org/W1501666754","https://openalex.org/W1505319644","https://openalex.org/W1505417279","https://openalex.org/W1524540558","https://openalex.org/W1531393147","https://openalex.org/W1540941492","https://openalex.org/W1565496454","https://openalex.org/W1602715148","https://openalex.org/W1607692727","https://openalex.org/W1967838053","https://openalex.org/W1968610357","https://openalex.org/W1972370755","https://openalex.org/W1981810445","https://openalex.org/W1983596426","https://openalex.org/W1985527771","https://openalex.org/W1988970153","https://openalex.org/W1991823217","https://openalex.org/W1994305152","https://openalex.org/W2000808409","https://openalex.org/W2005529016","https://openalex.org/W2011758204","https://openalex.org/W2012709757","https://openalex.org/W2015434298","https://openalex.org/W2023930824","https://openalex.org/W2027880769","https://openalex.org/W2035430953","https://openalex.org/W2037434894","https://openalex.org/W2045299802","https://openalex.org/W2047214302","https://openalex.org/W2055154910","https://openalex.org/W2057164642","https://openalex.org/W2076708431","https://openalex.org/W2077317888","https://openalex.org/W2080910520","https://openalex.org/W2083529249","https://openalex.org/W2089375674","https://openalex.org/W2090575139","https://openalex.org/W2093684643","https://openalex.org/W2129239354","https://openalex.org/W2152133730","https://openalex.org/W2155169715","https://openalex.org/W2167963365","https://openalex.org/W2229752110","https://openalex.org/W2403847317","https://openalex.org/W2426301864"],"related_works":["https://openalex.org/W2148112019","https://openalex.org/W2032243899","https://openalex.org/W2419093638","https://openalex.org/W1982641223","https://openalex.org/W2118399632","https://openalex.org/W1863376287","https://openalex.org/W2035430953","https://openalex.org/W1976634046","https://openalex.org/W2053978117","https://openalex.org/W2128826704"],"abstract_inverted_index":{"Thrombin":[0],"activates":[1],"phospholipase":[2,25,40,68,93,139],"C":[3],"in":[4,36,53,148],"human":[5,37],"platelets,":[6],"but":[7,76],"the":[8,13,29,88,100,105,108,117,131,149],"specific":[9,20],"isoenzymes":[10],"activated":[11],"and":[12,28,49,96,142],"signal":[14],"pathway":[15],"used":[16],"are":[17,34],"unknown.":[18],"Using":[19],"antibodies,":[21],"we":[22],"found":[23],"that":[24,58,144],"C-gamma":[26,41,69,94,140],"1":[27,42,70,95],"p21ras":[30],"GTPase-activating":[31],"protein,":[32],"rasGAP,":[33,56,104,138],"present":[35],"platelets.":[38],"Furthermore,":[39],"was":[43,74],"detectable,":[44],"based":[45],"on":[46,87,121],"enzyme":[47],"activity":[48],"Western":[50,123],"blot":[51,124],"analysis,":[52],"immunoprecipitates":[54],"of":[55,67,90,92,103,110,119,125,133],"suggesting":[57],"these":[59],"two":[60],"proteins":[61],"form":[62],"tight":[63],"complexes.":[64],"The":[65],"pool":[66],"associated":[71],"with":[72,112],"rasGAP":[73,111,126],"phosphorylated":[75],"not":[77],"through":[78],"tyrosine":[79,101],"phosphorylation.":[80],"Although":[81],"thrombin":[82],"stimulation":[83],"had":[84],"no":[85],"effect":[86],"level":[89],"phosphorylation":[91,102],"only":[97],"slightly":[98],"increased":[99],"agonist":[106],"induced":[107],"association":[109],"rap1B,":[113],"as":[114],"indicated":[115],"by":[116],"appearance":[118],"rap1B":[120,143],"a":[122,134],"immunoprecipitates.":[127],"Our":[128],"results":[129],"suggest":[130],"formation":[132],"signaling":[135],"complex":[136],"involving":[137],"1,":[141],"might":[145],"be":[146],"important":[147],"cascade":[150],"leading":[151],"to":[152],"platelet":[153],"activation.":[154]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
