{"id":"https://openalex.org/W2008558336","doi":"https://doi.org/10.1080/15287394.2011.595669","title":"Fibrogenic and Redox-Related but not Proinflammatory Genes are Upregulated in Lewis Rat Model of Chronic Silicosis","display_name":"Fibrogenic and Redox-Related but not Proinflammatory Genes are Upregulated in Lewis Rat Model of Chronic Silicosis","publication_year":2011,"publication_date":"2011-08-10","ids":{"openalex":"https://openalex.org/W2008558336","doi":"https://doi.org/10.1080/15287394.2011.595669","mag":"2008558336","pmid":"https://pubmed.ncbi.nlm.nih.gov/21830856","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4058997"},"language":"en","primary_location":{"id":"doi:10.1080/15287394.2011.595669","doi":"https://doi.org/10.1080/15287394.2011.595669","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15287394.2011.595669","pdf_url":null,"source":{"id":"https://openalex.org/S85071590","display_name":"Journal of Toxicology and Environmental Health","issn_l":"0098-4108","issn":["0098-4108","1087-2620"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicology and Environmental Health, Part A","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4058997","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038143566","display_name":"Raymond J. Langley","orcid":"https://orcid.org/0000-0001-8849-9325","observed_orcids":["https://orcid.org/0000-0001-8849-9325"]},"institutions":[{"id":"https://openalex.org/I1305258596","display_name":"Lovelace Respiratory Research Institute","ror":"https://ror.org/038qbqz41","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305258596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond J. Langley","raw_affiliation_strings":["Immunology Program, Lovelace Respiratory Research Institute, Albuquerque, New M\u00e9xico 87108, USA","Immunology Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Program, Lovelace Respiratory Research Institute, Albuquerque, New M\u00e9xico 87108, USA","institution_ids":["https://openalex.org/I1305258596"]},{"raw_affiliation_string":"Immunology Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA","institution_ids":["https://openalex.org/I1305258596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110492560","display_name":"Neerad C. Mishra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1305258596","display_name":"Lovelace Respiratory Research Institute","ror":"https://ror.org/038qbqz41","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305258596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neerad C. Mishra","raw_affiliation_strings":["Immunology Program, Lovelace Respiratory Research Institute, Albuquerque, New M\u00e9xico, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Program, Lovelace Respiratory Research Institute, Albuquerque, New M\u00e9xico, USA","institution_ids":["https://openalex.org/I1305258596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008812896","display_name":"Juan Carlos Pe\u00f1a-Philippides","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1305258596","display_name":"Lovelace Respiratory Research Institute","ror":"https://ror.org/038qbqz41","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305258596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan Carlos Pe\u00f1a-Philippides","raw_affiliation_strings":["Immunology Program, Lovelace Respiratory Research Institute, Albuquerque, New M\u00e9xico, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Program, Lovelace Respiratory Research Institute, Albuquerque, New M\u00e9xico, USA","institution_ids":["https://openalex.org/I1305258596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061362236","display_name":"Brandon Rice","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1310183320","display_name":"National Center for Genome Resources","ror":"https://ror.org/01p4cne93","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1310183320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandon J. Rice","raw_affiliation_strings":["Software Engineering Division, National Center for Genome Resources, Santa Fe, New M\u00e9xico, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Software Engineering Division, National Center for Genome Resources, Santa Fe, New M\u00e9xico, USA","institution_ids":["https://openalex.org/I1310183320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110056694","display_name":"JeanClare Seagrave","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1305258596","display_name":"Lovelace Respiratory Research Institute","ror":"https://ror.org/038qbqz41","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305258596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean-Clare Seagrave","raw_affiliation_strings":["Immunology Program, Lovelace Respiratory Research Institute, Albuquerque, New M\u00e9xico, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Program, Lovelace Respiratory Research Institute, Albuquerque, New M\u00e9xico, USA","institution_ids":["https://openalex.org/I1305258596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100675150","display_name":"Manisha Singh","orcid":"https://orcid.org/0000-0003-1505-4370","observed_orcids":["https://orcid.org/0000-0003-1505-4370"]},"institutions":[{"id":"https://openalex.org/I1305258596","display_name":"Lovelace Respiratory Research Institute","ror":"https://ror.org/038qbqz41","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305258596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shashi P. Singh","raw_affiliation_strings":["Immunology Program, Lovelace Respiratory Research Institute, Albuquerque, New M\u00e9xico, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Program, Lovelace Respiratory Research Institute, Albuquerque, New M\u00e9xico, USA","institution_ids":["https://openalex.org/I1305258596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034783926","display_name":"Mohan L. Sopori","orcid":"https://orcid.org/0000-0003-2146-0367","observed_orcids":["https://orcid.org/0000-0003-2146-0367"]},"institutions":[{"id":"https://openalex.org/I1305258596","display_name":"Lovelace Respiratory Research Institute","ror":"https://ror.org/038qbqz41","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305258596"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mohan L. Sopori","raw_affiliation_strings":["Immunology Program, Lovelace Respiratory Research Institute, Albuquerque, New M\u00e9xico, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Program, Lovelace Respiratory Research Institute, Albuquerque, New M\u00e9xico, USA","institution_ids":["https://openalex.org/I1305258596"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034783926"],"corresponding_institution_ids":["https://openalex.org/I1305258596"],"apc_list":null,"apc_paid":null,"fwci":1.2958,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.81410816,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"74","issue":"19","first_page":"1261","last_page":"1279"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.8978999853134155,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.8978999853134155,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.09960000216960907,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11571","display_name":"Sarcoidosis and Beryllium Toxicity Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-silicosis","display_name":"acute silicosis","score":0.9490000009536743},{"id":"https://openalex.org/keywords/silica-exposure","display_name":"silica exposure","score":0.7739999890327454},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8349999785423279},{"id":"https://openalex.org/keywords/oxidoreductases","display_name":"oxidative enzymes","score":0.8180000185966492},{"id":"https://openalex.org/keywords/manganese-superoxide-dismutase","display_name":"manganese superoxide dismutase","score":0.8730000257492065},{"id":"https://openalex.org/keywords/arginase-1","display_name":"arginase-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.8600000143051147},{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":0.9309999942779541},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.8100000023841858},{"id":"https://openalex.org/keywords/ccl7","display_name":"CCL7","score":0.9980000257492065},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.7609999775886536},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.9359999895095825},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9229999780654907},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.6970000267028809},{"id":"https://openalex.org/keywords/lewis-rat-model","display_name":"Lewis rat model","score":0.7390000224113464},{"id":"https://openalex.org/keywords/granuloma","display_name":"granuloma","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C2777811718","wikidata":"https://www.wikidata.org/wiki/Q653318","display_name":"Silicosis","level":2,"score":0.9081464409828186},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.7040265798568726},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6185774803161621},{"id":"https://openalex.org/C2781441816","wikidata":"https://www.wikidata.org/wiki/Q7075805","display_name":"Occupational lung disease","level":3,"score":0.5823458433151245},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5347354412078857},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4942812919616699},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.478469580411911},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4539312422275543},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3641325533390045},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.226321280002594},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12153273820877075},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08442342281341553},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.06774631142616272}],"mesh":[{"descriptor_ui":"D000099156","descriptor_name":"Superoxide Dismutase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001119","descriptor_name":"Arginase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001119","descriptor_name":"Arginase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011917","descriptor_name":"Rats, Inbred Lew","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012829","descriptor_name":"Silicosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012829","descriptor_name":"Silicosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012829","descriptor_name":"Silicosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013047","descriptor_name":"Specific Pathogen-Free Organisms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018093","descriptor_name":"Gelatinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018093","descriptor_name":"Gelatinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018945","descriptor_name":"Monocyte Chemoattractant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018945","descriptor_name":"Monocyte Chemoattractant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053495","descriptor_name":"Osteopontin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053495","descriptor_name":"Osteopontin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1080/15287394.2011.595669","doi":"https://doi.org/10.1080/15287394.2011.595669","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15287394.2011.595669","pdf_url":null,"source":{"id":"https://openalex.org/S85071590","display_name":"Journal of Toxicology and Environmental Health","issn_l":"0098-4108","issn":["0098-4108","1087-2620"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicology and Environmental Health, Part A","raw_type":"journal-article"},{"id":"pmid:21830856","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21830856","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of toxicology and environmental health. Part A","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3031189","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4058997","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4058997","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4058997","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Toxicol Environ Health A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3031189","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4058997","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4351806091","display_name":"Nicotine & Immunopathogenesis of Cryptococcal meningitis","funder_award_id":"R01DA017003","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G5053428008","display_name":null,"funder_award_id":"R01 DA04208-17","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G5737313509","display_name":"MECHANISM OF CIGARETTE SMOKE-INDUCED IMMUNOSUPPRESSION","funder_award_id":"R01DA004208","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W131017153","https://openalex.org/W1560919596","https://openalex.org/W1576693181","https://openalex.org/W1584581818","https://openalex.org/W1948204196","https://openalex.org/W1965237088","https://openalex.org/W1970612537","https://openalex.org/W1971435128","https://openalex.org/W1972030306","https://openalex.org/W1974934101","https://openalex.org/W1989392850","https://openalex.org/W1989428468","https://openalex.org/W2003796048","https://openalex.org/W2006556473","https://openalex.org/W2017344189","https://openalex.org/W2020541351","https://openalex.org/W2030347135","https://openalex.org/W2035471193","https://openalex.org/W2039983193","https://openalex.org/W2044708698","https://openalex.org/W2059440543","https://openalex.org/W2063808850","https://openalex.org/W2064940832","https://openalex.org/W2066632633","https://openalex.org/W2072407021","https://openalex.org/W2092692878","https://openalex.org/W2094688671","https://openalex.org/W2095054225","https://openalex.org/W2101099318","https://openalex.org/W2113467230","https://openalex.org/W2116650911","https://openalex.org/W2128421447","https://openalex.org/W2129577223","https://openalex.org/W2133094265","https://openalex.org/W2137064182","https://openalex.org/W2137801669","https://openalex.org/W2141728753","https://openalex.org/W2141924327","https://openalex.org/W2146271606","https://openalex.org/W2147861636","https://openalex.org/W2149112931","https://openalex.org/W2155323443","https://openalex.org/W2155486385","https://openalex.org/W2157099277","https://openalex.org/W2157531458","https://openalex.org/W2165652383","https://openalex.org/W2187241866","https://openalex.org/W2399874549","https://openalex.org/W2412779746","https://openalex.org/W2414682733"],"related_works":["https://openalex.org/W2318784483","https://openalex.org/W2969113202","https://openalex.org/W2782686629","https://openalex.org/W2064940832","https://openalex.org/W2467059366","https://openalex.org/W2391121910","https://openalex.org/W7161548107","https://openalex.org/W7134197221","https://openalex.org/W3172726936","https://openalex.org/W3044810201"],"abstract_inverted_index":{"Silicosis,":[0],"a":[1,27,108],"fibrotic":[2],"granulomatous":[3],"lung":[4,31,77,87,165],"disease,":[5],"may":[6,252],"occur":[7],"through":[8],"accidental":[9],"high-dose":[10,49],"or":[11,92],"occupational":[12],"inhalation":[13,57],"of":[14,37,58,62,111,116,141,207],"silica,":[15,63],"leading":[16],"to":[17,145,254],"acute/accelerated":[18],"and":[19,33,114,131,172,179,195,201,203,211,217,250,257],"chronic":[20,24,56,85,218,240,258],"silicosis,":[21,86,146],"respectively.":[22],"While":[23],"silicosis":[25,68,184,219],"has":[26],"long":[28],"asymptomatic":[29],"latency,":[30],"inflammation":[32],"apoptosis":[34],"are":[35,234],"hallmarks":[36],"acute":[38,183,216,229,237,256],"silicosis.":[39,230,241,259],"In":[40],"animal":[41],"models,":[42],"histiocytic":[43],"granulomas":[44,65],"develop":[45],"within":[46],"days":[47],"after":[48,71,103,175],"intratracheal":[50],"(IT)":[51],"silica":[52,104,177],"instillation.":[53],"However,":[54,221],"following":[55],"occupationally":[59],"relevant":[60,144],"doses":[61],"discrete":[64],"resembling":[66],"human":[67],"arise":[69],"months":[70],"the":[72,139,204],"final":[73],"exposure":[74,178],"without":[75],"significant":[76,109],"inflammation/apoptosis.":[78],"To":[79,137],"identify":[80],"molecular":[81],"events":[82],"associated":[83,133,235],"with":[84,134,181,236],"RNA":[88],"samples":[89],"from":[90,167],"controls":[91],"subchronic":[93,176],"silica-exposed":[94],"rats":[95],"were":[96,162,213,224],"analyzed":[97],"by":[98],"Affymetrix":[99],"at":[100],"28":[101,170],"wk":[102],"exposures.":[105],"Results":[106,186],"suggested":[107],"upregulation":[110],"144":[112],"genes":[113,121,132,189,245],"downregulation":[115],"7":[117],"genes.":[118],"The":[119],"upregulated":[120,214,226],"included":[122],"complement":[123],"cascade,":[124],"chemokines/chemokine":[125],"receptors,":[126],"G-protein":[127],"signaling":[128],"components,":[129],"metalloproteases,":[130],"oxidative":[135,248],"stress.":[136],"examine":[138],"kinetics":[140],"gene":[142],"expression":[143],"quantitative":[147],"polymerase":[148],"chain":[149],"reaction":[150],"(qPCR),":[151],"enzyme-linked":[152],"immunosorbent":[153],"assay":[154],"(ELISA),":[155],"Luminex-bead":[156],"assays,":[157],"Western":[158],"blotting,":[159],"and/or":[160],"zymography":[161],"performed":[163],"on":[164],"tissues":[166],"4":[168],"d,":[169],"wk,":[171],"intermediate":[173],"times":[174],"compared":[180],"14-d":[182],"samples.":[185],"indicated":[187],"that":[188,244],"regulating":[190,246],"fibrosis":[191],"(secreted":[192],"phosphoprotein-1,":[193],"Ccl2,":[194],"Ccl7),":[196],"redox":[197],"enzymes":[198],"(superoxide":[199],"dismutase-2":[200],"arginase-1),":[202],"enzymatic":[205],"activities":[206],"matrix":[208],"metalloproteinases":[209],"2":[210],"9":[212],"in":[215,228],"models.":[220],"proinflammatory":[222],"cytokines":[223,233],"strongly":[225],"only":[227],"Thus,":[231],"inflammatory":[232],"but":[238],"not":[239],"Data":[242],"suggest":[243],"fibrosis,":[247],"stress,":[249],"metalloproteases":[251],"contribute":[253],"both":[255]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
