{"id":"https://openalex.org/W2008524244","doi":"https://doi.org/10.1164/ajrccm.154.5.8912762","title":"Morphologic Determinants of Airway Responsiveness in Chronic Smokers","display_name":"Morphologic Determinants of Airway Responsiveness in Chronic Smokers","publication_year":1996,"publication_date":"1996-11-01","ids":{"openalex":"https://openalex.org/W2008524244","doi":"https://doi.org/10.1164/ajrccm.154.5.8912762","mag":"2008524244","pmid":"https://pubmed.ncbi.nlm.nih.gov/8912762"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm.154.5.8912762","doi":"https://doi.org/10.1164/ajrccm.154.5.8912762","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm.154.5.8912762","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory and critical care medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"A Riess","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"A Riess","raw_affiliation_strings":["Respiratory Health Network of Centres of Excellence, University of British Columbia, St. Paul's Hospital, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Health Network of Centres of Excellence, University of British Columbia, St. Paul's Hospital, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I2801362399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108497647","display_name":"Barry Wiggs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"B Wiggs","raw_affiliation_strings":["Respiratory Health Network of Centres of Excellence, University of British Columbia, St. Paul's Hospital, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Health Network of Centres of Excellence, University of British Columbia, St. Paul's Hospital, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I2801362399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060484288","display_name":"L Verburgt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"L Verburgt","raw_affiliation_strings":["Respiratory Health Network of Centres of Excellence, University of British Columbia, St. Paul's Hospital, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Health Network of Centres of Excellence, University of British Columbia, St. Paul's Hospital, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I2801362399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101583433","display_name":"James R. Wright","orcid":"https://orcid.org/0000-0002-8601-925X","observed_orcids":["https://orcid.org/0000-0002-8601-925X"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J L Wright","raw_affiliation_strings":["Respiratory Health Network of Centres of Excellence, University of British Columbia, St. Paul's Hospital, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Health Network of Centres of Excellence, University of British Columbia, St. Paul's Hospital, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I2801362399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091776168","display_name":"James C. Hogg","orcid":"https://orcid.org/0000-0001-9930-1935","observed_orcids":["https://orcid.org/0000-0001-9930-1935"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J C Hogg","raw_affiliation_strings":["Respiratory Health Network of Centres of Excellence, University of British Columbia, St. Paul's Hospital, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Health Network of Centres of Excellence, University of British Columbia, St. Paul's Hospital, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I2801362399"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107827687","display_name":"Peter D. Par\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"P D Par\u00e9","raw_affiliation_strings":["Respiratory Health Network of Centres of Excellence, University of British Columbia, St. Paul's Hospital, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Health Network of Centres of Excellence, University of British Columbia, St. Paul's Hospital, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I2801362399"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6609,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.92653243,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"154","issue":"5","first_page":"1444","last_page":"1449"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/airway-responsiveness","display_name":"airway responsiveness","score":0.8360000252723694},{"id":"https://openalex.org/keywords/chronic-smokers","display_name":"chronic smokers","score":0.9259999990463257},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9819999933242798},{"id":"https://openalex.org/keywords/airway-wall-thickness","display_name":"airway wall thickness","score":0.8859999775886536},{"id":"https://openalex.org/keywords/lung-elasticity","display_name":"lung elasticity","score":0.7889999747276306},{"id":"https://openalex.org/keywords/airway-morphometry","display_name":"airway morphometry","score":0.5920000076293945},{"id":"https://openalex.org/keywords/lung-resection","display_name":"lung resection","score":0.5400000214576721},{"id":"https://openalex.org/keywords/pulmonary-nodules","display_name":"pulmonary nodules","score":0.6840000152587891},{"id":"https://openalex.org/keywords/airflow-obstruction","display_name":"airflow obstruction","score":0.5270000100135803},{"id":"https://openalex.org/keywords/fev1","display_name":"FEV1","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9480297565460205},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.8988485932350159},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.8169841766357422},{"id":"https://openalex.org/C2778333281","wikidata":"https://www.wikidata.org/wiki/Q4330029","display_name":"Airway obstruction","level":3,"score":0.6580658555030823},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5216784477233887},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.47528210282325745},{"id":"https://openalex.org/C27101514","wikidata":"https://www.wikidata.org/wiki/Q206120","display_name":"Lung volumes","level":3,"score":0.467826783657074},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4532138705253601},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.4459533989429474},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3966943025588989},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.23710709810256958}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000402","descriptor_name":"Airway Obstruction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D000402","descriptor_name":"Airway Obstruction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008173","descriptor_name":"Lung Diseases, Obstructive","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008173","descriptor_name":"Lung Diseases, Obstructive","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012129","descriptor_name":"Respiratory Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016535","descriptor_name":"Bronchial Hyperreactivity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D016535","descriptor_name":"Bronchial Hyperreactivity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1164/ajrccm.154.5.8912762","doi":"https://doi.org/10.1164/ajrccm.154.5.8912762","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm.154.5.8912762","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory and critical care medicine","raw_type":"journal-article"},{"id":"pmid:8912762","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8912762","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory and critical care medicine","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W206035007","https://openalex.org/W1643514985","https://openalex.org/W1682043670","https://openalex.org/W1705185877","https://openalex.org/W1894189929","https://openalex.org/W1956940855","https://openalex.org/W1961136230","https://openalex.org/W1997820336","https://openalex.org/W2001463961","https://openalex.org/W2022987513","https://openalex.org/W2028436458","https://openalex.org/W2031234213","https://openalex.org/W2042027156","https://openalex.org/W2070401283","https://openalex.org/W2071863930","https://openalex.org/W2118596714","https://openalex.org/W2137401824","https://openalex.org/W2152549714","https://openalex.org/W2163426512","https://openalex.org/W2180527176","https://openalex.org/W2263355384","https://openalex.org/W2395601990","https://openalex.org/W2414545977","https://openalex.org/W2427004753","https://openalex.org/W2436438641","https://openalex.org/W2465314520","https://openalex.org/W3215119582"],"related_works":["https://openalex.org/W2121320860","https://openalex.org/W2071212613","https://openalex.org/W2333502980","https://openalex.org/W2156323177","https://openalex.org/W2055293408","https://openalex.org/W1990990168","https://openalex.org/W2321866194","https://openalex.org/W1986419204","https://openalex.org/W2134342786","https://openalex.org/W2390995816"],"abstract_inverted_index":{"Nonspecific":[0],"bronchial":[1,53],"hyperresponsiveness":[2],"(NSBH)":[3],"occurs":[4],"in":[5,8,21,28,39,58,108,204],"asthmatics":[6],"and":[7,45,91,95,115,152,154],"smokers":[9,29,60],"who":[10,61],"have":[11,182],"airway":[12,48,78,82,132,139,141,168,194,202],"obstruction.":[13,49],"NSBH":[14,27],"may":[15],"be":[16],"caused":[17,211],"by":[18,56,126,212],"different":[19],"mechanisms":[20],"these":[22,156],"conditions.":[23],"We":[24,50,76],"hypothesized":[25],"that":[26,37,199],"was":[30,124,146,163,172],"a":[31,73,136,174],"consequence":[32],"of":[33,100,121,131,138,192],"the":[34,118,128,177,189,193,213],"structural":[35,209],"changes":[36,210],"occur":[38],"chronic":[40],"obstructive":[41],"pulmonary":[42,74],"disease":[43],"(COPD)":[44],"lead":[46],"to":[47,64,69,80,87,106,117,149,167,181,208],"measured":[51],"nonspecific":[52,201],"responsiveness,":[54],"assessed":[55],"PC20,":[57],"77":[59],"had":[62],"mild":[63],"moderate":[65],"airflow":[66],"obstruction":[67],"prior":[68],"lung":[70,101],"resection":[71],"for":[72,176],"nodule.":[75],"related":[77,148,166],"responsiveness":[79],"baseline":[81],"function":[83],"(FEV1":[84],"%":[85],"predicted),":[86],"functional":[88,157],"(PLmax,":[89],"PL90,":[90],"P-V":[92],"curve":[93],"shape)":[94],"morphometric":[96],"(alveolar":[97],"attachments)":[98],"markers":[99],"elasticity":[102],"as":[103,105],"well":[104],"thickening":[107],"small":[109],"airways.":[110],"Airway":[111],"wall":[112,133,169],"thickness,":[113],"internal":[114,142],"external":[116,190],"outer":[119],"border":[120],"smooth":[122],"muscle":[123],"quantified":[125],"plotting":[127],"square":[129],"root":[130],"area":[134],"versus":[135],"marker":[137],"size,":[140],"perimeter":[143,191],"(Pi).":[144],"PC20":[145,162],"significantly":[147],"FEV1%":[150],"predicted":[151],"PLmax.":[153],"when":[155],"parameters":[158],"were":[159],"controlled":[160],"for,":[161],"also":[164,173],"inversely":[165],"thickness.":[170],"There":[171],"trend":[175],"most":[178],"responsive":[179],"patients":[180],"fewer":[183],"alveolar":[184],"attachments":[185],"per":[186],"millimeter":[187],"on":[188],"walls.":[195],"These":[196],"data":[197],"suggest":[198],"exaggerated":[200],"narrowing":[203],"COPD":[205],"is":[206],"secondary":[207],"disease.":[214]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}