{"id":"https://openalex.org/W2008511202","doi":"https://doi.org/10.1073/pnas.0910885107","title":"Pyrimidine biosynthesis links mitochondrial respiration to the p53 pathway","display_name":"Pyrimidine biosynthesis links mitochondrial respiration to the p53 pathway","publication_year":2010,"publication_date":"2010-06-21","ids":{"openalex":"https://openalex.org/W2008511202","doi":"https://doi.org/10.1073/pnas.0910885107","mag":"2008511202","pmid":"https://pubmed.ncbi.nlm.nih.gov/20566882","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2919937"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0910885107","doi":"https://doi.org/10.1073/pnas.0910885107","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0910885107","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2919937","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089760565","display_name":"Anastasia A. Khutornenko","orcid":"https://orcid.org/0000-0002-1573-9903","observed_orcids":["https://orcid.org/0000-0002-1573-9903"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Anastasia A. Khutornenko","raw_affiliation_strings":["Belozersky Institute of Physico-Chemical Biology, Moscow State University, 119992, Moscow, Russia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Belozersky Institute of Physico-Chemical Biology, Moscow State University, 119992, Moscow, Russia;","institution_ids":["https://openalex.org/I19880235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008691805","display_name":"Vladimir Roudko","orcid":"https://orcid.org/0000-0002-3835-6737","observed_orcids":["https://orcid.org/0000-0002-3835-6737"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Vladimir V. Roudko","raw_affiliation_strings":["Belozersky Institute of Physico-Chemical Biology, Moscow State University, 119992, Moscow, Russia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Belozersky Institute of Physico-Chemical Biology, Moscow State University, 119992, Moscow, Russia;","institution_ids":["https://openalex.org/I19880235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054201517","display_name":"Boris V. Chernyak","orcid":"https://orcid.org/0000-0003-1523-0864","observed_orcids":["https://orcid.org/0000-0003-1523-0864"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Boris V. Chernyak","raw_affiliation_strings":["Belozersky Institute of Physico-Chemical Biology, Moscow State University, 119992, Moscow, Russia;","Institute of Mitoengineering, Moscow State University, 119992, Moscow, Russia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Belozersky Institute of Physico-Chemical Biology, Moscow State University, 119992, Moscow, Russia;","institution_ids":["https://openalex.org/I19880235"]},{"raw_affiliation_string":"Institute of Mitoengineering, Moscow State University, 119992, Moscow, Russia;","institution_ids":["https://openalex.org/I19880235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004191171","display_name":"Andrey B. Vartapetian","orcid":"https://orcid.org/0000-0003-2296-0929","observed_orcids":["https://orcid.org/0000-0003-2296-0929"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Andrey B. Vartapetian","raw_affiliation_strings":["Belozersky Institute of Physico-Chemical Biology, Moscow State University, 119992, Moscow, Russia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Belozersky Institute of Physico-Chemical Biology, Moscow State University, 119992, Moscow, Russia;","institution_ids":["https://openalex.org/I19880235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055831992","display_name":"Peter M. Chumakov","orcid":"https://orcid.org/0000-0002-8078-2908","observed_orcids":["https://orcid.org/0000-0002-8078-2908"]},"institutions":[{"id":"https://openalex.org/I100098275","display_name":"Engelhardt Institute of Molecular Biology","ror":"https://ror.org/027hwkg23","country_code":"RU","type":"facility","lineage":["https://openalex.org/I100098275","https://openalex.org/I1313323035","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["RU","US"],"is_corresponding":true,"raw_author_name":"Peter M. Chumakov","raw_affiliation_strings":["Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilova Street 32, Moscow 119991, Russia","Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilova Street 32, Moscow 119991, Russia","institution_ids":["https://openalex.org/I100098275","https://openalex.org/I1313323035"]},{"raw_affiliation_string":"Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195; and","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061417875","display_name":"Alexandra G. Evstafieva","orcid":"https://orcid.org/0000-0001-6045-1434","observed_orcids":["https://orcid.org/0000-0001-6045-1434"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexandra G. Evstafieva","raw_affiliation_strings":["Belozersky Institute of Physico-Chemical Biology, Moscow State University, 119992, Moscow, Russia;","Institute of Mitoengineering, Moscow State University, 119992, Moscow, Russia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Belozersky Institute of Physico-Chemical Biology, Moscow State University, 119992, Moscow, Russia;","institution_ids":["https://openalex.org/I19880235"]},{"raw_affiliation_string":"Institute of Mitoengineering, Moscow State University, 119992, Moscow, Russia;","institution_ids":["https://openalex.org/I19880235"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5055831992"],"corresponding_institution_ids":["https://openalex.org/I100098275","https://openalex.org/I1313323035","https://openalex.org/I1316902750","https://openalex.org/I4405287411"],"apc_list":null,"apc_paid":null,"fwci":4.3843,"has_fulltext":false,"cited_by_count":166,"citation_normalized_percentile":{"value":0.9511627,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"107","issue":"29","first_page":"12828","last_page":"12833"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.7792999744415283,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.7792999744415283,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.07909999787807465,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.030899999663233757,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53-activation","display_name":"p53 activation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.8389999866485596},{"id":"https://openalex.org/keywords/pyrimidine-biosynthesis","display_name":"pyrimidine synthesis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/dihydroorotate-dehydrogenase","display_name":"dihydroorotate dehydrogenase","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cytochrome-bc1-complex","display_name":"cytochrome bc1 complex","score":0.8939999938011169},{"id":"https://openalex.org/keywords/electron-transport-inhibition","display_name":"electron transport inhibition","score":0.8240000009536743},{"id":"https://openalex.org/keywords/nqo1","display_name":"NQO1","score":0.9070000052452087},{"id":"https://openalex.org/keywords/nqo2","display_name":"NQO2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/p53-stabilization","display_name":"p53 stabilization","score":0.8669999837875366},{"id":"https://openalex.org/keywords/p14arf","display_name":"p14ARF","score":0.9359999895095825},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C2779865431","wikidata":"https://www.wikidata.org/wiki/Q1150909","display_name":"Dihydroorotate dehydrogenase","level":3,"score":0.847028374671936},{"id":"https://openalex.org/C200159599","wikidata":"https://www.wikidata.org/wiki/Q4893563","display_name":"Pyrimidine metabolism","level":4,"score":0.8167353868484497},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6915580034255981},{"id":"https://openalex.org/C24840226","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Electron transport chain","level":2,"score":0.6613521575927734},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5508874654769897},{"id":"https://openalex.org/C3020377403","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Respiratory chain","level":3,"score":0.5225067734718323},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.5182128548622131},{"id":"https://openalex.org/C182215343","wikidata":"https://www.wikidata.org/wiki/Q472287","display_name":"Respiration","level":2,"score":0.5113603472709656},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5043848752975464},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4790121912956238},{"id":"https://openalex.org/C66517615","wikidata":"https://www.wikidata.org/wiki/Q912751","display_name":"Cellular respiration","level":3,"score":0.4706037938594818},{"id":"https://openalex.org/C112243037","wikidata":"https://www.wikidata.org/wiki/Q22327117","display_name":"ATP synthase","level":3,"score":0.43622562289237976},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4042993485927582},{"id":"https://openalex.org/C2779321679","wikidata":"https://www.wikidata.org/wiki/Q207722","display_name":"Pyrimidine","level":2,"score":0.31011486053466797},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2540566921234131},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C2776476023","wikidata":"https://www.wikidata.org/wiki/Q188261","display_name":"Purine","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077339","descriptor_name":"Leflunomide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000090722","descriptor_name":"Dihydroorotate Dehydrogenase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008689","descriptor_name":"Methacrylates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011190","descriptor_name":"Potassium Cyanide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011808","descriptor_name":"Quinone Reductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014450","descriptor_name":"Electron Transport Complex III","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014450","descriptor_name":"Electron Transport Complex III","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016660","descriptor_name":"NAD(P)H Dehydrogenase (Quinone)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019069","descriptor_name":"Cell Respiration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D044925","descriptor_name":"Oxidoreductases Acting on CH-CH Group Donors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D044925","descriptor_name":"Oxidoreductases Acting on CH-CH Group Donors","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053078","descriptor_name":"Membrane Potential, Mitochondrial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.0910885107","doi":"https://doi.org/10.1073/pnas.0910885107","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0910885107","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2919937","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2919937","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:20566882","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20566882","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2919937","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2919937","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G478984334","display_name":null,"funder_award_id":"AG025276","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G660889260","display_name":"Potentials of reactivated mutant p53","funder_award_id":"R01CA104903","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8605811740","display_name":null,"funder_award_id":"55005603","funder_id":"https://openalex.org/F4320306082","funder_display_name":"Howard Hughes Medical Institute"},{"id":"https://openalex.org/G8673401335","display_name":null,"funder_award_id":"08-04","funder_id":"https://openalex.org/F4320334801","funder_display_name":"Russian Academy of Sciences"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320321079","display_name":"Russian Foundation for Basic Research","ror":"https://ror.org/02mh1ke95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334801","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W190488077","https://openalex.org/W1480951384","https://openalex.org/W1680634601","https://openalex.org/W1799768544","https://openalex.org/W1964717435","https://openalex.org/W1969747946","https://openalex.org/W1972650300","https://openalex.org/W1979731389","https://openalex.org/W1987952787","https://openalex.org/W1996834340","https://openalex.org/W2003894821","https://openalex.org/W2014947131","https://openalex.org/W2019622095","https://openalex.org/W2020817685","https://openalex.org/W2021491682","https://openalex.org/W2030665545","https://openalex.org/W2041574789","https://openalex.org/W2050854335","https://openalex.org/W2058073881","https://openalex.org/W2059190026","https://openalex.org/W2061227850","https://openalex.org/W2063461007","https://openalex.org/W2065776232","https://openalex.org/W2066359401","https://openalex.org/W2068549818","https://openalex.org/W2069915928","https://openalex.org/W2073976519","https://openalex.org/W2074545297","https://openalex.org/W2084034472","https://openalex.org/W2086993177","https://openalex.org/W2099952208","https://openalex.org/W2107446676","https://openalex.org/W2111210558","https://openalex.org/W2127793027","https://openalex.org/W2133836866","https://openalex.org/W2137817444","https://openalex.org/W2144334196","https://openalex.org/W2147852942","https://openalex.org/W2165997736","https://openalex.org/W2472958137","https://openalex.org/W3145257564"],"related_works":["https://openalex.org/W4297820864","https://openalex.org/W2791476227","https://openalex.org/W1986075042","https://openalex.org/W2000501612","https://openalex.org/W2127793027","https://openalex.org/W2901125126","https://openalex.org/W7129280282","https://openalex.org/W4401485783","https://openalex.org/W2044137980","https://openalex.org/W2063612254"],"abstract_inverted_index":{"While":[0],"many":[1,31],"functions":[2],"of":[3,13,20,61,80,98,126,143,159,166,174,180,196],"the":[4,11,39,75,81,99,115,127,141,183,188,194,200],"p53":[5,21,69,90,110,144,160,181,197],"tumor":[6],"suppressor":[7],"affect":[8],"mitochondrial":[9,15,26,62,100,130,148,204],"processes,":[10],"role":[12],"altered":[14],"physiology":[16],"in":[17,30,74,117,145,178,182,190,199],"a":[18,59,124,172],"modulation":[19],"response":[22,91,111,146,198],"remains":[23],"unclear.":[24],"As":[25],"respiration":[27,63],"is":[28,92,112,120],"affected":[29],"pathologic":[32],"conditions":[33],"such":[34],"as":[35,193],"hypoxia":[36],"and":[37,49,77,176],"intoxications,":[38],"impaired":[40,203],"electron":[41,104,149],"transport":[42,105,150],"chain":[43,83,106,151],"could":[44],"emit":[45],"additional":[46],"p53-inducing":[47],"signals":[48],"thereby":[50],"contribute":[51],"to":[52,123,147],"tissue":[53],"damage.":[54],"Here":[55],"we":[56],"show":[57],"that":[58,119],"shutdown":[60],"per":[64],"se":[65],"does":[66,155],"not":[67,85,156],"trigger":[68],"response,":[70],"because":[71],"inhibitors":[72,154],"acting":[73],"proximal":[76],"distal":[78],"segments":[79],"respiratory":[82],"do":[84],"activate":[86],"p53.":[87],"However,":[88],"strong":[89],"induced":[93],"specifically":[94],"after":[95],"an":[96],"inhibition":[97],"cytochrome":[101],"bc1":[102],"(the":[103],"complex":[107,152],"III).":[108],"The":[109,185],"triggered":[113],"by":[114],"deficiency":[116,189],"pyrimidines":[118],"developed":[121],"due":[122],"suppression":[125],"functionally":[128],"coupled":[129],"pyrimidine":[131,191],"biosynthesis":[132,192],"enzyme":[133],"dihydroorotate":[134],"dehydrogenase":[135],"(DHODH).":[136],"In":[137],"epithelial":[138],"carcinoma":[139],"cells":[140,201],"activation":[142],"III":[153],"require":[157],"phosphorylation":[158],"at":[161],"Serine":[162],"15":[163],"or":[164],"up-regulation":[165],"p14(ARF).":[167],"Instead,":[168],"our":[169],"data":[170],"suggest":[171],"contribution":[173],"NQO1":[175],"NQO2":[177],"stabilization":[179],"nuclei.":[184],"results":[186],"establish":[187],"cause":[195],"with":[202],"respiration.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":22},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}