{"id":"https://openalex.org/W2008509697","doi":"https://doi.org/10.3389/fnins.2015.00035","title":"Binge ethanol exposure during adolescence leads to a persistent loss of neurogenesis in the dorsal and ventral hippocampus that is associated with impaired adult cognitive functioning","display_name":"Binge ethanol exposure during adolescence leads to a persistent loss of neurogenesis in the dorsal and ventral hippocampus that is associated with impaired adult cognitive functioning","publication_year":2015,"publication_date":"2015-02-12","ids":{"openalex":"https://openalex.org/W2008509697","doi":"https://doi.org/10.3389/fnins.2015.00035","mag":"2008509697","pmid":"https://pubmed.ncbi.nlm.nih.gov/25729346","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4325907"},"language":"en","primary_location":{"id":"doi:10.3389/fnins.2015.00035","doi":"https://doi.org/10.3389/fnins.2015.00035","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2015.00035","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2015.00035/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fnins.2015.00035/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077109422","display_name":"Ryan P. Vetreno","orcid":"https://orcid.org/0000-0003-0449-395X","observed_orcids":["https://orcid.org/0000-0003-0449-395X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ryan P. Vetreno","raw_affiliation_strings":["Department of Psychiatry, Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031569610","display_name":"Fulton T. Crews","orcid":"https://orcid.org/0000-0003-2393-4976","observed_orcids":["https://orcid.org/0000-0003-2393-4976"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fulton T. Crews","raw_affiliation_strings":["Department of Psychiatry, Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5077109422"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":6.5737,"has_fulltext":true,"cited_by_count":174,"citation_normalized_percentile":{"value":0.97737027,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"9","issue":null,"first_page":"35","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hippocampal-neurogenesis","display_name":"hippocampal neurogenesis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/dentate-gyrus","display_name":"dentate gyrus","score":0.9200000166893005},{"id":"https://openalex.org/keywords/doublecortin","display_name":"doublecortin","score":0.6970000267028809},{"id":"https://openalex.org/keywords/neuroimmune-signaling","display_name":"neuroimmune signaling","score":0.6209999918937683},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9959999918937683},{"id":"https://openalex.org/keywords/high-mobility-group-box-1","display_name":"high mobility group box 1","score":0.9319999814033508},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9940000176429749},{"id":"https://openalex.org/keywords/object-recognition-memory","display_name":"object recognition memory","score":0.8339999914169312},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.753000020980835},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.4490000009536743},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.7429999709129333},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.8289999961853027},{"id":"https://openalex.org/keywords/brain-maturation","display_name":"brain maturation","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.9060590863227844},{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.8652216196060181},{"id":"https://openalex.org/C2781461022","wikidata":"https://www.wikidata.org/wiki/Q14912973","display_name":"Doublecortin","level":4,"score":0.7888142466545105},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6982601284980774},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5443664193153381},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4910910129547119},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.48111170530319214},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45857909321784973},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.42800062894821167},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4262763559818268},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2835909128189087},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21328774094581604}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.3389/fnins.2015.00035","doi":"https://doi.org/10.3389/fnins.2015.00035","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2015.00035","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2015.00035/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3305603","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4325907","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4325907","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4325907","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Neurosci","raw_type":"Text"},{"id":"pmid:25729346","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25729346","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neuroscience","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:9w032862h","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.17615/efvj-pw41","pdf_url":null,"source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Alcoholism - Clinical and Experimental Research, 9(feb)","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:d4f2cc5096cb40c3a089a9d86c776864","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d4f2cc5096cb40c3a089a9d86c776864","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neuroscience, Vol 9 (2015)","raw_type":"article"},{"id":"doi:10.17615/efvj-pw41","doi":"https://doi.org/10.17615/efvj-pw41","is_oa":true,"landing_page_url":"https://doi.org/10.17615/efvj-pw41","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.3389/fnins.2015.00035","doi":"https://doi.org/10.3389/fnins.2015.00035","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2015.00035","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2015.00035/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1288965875","display_name":"MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISM","funder_award_id":"P50AA011605","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G1462972023","display_name":"UNC-CH NADIA  Scientific Core","funder_award_id":"U24AA020022","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G1944050632","display_name":"5/8 NADIA U01 Effects of Adolescent Alcohol on adult brain Neurocircuitry","funder_award_id":"U01AA020023","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G3338828332","display_name":null,"funder_award_id":"L40 AA021590","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G6288513181","display_name":"Adult neurobiology following adolescent drinking","funder_award_id":"F32AA021040","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G7097348119","display_name":"1/1 NADIA U24 Administrative Core","funder_award_id":"U24AA020024","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G718878517","display_name":"2/2 Mechanisms of alcohol pathology:  A collaborative partnership between NCCU & UNC","funder_award_id":"U54AA019767","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000102076","display_name":null,"funder_award_id":"AA-11605","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000148061","display_name":null,"funder_award_id":"AA007573","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000862483","display_name":"Molecular and Circuit Pathogenesis of Alcohol Use Disorders","funder_award_id":"P60AA011605","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000891745","display_name":"Molecular and Cellular Alcohol Research Training","funder_award_id":"T32AA007573","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320326600","display_name":"Center for Alcohol Studies","ror":"https://ror.org/00sef7t37"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2008509697.pdf","grobid_xml":"https://content.openalex.org/works/W2008509697.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W249845531","https://openalex.org/W652244874","https://openalex.org/W1530758488","https://openalex.org/W1581458838","https://openalex.org/W1959902108","https://openalex.org/W1965279522","https://openalex.org/W1974208182","https://openalex.org/W1976142627","https://openalex.org/W1988178045","https://openalex.org/W2001478447","https://openalex.org/W2002112050","https://openalex.org/W2003966687","https://openalex.org/W2005805321","https://openalex.org/W2010526028","https://openalex.org/W2014371439","https://openalex.org/W2015497878","https://openalex.org/W2018062658","https://openalex.org/W2026257161","https://openalex.org/W2028662192","https://openalex.org/W2030338901","https://openalex.org/W2040692117","https://openalex.org/W2042662932","https://openalex.org/W2045642954","https://openalex.org/W2055750901","https://openalex.org/W2057608998","https://openalex.org/W2064424963","https://openalex.org/W2065323453","https://openalex.org/W2067318929","https://openalex.org/W2067856703","https://openalex.org/W2068431065","https://openalex.org/W2072492410","https://openalex.org/W2073295417","https://openalex.org/W2076874426","https://openalex.org/W2079885871","https://openalex.org/W2080361651","https://openalex.org/W2083268412","https://openalex.org/W2083743152","https://openalex.org/W2084081279","https://openalex.org/W2089178573","https://openalex.org/W2089394861","https://openalex.org/W2089714619","https://openalex.org/W2090660571","https://openalex.org/W2094050668","https://openalex.org/W2094790810","https://openalex.org/W2104792456","https://openalex.org/W2105086774","https://openalex.org/W2106638112","https://openalex.org/W2111051690","https://openalex.org/W2116806046","https://openalex.org/W2120107945","https://openalex.org/W2136863044","https://openalex.org/W2143057868","https://openalex.org/W2143384095","https://openalex.org/W2145235967","https://openalex.org/W2151400960","https://openalex.org/W2161800657","https://openalex.org/W6643624514","https://openalex.org/W7046493686"],"related_works":["https://openalex.org/W7099928031","https://openalex.org/W2741430572","https://openalex.org/W2794550911","https://openalex.org/W2991514427","https://openalex.org/W2094790810","https://openalex.org/W3217198276","https://openalex.org/W2761811648","https://openalex.org/W4308358954","https://openalex.org/W7154863931","https://openalex.org/W3209264839"],"abstract_inverted_index":{"Adolescence":[0],"is":[1,16],"a":[2,26,94,115,144,156],"developmental":[3],"period":[4],"that":[5,53,80,164,233],"coincides":[6],"with":[7,195,220],"the":[8,66,110,177,201,212,215,225,242],"maturation":[9],"of":[10,29,73,118,142,159,214],"adult":[11,152,253],"cognitive":[12,254],"faculties.":[13],"Binge":[14],"drinking":[15],"common":[17],"during":[18,82],"adolescence":[19],"and":[20,68,101,126,203,255],"can":[21],"impact":[22],"brain":[23],"maturation.":[24],"Using":[25],"rodent":[27],"model":[28],"adolescent":[30,75,234],"intermittent":[31],"ethanol":[32,236],"(AIE;":[33],"5.0":[34],"g/kg,":[35],"i.g.,":[36],"20%":[37],"EtOH":[38],"w/v;":[39],"2":[40],"days":[41,43],"on/2":[42],"off":[44],"from":[45,184],"postnatal":[46],"day":[47],"[P]25":[48],"to":[49,150,186,210,251],"P55),":[50],"we":[51],"discovered":[52],"AIE":[54,112,171],"treatment":[55,113,172],"reduced":[56],"neurogenesis":[57,90,240],"(i.e.,":[58],"doublecortin-immunoreactive":[59],"[DCX":[60],"+":[61,161,197,222],"IR]":[62],"cells)":[63],"in":[64,89,97,104,167,199,224],"both":[65,200],"dorsal":[67,202],"ventral":[69,204,226],"hippocampal":[70,205],"dentate":[71,206,227],"gyrus":[72,207],"late":[74],"(P56)":[76],"male":[77],"Wistar":[78],"rats":[79,153],"persisted":[81],"abstinence":[83],"into":[84],"adulthood":[85],"(P220).":[86],"This":[87],"reduction":[88,96,158],"was":[91,165,192,217],"accompanied":[92],"by":[93],"concomitant":[95],"proliferating":[98],"cells":[99,163],"(Ki-67)":[100],"an":[102],"increase":[103],"cell":[105],"death":[106],"(cleaved":[107],"caspase-3).":[108],"In":[109],"hippocampus,":[111,243],"induced":[114],"long-term":[116],"upregulation":[117],"neuroimmune":[119,246],"genes,":[120],"including":[121],"Toll-like":[122],"receptor":[123],"4":[124],"(TLR4)":[125],"its":[127],"endogenous":[128],"agonist":[129,147],"high-mobility":[130],"group":[131],"box":[132],"1":[133],"as":[134,136],"well":[135],"several":[137],"proinflammatory":[138],"signaling":[139],"molecules.":[140],"Administration":[141],"lipopolysaccharide,":[143],"gram-negative":[145],"endotoxin":[146],"at":[148],"TLR4,":[149],"young":[151],"(P70)":[154],"produced":[155],"similar":[157],"DCX":[160,196,221],"IR":[162,198,223],"observed":[166],"AIE-treated":[168],"animals.":[169],"Behaviorally,":[170],"impaired":[173],"object":[174,179,189],"recognition":[175,180,190],"on":[176],"novel":[178],"task":[181],"when":[182],"assessed":[183],"P163":[185],"P165.":[187],"Interestingly,":[188],"memory":[191],"positively":[193],"correlated":[194,219],"while":[208],"latency":[209],"enter":[211],"center":[213],"apparatus":[216],"negatively":[218],"gyrus.":[228],"Together,":[229],"these":[230],"data":[231],"reveal":[232],"binge":[235],"exposure":[237],"persistently":[238],"inhibits":[239],"throughout":[241],"possibly":[244],"through":[245],"mechanisms,":[247],"which":[248],"might":[249],"contribute":[250],"altered":[252],"emotive":[256],"function.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":20},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}