{"id":"https://openalex.org/W2008488128","doi":"https://doi.org/10.1016/j.gde.2008.12.004","title":"A little CIN may cost a lot: revisiting aneuploidy and cancer","display_name":"A little CIN may cost a lot: revisiting aneuploidy and cancer","publication_year":2009,"publication_date":"2009-02-01","ids":{"openalex":"https://openalex.org/W2008488128","doi":"https://doi.org/10.1016/j.gde.2008.12.004","mag":"2008488128","pmid":"https://pubmed.ncbi.nlm.nih.gov/19195877"},"language":"en","primary_location":{"id":"doi:10.1016/j.gde.2008.12.004","doi":"https://doi.org/10.1016/j.gde.2008.12.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.gde.2008.12.004","pdf_url":null,"source":{"id":"https://openalex.org/S116174365","display_name":"Current Opinion in Genetics & Development","issn_l":"0959-437X","issn":["0959-437X","1879-0380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Genetics &amp; Development","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058367777","display_name":"Namrata S. Chandhok","orcid":"https://orcid.org/0000-0002-7464-4509","observed_orcids":["https://orcid.org/0000-0002-7464-4509"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Namrata S Chandhok","raw_affiliation_strings":["Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA. Namrata_Chandhok@dfci.harvard.edu","Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Rm. M663, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA. Namrata_Chandhok@dfci.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"raw_affiliation_string":"Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Rm. M663, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024739591","display_name":"David S. Pellman","orcid":"https://orcid.org/0000-0001-5306-8031","observed_orcids":["https://orcid.org/0000-0001-5306-8031"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David Pellman","raw_affiliation_strings":["Department of Pediatric Hematology/Oncology, Children's Hospital, Boston, MA 02115, USA","Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Rm. M663, Boston, MA 02115, USA","Howard Hughes Medical Institute, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Hematology/Oncology, Children's Hospital, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Rm. M663, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1344073410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5024739591","https://openalex.org/A5058367777"],"corresponding_institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.792,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.59821429,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"19","issue":"1","first_page":"74","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aneuploidy","display_name":"aneuploidy","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.9539999961853027},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.7049999833106995},{"id":"https://openalex.org/keywords/telomere-shortening","display_name":"telomere shortening","score":0.890999972820282},{"id":"https://openalex.org/keywords/chromosomal-instability","display_name":"chromosomal instability","score":0.5120000243186951}],"concepts":[{"id":"https://openalex.org/C2779672484","wikidata":"https://www.wikidata.org/wiki/Q529622","display_name":"Aneuploidy","level":4,"score":0.9489466547966003},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8224167823791504},{"id":"https://openalex.org/C140752955","wikidata":"https://www.wikidata.org/wiki/Q1087752","display_name":"Chromosome instability","level":4,"score":0.7510102987289429},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.6163837313652039},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5198379158973694},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.5042668581008911},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4643217921257019},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3854368031024933},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.1755460798740387},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.1741270124912262},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11573690176010132},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.10260239243507385}],"mesh":[{"descriptor_ui":"D000782","descriptor_name":"Aneuploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.gde.2008.12.004","doi":"https://doi.org/10.1016/j.gde.2008.12.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.gde.2008.12.004","pdf_url":null,"source":{"id":"https://openalex.org/S116174365","display_name":"Current Opinion in Genetics & Development","issn_l":"0959-437X","issn":["0959-437X","1879-0380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Genetics &amp; Development","raw_type":"journal-article"},{"id":"pmid:19195877","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19195877","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in genetics & development","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4757422834","display_name":null,"funder_award_id":"GM 083299","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5376946404","display_name":"Polyploidy, aneuploidy and genome stability","funder_award_id":"R01GM083299","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1535354154","https://openalex.org/W1583265575","https://openalex.org/W1635186783","https://openalex.org/W1963853682","https://openalex.org/W1965560988","https://openalex.org/W1966622127","https://openalex.org/W1967071353","https://openalex.org/W1968407767","https://openalex.org/W1969348568","https://openalex.org/W1970442105","https://openalex.org/W1973017365","https://openalex.org/W1973082742","https://openalex.org/W1978302017","https://openalex.org/W1978398706","https://openalex.org/W1984542357","https://openalex.org/W1995940821","https://openalex.org/W1996152576","https://openalex.org/W2002470273","https://openalex.org/W2006141070","https://openalex.org/W2006873092","https://openalex.org/W2012276721","https://openalex.org/W2022527641","https://openalex.org/W2023583823","https://openalex.org/W2025183726","https://openalex.org/W2025829112","https://openalex.org/W2029971236","https://openalex.org/W2030086669","https://openalex.org/W2030202463","https://openalex.org/W2036165466","https://openalex.org/W2040827479","https://openalex.org/W2048938594","https://openalex.org/W2064980447","https://openalex.org/W2066455674","https://openalex.org/W2066985045","https://openalex.org/W2074548008","https://openalex.org/W2075601868","https://openalex.org/W2076814468","https://openalex.org/W2080308138","https://openalex.org/W2102922697","https://openalex.org/W2102960342","https://openalex.org/W2103177765","https://openalex.org/W2103909278","https://openalex.org/W2105337907","https://openalex.org/W2108356291","https://openalex.org/W2121533623","https://openalex.org/W2123820544","https://openalex.org/W2127332710","https://openalex.org/W2128126810","https://openalex.org/W2132903556","https://openalex.org/W2137683543","https://openalex.org/W2138155367","https://openalex.org/W2145329735","https://openalex.org/W2147101023","https://openalex.org/W2150195554","https://openalex.org/W2152147560","https://openalex.org/W2153304690","https://openalex.org/W2154428950","https://openalex.org/W2154457034","https://openalex.org/W2154603906","https://openalex.org/W2156393663","https://openalex.org/W2156492707","https://openalex.org/W2159656070","https://openalex.org/W2530014580","https://openalex.org/W2977987507","https://openalex.org/W4240762047","https://openalex.org/W6667219394"],"related_works":["https://openalex.org/W1965707365","https://openalex.org/W2028666395","https://openalex.org/W2119147780","https://openalex.org/W2006620593","https://openalex.org/W1980493852","https://openalex.org/W3119400275","https://openalex.org/W2182416406","https://openalex.org/W1558701786","https://openalex.org/W4414642870","https://openalex.org/W2973350525"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
