{"id":"https://openalex.org/W2008478914","doi":"https://doi.org/10.1038/emboj.2009.118","title":"NRH2 is a trafficking switch to regulate sortilin localization and permit proneurotrophin\u2010induced cell death","display_name":"NRH2 is a trafficking switch to regulate sortilin localization and permit proneurotrophin\u2010induced cell death","publication_year":2009,"publication_date":"2009-04-30","ids":{"openalex":"https://openalex.org/W2008478914","doi":"https://doi.org/10.1038/emboj.2009.118","mag":"2008478914","pmid":"https://pubmed.ncbi.nlm.nih.gov/19407813","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2693153"},"language":"en","primary_location":{"id":"doi:10.1038/emboj.2009.118","doi":"https://doi.org/10.1038/emboj.2009.118","is_oa":true,"landing_page_url":"https://doi.org/10.1038/emboj.2009.118","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/emboj.2009.118","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/emboj.2009.118","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100452198","display_name":"Taeho Kim","orcid":"https://orcid.org/0000-0002-7500-8918","observed_orcids":["https://orcid.org/0000-0002-7500-8918"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taeho Kim","raw_affiliation_strings":["Graduate Program in Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA","Graduate Program in Neuroscience, Weill Medical College of Cornell University New York NY USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Graduate Program in Neuroscience, Weill Medical College of Cornell University New York NY USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086974646","display_name":"Barbara L. Hempstead","orcid":"https://orcid.org/0009-0002-9957-564X","observed_orcids":["https://orcid.org/0009-0002-9957-564X"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Barbara L Hempstead","raw_affiliation_strings":["Department of Medicine, Weill Medical College of Cornell University New York NY USA","Graduate Program in Neuroscience, Weill Medical College of Cornell University New York NY USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Weill Medical College of Cornell University New York NY USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Graduate Program in Neuroscience, Weill Medical College of Cornell University New York NY USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5086974646"],"corresponding_institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"],"apc_list":{"value":7990,"currency":"USD","value_usd":7990},"apc_paid":null,"fwci":1.9581,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.83800405,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"28","issue":"11","first_page":"1612","last_page":"1623"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.03669999912381172,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sortilin","display_name":"sortilin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/p75-neurotrophin-receptor","display_name":"p75 neurotrophin receptor","score":0.9409999847412109},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.9380000233650208},{"id":"https://openalex.org/keywords/receptor-trafficking","display_name":"receptor trafficking","score":0.6480000019073486},{"id":"https://openalex.org/keywords/lysosomal-degradation","display_name":"lysosomal degradation","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cell-surface-receptors","display_name":"cell surface receptors","score":0.32600000500679016},{"id":"https://openalex.org/keywords/neurotrophin-signaling","display_name":"neurotrophin signaling","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7676033973693848},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7538416385650635},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.6189126968383789},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5542433261871338},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5496641993522644},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.544873058795929},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.49243053793907166},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4509083032608032},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.43851327896118164},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.42532408237457275},{"id":"https://openalex.org/C197462201","wikidata":"https://www.wikidata.org/wiki/Q2476074","display_name":"Cell surface receptor","level":3,"score":0.41325443983078003},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.35791242122650146},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15455475449562073},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10157579183578491}],"mesh":[{"descriptor_ui":"D000099183","descriptor_name":"Sortilin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017475","descriptor_name":"Receptors, Nerve Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033942","descriptor_name":"Adaptor Proteins, Vesicular Transport","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/emboj.2009.118","doi":"https://doi.org/10.1038/emboj.2009.118","is_oa":true,"landing_page_url":"https://doi.org/10.1038/emboj.2009.118","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/emboj.2009.118","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2693153","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2693153","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO J","raw_type":"Text"},{"id":"pmid:19407813","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19407813","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/emboj.2009.118","doi":"https://doi.org/10.1038/emboj.2009.118","is_oa":true,"landing_page_url":"https://doi.org/10.1038/emboj.2009.118","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/emboj.2009.118","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3021697048","display_name":null,"funder_award_id":"NS30687","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4734294771","display_name":"Receptor-Mediated Control of Cell Differentiation","funder_award_id":"R01NS030687","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2008478914.pdf","grobid_xml":"https://content.openalex.org/works/W2008478914.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1561325891","https://openalex.org/W1605328799","https://openalex.org/W1607357356","https://openalex.org/W1835200336","https://openalex.org/W1967336797","https://openalex.org/W1967636949","https://openalex.org/W1969479602","https://openalex.org/W1975432307","https://openalex.org/W1986126218","https://openalex.org/W1986247887","https://openalex.org/W1988619763","https://openalex.org/W1989378863","https://openalex.org/W1993655108","https://openalex.org/W1997957892","https://openalex.org/W2000797303","https://openalex.org/W2005288981","https://openalex.org/W2005753856","https://openalex.org/W2011724363","https://openalex.org/W2012299945","https://openalex.org/W2012423618","https://openalex.org/W2016203088","https://openalex.org/W2030614715","https://openalex.org/W2030662833","https://openalex.org/W2033744604","https://openalex.org/W2039414588","https://openalex.org/W2046344792","https://openalex.org/W2048388437","https://openalex.org/W2062644850","https://openalex.org/W2065482131","https://openalex.org/W2080234581","https://openalex.org/W2087085993","https://openalex.org/W2087090756","https://openalex.org/W2089056437","https://openalex.org/W2089124684","https://openalex.org/W2111112233","https://openalex.org/W2138182618","https://openalex.org/W2148351021","https://openalex.org/W2153068303","https://openalex.org/W2157047802","https://openalex.org/W2161992241","https://openalex.org/W2330956224"],"related_works":["https://openalex.org/W1969479602","https://openalex.org/W2003628819","https://openalex.org/W7081548423","https://openalex.org/W4246702188","https://openalex.org/W1965646229","https://openalex.org/W2033744604","https://openalex.org/W1970310239","https://openalex.org/W7020998294","https://openalex.org/W2385433995","https://openalex.org/W2120368646"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}