{"id":"https://openalex.org/W2008451564","doi":"https://doi.org/10.1111/j.1440-1827.2006.01979.x","title":"Carcinosarcoma of the liver producing granulocyte\u2010colony stimulating factor","display_name":"Carcinosarcoma of the liver producing granulocyte\u2010colony stimulating factor","publication_year":2006,"publication_date":"2006-06-21","ids":{"openalex":"https://openalex.org/W2008451564","doi":"https://doi.org/10.1111/j.1440-1827.2006.01979.x","mag":"2008451564","pmid":"https://pubmed.ncbi.nlm.nih.gov/16792552"},"language":"en","primary_location":{"id":"doi:10.1111/j.1440-1827.2006.01979.x","doi":"https://doi.org/10.1111/j.1440-1827.2006.01979.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1440-1827.2006.01979.x","pdf_url":null,"source":{"id":"https://openalex.org/S70002872","display_name":"Pathology International","issn_l":"1320-5463","issn":["1320-5463","1440-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathology International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029396822","display_name":"Kumi Aita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kumi Aita","raw_affiliation_strings":["Molecular Pathology, Institute of Basic Medical Science, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukubashi, Ibaraki, Japan. kumiaita@md.tsukuba.ac.jp","Molecular Pathology, Institute of Basic Medical Science, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Ibaraki and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Pathology, Institute of Basic Medical Science, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukubashi, Ibaraki, Japan. kumiaita@md.tsukuba.ac.jp","institution_ids":["https://openalex.org/I146399215"]},{"raw_affiliation_string":"Molecular Pathology, Institute of Basic Medical Science, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Ibaraki and","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087062889","display_name":"Kunihiko Seki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285273","display_name":"National Cancer Center Hospital","ror":"https://ror.org/053hhpd64","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405285273"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kunihiko Seki","raw_affiliation_strings":["Pathology, Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan","institution_ids":["https://openalex.org/I4405285273"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5029396822"],"corresponding_institution_ids":["https://openalex.org/I146399215"],"apc_list":{"value":3610,"currency":"USD","value_usd":3610},"apc_paid":null,"fwci":1.0977,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.78934029,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"56","issue":"7","first_page":"413","last_page":"419"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.7304999828338623,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.7304999828338623,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12992","display_name":"Metastasis and carcinoma case studies","score":0.20389999449253082,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.016300000250339508,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.968999981880188},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8970000147819519},{"id":"https://openalex.org/keywords/leukocytosis","display_name":"leukocytosis","score":0.6809999942779541},{"id":"https://openalex.org/keywords/g-csf-producing-tumor","display_name":"G-CSF-producing tumor","score":0.6800000071525574},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.8619999885559082},{"id":"https://openalex.org/keywords/desmin","display_name":"desmin","score":0.996999979019165},{"id":"https://openalex.org/keywords/heterologous-differentiation","display_name":"heterologous differentiation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/high-grade-transformation","display_name":"high-grade transformation","score":0.703000009059906},{"id":"https://openalex.org/keywords/monoclonal-origin","display_name":"monoclonal origin","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C2778938455","wikidata":"https://www.wikidata.org/wiki/Q5038170","display_name":"Carcinosarcoma","level":3,"score":0.842681884765625},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.799950122833252},{"id":"https://openalex.org/C2779504383","wikidata":"https://www.wikidata.org/wiki/Q41482","display_name":"Autopsy","level":2,"score":0.6185457706451416},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5258063673973083},{"id":"https://openalex.org/C2777767877","wikidata":"https://www.wikidata.org/wiki/Q419327","display_name":"Granulocyte colony-stimulating factor","level":3,"score":0.4831952154636383},{"id":"https://openalex.org/C2778923028","wikidata":"https://www.wikidata.org/wiki/Q974869","display_name":"Leukocytosis","level":2,"score":0.41690051555633545},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3939468264579773},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.3842828571796417},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36218103766441345},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1634189486503601},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002296","descriptor_name":"Carcinosarcoma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002296","descriptor_name":"Carcinosarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003893","descriptor_name":"Desmin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007964","descriptor_name":"Leukocytosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D017809","descriptor_name":"Fatal Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1440-1827.2006.01979.x","doi":"https://doi.org/10.1111/j.1440-1827.2006.01979.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1440-1827.2006.01979.x","pdf_url":null,"source":{"id":"https://openalex.org/S70002872","display_name":"Pathology International","issn_l":"1320-5463","issn":["1320-5463","1440-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathology International","raw_type":"journal-article"},{"id":"pmid:16792552","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16792552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathology international","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W28926443","https://openalex.org/W90047736","https://openalex.org/W630382856","https://openalex.org/W1518701063","https://openalex.org/W1975947992","https://openalex.org/W1985819134","https://openalex.org/W1996420171","https://openalex.org/W1998531398","https://openalex.org/W2029544926","https://openalex.org/W2041264729","https://openalex.org/W2042477762","https://openalex.org/W2049105888","https://openalex.org/W2071100603","https://openalex.org/W2086640810","https://openalex.org/W2121185627","https://openalex.org/W2157686292","https://openalex.org/W2185694541","https://openalex.org/W2292859505","https://openalex.org/W2725173633"],"related_works":["https://openalex.org/W2056045053","https://openalex.org/W2106758950","https://openalex.org/W2894395617","https://openalex.org/W3148811223","https://openalex.org/W2332767277","https://openalex.org/W2075500552","https://openalex.org/W7100252122","https://openalex.org/W2323604914","https://openalex.org/W3092746099","https://openalex.org/W2528173331"],"abstract_inverted_index":{"An":[0],"autopsy":[1],"case":[2,134],"of":[3,5,38,64,82,87,91,99,121,131,143,160,182,192],"carcinosarcoma":[4,61],"the":[6,85,92,109,115,119,125,128,132,158,164,168,179,183,189],"liver":[7,24,60],"producing":[8,195],"granulocyte-colony":[9],"stimulating":[10],"factor":[11],"(G-CSF)":[12],"is":[13,172],"reported.":[14],"The":[15,43],"patient,":[16],"a":[17,35,46,59,140,152],"74-year-old":[18],"Japanese":[19],"man,":[20],"presented":[21],"with":[22,72,178],"multiple":[23],"masses.":[25],"His":[26],"serum":[27],"G-CSF":[28,83,100,161,175],"was":[29,41,95,101,176],"elevated":[30],"to":[31,118,157],"286":[32],"pg/mL":[33],"and":[34,51,68,76],"marked":[36],"leukocytosis":[37],"19":[39],"100/microL":[40],"observed.":[42],"patient":[44],"had":[45],"rapidly":[47],"aggravated":[48],"clinical":[49],"course":[50],"died":[52],"57":[53],"days":[54],"after":[55],"admission.":[56],"Autopsy":[57],"revealed":[58,79],"composed":[62],"both":[63],"hepatocellular":[65],"carcinoma":[66],"(HCC)":[67],"sarcomatous":[69],"elements":[70,130],"immunoreactive":[71],"alpha-smooth":[73],"muscle":[74],"actin":[75],"desmin.":[77],"Immunohistochemistry":[78],"positive":[80],"staining":[81],"in":[84,124,163,167],"cytoplasm":[86],"HCC,":[88],"whereas":[89],"none":[90],"spindle":[93],"cells":[94],"positively":[96],"stained.":[97],"Production":[98],"also":[102],"confirmed":[103],"by":[104],"enzyme-linked":[105],"immunosorbent":[106],"assay,":[107],"using":[108],"frozen":[110],"tumor":[111],"tissue":[112],"taken":[113],"at":[114],"autopsy.":[116],"Similar":[117],"majority":[120],"G-CSF-producing":[122],"tumors":[123],"literature,":[126],"only":[127,162],"epithelial":[129,165,184],"present":[133,169],"were":[135],"immunopositive":[136],"for":[137],"G-CSF.":[138,196],"Although":[139],"monoclonal":[141],"origin":[142],"carcinosarcomas":[144],"has":[145],"generally":[146],"been":[147],"proposed,":[148],"heterologous":[149],"differentiation":[150],"from":[151],"single":[153],"clone":[154],"might":[155],"lead":[156],"production":[159],"element":[166],"case.":[170],"It":[171],"suggested":[173],"that":[174],"associated":[177],"high-grade":[180],"transformation":[181],"elements,":[185],"as":[186,188],"well":[187],"reported":[190],"phenomenon":[191],"conventional":[193],"HCC":[194]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
