{"id":"https://openalex.org/W2008441285","doi":"https://doi.org/10.1155/2013/594012","title":"Acute Toxicity and the Effect of Andrographolide onPorphyromonas gingivalis-Induced Hyperlipidemia in Rats","display_name":"Acute Toxicity and the Effect of Andrographolide onPorphyromonas gingivalis-Induced Hyperlipidemia in Rats","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2008441285","doi":"https://doi.org/10.1155/2013/594012","mag":"2008441285","pmid":"https://pubmed.ncbi.nlm.nih.gov/23844365","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3703379"},"language":"en","primary_location":{"id":"doi:10.1155/2013/594012","doi":"https://doi.org/10.1155/2013/594012","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2013/594012","pdf_url":"https://downloads.hindawi.com/journals/bmri/2013/594012.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed Research International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/bmri/2013/594012.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003760407","display_name":"Rami Al Batran","orcid":"https://orcid.org/0000-0001-5412-3346","observed_orcids":["https://orcid.org/0000-0001-5412-3346"]},"institutions":[{"id":"https://openalex.org/I4210138650","display_name":"Universiti Teknologi MARA System","ror":"https://ror.org/030847t23","country_code":"MY","type":"education","lineage":["https://openalex.org/I4210138650","https://openalex.org/I82724352"]},{"id":"https://openalex.org/I82724352","display_name":"Universiti Teknologi MARA","ror":"https://ror.org/05n8tts92","country_code":"MY","type":"education","lineage":["https://openalex.org/I82724352"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Rami Al Batran","raw_affiliation_strings":["Center of Studies for Periodontology, Faculty of Dentistry, University Technology MARA (UiTM), 40450 Shah Alam, Selangor, Malaysia"],"raw_orcid":"https://orcid.org/0000-0001-5412-3346","affiliations":[{"raw_affiliation_string":"Center of Studies for Periodontology, Faculty of Dentistry, University Technology MARA (UiTM), 40450 Shah Alam, Selangor, Malaysia","institution_ids":["https://openalex.org/I4210138650","https://openalex.org/I82724352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083137886","display_name":"Fouad Hussain Al-Bayaty","orcid":"https://orcid.org/0000-0002-3117-595X","observed_orcids":["https://orcid.org/0000-0002-3117-595X"]},"institutions":[{"id":"https://openalex.org/I4210138650","display_name":"Universiti Teknologi MARA System","ror":"https://ror.org/030847t23","country_code":"MY","type":"education","lineage":["https://openalex.org/I4210138650","https://openalex.org/I82724352"]},{"id":"https://openalex.org/I82724352","display_name":"Universiti Teknologi MARA","ror":"https://ror.org/05n8tts92","country_code":"MY","type":"education","lineage":["https://openalex.org/I82724352"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"Fouad Al-Bayaty","raw_affiliation_strings":["Center of Studies for Periodontology, Faculty of Dentistry, University Technology MARA (UiTM), 40450 Shah Alam, Selangor, Malaysia"],"raw_orcid":"https://orcid.org/0000-0002-3117-595X","affiliations":[{"raw_affiliation_string":"Center of Studies for Periodontology, Faculty of Dentistry, University Technology MARA (UiTM), 40450 Shah Alam, Selangor, Malaysia","institution_ids":["https://openalex.org/I4210138650","https://openalex.org/I82724352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022517381","display_name":"Mazen M. Jamil Al\u2010Obaidi","orcid":"https://orcid.org/0000-0001-5950-4498","observed_orcids":["https://orcid.org/0000-0001-5950-4498"]},"institutions":[{"id":"https://openalex.org/I4210138650","display_name":"Universiti Teknologi MARA System","ror":"https://ror.org/030847t23","country_code":"MY","type":"education","lineage":["https://openalex.org/I4210138650","https://openalex.org/I82724352"]},{"id":"https://openalex.org/I82724352","display_name":"Universiti Teknologi MARA","ror":"https://ror.org/05n8tts92","country_code":"MY","type":"education","lineage":["https://openalex.org/I82724352"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Mazen M. Jamil Al-Obaidi","raw_affiliation_strings":["Center of Studies for Periodontology, Faculty of Dentistry, University Technology MARA (UiTM), 40450 Shah Alam, Selangor, Malaysia"],"raw_orcid":"https://orcid.org/0000-0001-5950-4498","affiliations":[{"raw_affiliation_string":"Center of Studies for Periodontology, Faculty of Dentistry, University Technology MARA (UiTM), 40450 Shah Alam, Selangor, Malaysia","institution_ids":["https://openalex.org/I4210138650","https://openalex.org/I82724352"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103033664","display_name":"Mahmood Ameen Abdulla","orcid":"https://orcid.org/0000-0001-9546-4008","observed_orcids":["https://orcid.org/0000-0001-9546-4008","https://orcid.org/0000-0003-4784-6313"]},"institutions":[{"id":"https://openalex.org/I33849332","display_name":"University of Malaya","ror":"https://ror.org/00rzspn62","country_code":"MY","type":"education","lineage":["https://openalex.org/I33849332"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Mahmood A. Abdulla","raw_affiliation_strings":["Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia"],"raw_orcid":"https://orcid.org/0000-0001-9546-4008","affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I33849332"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5083137886"],"corresponding_institution_ids":["https://openalex.org/I4210138650","https://openalex.org/I82724352"],"apc_list":{"value":2680,"currency":"USD","value_usd":2680},"apc_paid":{"value":2680,"currency":"USD","value_usd":2680},"fwci":4.4169,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.9259001,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"2013","issue":null,"first_page":"1","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13281","display_name":"Andrographolide Research and Applications","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13281","display_name":"Andrographolide Research and Applications","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/andrographolide","display_name":"andrographolide","score":1.0},{"id":"https://openalex.org/keywords/porphyromonas-gingivalis","display_name":"Porphyromonas gingivalis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.9309999942779541},{"id":"https://openalex.org/keywords/acute-toxicity","display_name":"acute toxicity","score":0.7770000100135803},{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":0.7400000095367432},{"id":"https://openalex.org/keywords/total-cholesterol","display_name":"total cholesterol","score":0.6510000228881836},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.8679999709129333},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":1.0},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.8949999809265137},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.8389999866485596},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9670000076293945},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":1.0},{"id":"https://openalex.org/keywords/hepatic-lipid-accumulation","display_name":"hepatic lipid accumulation","score":0.8199999928474426},{"id":"https://openalex.org/keywords/periodontal-pathogens","display_name":"periodontal pathogens","score":0.5550000071525574},{"id":"https://openalex.org/keywords/lipid-lowering-effect","display_name":"hypolipidemic effect","score":0.4429999887943268}],"concepts":[{"id":"https://openalex.org/C2781357234","wikidata":"https://www.wikidata.org/wiki/Q4759444","display_name":"Andrographolide","level":2,"score":0.9392855763435364},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.7719826698303223},{"id":"https://openalex.org/C2779091943","wikidata":"https://www.wikidata.org/wiki/Q1079120","display_name":"Hyperlipidemia","level":3,"score":0.696405291557312},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.6882529854774475},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.6456993818283081},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5871348977088928},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5509034991264343},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5094416737556458},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49533215165138245},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.48279011249542236},{"id":"https://openalex.org/C2778096610","wikidata":"https://www.wikidata.org/wiki/Q1476525","display_name":"Dyslipidemia","level":3,"score":0.4777771234512329},{"id":"https://openalex.org/C2780183776","wikidata":"https://www.wikidata.org/wiki/Q3214147","display_name":"Porphyromonas gingivalis","level":3,"score":0.46281731128692627},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3688995838165283},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32232409715652466},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.30416783690452576},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27996861934661865},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.22657734155654907},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.2017636001110077},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.0},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004224","descriptor_name":"Diterpenes","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016966","descriptor_name":"Porphyromonas gingivalis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023382","descriptor_name":"Toxicity Tests, Acute","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1155/2013/594012","doi":"https://doi.org/10.1155/2013/594012","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2013/594012","pdf_url":"https://downloads.hindawi.com/journals/bmri/2013/594012.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed Research International","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2702408","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3703379","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23844365","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23844365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed research international","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3703379","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3703379/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomed Res Int","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:d5b36846ac5c4a8498db39f194f05081","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d5b36846ac5c4a8498db39f194f05081","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioMed Research International, Vol 2013 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2013/594012","doi":"https://doi.org/10.1155/2013/594012","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2013/594012","pdf_url":"https://downloads.hindawi.com/journals/bmri/2013/594012.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed Research International","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2008441285.pdf","grobid_xml":"https://content.openalex.org/works/W2008441285.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W109115322","https://openalex.org/W1538399032","https://openalex.org/W1969571975","https://openalex.org/W2001332591","https://openalex.org/W2005404897","https://openalex.org/W2008428005","https://openalex.org/W2009720537","https://openalex.org/W2032837365","https://openalex.org/W2050111264","https://openalex.org/W2076272231","https://openalex.org/W2080351177","https://openalex.org/W2101077035","https://openalex.org/W2127673745","https://openalex.org/W2133664523","https://openalex.org/W2143134381","https://openalex.org/W2144345929","https://openalex.org/W2146865678","https://openalex.org/W2161464071","https://openalex.org/W2161713866","https://openalex.org/W2168305269","https://openalex.org/W2171919356","https://openalex.org/W2282054059","https://openalex.org/W2399840390","https://openalex.org/W2415742497","https://openalex.org/W4238609441"],"related_works":["https://openalex.org/W2038199647","https://openalex.org/W2808933938","https://openalex.org/W2162970426","https://openalex.org/W7096990547","https://openalex.org/W1948531710","https://openalex.org/W2373654077","https://openalex.org/W3161210001","https://openalex.org/W4245619102","https://openalex.org/W2626995633","https://openalex.org/W2286878840"],"abstract_inverted_index":{"The":[0,111,132],"aim":[1],"of":[2,11,57,162,171],"the":[3,9,163,169],"current":[4],"study":[5],"is":[6],"to":[7,77],"evaluate":[8],"effect":[10],"andrographolide":[12,101,167],"on":[13],"hyperlipidemia":[14],"induced":[15],"by":[16],"Porphyromonas":[17],"gingivalis":[18,52],"in":[19,62,127,138,154,174,188],"rats.":[20,189],"Thirty":[21],"male":[22],"Sprague":[23],"Dawley":[24],"(SD)":[25],"rats":[26],"were":[27,47,124,151],"divided":[28],"into":[29],"five":[30,70],"groups":[31,40,93,128,156,164],"as":[32],"follows:":[33],"group":[34,81],"1":[35],"(vehicle)":[36],"and":[37,45,92,95,104,121,147],"four":[38],"experimental":[39],"(groups":[41],"2,":[42],"3,":[43],"4,":[44],"5)":[46],"challenged":[48],"orally":[49],"with":[50,66,88,100,130,166],"P.":[51],"ATCC":[53],"33277":[54],"(0.2":[55],"mL":[56],"1.5":[58],"\u00d710(12)":[59],"bacterial":[60],"cells/mL":[61],"2%":[63],"carboxymethylcellulose":[64],"(CMC)":[65],"phosphate-buffered":[67],"saline":[68],"(PBS))":[69],"times":[71],"a":[72,84],"week":[73],"for":[74,108],"one":[75],"month":[76],"induce":[78],"hyperlipidemia.":[79],"Then,":[80],"3":[82],"received":[83,97],"standard":[85],"oral":[86,98],"treatment":[87,99],"simvastatin":[89],"100":[90],"mg/kg,":[91,106],"4":[94],"5":[96],"20":[102],"mg/kg":[103],"10":[105],"respectively,":[107],"another":[109],"month.":[110],"results":[112],"showed":[113],"that":[114],"total":[115],"cholesterol":[116],"(TC),":[117],"low-density":[118],"lipoprotein":[119],"(LDL-C),":[120],"triglycerides":[122],"(TG)":[123],"reduced":[125],"significantly":[126,152],"treated":[129,139,165],"andrographolide.":[131],"malondialdehyde":[133],"(MDA)":[134],"level":[135],"was":[136],"low":[137],"groups,":[140],"while":[141],"antioxidant":[142],"enzymes,":[143],"superoxide":[144],"dismutase":[145],"(SOD),":[146],"glutathione":[148],"peroxidase":[149],"(GPx)":[150],"increased":[153],"these":[155],"(P":[157],"<":[158],"0.05).":[159],"Liver":[160],"tissues":[161],"reduce":[168],"accumulation":[170],"lipid":[172],"droplets":[173],"hepatic":[175],"tissue":[176],"cells.":[177],"An":[178],"acute":[179],"toxicity":[180],"test":[181],"did":[182],"not":[183],"show":[184],"any":[185],"toxicological":[186],"symptoms":[187]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}