{"id":"https://openalex.org/W2008405086","doi":"https://doi.org/10.1186/s12917-014-0180-0","title":"Administration of trimethoprim-sulphadimidine does not improve healing of glandular gastric ulceration in horses receiving omeprazole: a randomised, blinded, clinical study","display_name":"Administration of trimethoprim-sulphadimidine does not improve healing of glandular gastric ulceration in horses receiving omeprazole: a randomised, blinded, clinical study","publication_year":2014,"publication_date":"2014-08-22","ids":{"openalex":"https://openalex.org/W2008405086","doi":"https://doi.org/10.1186/s12917-014-0180-0","mag":"2008405086","pmid":"https://pubmed.ncbi.nlm.nih.gov/25927827","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4445647"},"language":"en","primary_location":{"id":"doi:10.1186/s12917-014-0180-0","doi":"https://doi.org/10.1186/s12917-014-0180-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12917-014-0180-0","pdf_url":"https://bmcvetres.biomedcentral.com/counter/pdf/10.1186/s12917-014-0180-0","source":{"id":"https://openalex.org/S197820984","display_name":"BMC Veterinary Research","issn_l":"1746-6148","issn":["1746-6148"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Veterinary Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcvetres.biomedcentral.com/counter/pdf/10.1186/s12917-014-0180-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064197445","display_name":"Ben William Sykes","orcid":"https://orcid.org/0000-0002-0505-6228","observed_orcids":["https://orcid.org/0000-0002-0505-6228"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ben W Sykes","raw_affiliation_strings":["BW Sykes Consultancy, Upper Orara, NSW, Australia. bensykes21@hotmail.com","BW Sykes Consultancy, Upper Orara, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BW Sykes Consultancy, Upper Orara, NSW, Australia. bensykes21@hotmail.com","institution_ids":[]},{"raw_affiliation_string":"BW Sykes Consultancy, Upper Orara, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081017793","display_name":"K. M. Sykes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katja M Sykes","raw_affiliation_strings":["BW Sykes Consultancy, Upper Orara, NSW, Australia. katjasykes@hotmail.com","BW Sykes Consultancy, Upper Orara, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BW Sykes Consultancy, Upper Orara, NSW, Australia. katjasykes@hotmail.com","institution_ids":[]},{"raw_affiliation_string":"BW Sykes Consultancy, Upper Orara, Australia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061687766","display_name":"Gayle Davina Hallowell","orcid":"https://orcid.org/0000-0003-2294-6502","observed_orcids":["https://orcid.org/0000-0003-2294-6502"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Gayle D Hallowell","raw_affiliation_strings":["School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, UK. gaylehallowell@yahoo.co.uk","School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, UK;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, UK. gaylehallowell@yahoo.co.uk","institution_ids":["https://openalex.org/I142263535"]},{"raw_affiliation_string":"School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, UK;","institution_ids":["https://openalex.org/I142263535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5061687766"],"corresponding_institution_ids":["https://openalex.org/I142263535"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":5.0426,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.94777829,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"10","issue":"1","first_page":"180","last_page":"180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10872","display_name":"Veterinary Equine Medical Research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/3402","display_name":"Equine"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10872","display_name":"Veterinary Equine Medical Research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/3402","display_name":"Equine"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/equine-gastric-ulcer-syndrome","display_name":"equine gastric ulcer syndrome","score":0.9079999923706055},{"id":"https://openalex.org/keywords/omeprazole","display_name":"omeprazole","score":0.878000020980835},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7829999923706055},{"id":"https://openalex.org/keywords/ulcer-healing","display_name":"ulcer healing","score":0.7720000147819519},{"id":"https://openalex.org/keywords/horses","display_name":"horses","score":0.652999997138977},{"id":"https://openalex.org/keywords/gastric-mucosa","display_name":"gastric mucosa","score":0.5730000138282776},{"id":"https://openalex.org/keywords/treatment-efficacy-comparison","display_name":"treatment efficacy comparison","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C2777498785","wikidata":"https://www.wikidata.org/wiki/Q422210","display_name":"Omeprazole","level":2,"score":0.9423661828041077},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8516958951950073},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6154724955558777},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6148947477340698},{"id":"https://openalex.org/C2780728791","wikidata":"https://www.wikidata.org/wiki/Q422665","display_name":"Trimethoprim","level":3,"score":0.5292811989784241},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.13025182485580444},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000897","descriptor_name":"Anti-Ulcer Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000897","descriptor_name":"Anti-Ulcer Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006734","descriptor_name":"Horse Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006736","descriptor_name":"Horses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009853","descriptor_name":"Omeprazole","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009853","descriptor_name":"Omeprazole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013276","descriptor_name":"Stomach Ulcer","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013276","descriptor_name":"Stomach Ulcer","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D015662","descriptor_name":"Trimethoprim, Sulfamethoxazole Drug Combination","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015662","descriptor_name":"Trimethoprim, Sulfamethoxazole Drug Combination","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016037","descriptor_name":"Single-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/s12917-014-0180-0","doi":"https://doi.org/10.1186/s12917-014-0180-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12917-014-0180-0","pdf_url":"https://bmcvetres.biomedcentral.com/counter/pdf/10.1186/s12917-014-0180-0","source":{"id":"https://openalex.org/S197820984","display_name":"BMC Veterinary Research","issn_l":"1746-6148","issn":["1746-6148"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Veterinary Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4445647","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4445647","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Vet Res","raw_type":"Text"},{"id":"pmid:25927827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25927827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC veterinary research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/s12917-014-0180-0","doi":"https://doi.org/10.1186/s12917-014-0180-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12917-014-0180-0","pdf_url":"https://bmcvetres.biomedcentral.com/counter/pdf/10.1186/s12917-014-0180-0","source":{"id":"https://openalex.org/S197820984","display_name":"BMC Veterinary Research","issn_l":"1746-6148","issn":["1746-6148"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Veterinary Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2008405086.pdf","grobid_xml":"https://content.openalex.org/works/W2008405086.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W103315091","https://openalex.org/W1508395426","https://openalex.org/W1975146065","https://openalex.org/W1981148190","https://openalex.org/W1984257229","https://openalex.org/W1991434347","https://openalex.org/W2026915762","https://openalex.org/W2063636436","https://openalex.org/W2073169265","https://openalex.org/W2090348407","https://openalex.org/W2093185371","https://openalex.org/W2108433842","https://openalex.org/W2117229114","https://openalex.org/W2118234855","https://openalex.org/W2118713617","https://openalex.org/W2129432414","https://openalex.org/W2131755561","https://openalex.org/W2137340313","https://openalex.org/W2140132276","https://openalex.org/W2145831363","https://openalex.org/W2155643316","https://openalex.org/W2156992489","https://openalex.org/W2160423775","https://openalex.org/W2317727391","https://openalex.org/W2905460682","https://openalex.org/W3147465689","https://openalex.org/W4242915689"],"related_works":["https://openalex.org/W2975682043","https://openalex.org/W1920523792","https://openalex.org/W2094324744","https://openalex.org/W2916866789","https://openalex.org/W2156992489","https://openalex.org/W7161779302","https://openalex.org/W4362458397","https://openalex.org/W2793049643","https://openalex.org/W2802045074","https://openalex.org/W3196991627"],"abstract_inverted_index":{"BACKGROUND:":[0],"Interest":[1],"in":[2,11,112,149,167,192,210,253,285],"Equine":[3],"Gastric":[4],"Ulcer":[5],"Syndrome":[6],"(EGUS)":[7],"has":[8,40,60,83],"recently":[9,38],"increased":[10],"part":[12],"due":[13],"to":[14,50,100,107,136,139,155,163,180,198,206,223,242],"a":[15],"growing":[16],"awareness":[17],"of":[18,30,46,89,96,105,115,128,143,165,186,208,231,240,259,279,283],"the":[19,44,87,103,144,168,187,211,232,238,254,257,270,276,281],"differences":[20,58],"between":[21],"squamous":[22,31],"and":[23,28,32,37,73,157,170,200,213,256],"glandular":[24,33,47,71,119,145,188,247],"disease.":[25],"The":[26,94,229],"pathophysiology":[27],"epidemiology":[29],"disease":[34,72],"are":[35],"different":[36],"it":[39,59,82],"been":[41,61,84],"shown":[42],"that":[43,63,74,86],"response":[45],"gastric":[48],"ulceration":[49,120],"monotherapy":[51],"with":[52,122,275],"omeprazole":[53,108,123,129,140],"is":[54,290,296],"poor.":[55],"Given":[56],"these":[57,80],"recommended":[62],"specific":[64],"treatment":[65,264,286],"guidelines":[66],"be":[67,77,134,137],"formulated":[68],"for":[69,245,288],"equine":[70,118,246],"adjunctive":[75,263],"therapies":[76],"investigated.":[78],"Along":[79],"lines":[81],"suggested":[85],"addition":[88,104,239],"antimicrobials":[90,260,284],"may":[91],"enhance":[92],"healing.":[93],"objective":[95],"this":[97],"study":[98,234,255],"was":[99,147,190],"investigate":[101],"whether":[102],"trimethoprim-sulphadimidine":[106,131,241],"therapy":[109,127],"would":[110],"result":[111],"superior":[113,138],"healing":[114],"naturally":[116],"occurring":[117],"compared":[121],"monotherapy.":[124,141],"RESULTS:":[125],"Combination":[126],"plus":[130],"could":[132],"not":[133,236,291],"demonstrated":[135],"Healing":[142],"mucosa":[146,189],"observed":[148,191],"7/15":[150],"(47%;":[151],"95%":[152,160,177,195,203,220],"CI":[153,161,178,196,204,221],"24":[154],"71%)":[156],"3/13":[158],"(23%;":[159],"7%":[162],"50%)":[164],"horses":[166,209],"TMPS":[169,212],"OMEP":[171,214],"groups,":[172,215],"respectively":[173,216],"(OR":[174,217],"=":[175,183,218,226],"1.8;":[176],"0.32":[179],"10.0;":[181],"p":[182,225],"0.67).":[184],"Improvement":[185],"12/15":[193],"(80%;":[194],"56":[197],"94%)":[199],"9/13":[201],"(69%;":[202],"42":[205],"89%)":[207],"2.9;":[219],"0.6":[222],"15.0;":[224],"0.25).":[227],"CONCLUSIONS:":[228],"results":[230],"present":[233,252],"do":[235],"support":[237],"therapeutic":[243],"protocols":[244],"ulceration.":[248],"Several":[249],"limitations":[250],"were":[251],"use":[258,278],"as":[261],"an":[262],"warrants":[265],"further":[266,297],"investigation.":[267],"However,":[268],"given":[269],"potential":[271],"deleterious":[272],"consequences":[273],"associated":[274],"indiscriminate":[277],"antimicrobials,":[280],"inclusion":[282],"regimes":[287],"EGUS":[289],"justified":[292],"until":[293],"their":[294],"efficacy":[295],"validated.":[298]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
