{"id":"https://openalex.org/W2008404672","doi":"https://doi.org/10.1002/(sici)1097-0142(19980501)82:9<1677::aid-cncr13>3.0.co;2-1","title":"Interferon-\u03b1 and chemohormonal therapy for patients with advanced melanoma","display_name":"Interferon-\u03b1 and chemohormonal therapy for patients with advanced melanoma","publication_year":1998,"publication_date":"1998-05-01","ids":{"openalex":"https://openalex.org/W2008404672","doi":"https://doi.org/10.1002/(sici)1097-0142(19980501)82:9<1677::aid-cncr13>3.0.co;2-1","mag":"2008404672","pmid":"https://pubmed.ncbi.nlm.nih.gov/9576288"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1097-0142(19980501)82:9<1677::aid-cncr13>3.0.co;2-1","doi":"https://doi.org/10.1002/(sici)1097-0142(19980501)82:9<1677::aid-cncr13>3.0.co;2-1","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0142(19980501)82:9<1677::aid-cncr13>3.0.co;2-1","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0142%2819980501%2982%3A9%3C1677%3A%3AAID-CNCR13%3E3.0.CO%3B2-1","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0142%2819980501%2982%3A9%3C1677%3A%3AAID-CNCR13%3E3.0.CO%3B2-1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110295471","display_name":"James J. Stark","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142412","display_name":"Perry Point VA Medical Center","ror":"https://ror.org/036adbz09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210111569","https://openalex.org/I4210142412","https://openalex.org/I4210163125"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James J. Stark","raw_affiliation_strings":["Maryview Medical Center, Portsmouth Virginia, USA","Maryview Medical Center, Portsmouth, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maryview Medical Center, Portsmouth Virginia, USA","institution_ids":[]},{"raw_affiliation_string":"Maryview Medical Center, Portsmouth, Virginia","institution_ids":["https://openalex.org/I4210142412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013377891","display_name":"Robert Owen Dillman","orcid":"https://orcid.org/0000-0002-2975-926X","observed_orcids":["https://orcid.org/0000-0002-2975-926X"]},"institutions":[{"id":"https://openalex.org/I1307629703","display_name":"Hoag Memorial Hospital Presbyterian","ror":"https://ror.org/05nmfef18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1307629703"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert O. Dillman","raw_affiliation_strings":["Patty and George Hoag Cancer Center, Newport Beach, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Patty and George Hoag Cancer Center, Newport Beach, California","institution_ids":["https://openalex.org/I1307629703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111607016","display_name":"Richard S. Schulof","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146389","display_name":"Presbyterian St. Luke's Medical Center","ror":"https://ror.org/04gka6q50","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210146389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Schulof","raw_affiliation_strings":["Presbyterian/St. Lukes Medical Center, Denver, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Presbyterian/St. Lukes Medical Center, Denver, Colorado","institution_ids":["https://openalex.org/I4210146389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102769745","display_name":"Michael C. Wiemann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800041687","display_name":"St Vincent Hospital","ror":"https://ror.org/04mynmf89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320343167","https://openalex.org/I2800041687"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael C. Wiemann","raw_affiliation_strings":["St. Vincent Cancer Center, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Vincent Cancer Center, Indianapolis, Indiana","institution_ids":["https://openalex.org/I2800041687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005033200","display_name":"Neil M. Barth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307629703","display_name":"Hoag Memorial Hospital Presbyterian","ror":"https://ror.org/05nmfef18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1307629703"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil M. Barth","raw_affiliation_strings":["Patty and George Hoag Cancer Center, Newport Beach, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Patty and George Hoag Cancer Center, Newport Beach, California","institution_ids":["https://openalex.org/I1307629703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088866062","display_name":"Pamela J. Honeycutt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166319","display_name":"University of Missouri Women's and Children's Hospital","ror":"https://ror.org/00cafxy65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800649613","https://openalex.org/I4210166319"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela J. Honeycutt","raw_affiliation_strings":["Columbia Regional Hospital, Columbia, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia Regional Hospital, Columbia, Missouri","institution_ids":["https://openalex.org/I4210166319"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015875841","display_name":"Gamini S. Soori","orcid":"https://orcid.org/0009-0004-8859-4401","observed_orcids":["https://orcid.org/0009-0004-8859-4401"]},"institutions":[{"id":"https://openalex.org/I2800482329","display_name":"CHI Health Creighton University Medical Center - Bergan Mercy","ror":"https://ror.org/03z1w3b90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800482329","https://openalex.org/I2802665030","https://openalex.org/I2802797007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gamini Soori","raw_affiliation_strings":["Bergan Mercy Medical Center, Omaha, Nebraska"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bergan Mercy Medical Center, Omaha, Nebraska","institution_ids":["https://openalex.org/I2800482329"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5013377891"],"corresponding_institution_ids":["https://openalex.org/I1307629703"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.8767,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.74421586,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"82","issue":"9","first_page":"1677","last_page":"1681"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"metastatic melanoma","score":0.9309999942779541},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.8619999885559082},{"id":"https://openalex.org/keywords/chemohormonal-therapy","display_name":"chemohormonal therapy","score":0.9760000109672546},{"id":"https://openalex.org/keywords/dacarbazine","display_name":"dacarbazine","score":0.890999972820282},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/carmustine","display_name":"BCNU","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":0.9990000128746033},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.5759999752044678},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.8759999871253967},{"id":"https://openalex.org/keywords/tumor-response","display_name":"tumor response","score":0.7350000143051147},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.7450000047683716},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.875},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8856179118156433},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6401928663253784},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.41923946142196655},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3758789598941803},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27989885210990906},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.23769670724868774}],"mesh":[{"descriptor_ui":"D000077190","descriptor_name":"Interferon alpha-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002330","descriptor_name":"Carmustine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003606","descriptor_name":"Dacarbazine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/(sici)1097-0142(19980501)82:9<1677::aid-cncr13>3.0.co;2-1","doi":"https://doi.org/10.1002/(sici)1097-0142(19980501)82:9<1677::aid-cncr13>3.0.co;2-1","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0142(19980501)82:9<1677::aid-cncr13>3.0.co;2-1","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0142%2819980501%2982%3A9%3C1677%3A%3AAID-CNCR13%3E3.0.CO%3B2-1","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:9576288","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9576288","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1002/(sici)1097-0142(19980501)82:9<1677::aid-cncr13>3.0.co;2-1","doi":"https://doi.org/10.1002/(sici)1097-0142(19980501)82:9<1677::aid-cncr13>3.0.co;2-1","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0142(19980501)82:9<1677::aid-cncr13>3.0.co;2-1","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0142%2819980501%2982%3A9%3C1677%3A%3AAID-CNCR13%3E3.0.CO%3B2-1","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7799999713897705,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2008404672.pdf","grobid_xml":"https://content.openalex.org/works/W2008404672.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W31741165","https://openalex.org/W1502284045","https://openalex.org/W1545320152","https://openalex.org/W1752324982","https://openalex.org/W1966732847","https://openalex.org/W1979300931","https://openalex.org/W2009041500","https://openalex.org/W2016901575","https://openalex.org/W2027313910","https://openalex.org/W2054415856","https://openalex.org/W2066629454","https://openalex.org/W2072778369","https://openalex.org/W2088918780","https://openalex.org/W2092690255","https://openalex.org/W2164569272","https://openalex.org/W2245369264","https://openalex.org/W2289439804","https://openalex.org/W2413740398","https://openalex.org/W2417679862","https://openalex.org/W2469371547","https://openalex.org/W4293241248"],"related_works":["https://openalex.org/W2119427303","https://openalex.org/W2037402411","https://openalex.org/W1984362740","https://openalex.org/W2048080835","https://openalex.org/W2164569272","https://openalex.org/W1858238123","https://openalex.org/W2407291975","https://openalex.org/W2071703736","https://openalex.org/W2419677647","https://openalex.org/W2282985545"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,43,290],"treatment":[2,218],"of":[3,84,97,115,157,188,220,260,292],"metastatic":[4,35,312],"melanoma":[5,36],"remains":[6],"unsatisfactory":[7],"despite":[8],"encouraging":[9],"results":[10],"with":[11,153,311],"biotherapy":[12],"and":[13,37,51,80,95,112,129,140,166,182,215,235,254,273],"combination":[14],"chemotherapy.":[15],"Combining":[16],"these":[17],"two":[18],"modalities":[19],"may":[20],"improve":[21],"outcomes":[22],"for":[23,31,108,175,193,246,309],"such":[24],"patients.":[25],"METHODS:":[26],"Patients":[27,105],"who":[28],"were":[29,38,106,131,160,173,191,249,277],"eligible":[30],"this":[32,295],"study":[33,281],"had":[34,163,168,205,211,227,237],"in":[39],"good":[40],"medical":[41],"condition.":[42],"following":[44],"regimen":[45,123,298],"was":[46,102,124,142,197,263,268],"used:":[47],"dacarbazine":[48,128],"220":[49],"mg/m2":[50,54,67,146],"cisplatin":[52,130],"25":[53],"administered":[55,75,89],"intravenously":[56],"(i.v.)":[57],"daily":[58],"x":[59],"3":[60,63],"days":[61],"every":[62,69,137,147],"weeks,":[64,71,139],"carmustine":[65,141],"150":[66],"i.v.":[68],"6":[70],"tamoxifen":[72],"10":[73,203,210,236,250],"mg":[74],"orally":[76],"twice":[77],"a":[78,100,154,206,228],"day,":[79],"interferon-alpha2b":[81],"3.0":[82],"thousandths":[83],"an":[85],"International":[86],"Unit":[87],"(mIU)/m2":[88],"subcutaneously":[90],"on":[91,103],"Days":[92],"1,":[93],"3,":[94],"5":[96,226],"each":[98],"week":[99],"patient":[101],"study.":[104],"analyzed":[107],"toxicity,":[109,117,176],"tumor":[110],"response,":[111,247],"survival.":[113],"Because":[114],"severe":[116,198],"partway":[118],"through":[119],"the":[120,122,134,179,185,200,223,242,280,304],"trial":[121],"modified":[125],"as":[126],"follows:":[127],"given":[132],"at":[133,178,184,199],"same":[135],"dose":[136,181],"4":[138,264],"reduced":[143,224],"to":[144,294],"100":[145],"8":[148],"weeks.":[149],"RESULTS:":[150],"Forty-two":[151],"patients":[152,172,204,244,310],"median":[155],"age":[156],"61":[158],"years":[159],"enrolled.":[161],"Twenty":[162],"liver":[164],"metastases":[165],"18":[167],"lung":[169],"metastases.":[170],"Forty":[171],"evaluable":[174,192,245],"17":[177],"original":[180,201],"23":[183],"new":[186],"dose;":[187],"these,":[189],"35":[190,243],"response.":[194],"Hematologic":[195],"toxicity":[196,285,301],"dose:":[202],"nadir":[207,229],"<":[208,213,233,239],"500/microL,":[209],"platelets":[212,238],"25,000/microL,":[214],"2":[216,255],"discontinued":[217],"because":[219,282],"toxicity.":[221],"At":[222],"dose,":[225],"absolute":[230],"neutrophil":[231],"count":[232],"500,":[234],"25,000.":[240],"Of":[241],"there":[248],"partial":[251,272],"responses":[252],"(29%)":[253],"minimal":[256,275],"responses.":[257],"Median":[258,266],"duration":[259],"disease":[261],"control":[262],"months.":[265,270],"survival":[267,308],"8.9":[269],"One":[271],"one":[274],"responder":[276],"removed":[278],"from":[279],"they":[283],"experienced":[284],"while":[286],"still":[287],"responding.":[288],"CONCLUSIONS:":[289],"addition":[291],"interferon-alpha":[293],"chemohormonal":[296],"therapy":[297],"greatly":[299],"increased":[300],"without":[302],"improving":[303],"response":[305],"rate":[306],"or":[307],"melanoma.":[313]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
