{"id":"https://openalex.org/W2008396196","doi":"https://doi.org/10.1002/jcb.21800","title":"Un\u2010nicked BoNT/B activity in human SHSY\u20105Y neuronal cells","display_name":"Un\u2010nicked BoNT/B activity in human SHSY\u20105Y neuronal cells","publication_year":2008,"publication_date":"2008-05-05","ids":{"openalex":"https://openalex.org/W2008396196","doi":"https://doi.org/10.1002/jcb.21800","mag":"2008396196","pmid":"https://pubmed.ncbi.nlm.nih.gov/18459116"},"language":"en","primary_location":{"id":"doi:10.1002/jcb.21800","doi":"https://doi.org/10.1002/jcb.21800","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.21800","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018877979","display_name":"Xuerong Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xuerong Shi","raw_affiliation_strings":["Department of Biochemical Pharmacology, Division of Biochemistry, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910-7500, USA. xuerong.shi@amedd.army.mil","Department of Biochemical Pharmacology, Division of Biochemistry, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910\u20107500"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Pharmacology, Division of Biochemistry, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910-7500, USA. xuerong.shi@amedd.army.mil","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"Department of Biochemical Pharmacology, Division of Biochemistry, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910\u20107500","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110150237","display_name":"Gregory E. Garcia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory E. Garcia","raw_affiliation_strings":["Department of Biochemical Pharmacology, Division of Biochemistry, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910-7500"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Pharmacology, Division of Biochemistry, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910-7500","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017819842","display_name":"Madhusoodana P. Nambiar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madhusoodana P. Nambiar","raw_affiliation_strings":["Department of Biochemical Pharmacology, Division of Biochemistry, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910-7500"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Pharmacology, Division of Biochemistry, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910-7500","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108540743","display_name":"Richard Keith Gordon","orcid":"https://orcid.org/0009-0008-9240-4577","observed_orcids":["https://orcid.org/0009-0008-9240-4577"]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard K. Gordon","raw_affiliation_strings":["Department of Biochemical Pharmacology, Division of Biochemistry, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910-7500"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Pharmacology, Division of Biochemistry, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910-7500","institution_ids":["https://openalex.org/I92664306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018877979"],"corresponding_institution_ids":["https://openalex.org/I92664306"],"apc_list":{"value":5110,"currency":"USD","value_usd":5110},"apc_paid":null,"fwci":0.8492,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.75815673,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"105","issue":"1","first_page":"129","last_page":"135"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11515","display_name":"Bacillus and Francisella bacterial research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/botulinum-toxin-type-b","display_name":"botulinum toxin type B","score":0.8209999799728394},{"id":"https://openalex.org/keywords/trypsin-activation","display_name":"trypsin activation","score":0.6539999842643738},{"id":"https://openalex.org/keywords/noradrenaline-release","display_name":"noradrenaline release","score":0.828000009059906},{"id":"https://openalex.org/keywords/vesicular-trafficking","display_name":"vesicle trafficking","score":0.8859999775886536},{"id":"https://openalex.org/keywords/snare-proteins","display_name":"SNARE proteins","score":0.9539999961853027},{"id":"https://openalex.org/keywords/vamp2","display_name":"VAMP2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/biological-warfare-agents","display_name":"biological warfare agents","score":0.8880000114440918},{"id":"https://openalex.org/keywords/toxin-absorption","display_name":"toxin uptake","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C2777265534","wikidata":"https://www.wikidata.org/wiki/Q14916427","display_name":"Furin","level":3,"score":0.6359363198280334},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5868368744850159},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5280797481536865},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5270215272903442},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.5071792602539062},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.47091981768608093},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4458490312099457},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.43303436040878296},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41939157247543335},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3698303699493408},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30284637212753296},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.27588963508605957},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006027","descriptor_name":"Glycosides","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D006027","descriptor_name":"Glycosides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006027","descriptor_name":"Glycosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050988","descriptor_name":"Vesicle-Associated Membrane Protein 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcb.21800","doi":"https://doi.org/10.1002/jcb.21800","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.21800","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},{"id":"pmid:18459116","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18459116","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1495524572","https://openalex.org/W1498074292","https://openalex.org/W1506651516","https://openalex.org/W1536306056","https://openalex.org/W1943620681","https://openalex.org/W1947863176","https://openalex.org/W1967447408","https://openalex.org/W1975085160","https://openalex.org/W1976266702","https://openalex.org/W1987725158","https://openalex.org/W1988075499","https://openalex.org/W1999582455","https://openalex.org/W2018321735","https://openalex.org/W2031575666","https://openalex.org/W2037498692","https://openalex.org/W2042333331","https://openalex.org/W2049873020","https://openalex.org/W2051914752","https://openalex.org/W2058079730","https://openalex.org/W2075449190","https://openalex.org/W2075826540","https://openalex.org/W2091413695","https://openalex.org/W2093235237","https://openalex.org/W2094406496","https://openalex.org/W2098776203","https://openalex.org/W2100453242","https://openalex.org/W2122977798","https://openalex.org/W2137373966","https://openalex.org/W2143978566","https://openalex.org/W2157512308","https://openalex.org/W2160527711","https://openalex.org/W2186092926","https://openalex.org/W2334565854","https://openalex.org/W2410949874","https://openalex.org/W2436188026","https://openalex.org/W4231852465"],"related_works":["https://openalex.org/W2019573587","https://openalex.org/W2171735534","https://openalex.org/W2030882930","https://openalex.org/W2106089413","https://openalex.org/W2038452852","https://openalex.org/W2071932199","https://openalex.org/W1986990432","https://openalex.org/W2010605414","https://openalex.org/W7100738752","https://openalex.org/W2072108954"],"abstract_inverted_index":{"BoNT/B":[0,236],"holotoxin":[1],"(HT)":[2],"from":[3,77,238],"the":[4,60,117,127,177,181,197,228,233,239],"native":[5,240],"source":[6,246],"is":[7,43,56,243],"a":[8,244],"mixture":[9],"of":[10,63,116,126,153,247],"nicked":[11,178,214,229],"and":[12,80,90,93,141],"un-nicked":[13,21,64,75,100,118,164,204,221],"forms.":[14],"A":[15],"previous":[16],"study":[17],"showed":[18],"that":[19,161,199,219],"while":[20],"HT":[22,42,65,76,101,139,165,222],"could":[23],"be":[24,46,148],"transcytosed":[25],"by":[26,196],"intestinal":[27],"epithelial":[28],"cells,":[29],"they":[30],"did":[31,166],"not":[32],"correlate":[33],"this":[34,67,71],"with":[35,120,156,213],"proteolytic":[36,112,129],"activity":[37],"or":[38],"biological":[39,50],"effect(s).":[40],"Un-nicked":[41],"likely":[44],"to":[45,58,84,104,137,176,188,232],"present":[47],"in":[48,66,88,91,110,123,143,183,203,235],"BoNT":[49,189],"warfare":[51],"agents":[52],"(BWA),":[53],"so":[54],"it":[55,242],"important":[57],"investigate":[59],"relative":[61],"toxicity":[62,226],"BWA.":[68],"To":[69],"address":[70],"issue,":[72],"we":[73],"purified":[74,163],"commercial":[78],"sources":[79],"evaluated":[81],"its":[82,94],"ability":[83],"cleave":[85,105],"substrates":[86],"both":[87],"vitro":[89,111],"vivo,":[92],"effects":[95,190],"on":[96,191],"vesicle":[97],"trafficking.":[98],"The":[99],"was":[102,186,194,208],"unable":[103],"VAMPTide":[106],"substrate":[107],"used":[108,136],"for":[109],"assays.":[113],"Brief":[114],"digestion":[115],"toxin":[119,128,205],"trypsin":[121],"resulted":[122],"significant":[124],"activation":[125,142],"ability.":[130],"SHSY-5Y":[131],"human":[132],"neuroblastoma":[133],"cells":[134,154,207],"were":[135],"examine":[138],"uptake":[140],"vivo.":[144],"Vesicle":[145],"trafficking":[146],"can":[147],"measured":[149],"following":[150],"K(+)":[151],"stimulation":[152],"preloaded":[155],"[(3)H]-noradrenaline":[157],"(NA).":[158],"We":[159],"found":[160],"highly":[162],"inhibit":[167],"NA":[168,184],"release":[169,185],"but":[170],"at":[171],"much":[172],"reduced":[173,225],"levels":[174,202],"compared":[175],"toxin.":[179,215],"That":[180],"reduction":[182],"due":[187,231],"SNARE":[192],"proteins":[193],"supported":[195],"finding":[198],"VAMP-2":[200],"protein":[201],"treated":[206,212],"greater":[209],"than":[210,227],"those":[211],"These":[216],"results":[217],"demonstrate":[218],"although":[220],"has":[223],"markedly":[224],"form,":[230],"preponderance":[234],"preparations":[237],"bacteria,":[241],"major":[245],"toxicity.":[248]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
