{"id":"https://openalex.org/W2008359529","doi":"https://doi.org/10.1007/s00432-005-0050-z","title":"Phase-I/II study to evaluate dose limiting toxicity, maximum tolerated dose, and tolerability of bendamustine HCl in pre-treated patients with B-chronic lymphocytic leukaemia (Binet stages B and C) requiring therapy","display_name":"Phase-I/II study to evaluate dose limiting toxicity, maximum tolerated dose, and tolerability of bendamustine HCl in pre-treated patients with B-chronic lymphocytic leukaemia (Binet stages B and C) requiring therapy","publication_year":2005,"publication_date":"2005-11-14","ids":{"openalex":"https://openalex.org/W2008359529","doi":"https://doi.org/10.1007/s00432-005-0050-z","mag":"2008359529","pmid":"https://pubmed.ncbi.nlm.nih.gov/16292542","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12161039"},"language":"en","primary_location":{"id":"doi:10.1007/s00432-005-0050-z","doi":"https://doi.org/10.1007/s00432-005-0050-z","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00432-005-0050-z","pdf_url":null,"source":{"id":"https://openalex.org/S10075937","display_name":"Journal of Cancer Research and Clinical Oncology","issn_l":"0084-5353","issn":["0084-5353","0171-5216","0301-1585","1432-1335"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer Research and Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12161039/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054363370","display_name":"Toshko Jelev Lissitchkov","orcid":"https://orcid.org/0000-0003-2238-8598","observed_orcids":["https://orcid.org/0000-0003-2238-8598"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"T. Lissitchkov","raw_affiliation_strings":["National Center of Haematology and Transfusiology, 6 Plovdivsko Pole, 1746 Sofia, Bulgaria. tlissitchkov@yahoo.com","National Center of Haematology and Transfusiology, Sofia, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center of Haematology and Transfusiology, 6 Plovdivsko Pole, 1746 Sofia, Bulgaria. tlissitchkov@yahoo.com","institution_ids":[]},{"raw_affiliation_string":"National Center of Haematology and Transfusiology, Sofia, Bulgaria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005012843","display_name":"G. Arnaudov","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Arnaudov","raw_affiliation_strings":["National Center of Haematology and Transfusiology, 6 Plovdivsko Pole, 1746, Sofia, Bulgaria","National Center of Haematology and Transfusiology, Sofia, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center of Haematology and Transfusiology, 6 Plovdivsko Pole, 1746, Sofia, Bulgaria","institution_ids":[]},{"raw_affiliation_string":"National Center of Haematology and Transfusiology, Sofia, Bulgaria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079537750","display_name":"Dontcho Peytchev","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Peytchev","raw_affiliation_strings":["National Center of Haematology and Transfusiology, 6 Plovdivsko Pole, 1746, Sofia, Bulgaria","National Center of Haematology and Transfusiology, Sofia, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center of Haematology and Transfusiology, 6 Plovdivsko Pole, 1746, Sofia, Bulgaria","institution_ids":[]},{"raw_affiliation_string":"National Center of Haematology and Transfusiology, Sofia, Bulgaria","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108765574","display_name":"Kh. Merkle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kh. Merkle","raw_affiliation_strings":["Ribosepharm GmbH Clinical Research, Berg-am-Laim-Strasse 127, 81673, Munchen, Germany","Ribosepharm GmbH Clinical Research, Munchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ribosepharm GmbH Clinical Research, Berg-am-Laim-Strasse 127, 81673, Munchen, Germany","institution_ids":[]},{"raw_affiliation_string":"Ribosepharm GmbH Clinical Research, Munchen, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5054363370"],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":1.533,"has_fulltext":false,"cited_by_count":79,"citation_normalized_percentile":{"value":0.83072213,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"132","issue":"2","first_page":"99","last_page":"104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bendamustine-hydrochloride","display_name":"bendamustine hydrochloride","score":0.9190000295639038},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.9459999799728394},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.8240000009536743},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.9990000128746033},{"id":"https://openalex.org/keywords/relapsed-cll","display_name":"relapsed CLL","score":0.609000027179718},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.5120000243186951},{"id":"https://openalex.org/keywords/elevated-bilirubin","display_name":"bilirubin elevation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.6159999966621399},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.5809999704360962},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.4320000112056732},{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C2781442060","wikidata":"https://www.wikidata.org/wiki/Q425745","display_name":"Bendamustine","level":4,"score":0.9920523166656494},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.794996440410614},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.6235255002975464},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5510032773017883},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4376709461212158},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4367060363292694},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.33984601497650146},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.29660868644714355},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.14668214321136475}],"mesh":[{"descriptor_ui":"D000069461","descriptor_name":"Bendamustine Hydrochloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009588","descriptor_name":"Nitrogen Mustard Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D009588","descriptor_name":"Nitrogen Mustard Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00432-005-0050-z","doi":"https://doi.org/10.1007/s00432-005-0050-z","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00432-005-0050-z","pdf_url":null,"source":{"id":"https://openalex.org/S10075937","display_name":"Journal of Cancer Research and Clinical Oncology","issn_l":"0084-5353","issn":["0084-5353","0171-5216","0301-1585","1432-1335"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer Research and Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:16292542","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16292542","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cancer research and clinical oncology","raw_type":"Clinical Trial, Phase I"},{"id":"pmh:oai:pubmedcentral.nih.gov:12161039","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12161039/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cancer Res Clin Oncol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:12161039","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12161039/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cancer Res Clin Oncol","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W60865865","https://openalex.org/W1172278157","https://openalex.org/W1581243929","https://openalex.org/W1976127594","https://openalex.org/W1987087385","https://openalex.org/W1997101371","https://openalex.org/W2014631400","https://openalex.org/W2046400921","https://openalex.org/W2082300581","https://openalex.org/W2279929035","https://openalex.org/W2338688732","https://openalex.org/W4239735015"],"related_works":["https://openalex.org/W2142881547","https://openalex.org/W2054789032","https://openalex.org/W2578562714","https://openalex.org/W2014631400","https://openalex.org/W2049660830","https://openalex.org/W2247136531","https://openalex.org/W2584237613","https://openalex.org/W2601214619","https://openalex.org/W4284880971","https://openalex.org/W2163348695"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
