{"id":"https://openalex.org/W2008357770","doi":"https://doi.org/10.1021/ja026668q","title":"Contribution of Aromatic Interactions to \u03b1-Helix Stability","display_name":"Contribution of Aromatic Interactions to \u03b1-Helix Stability","publication_year":2002,"publication_date":"2002-07-27","ids":{"openalex":"https://openalex.org/W2008357770","doi":"https://doi.org/10.1021/ja026668q","mag":"2008357770","pmid":"https://pubmed.ncbi.nlm.nih.gov/12175233"},"language":"en","primary_location":{"id":"doi:10.1021/ja026668q","doi":"https://doi.org/10.1021/ja026668q","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja026668q","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021480202","display_name":"Sara M. Butterfield","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara M. Butterfield","raw_affiliation_strings":["Contribution from the Department of Chemistry, UNC Chapel Hill, Venable and Kenan Laboratories, CB 3290, Chapel Hill, North Carolina 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry, UNC Chapel Hill, Venable and Kenan Laboratories, CB 3290, Chapel Hill, North Carolina 27599","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065979183","display_name":"Paresma Patel","orcid":"https://orcid.org/0000-0002-7121-858X","observed_orcids":["https://orcid.org/0000-0002-7121-858X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paresma R. Patel","raw_affiliation_strings":["Contribution from the Department of Chemistry, UNC Chapel Hill, Venable and Kenan Laboratories, CB 3290, Chapel Hill, North Carolina 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry, UNC Chapel Hill, Venable and Kenan Laboratories, CB 3290, Chapel Hill, North Carolina 27599","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034116233","display_name":"Marcey L. Waters","orcid":"https://orcid.org/0000-0002-4917-5755","observed_orcids":["https://orcid.org/0000-0002-4917-5755"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marcey L. Waters","raw_affiliation_strings":["Contribution from the Department of Chemistry, UNC Chapel Hill, Venable and Kenan Laboratories, CB 3290, Chapel Hill, North Carolina 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry, UNC Chapel Hill, Venable and Kenan Laboratories, CB 3290, Chapel Hill, North Carolina 27599","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5034116233"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.1281,"has_fulltext":false,"cited_by_count":172,"citation_normalized_percentile":{"value":0.92027366,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"124","issue":"33","first_page":"9751","last_page":"9755"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.8916000127792358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.8916000127792358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.08150000125169754,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10798","display_name":"Crystallography and molecular interactions","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-helix-stability","display_name":"alpha-helix stability","score":0.8989999890327454},{"id":"https://openalex.org/keywords/face-to-face-stacking","display_name":"face-to-face stacking","score":0.7160000205039978},{"id":"https://openalex.org/keywords/helix-coil-transition","display_name":"helix-coil transition","score":0.7509999871253967},{"id":"https://openalex.org/keywords/unnatural-amino-acids","display_name":"unnatural amino acids","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.91554856300354},{"id":"https://openalex.org/C204921945","wikidata":"https://www.wikidata.org/wiki/Q899689","display_name":"Side chain","level":3,"score":0.7567868232727051},{"id":"https://openalex.org/C2778530040","wikidata":"https://www.wikidata.org/wiki/Q1937315","display_name":"Helix (gastropod)","level":3,"score":0.6921833157539368},{"id":"https://openalex.org/C133571119","wikidata":"https://www.wikidata.org/wiki/Q899102","display_name":"Circular dichroism","level":2,"score":0.6812063455581665},{"id":"https://openalex.org/C2777431362","wikidata":"https://www.wikidata.org/wiki/Q170545","display_name":"Phenylalanine","level":3,"score":0.552671492099762},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5212538838386536},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.5128700733184814},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.22536951303482056},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08155420422554016},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.060896486043930054},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.06073930859565735},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/ja026668q","doi":"https://doi.org/10.1021/ja026668q","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja026668q","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:12175233","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12175233","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W104793819","https://openalex.org/W191194037","https://openalex.org/W1969467754","https://openalex.org/W1970417043","https://openalex.org/W1973956435","https://openalex.org/W1986476601","https://openalex.org/W1987644596","https://openalex.org/W1990198570","https://openalex.org/W1997597222","https://openalex.org/W1999696019","https://openalex.org/W2003434089","https://openalex.org/W2006363528","https://openalex.org/W2007886752","https://openalex.org/W2008747699","https://openalex.org/W2026395206","https://openalex.org/W2043926805","https://openalex.org/W2045403572","https://openalex.org/W2047291713","https://openalex.org/W2049708286","https://openalex.org/W2059001690","https://openalex.org/W2082329958","https://openalex.org/W2083023443","https://openalex.org/W2088390609","https://openalex.org/W2092826347","https://openalex.org/W2094186244","https://openalex.org/W2114532108","https://openalex.org/W2126912623","https://openalex.org/W2134769748","https://openalex.org/W2146210326","https://openalex.org/W2155744992","https://openalex.org/W2165716111","https://openalex.org/W2475018751","https://openalex.org/W2574328790","https://openalex.org/W3047703793"],"related_works":["https://openalex.org/W2165716111","https://openalex.org/W2484380541","https://openalex.org/W2006543300","https://openalex.org/W2059001690","https://openalex.org/W2012992232","https://openalex.org/W2031477441","https://openalex.org/W2154910270","https://openalex.org/W2141810500","https://openalex.org/W2017520051","https://openalex.org/W2092880728"],"abstract_inverted_index":{"The":[0],"influence":[1],"of":[2,66,106,127,142,166,177],"natural":[3],"and":[4,40,78],"unnatural":[5],"i,":[6,56],"i":[7,57],"+":[8,58],"4":[9],"aromatic":[10,172,181],"side":[11,129,182],"chain-side":[12,183],"chain":[13,184],"interactions":[14,29,43,68,147,155,185],"on":[15],"alpha-helix":[16,189],"stability":[17,33],"was":[18],"determined":[19],"in":[20,45,49,87,99,131],"Ala-Lys":[21],"host":[22],"peptides":[23,61],"by":[24],"circular":[25],"dichroism":[26],"(CD).":[27],"All":[28],"investigated":[30],"provided":[31],"some":[32],"to":[34,133,152],"the":[35,46,52,76,88,97,104,125,128,140,146,149],"helix;":[36],"however,":[37],"phenylalanine-phenylalanine":[38],"(F-F)":[39],"phenylalanine-pentafluorophenylalanine":[41],"(F-f5F)":[42],"resulted":[44],"greatest":[47],"enhancement":[48],"helicity,":[50],"doubling":[51],"helical":[53],"content":[54],"over":[55],"5":[59],"control":[60],"at":[62,84,148,174],"internal":[63,85],"positions.":[64],"Quantification":[65],"these":[67],"using":[69],"AGADIR":[70],"multistate":[71],"helix-coil":[72],"algorithm":[73],"revealed":[74],"that":[75,180],"F-F":[77],"F-f5F":[79,132],"interaction":[80,111],"energies":[81],"are":[82,186],"equivalent":[83],"positions":[86],"sequence":[89],"(deltaGF-F":[90,156],"=":[91,93,157,161],"deltaGF-f5F":[92,160],"-0.27":[94],"kcal/mol),":[95],"despite":[96],"differences":[98],"their":[100],"expected":[101],"geometries.":[102],"As":[103],"strength":[105],"a":[107,135],"face-to-face":[108],"stacked":[109,137],"phenyl-pentafluorophenyl":[110],"should":[112],"surpass":[113],"an":[114,143,187],"edge-to-face":[115],"or":[116],"offset-stacked":[117],"phenyl-phenyl":[118],"interaction,":[119],"we":[120],"believe":[121],"this":[122],"result":[123],"reflects":[124],"inability":[126],"chains":[130],"attain":[134],"fully":[136],"geometry":[138],"within":[139],"context":[141],"alpha-helix.":[144],"Positioning":[145],"C-terminus":[150],"led":[151],"much":[153],"stronger":[154],"-0.8":[158],"kcal/mol;":[159],"-0.55":[162],"kcal/mol)":[163],"likely":[164],"because":[165],"favorable":[167],"chi(1)":[168],"rotameric":[169],"preferences":[170],"for":[171],"residues":[173],"C-capping":[175,190],"regions":[176],"alpha-helices,":[178],"suggesting":[179],"effective":[188],"method.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}