{"id":"https://openalex.org/W2008355024","doi":"https://doi.org/10.1183/09031936.03.00403203","title":"Mechanism of lung injury caused by PM10and ultrafine particles with special reference to COPD","display_name":"Mechanism of lung injury caused by PM10and ultrafine particles with special reference to COPD","publication_year":2003,"publication_date":"2003-05-01","ids":{"openalex":"https://openalex.org/W2008355024","doi":"https://doi.org/10.1183/09031936.03.00403203","mag":"2008355024","pmid":"https://pubmed.ncbi.nlm.nih.gov/12762574"},"language":"en","primary_location":{"id":"doi:10.1183/09031936.03.00403203","doi":"https://doi.org/10.1183/09031936.03.00403203","is_oa":true,"landing_page_url":"https://doi.org/10.1183/09031936.03.00403203","pdf_url":"https://erj.ersjournals.com/content/erj/21/40_suppl/47s.full.pdf","source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Respiratory Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://erj.ersjournals.com/content/erj/21/40_suppl/47s.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050425677","display_name":"William MacNee","orcid":"https://orcid.org/0000-0002-3692-1448","observed_orcids":["https://orcid.org/0000-0002-3692-1448"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"W. MacNee","raw_affiliation_strings":["Edinburgh Lung and the Environment Group Initiative Colt Research Laboratories, Dept of Clinical and Radiological Sciences, University of Edinburgh, Medical School, UK. w.macnee@ed.ac.uk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Edinburgh Lung and the Environment Group Initiative Colt Research Laboratories, Dept of Clinical and Radiological Sciences, University of Edinburgh, Medical School, UK. w.macnee@ed.ac.uk","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109224244","display_name":"Kenneth Donaldson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K. Donaldson","raw_affiliation_strings":["Edinburgh Lung and the Environment Group Initiative Colt Research Laboratories, Dept of Clinical and Radiological Sciences, University of Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Edinburgh Lung and the Environment Group Initiative Colt Research Laboratories, Dept of Clinical and Radiological Sciences, University of Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I98677209"],"apc_list":null,"apc_paid":null,"fwci":6.7455,"has_fulltext":true,"cited_by_count":290,"citation_normalized_percentile":{"value":0.97587269,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"21","issue":"40 suppl","first_page":"47s","last_page":"51s"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11002","display_name":"Indoor Air Quality and Microbial Exposure","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/particulate-matter","display_name":"particulate matter","score":0.7940000295639038},{"id":"https://openalex.org/keywords/pm10","display_name":"PM10","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ultrafine-particles","display_name":"ultrafine particles","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ultrafine-carbon-black","display_name":"ultrafine carbon black","score":0.8410000205039978},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9769999980926514},{"id":"https://openalex.org/keywords/lung-injury","display_name":"lung injury","score":0.7950000166893005},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8960000276565552},{"id":"https://openalex.org/keywords/transition-metals","display_name":"transition metals","score":0.7649999856948853},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.968999981880188},{"id":"https://openalex.org/keywords/transcription-factor-activation","display_name":"transcription factor activation","score":0.7149999737739563},{"id":"https://openalex.org/keywords/proinflammatory-gene-expression","display_name":"pro-inflammatory gene expression","score":0.8479999899864197},{"id":"https://openalex.org/keywords/air-pollution","display_name":"air pollution","score":0.5070000290870667},{"id":"https://openalex.org/keywords/free-radicals","display_name":"free radicals","score":0.6899999976158142},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.7860000133514404},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.45500001311302185},{"id":"https://openalex.org/keywords/epithelial-permeability","display_name":"epithelial permeability","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9323446750640869},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.7572188377380371},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.5774150490760803},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4662567377090454},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3936854600906372},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13466474413871765},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.08924567699432373},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000393","descriptor_name":"Air Pollutants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000397","descriptor_name":"Air Pollution","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1183/09031936.03.00403203","doi":"https://doi.org/10.1183/09031936.03.00403203","is_oa":true,"landing_page_url":"https://doi.org/10.1183/09031936.03.00403203","pdf_url":"https://erj.ersjournals.com/content/erj/21/40_suppl/47s.full.pdf","source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Respiratory Journal","raw_type":"journal-article"},{"id":"pmid:12762574","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12762574","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The European respiratory journal. Supplement","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1183/09031936.03.00403203","doi":"https://doi.org/10.1183/09031936.03.00403203","is_oa":true,"landing_page_url":"https://doi.org/10.1183/09031936.03.00403203","pdf_url":"https://erj.ersjournals.com/content/erj/21/40_suppl/47s.full.pdf","source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Respiratory Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8100000023841858}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2008355024.pdf","grobid_xml":"https://content.openalex.org/works/W2008355024.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W5318797","https://openalex.org/W154593223","https://openalex.org/W1509689223","https://openalex.org/W1793238069","https://openalex.org/W1879805678","https://openalex.org/W1985892272","https://openalex.org/W1990674750","https://openalex.org/W1991880580","https://openalex.org/W2001426024","https://openalex.org/W2024772477","https://openalex.org/W2031033693","https://openalex.org/W2035839412","https://openalex.org/W2036438354","https://openalex.org/W2040066643","https://openalex.org/W2048164778","https://openalex.org/W2057465099","https://openalex.org/W2083756305","https://openalex.org/W2088729275","https://openalex.org/W2090790151","https://openalex.org/W2115272086","https://openalex.org/W2115846243","https://openalex.org/W2135297085","https://openalex.org/W2156895145","https://openalex.org/W2158822760","https://openalex.org/W2165298408","https://openalex.org/W3058700394","https://openalex.org/W4248285292","https://openalex.org/W4249759827","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2100923302","https://openalex.org/W2132303140","https://openalex.org/W1964180561","https://openalex.org/W1971036115","https://openalex.org/W7097552528","https://openalex.org/W2001426024","https://openalex.org/W2096996607","https://openalex.org/W3038805293","https://openalex.org/W2156895145","https://openalex.org/W74990001"],"abstract_inverted_index":{"Particulate":[0],"air":[1,89,235,256],"pollution":[2,90,236],"(particles":[3],"with":[4,17],"a":[5,178,198],"50%":[6],"cut-off":[7],"aerodynamic":[8],"diameter":[9],"of":[10,43,69,104,109,140,180,223,229,233,255],"10":[11],"microm":[12],"(PM10))":[13],"has":[14],"strong":[15],"associations":[16],"the":[18,40,67,82,141,227,230,253],"adverse":[19,143],"health":[20],"events":[21,95],"detected":[22],"by":[23,54,101,177],"epidemiological":[24],"studies":[25],"in":[26,32,57,75,200,207,237,244],"chronic":[27,238],"obstructive":[28,239],"pulmonary":[29,240],"disease":[30,241],"patients":[31],"diverse":[33],"geographical":[34],"locations.":[35],"Transition":[36],"metals":[37],"may":[38,49,62,91,135,215,242],"determine":[39],"toxic":[41],"effects":[42,159,232,254],"PM10":[44,142],"through":[45,66],"oxidative":[46,188,211],"stress":[47,189,212],"which":[48,131],"be":[50,136,197,216],"injurious":[51],"as":[52,175],"shown":[53,86],"an":[55,217],"increase":[56],"airspace":[58],"epithelial":[59,79],"permeability":[60],"and":[61,78,118,166,183,192],"lead":[63],"to":[64,107,186,190,196,203,221,252],"inflammation":[65],"activation":[68,100],"transcription":[70,98,114,120,222],"factors":[71],"for":[72,121,138,247],"pro-inflammatory":[73,122,224],"genes":[74],"both":[76],"macrophages":[77],"cells.":[80],"Recently,":[81],"present":[83],"authors":[84,147],"have":[85,132,148,157],"that":[87,96,150],"particulate":[88,234],"cause":[92,187,204],"further":[93],"molecular":[94],"enhance":[97],"factor":[99,115,199,219],"causing":[102],"acetylation":[103],"histones":[105],"leading":[106,220],"unwinding":[108],"deoxyribonucleic":[110],"acid":[111],"(DNA)":[112],"enhancing":[113],"DNA":[116],"binding":[117],"increasing":[119],"genes.":[123,225],"Further,":[124],"ultrafine":[125,151],"particles":[126],"(<":[127],"100":[128],"nm":[129],"diameter),":[130],"marked":[133],"toxicity,":[134],"responsible":[137],"some":[139],"effects.":[144],"The":[145],"current":[146],"demonstrated":[149],"carbon":[152],"black":[153],"(ufCB)":[154],"does":[155],"not":[156],"its":[158],"via":[160],"transition":[161],"metal-mediated":[162],"mechanisms.":[163],"However,":[164],"ufCB":[165],"other":[167],"ultrafines":[168],"generate":[169],"free":[170],"radicals":[171],"at":[172],"their":[173,201],"surface":[174],"measured":[176],"number":[179],"chemical":[181],"assays":[182],"are":[184,250],"able":[185],"cells":[191,214],"this":[193],"is":[194],"likely":[195],"ability":[202],"inflammation.":[205],"Changes":[206],"calcium":[208],"resulting":[209],"from":[210],"within":[213],"additional":[218],"Understanding":[226],"mechanisms":[228],"harmful":[231],"help":[243],"risk":[245],"strategy":[246],"individuals":[248],"who":[249],"susceptible":[251],"pollution.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":19},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":13}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}