{"id":"https://openalex.org/W2008351667","doi":"https://doi.org/10.1111/j.1365-2141.2012.09253.x","title":"Methyljasmonate displays in vitro and in vivo activity against multiple myeloma cells","display_name":"Methyljasmonate displays in vitro and in vivo activity against multiple myeloma cells","publication_year":2012,"publication_date":"2012-09-13","ids":{"openalex":"https://openalex.org/W2008351667","doi":"https://doi.org/10.1111/j.1365-2141.2012.09253.x","mag":"2008351667","pmid":"https://pubmed.ncbi.nlm.nih.gov/22970818","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4414399"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2141.2012.09253.x","doi":"https://doi.org/10.1111/j.1365-2141.2012.09253.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2141.2012.09253.x","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4414399","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069524712","display_name":"Steffen Klippel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steffen Klippel","raw_affiliation_strings":["Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065898212","display_name":"Jana Jakub\u0131\u0301kov\u00e1","orcid":"https://orcid.org/0000-0003-2593-569X","observed_orcids":["https://orcid.org/0000-0003-2593-569X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jana Jakubikova","raw_affiliation_strings":["Department of Medical Oncology Dana\u2010Farber Cancer Institute Harvard Medical School Boston MA 02215 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology Dana\u2010Farber Cancer Institute Harvard Medical School Boston MA 02215 USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091354090","display_name":"Jake E. Delmore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jake Delmore","raw_affiliation_strings":["Department of Medical Oncology Dana\u2010Farber Cancer Institute Harvard Medical School Boston MA 02215 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology Dana\u2010Farber Cancer Institute Harvard Medical School Boston MA 02215 USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006357976","display_name":"Melissa Gaik Ming Ooi","orcid":"https://orcid.org/0000-0002-7392-0655","observed_orcids":["https://orcid.org/0000-0002-7392-0655"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa Ooi","raw_affiliation_strings":["Department of Medical Oncology Dana\u2010Farber Cancer Institute Harvard Medical School Boston MA 02215 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology Dana\u2010Farber Cancer Institute Harvard Medical School Boston MA 02215 USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115591881","display_name":"Douglas W. McMillin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas McMillin","raw_affiliation_strings":["Department of Medical Oncology Dana\u2010Farber Cancer Institute Harvard Medical School Boston MA 02215 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology Dana\u2010Farber Cancer Institute Harvard Medical School Boston MA 02215 USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018522443","display_name":"Efstathios Kastritis","orcid":"https://orcid.org/0000-0001-8191-5832","observed_orcids":["https://orcid.org/0000-0001-8191-5832"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Efstathios Kastritis","raw_affiliation_strings":["Department of Medical Oncology Dana\u2010Farber Cancer Institute Harvard Medical School Boston MA 02215 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology Dana\u2010Farber Cancer Institute Harvard Medical School Boston MA 02215 USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049711954","display_name":"Jacob P. Laubach","orcid":"https://orcid.org/0000-0001-7565-2052","observed_orcids":["https://orcid.org/0000-0001-7565-2052"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob Laubach","raw_affiliation_strings":["Department of Medical Oncology Dana\u2010Farber Cancer Institute Harvard Medical School Boston MA 02215 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology Dana\u2010Farber Cancer Institute Harvard Medical School Boston MA 02215 USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043526996","display_name":"Paul Gerard Guy Richardson","orcid":"https://orcid.org/0000-0002-7426-8865","observed_orcids":["https://orcid.org/0000-0002-7426-8865"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul G. Richardson","raw_affiliation_strings":["Department of Medical Oncology Dana\u2010Farber Cancer Institute Harvard Medical School Boston MA 02215 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology Dana\u2010Farber Cancer Institute Harvard Medical School Boston MA 02215 USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032464400","display_name":"Kenneth Carl Anderson","orcid":"https://orcid.org/0000-0002-6418-0886","observed_orcids":["https://orcid.org/0000-0002-6418-0886"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth C. Anderson","raw_affiliation_strings":["Department of Medical Oncology Dana\u2010Farber Cancer Institute Harvard Medical School Boston MA 02215 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology Dana\u2010Farber Cancer Institute Harvard Medical School Boston MA 02215 USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012712111","display_name":"Constantine S. Mitsiades","orcid":"https://orcid.org/0000-0003-2321-8005","observed_orcids":["https://orcid.org/0000-0003-2321-8005"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Constantine S. Mitsiades","raw_affiliation_strings":["Department of Medical Oncology Dana\u2010Farber Cancer Institute Harvard Medical School Boston MA 02215 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology Dana\u2010Farber Cancer Institute Harvard Medical School Boston MA 02215 USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012712111"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":1.9152,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.86339981,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"159","issue":"3","first_page":"340","last_page":"351"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methyl-jasmonate","display_name":"methyl jasmonate","score":0.9900000095367432},{"id":"https://openalex.org/keywords/jasmonates","display_name":"jasmonates","score":0.8769999742507935},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6150000095367432},{"id":"https://openalex.org/keywords/hexokinase-2","display_name":"hexokinase 2","score":0.9399999976158142},{"id":"https://openalex.org/keywords/atp-depletion","display_name":"ATP depletion","score":0.9380000233650208},{"id":"https://openalex.org/keywords/akr1c1","display_name":"AKR1C1","score":0.8619999885559082},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.7730000019073486},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5720000267028809},{"id":"https://openalex.org/keywords/antitumour-activity","display_name":"antitumour activity","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6705806851387024},{"id":"https://openalex.org/C2777478702","wikidata":"https://www.wikidata.org/wiki/Q419319","display_name":"Bortezomib","level":3,"score":0.6532053351402283},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6051411032676697},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6047126054763794},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5752641558647156},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.48877379298210144},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4764443039894104},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.453870952129364},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.45350292325019836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44623735547065735},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37509065866470337},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34063640236854553},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27195659279823303},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25486451387405396},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000085","descriptor_name":"Acetates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000085","descriptor_name":"Acetates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003517","descriptor_name":"Cyclopentanes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003517","descriptor_name":"Cyclopentanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D010937","descriptor_name":"Plant Growth Regulators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054883","descriptor_name":"Oxylipins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D054883","descriptor_name":"Oxylipins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D059447","descriptor_name":"Cell Cycle Checkpoints","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2141.2012.09253.x","doi":"https://doi.org/10.1111/j.1365-2141.2012.09253.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2141.2012.09253.x","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:22970818","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22970818","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of haematology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4414399","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4414399","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Br J Haematol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4414399","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4414399","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Br J Haematol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4933731489","display_name":"SPORE in Multiple Myeloma","funder_award_id":"P50CA100707","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5276536440","display_name":"Molecular Sequelae of Myeloma-Bone Marrow Interactions: Therapeutic Applications","funder_award_id":"R01CA050947","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G896876037","display_name":null,"funder_award_id":"R0-1 50947","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1501296331","https://openalex.org/W1528751727","https://openalex.org/W1970951397","https://openalex.org/W1997353298","https://openalex.org/W1999620129","https://openalex.org/W2002726977","https://openalex.org/W2009884504","https://openalex.org/W2013250681","https://openalex.org/W2024412406","https://openalex.org/W2035517801","https://openalex.org/W2049150145","https://openalex.org/W2052543023","https://openalex.org/W2077301757","https://openalex.org/W2083133991","https://openalex.org/W2083348851","https://openalex.org/W2095573466","https://openalex.org/W2102322990","https://openalex.org/W2123728867","https://openalex.org/W2124560610","https://openalex.org/W2143597100","https://openalex.org/W2144569256","https://openalex.org/W2150662398","https://openalex.org/W2162803937","https://openalex.org/W2171180960","https://openalex.org/W2171504422","https://openalex.org/W2171585055"],"related_works":["https://openalex.org/W2593149089","https://openalex.org/W2042358042","https://openalex.org/W2086960564","https://openalex.org/W2027510137","https://openalex.org/W3118669603","https://openalex.org/W2564010876","https://openalex.org/W2155098156","https://openalex.org/W7095079407","https://openalex.org/W3135660853","https://openalex.org/W4236301055"],"abstract_inverted_index":{"Jasmonates,":[0],"plant":[1],"stress":[2],"hormones,":[3],"have":[4],"been":[5],"demonstrated":[6],"to":[7,43,90,130,169,185],"be":[8],"effective":[9],"in":[10,29,32,45,143,154],"killing":[11],"various":[12],"types":[13],"of":[14,63,68,78,108,128,159,165],"cancer":[15],"cells.":[16],"We":[17],"therefore":[18],"tested":[19],"if":[20],"methyljasmonate":[21],"(MJ)":[22],"has":[23],"activity":[24],"against":[25],"multiple":[26],"myeloma":[27],"(MM)":[28],"vitro":[30,46,155],"and":[31,37,83,98,116,156],"vivo.":[33],"MM":[34,39,64,147],"cell":[35,87],"lines":[36],"primary":[38],"tumour":[40],"cells":[41,65,167],"responded":[42],"MJ":[44,61,91,131,150],"at":[47],"concentrations":[48],"that":[49,178],"did":[50],"not":[51],"significantly":[52],"affect":[53],"normal":[54],"haematopoietic":[55],"cells,":[56],"without":[57],"stroma-mediated":[58],"resistance.":[59],"Brief":[60],"exposures":[62],"caused":[66],"release":[67],"Hexokinase":[69],"2":[70],"(HK2)":[71],"from":[72],"mitochondria,":[73],"rapid":[74],"ATP":[75],"depletion,":[76],"perturbation":[77],"major":[79],"intracellular":[80,105],"signalling":[81],"pathways,":[82],"ensuing":[84],"mainly":[85],"apoptotic":[86],"death.":[88],"Sensitivity":[89],"correlated":[92],"with":[93,140,152],"lower":[94,104],"cellular":[95],"glucose":[96],"consumption":[97],"lactate":[99],"production,":[100],"as":[101,103,134],"well":[102],"protein":[106],"levels":[107,137],"HK2,":[109],"phosphorylated":[110],"Voltage-dependent":[111],"anion":[112],"channel":[113],"2/3":[114],"(pVDAC2/3)":[115],"Aldo-keto":[117],"reductase":[118],"family":[119],"1":[120],"member":[121],"C1":[122],"(AKR1C1),":[123],"which":[124],"represent":[125,180],"potential":[126],"biomarkers":[127],"responsiveness":[129],"treatment,":[132],"especially":[133],"AKR1C1":[135],"transcript":[136],"also":[138],"correlate":[139],"clinical":[141],"outcome":[142],"bortezomib-":[144],"or":[145],"dexamethasone-treated":[146],"patients.":[148],"Interestingly,":[149],"synergized":[151],"bortezomib":[153],"prolonged":[157],"survival":[158],"immunocompromised":[160],"mice":[161,171],"harbouring":[162],"diffuse":[163],"lesions":[164],"MM.1S":[166],"compared":[168],"vehicle-treated":[170],"(P":[172],"=":[173],"0\u00b70046).":[174],"These":[175],"studies":[176],"indicate":[177],"jasmonates":[179],"a":[181],"new,":[182],"promising":[183],"strategy":[184],"treat":[186],"MM.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}