{"id":"https://openalex.org/W2008349270","doi":"https://doi.org/10.1080/13693780601028691","title":"Hemoglobin is an effective inducer of hyphal differentiation inCandidaalbicans","display_name":"Hemoglobin is an effective inducer of hyphal differentiation inCandidaalbicans","publication_year":2006,"publication_date":"2006-10-25","ids":{"openalex":"https://openalex.org/W2008349270","doi":"https://doi.org/10.1080/13693780601028691","mag":"2008349270","pmid":"https://pubmed.ncbi.nlm.nih.gov/17325946"},"language":"en","primary_location":{"id":"doi:10.1080/13693780601028691","doi":"https://doi.org/10.1080/13693780601028691","is_oa":false,"landing_page_url":"https://doi.org/10.1080/13693780601028691","pdf_url":null,"source":{"id":"https://openalex.org/S93288122","display_name":"Medical Mycology","issn_l":"0268-1218","issn":["0268-1218","1365-280X","1369-3786","1460-2709"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Mycology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080748987","display_name":"Michael L. Pendrak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael L. Pendrak","raw_affiliation_strings":["Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1500, USA. mpendrak@helix.nih.gov","Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892-1500, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1500, USA. mpendrak@helix.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892-1500, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031078822","display_name":"David D. Roberts","orcid":"https://orcid.org/0000-0002-2481-2981","observed_orcids":["https://orcid.org/0000-0002-2481-2981"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David D. Roberts","raw_affiliation_strings":["Laboratory of Pathology Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pathology Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4889,"currency":"USD","value_usd":4889},"apc_paid":null,"fwci":0.815,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.67481807,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"45","issue":"1","first_page":"61","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.03240000084042549,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemoglobin","display_name":"hemoglobin","score":0.8619999885559082},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hyphal-differentiation","display_name":"hyphal differentiation","score":0.9700000286102295},{"id":"https://openalex.org/keywords/hwp1","display_name":"HWP1","score":0.6949999928474426},{"id":"https://openalex.org/keywords/ece1","display_name":"endothelin-converting enzyme-1","score":0.996999979019165},{"id":"https://openalex.org/keywords/host-pathogen-signaling","display_name":"host-pathogen signaling","score":0.6320000290870667},{"id":"https://openalex.org/keywords/iron-acquisition","display_name":"iron acquisition","score":0.8019999861717224},{"id":"https://openalex.org/keywords/germ-tube-formation","display_name":"germ tube formation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/hyphal-morphogenesis","display_name":"hyphal morphogenesis","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.6754000186920166},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5921952128410339},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5286688804626465},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.5258229970932007},{"id":"https://openalex.org/C90080823","wikidata":"https://www.wikidata.org/wiki/Q193129","display_name":"Hypha","level":2,"score":0.5222183465957642},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.486390620470047},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44572368264198303},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33670157194137573},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3298795819282532},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07381457090377808}],"mesh":[{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009584","descriptor_name":"Nitrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D025301","descriptor_name":"Hyphae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D025301","descriptor_name":"Hyphae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025301","descriptor_name":"Hyphae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D025301","descriptor_name":"Hyphae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/13693780601028691","doi":"https://doi.org/10.1080/13693780601028691","is_oa":false,"landing_page_url":"https://doi.org/10.1080/13693780601028691","pdf_url":null,"source":{"id":"https://openalex.org/S93288122","display_name":"Medical Mycology","issn_l":"0268-1218","issn":["0268-1218","1365-280X","1369-3786","1460-2709"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Mycology","raw_type":"journal-article"},{"id":"pmid:17325946","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17325946","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical mycology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310702","display_name":"National Cancer Research Institute","ror":"https://ror.org/02mp0vf47"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W260326651","https://openalex.org/W1012963668","https://openalex.org/W1490463836","https://openalex.org/W1490999179","https://openalex.org/W1495496122","https://openalex.org/W1540955234","https://openalex.org/W1582560245","https://openalex.org/W1608068193","https://openalex.org/W1892030338","https://openalex.org/W1912625738","https://openalex.org/W1917430189","https://openalex.org/W1940720973","https://openalex.org/W1966022765","https://openalex.org/W1970623997","https://openalex.org/W1983556745","https://openalex.org/W1993393187","https://openalex.org/W1998871484","https://openalex.org/W1999340863","https://openalex.org/W2002379595","https://openalex.org/W2002853127","https://openalex.org/W2014513665","https://openalex.org/W2026786156","https://openalex.org/W2044887314","https://openalex.org/W2049219353","https://openalex.org/W2058216045","https://openalex.org/W2058354220","https://openalex.org/W2071105781","https://openalex.org/W2074994854","https://openalex.org/W2076305614","https://openalex.org/W2103433414","https://openalex.org/W2103753616","https://openalex.org/W2108244474","https://openalex.org/W2109834859","https://openalex.org/W2113880496","https://openalex.org/W2115834673","https://openalex.org/W2116142653","https://openalex.org/W2117464846","https://openalex.org/W2121738871","https://openalex.org/W2125458302","https://openalex.org/W2130252243","https://openalex.org/W2131942193","https://openalex.org/W2148698017","https://openalex.org/W2149488786","https://openalex.org/W2151067242","https://openalex.org/W2152383582","https://openalex.org/W2152745547","https://openalex.org/W2156046842","https://openalex.org/W2157819664","https://openalex.org/W2158313582","https://openalex.org/W2161849939","https://openalex.org/W2163110564","https://openalex.org/W2164846665","https://openalex.org/W2167880806","https://openalex.org/W4240065971"],"related_works":["https://openalex.org/W2038824665","https://openalex.org/W2026786156","https://openalex.org/W2014513665","https://openalex.org/W4392688308","https://openalex.org/W2074994854","https://openalex.org/W2156046842","https://openalex.org/W4295298956","https://openalex.org/W3162666137","https://openalex.org/W2157725957","https://openalex.org/W2032691398"],"abstract_inverted_index":{"Hemoglobin":[0,62],"is":[1],"an":[2,31],"abundant":[3],"protein":[4],"in":[5,167,202],"the":[6,75,83,112,141,162,176,179,184,199],"host":[7],"vascular":[8],"compartment":[9],"and":[10,16,44,79,97,103,125],"a":[11,37,196],"source":[12,33],"of":[13,74,85,143,178],"iron,":[14],"heme,":[15],"amino":[17],"acids":[18],"for":[19,111,198],"many":[20],"pathogens.":[21],"The":[22],"human":[23],"fungal":[24],"pathogen":[25],"Candida":[26],"albicans":[27],"uses":[28],"hemoglobin":[29,56,137,144,201],"as":[30,34,36],"iron":[32],"well":[35],"signaling":[38],"molecule":[39],"to":[40,47,64,114,145],"alter":[41],"gene":[42,151],"expression":[43,73,152],"induce":[45,146],"adhesion":[46],"several":[48],"extracellular":[49],"matrix":[50],"proteins.":[51],"We":[52],"now":[53],"report":[54],"that":[55],"can":[57],"promote":[58],"true":[59],"hyphal":[60,86,168,204],"morphogenesis.":[61],"added":[63],"yeast":[65],"cells":[66],"at":[67,94,153],"37":[68,154],"degrees":[69,155],"C":[70,156],"rapidly":[71],"induced":[72],"hypha-specific":[76,150],"genes":[77],"HWP1":[78],"ECE1":[80],"coincident":[81],"with":[82,92],"pattern":[84],"development.":[87,205],"A":[88],"synthetic":[89],"medium":[90],"buffered":[91],"phosphate":[93],"pH":[95],"7.2":[96],"containing":[98],"physiological":[99],"glucose":[100,117],"(5":[101],"mM)":[102,108],"low":[104],"ammonium":[105,121],"ion":[106,122],"(0.1":[107],"was":[109,172,190],"optimal":[110],"response":[113,171],"hemoglobin.":[115],"High":[116],"(110":[118],"mM),":[119,124],"high":[120],"(20":[123],"0.1":[126],"mM":[127],"glutamine":[128],"were":[129],"all":[130],"inhibitory.":[131],"Heme,":[132],"free":[133],"globin,":[134],"or":[135,149],"immobilized":[136],"could":[138],"not":[139,191],"replicate":[140],"activity":[142],"germ":[147],"tubes":[148],"under":[157],"optimized":[158],"conditions.":[159],"This":[160,170],"implicates":[161],"previously":[163],"described":[164],"Hb-signaling":[165],"receptor":[166],"formation.":[169],"also":[173],"dependent":[174],"upon":[175],"presence":[177],"morphogenesis":[180],"regulator":[181],"Efg1p,":[182],"but":[183],"MAP-kinase":[185],"specific":[186],"transcription":[187],"factor":[188],"Cph1p":[189],"required.":[192],"These":[193],"data":[194],"define":[195],"role":[197],"host-factor":[200],"Efg1p-dependent":[203]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
