{"id":"https://openalex.org/W2008339157","doi":"https://doi.org/10.1055/s-2004-817978","title":"Protein Kinase C and Myocardial Calcium Handling during Ischemia and Reperfusion: Lessons Learned using Rhod-2 Spectrofluorometry","display_name":"Protein Kinase C and Myocardial Calcium Handling during Ischemia and Reperfusion: Lessons Learned using Rhod-2 Spectrofluorometry","publication_year":2004,"publication_date":"2004-06-01","ids":{"openalex":"https://openalex.org/W2008339157","doi":"https://doi.org/10.1055/s-2004-817978","mag":"2008339157","pmid":"https://pubmed.ncbi.nlm.nih.gov/15192771"},"language":"en","primary_location":{"id":"doi:10.1055/s-2004-817978","doi":"https://doi.org/10.1055/s-2004-817978","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2004-817978","pdf_url":null,"source":{"id":"https://openalex.org/S81394012","display_name":"The Thoracic and Cardiovascular Surgeon","issn_l":"0171-6425","issn":["0171-6425","1439-1902"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Thoracic and Cardiovascular Surgeon","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072408501","display_name":"Christof Stamm","orcid":"https://orcid.org/0000-0003-3035-2106","observed_orcids":["https://orcid.org/0000-0003-3035-2106"]},"institutions":[{"id":"https://openalex.org/I4210136182","display_name":"Universit\u00e4tsmedizin Rostock","ror":"https://ror.org/04dm1cm79","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210136182"]},{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C. Stamm","raw_affiliation_strings":["Klinik und Poliklinik f\u00fcr Herzchirurgie, Universit\u00e4t Rostock, Rostock, Germany. christoff.stamm@med.uni-rostock.de","Klinik und Poliklinik f\u00fcr Herzchirurgie, Universit\u00e4t Rostock, Rostock, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik und Poliklinik f\u00fcr Herzchirurgie, Universit\u00e4t Rostock, Rostock, Germany. christoff.stamm@med.uni-rostock.de","institution_ids":["https://openalex.org/I4210136182","https://openalex.org/I4665924"]},{"raw_affiliation_string":"Klinik und Poliklinik f\u00fcr Herzchirurgie, Universit\u00e4t Rostock, Rostock, Germany","institution_ids":["https://openalex.org/I4210136182","https://openalex.org/I4665924"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001927963","display_name":"Pedro J. del Nido","orcid":"https://orcid.org/0000-0003-4252-8789","observed_orcids":["https://orcid.org/0000-0003-4252-8789"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. J. del Nido","raw_affiliation_strings":["Children's Hospital Boston, Harvard Medical School, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Boston, Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3415,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.79527748,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"52","issue":"3","first_page":"127","last_page":"134"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9990000128746033},{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.9179999828338623},{"id":"https://openalex.org/keywords/calcium-handling","display_name":"calcium handling","score":0.8119999766349792},{"id":"https://openalex.org/keywords/excitation-contraction-coupling","display_name":"excitation-contraction coupling","score":0.9240000247955322},{"id":"https://openalex.org/keywords/rhod-2","display_name":"Rhod-2","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cytosolic-calcium-transients","display_name":"cytosolic calcium transients","score":0.9649999737739563},{"id":"https://openalex.org/keywords/pkc-translocation","display_name":"PKC translocation","score":0.7620000243186951},{"id":"https://openalex.org/keywords/phosphatidylinositol-specific-phospholipase-c","display_name":"phosphatidylinositol-specific phospholipase C","score":0.9330000281333923},{"id":"https://openalex.org/keywords/troponin-i-phosphorylation","display_name":"troponin I phosphorylation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/calcium-sensitivity","display_name":"calcium sensitivity","score":0.7269999980926514},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.9129999876022339},{"id":"https://openalex.org/keywords/langendorff-perfused-heart","display_name":"Langendorff-perfused heart","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.6865627765655518},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6637208461761475},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.6430147290229797},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.592587411403656},{"id":"https://openalex.org/C2779676291","wikidata":"https://www.wikidata.org/wiki/Q25325349","display_name":"Cardioprotection","level":3,"score":0.5569660663604736},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.4405378997325897},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3622973561286926},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.36180880665779114},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.31864309310913086},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2965548038482666},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20271512866020203},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19834986329078674},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17191413044929504}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006575","descriptor_name":"Heterocyclic Compounds, 3-Ring","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015425","descriptor_name":"Myocardial Reperfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019210","descriptor_name":"Troponin I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-2004-817978","doi":"https://doi.org/10.1055/s-2004-817978","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2004-817978","pdf_url":null,"source":{"id":"https://openalex.org/S81394012","display_name":"The Thoracic and Cardiovascular Surgeon","issn_l":"0171-6425","issn":["0171-6425","1439-1902"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Thoracic and Cardiovascular Surgeon","raw_type":"journal-article"},{"id":"pmid:15192771","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15192771","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Thoracic and cardiovascular surgeon","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2093736023","https://openalex.org/W1930873456","https://openalex.org/W2011733910","https://openalex.org/W2387867227","https://openalex.org/W2167711235","https://openalex.org/W2051896709","https://openalex.org/W2133606772","https://openalex.org/W2022617808","https://openalex.org/W2171983034","https://openalex.org/W1989261342"],"abstract_inverted_index":{"OBJECTIVE:":[0],"We":[1,46,89],"sought":[2],"to":[3,20,73,104],"assess":[4],"myocardial":[5,80,132,234],"Ca":[6,51,60,81,99,128,190,198,217],"(2+)":[7,52,61,82,100,129,191,199,218],"handling":[8,83],"and":[9,19,35,67,70,86,98,110,114,124,144,149,166,180,194,224],"excitation-contraction":[10],"coupling":[11],"in":[12,41,63,108,152,219],"surgically":[13,220],"relevant":[14,221],"models":[15,223],"of":[16,24,58,77,126,139,161,176,178,188,203,215,229],"ischemia-reperfusion":[17],"injury":[18],"clarify":[21],"the":[22,48,75,93,122,140,147,174,186,227],"importance":[23],"protein":[25,197],"kinase":[26],"C":[27,164],"(PKC)":[28],"for":[29,55,96,106,213,233],"cardioprotection.":[30],"METHODS:":[31],"Experimentally,":[32],"surgical":[33],"ischemia":[34,85,113],"reperfusion":[36,193],"can":[37,225],"only":[38],"be":[39,102],"mimicked":[40],"intact":[42],"perfused":[43],"heart":[44],"models.":[45],"introduced":[47],"long-wavelength":[49],"fluorescent":[50],"indicator":[53],"Rhod-2":[54,97,207],"real-time":[56],"recording":[57],"cytosolic":[59,127,148,189,216],"transients":[62],"Langendorff-perfused":[64],"rabbit,":[65],"rat,":[66],"mouse":[68],"hearts,":[69],"utilized":[71],"it":[72,183],"study":[74],"impact":[76],"PKC":[78,141,155,179],"on":[79,117],"during":[84,112,131,192],"reperfusion.":[87,115],"RESULTS:":[88],"first":[90],"established":[91],"that":[92,182],"dissociation":[94],"constant":[95],"must":[101],"adjusted":[103],"account":[105],"changes":[107],"pH":[109],"temperature":[111],"Based":[116],"this":[118],"method,":[119],"we":[120,172],"determined":[121],"time-course":[123],"extent":[125],"accumulation":[130,187],"ischemia,":[133],"which":[134],"is":[135,157,209],"associated":[136],"with":[137],"translocation":[138,156],"isoforms":[142],"alpha":[143],"epsilon":[145],"between":[146],"particulate":[150],"compartments":[151],"cardiomyocytes.":[153],"The":[154],"mediated":[158],"by":[159],"activation":[160],"phosphatidyl-inositol-specific":[162],"phospholipase":[163],"(PI-PLC),":[165],"represents":[167],"a":[168,210],"cardioprotective":[169],"mechanism.":[170],"Finally,":[171],"studied":[173],"mechanism":[175],"action":[177],"found":[181],"both":[184],"limits":[185],"attenuates":[195],"contractile":[196],"sensitivity":[200],"via":[201],"phosphorylation":[202],"troponin":[204],"I.":[205],"CONCLUSIONS:":[206],"spectrofluorometry":[208],"valuable":[211],"tool":[212],"assessment":[214],"experimental":[222],"aid":[226],"development":[228],"more":[230],"effective":[231],"methods":[232],"protection.":[235]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
