{"id":"https://openalex.org/W2008334346","doi":"https://doi.org/10.1124/dmd.108.022525","title":"Metabolic Profiling and Cytochrome P450 Reaction Phenotyping of Medroxyprogesterone Acetate","display_name":"Metabolic Profiling and Cytochrome P450 Reaction Phenotyping of Medroxyprogesterone Acetate","publication_year":2008,"publication_date":"2008-08-26","ids":{"openalex":"https://openalex.org/W2008334346","doi":"https://doi.org/10.1124/dmd.108.022525","mag":"2008334346","pmid":"https://pubmed.ncbi.nlm.nih.gov/18725509"},"language":"en","primary_location":{"id":"doi:10.1124/dmd.108.022525","doi":"https://doi.org/10.1124/dmd.108.022525","is_oa":false,"landing_page_url":"https://doi.org/10.1124/dmd.108.022525","pdf_url":null,"source":{"id":"https://openalex.org/S145039780","display_name":"Drug Metabolism and Disposition","issn_l":"0090-9556","issn":["0090-9556","1521-009X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism and Disposition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071929911","display_name":"Jiang-Wei Zhang","orcid":"https://orcid.org/0000-0003-4725-2507","observed_orcids":["https://orcid.org/0000-0003-4725-2507"]},"institutions":[{"id":"https://openalex.org/I180585399","display_name":"Dalian Institute of Chemical Physics","ror":"https://ror.org/00prkya54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I180585399","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiang-Wei Zhang","raw_affiliation_strings":["Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China","institution_ids":["https://openalex.org/I180585399","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115501056","display_name":"Yong Liu","orcid":"https://orcid.org/0000-0001-9945-8131","observed_orcids":["https://orcid.org/0000-0001-9945-8131"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024340201","display_name":"Jiuyang Zhao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiu-Yang Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Li-Ming Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li-Ming Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102735071","display_name":"Guangbo Ge","orcid":"https://orcid.org/0000-0002-8437-9155","observed_orcids":["https://orcid.org/0000-0002-8437-9155"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guang-Bo Ge","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030381486","display_name":"Yang Gao","orcid":"https://orcid.org/0000-0002-1190-4561","observed_orcids":["https://orcid.org/0000-0002-1190-4561"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yang Gao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318325","display_name":"W\u011bi Li","orcid":"https://orcid.org/0000-0002-9522-4474","observed_orcids":["https://orcid.org/0000-0002-9522-4474","https://orcid.org/0000-0003-4136-3409","https://orcid.org/0009-0009-9141-6389"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100444846","display_name":"Hongtao Liu","orcid":"https://orcid.org/0000-0002-6363-7450","observed_orcids":["https://orcid.org/0000-0002-6363-7450"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong-Tao Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032685603","display_name":"Huixin Liu","orcid":"https://orcid.org/0000-0002-8981-9981","observed_orcids":["https://orcid.org/0000-0002-8981-9981"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hui-Xin Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037160431","display_name":"Yanyan Zhang","orcid":"https://orcid.org/0000-0002-4229-1470","observed_orcids":["https://orcid.org/0000-0002-4229-1470"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan-Yan Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045023952","display_name":"Jie Sun","orcid":"https://orcid.org/0000-0002-6475-4667","observed_orcids":["https://orcid.org/0000-0002-6475-4667"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jie Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108009601","display_name":"Ling Yang","orcid":"https://orcid.org/0000-0001-7093-5926","observed_orcids":["https://orcid.org/0000-0001-7093-5926"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ling Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.8738,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.82556488,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"36","issue":"11","first_page":"2292","last_page":"2298"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medroxyprogesterone-acetate","display_name":"medroxyprogesterone acetate","score":1.0},{"id":"https://openalex.org/keywords/progestins","display_name":"progestins","score":0.8659999966621399},{"id":"https://openalex.org/keywords/phase-i-metabolism","display_name":"phase I metabolism","score":0.824999988079071},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":1.0},{"id":"https://openalex.org/keywords/hydroxylation","display_name":"hydroxylation","score":0.7820000052452087},{"id":"https://openalex.org/keywords/human-liver-microsomes","display_name":"human liver microsomes","score":0.8100000023841858},{"id":"https://openalex.org/keywords/rat-liver-microsomes","display_name":"rat liver microsomes","score":0.9940000176429749},{"id":"https://openalex.org/keywords/species-differences","display_name":"species differences","score":0.7799999713897705},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.49399998784065247},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.3190000057220459}],"concepts":[{"id":"https://openalex.org/C109650736","wikidata":"https://www.wikidata.org/wiki/Q424440","display_name":"CYP3A4","level":4,"score":0.741230309009552},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.7209563255310059},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.7192992568016052},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6915284395217896},{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.5200783610343933},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5061973929405212},{"id":"https://openalex.org/C2775934596","wikidata":"https://www.wikidata.org/wiki/Q416667","display_name":"Medroxyprogesterone","level":4,"score":0.5005214214324951},{"id":"https://openalex.org/C2776306185","wikidata":"https://www.wikidata.org/wiki/Q2823834","display_name":"Medroxyprogesterone acetate","level":3,"score":0.4909367859363556},{"id":"https://openalex.org/C2779907587","wikidata":"https://www.wikidata.org/wiki/Q14901439","display_name":"Glucuronidation","level":4,"score":0.4654199779033661},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.4535658061504364},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.4529135227203369},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.43786317110061646},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2979068160057068},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29316097497940063},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2801322937011719},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.20921143889427185},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13444054126739502}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013556","descriptor_name":"Swine, Miniature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017258","descriptor_name":"Medroxyprogesterone Acetate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1124/dmd.108.022525","doi":"https://doi.org/10.1124/dmd.108.022525","is_oa":false,"landing_page_url":"https://doi.org/10.1124/dmd.108.022525","pdf_url":null,"source":{"id":"https://openalex.org/S145039780","display_name":"Drug Metabolism and Disposition","issn_l":"0090-9556","issn":["0090-9556","1521-009X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism and Disposition","raw_type":"journal-article"},{"id":"pmid:18725509","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18725509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug metabolism and disposition: the biological fate of chemicals","raw_type":"Comparative Study"},{"id":"pmh:oai:cas-ir.dicp.ac.cn:321008/100717","doi":null,"is_oa":false,"landing_page_url":"http://159.226.238.44/handle/321008/100717","pdf_url":null,"source":{"id":"https://openalex.org/S7407064340","display_name":"Dalian Institute of Chemical Physics, CAS Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"\u671f\u520a\u8bba\u6587"},{"id":"pmh:oai:cas-ir.dicp.ac.cn:321008/141129","doi":null,"is_oa":false,"landing_page_url":"http://cas-ir.dicp.ac.cn/handle/321008/141129","pdf_url":null,"source":{"id":"https://openalex.org/S7407064340","display_name":"Dalian Institute of Chemical Physics, CAS Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"mag:2463745145","doi":null,"is_oa":false,"landing_page_url":"http://www.irgrid.ac.cn/handle/1471x/237607","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W30228135","https://openalex.org/W1570808326","https://openalex.org/W1588063231","https://openalex.org/W1593442063","https://openalex.org/W1775749144","https://openalex.org/W1867169935","https://openalex.org/W1951469402","https://openalex.org/W1965965669","https://openalex.org/W1983412431","https://openalex.org/W1983521550","https://openalex.org/W2004361944","https://openalex.org/W2006785961","https://openalex.org/W2008928614","https://openalex.org/W2014884679","https://openalex.org/W2017694926","https://openalex.org/W2027276257","https://openalex.org/W2031832430","https://openalex.org/W2033717872","https://openalex.org/W2036312579","https://openalex.org/W2039395322","https://openalex.org/W2070925397","https://openalex.org/W2078390130","https://openalex.org/W2084331368","https://openalex.org/W2089687903","https://openalex.org/W2101207155","https://openalex.org/W2106933588","https://openalex.org/W2129353515","https://openalex.org/W2141364356","https://openalex.org/W2145560149","https://openalex.org/W2150484711","https://openalex.org/W2165886950","https://openalex.org/W2168786728","https://openalex.org/W2169723565","https://openalex.org/W2181050057","https://openalex.org/W2356351198","https://openalex.org/W2412720138","https://openalex.org/W2418159889","https://openalex.org/W2524198559","https://openalex.org/W4206062841","https://openalex.org/W4298048951","https://openalex.org/W6676148281","https://openalex.org/W6681655428","https://openalex.org/W6684901889","https://openalex.org/W6726997077"],"related_works":["https://openalex.org/W2410068056","https://openalex.org/W2433905365","https://openalex.org/W2145560149","https://openalex.org/W1986241251","https://openalex.org/W2006785961","https://openalex.org/W6958723975","https://openalex.org/W2049513349","https://openalex.org/W2487396842","https://openalex.org/W2431908547","https://openalex.org/W1988026737"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
