{"id":"https://openalex.org/W2008308525","doi":"https://doi.org/10.1016/0014-5793(90)80076-u","title":"Brain natriuretic peptide is cosecreted with atrial natriuretic peptide from porcine cardiocytes","display_name":"Brain natriuretic peptide is cosecreted with atrial natriuretic peptide from porcine cardiocytes","publication_year":1990,"publication_date":"1990-01-15","ids":{"openalex":"https://openalex.org/W2008308525","doi":"https://doi.org/10.1016/0014-5793(90)80076-u","mag":"2008308525","pmid":"https://pubmed.ncbi.nlm.nih.gov/2137097"},"language":"en","primary_location":{"id":"doi:10.1016/0014-5793(90)80076-u","doi":"https://doi.org/10.1016/0014-5793(90)80076-u","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-5793(90)80076-u","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110181011","display_name":"Tatsuyoshi Iida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuyoshi Iida","raw_affiliation_strings":["Department of Biochemistry, Nihon University School of Medicine, Tokyo, Japan","Department of Biochemistry, Nihon University School of Medicine, Tokyo 173, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Nihon University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I104946051"]},{"raw_affiliation_string":"Department of Biochemistry, Nihon University School of Medicine, Tokyo 173, Japan","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105250024","display_name":"Yukio Hirata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukio Hirata","raw_affiliation_strings":["Department of Medicine, Tokyo Medical and Dental University, Tokyo 113, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Tokyo Medical and Dental University, Tokyo 113, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046563797","display_name":"Naoyuki TAKEMURA","orcid":"https://orcid.org/0000-0002-4571-2701","observed_orcids":["https://orcid.org/0000-0002-4571-2701"]},"institutions":[{"id":"https://openalex.org/I130126513","display_name":"Nippon Veterinary and Life Science University","ror":"https://ror.org/04wsgqy55","country_code":"JP","type":"education","lineage":["https://openalex.org/I130126513"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoyuki Takemura","raw_affiliation_strings":["Nippon Veterinary and Zootechnical College, Tokyo 180, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nippon Veterinary and Zootechnical College, Tokyo 180, Japan","institution_ids":["https://openalex.org/I130126513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030341979","display_name":"\u548c\u7f8e \u5bcc\u6a2b","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazumi Togashi","raw_affiliation_strings":["Kitazato Biochemical Laboratories, Sagamihara 228, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kitazato Biochemical Laboratories, Sagamihara 228, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shigeki Nakagawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeki Nakagawa","raw_affiliation_strings":["Department of Biochemistry, Nihon University School of Medicine, Tokyo 173, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Nihon University School of Medicine, Tokyo 173, Japan","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108390050","display_name":"Fumiaki Marumo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumiaki Marumo","raw_affiliation_strings":["Department of Medicine, Tokyo Medical and Dental University, Tokyo 113, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Tokyo Medical and Dental University, Tokyo 113, Japan","institution_ids":["https://openalex.org/I125602781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":5.5527,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.95543442,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"260","issue":"1","first_page":"98","last_page":"100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.70169997215271,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.70169997215271,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.20260000228881836,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.027400000020861626,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-natriuretic-peptide","display_name":"brain natriuretic peptide","score":1.0},{"id":"https://openalex.org/keywords/atrial-natriuretic-peptide","display_name":"atrial natriuretic peptide","score":0.9980000257492065},{"id":"https://openalex.org/keywords/phorbol-ester","display_name":"phorbol ester","score":0.847000002861023},{"id":"https://openalex.org/keywords/calcium-ionophore","display_name":"calcium ionophore","score":0.9340000152587891},{"id":"https://openalex.org/keywords/natriuretic-peptides","display_name":"natriuretic peptides","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C2778069365","wikidata":"https://www.wikidata.org/wiki/Q78185357","display_name":"Atrial natriuretic peptide","level":2,"score":0.8445420265197754},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8167797327041626},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6681710481643677},{"id":"https://openalex.org/C2775915353","wikidata":"https://www.wikidata.org/wiki/Q1571529","display_name":"Natriuretic peptide","level":3,"score":0.6380810737609863},{"id":"https://openalex.org/C2775846464","wikidata":"https://www.wikidata.org/wiki/Q66360952","display_name":"Brain natriuretic peptide","level":3,"score":0.6290834546089172},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6108826398849487},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.601722240447998},{"id":"https://openalex.org/C3156946","wikidata":"https://www.wikidata.org/wiki/Q18030205","display_name":"NPR2","level":4,"score":0.5294466018676758},{"id":"https://openalex.org/C8741621","wikidata":"https://www.wikidata.org/wiki/Q18030203","display_name":"NPR1","level":4,"score":0.524506688117981},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48034918308258057},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.45280152559280396},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30593061447143555},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.2354143261909485},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11814010143280029}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009320","descriptor_name":"Atrial Natriuretic Factor","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D009320","descriptor_name":"Atrial Natriuretic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020097","descriptor_name":"Natriuretic Peptide, Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0014-5793(90)80076-u","doi":"https://doi.org/10.1016/0014-5793(90)80076-u","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-5793(90)80076-u","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:2137097","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2137097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W202078600","https://openalex.org/W1981438457","https://openalex.org/W2002859169","https://openalex.org/W2019950528","https://openalex.org/W2025571019","https://openalex.org/W2049934241","https://openalex.org/W2126548160","https://openalex.org/W4239995088"],"related_works":["https://openalex.org/W2063276064","https://openalex.org/W2126548160","https://openalex.org/W2465193790","https://openalex.org/W7096665228","https://openalex.org/W3140596081","https://openalex.org/W2209216813","https://openalex.org/W2034484623","https://openalex.org/W2597582726","https://openalex.org/W2212848802","https://openalex.org/W2050385043"],"abstract_inverted_index":{"Using":[0],"primary":[1],"cultures":[2],"of":[3,43,50,63,67,71],"atrial":[4,16],"cardiocytes":[5,27],"from":[6,102],"neonatal":[7],"pig,":[8],"the":[9,41,72],"secretion":[10,62],"brain":[11],"natriuretic":[12,17],"peptide":[13,18],"(BNP)":[14],"and":[15,32,54],"(ANP)-like":[19],"immunoreactivities":[20],"(LI)":[21],"was":[22,46],"studied":[23],"in":[24],"vitro.":[25],"Porcine":[26],"time-dependently":[28],"secreted":[29,45],"both":[30],"BNP-LI":[31,44,64,79],"ANP-LI":[33],"into":[34],"medium":[35,74],"under":[36],"a":[37,76,90],"serum-free":[38],"condition,":[39],"although":[40],"amount":[42],"about":[47],"one-third":[48],"that":[49,66,89],"ANP-LI.":[51,68],"Phorbol":[52],"ester":[53],"Ca2+":[55],"ionophore":[56],"had":[57],"less":[58],"stimulatory":[59],"effects":[60],"on":[61],"than":[65],"Reverse-phase":[69],"HPLC":[70],"conditioned":[73],"revealed":[75],"single":[77],"major":[78],"component":[80],"corresponding":[81],"to":[82],"synthetic":[83],"porcine":[84,103],"BNP(1-26).":[85],"These":[86],"data":[87],"suggest":[88],"small":[91],"molecular":[92],"weight":[93],"form":[94],"BNP,":[95],"possibly":[96],"BNP(1-26),":[97],"is":[98],"cosecreted":[99],"with":[100],"ANP":[101],"cardiocytes.":[104]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}