{"id":"https://openalex.org/W2008301161","doi":"https://doi.org/10.1073/pnas.79.16.4997","title":"Molecular cloning of a DNA sequence complementary to creatine kinase M mRNA from chickens.","display_name":"Molecular cloning of a DNA sequence complementary to creatine kinase M mRNA from chickens.","publication_year":1982,"publication_date":"1982-08-01","ids":{"openalex":"https://openalex.org/W2008301161","doi":"https://doi.org/10.1073/pnas.79.16.4997","mag":"2008301161","pmid":"https://pubmed.ncbi.nlm.nih.gov/6956910","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/346813"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.79.16.4997","doi":"https://doi.org/10.1073/pnas.79.16.4997","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.79.16.4997","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/346813","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088120266","display_name":"Clifford W. Schweinfest","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C W Schweinfest","raw_affiliation_strings":["Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103150730","display_name":"Robert Kwiatkowski","orcid":"https://orcid.org/0000-0003-2953-7146","observed_orcids":["https://orcid.org/0000-0003-2953-7146"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R W Kwiatkowski","raw_affiliation_strings":["Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064860256","display_name":"Robert P. Dottin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R P Dottin","raw_affiliation_strings":["Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":1.8704,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.85157646,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"79","issue":"16","first_page":"4997","last_page":"5000"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.6894999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.6894999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.04600000008940697,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0430000014603138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/creatine-kinase-m","display_name":"creatine kinase M","score":0.8410000205039978},{"id":"https://openalex.org/keywords/creatine-kinase-isozymes","display_name":"creatine kinase isoenzymes","score":0.8009999990463257},{"id":"https://openalex.org/keywords/mrna-cloning","display_name":"mRNA cloning","score":0.746999979019165},{"id":"https://openalex.org/keywords/chickens","display_name":"chickens","score":0.49000000953674316},{"id":"https://openalex.org/keywords/myoblasts","display_name":"myoblasts","score":0.7850000262260437},{"id":"https://openalex.org/keywords/mrna-heterogeneity","display_name":"mRNA heterogeneity","score":0.5619999766349792},{"id":"https://openalex.org/keywords/isoelectric-point","display_name":"isoelectric point","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.8174189329147339},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.73436439037323},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6480096578598022},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.6187174320220947},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.5968620777130127},{"id":"https://openalex.org/C36880943","wikidata":"https://www.wikidata.org/wiki/Q409458","display_name":"Creatine kinase","level":2,"score":0.5188820958137512},{"id":"https://openalex.org/C65666806","wikidata":"https://www.wikidata.org/wiki/Q970614","display_name":"Polysome","level":5,"score":0.46069878339767456},{"id":"https://openalex.org/C205225487","wikidata":"https://www.wikidata.org/wiki/Q287604","display_name":"PBR322","level":4,"score":0.4504196047782898},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4385954439640045},{"id":"https://openalex.org/C19924922","wikidata":"https://www.wikidata.org/wiki/Q408351","display_name":"Molecular cloning","level":4,"score":0.4257392883300781},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3937492072582245},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2830125093460083},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28206080198287964},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.09173181653022766}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003402","descriptor_name":"Creatine Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.79.16.4997","doi":"https://doi.org/10.1073/pnas.79.16.4997","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.79.16.4997","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:346813","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/346813","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:6956910","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6956910","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:346813","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/346813","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life on land","score":0.5199999809265137}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306182","display_name":"March of Dimes Foundation","ror":"https://ror.org/04bd5p711"},{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W157671676","https://openalex.org/W1477065389","https://openalex.org/W1588885776","https://openalex.org/W1606423922","https://openalex.org/W1914532157","https://openalex.org/W1988983285","https://openalex.org/W2009959065","https://openalex.org/W2012005070","https://openalex.org/W2018289835","https://openalex.org/W2025675183","https://openalex.org/W2032776824","https://openalex.org/W2034925747","https://openalex.org/W2051677832","https://openalex.org/W2074738418","https://openalex.org/W2081349719","https://openalex.org/W2088876976","https://openalex.org/W2092783021","https://openalex.org/W2100837269","https://openalex.org/W2139864850","https://openalex.org/W2150726870","https://openalex.org/W2154318575","https://openalex.org/W2164358316","https://openalex.org/W2165046801","https://openalex.org/W2170237019"],"related_works":["https://openalex.org/W2030406261","https://openalex.org/W2139864850","https://openalex.org/W1998557764","https://openalex.org/W2043201277","https://openalex.org/W1969691270","https://openalex.org/W1715981931","https://openalex.org/W1565958037","https://openalex.org/W1551959403","https://openalex.org/W2018261167","https://openalex.org/W1569136570"],"abstract_inverted_index":{"We":[0],"have":[1],"cloned":[2],"and":[3,35,69,87,99,114,138],"identified":[4],"a":[5,22,47],"DNA":[6,60,83],"sequence":[7],"complementary":[8,61],"to":[9,62,84,161],"the":[10,19,26,55,72,78,81,120,135,156,162],"mRNA":[11,20,28,45,64,90,107,158],"of":[12,25,38,50,57,80,119,141,145,155],"creatine":[13],"kinase":[14],"(CK)":[15],"isozyme":[16],"M,":[17],"although":[18],"is":[21],"minor":[23],"species":[24],"total":[27,92],"in":[29,54,111,121,131,148],"developing":[30],"myoblasts.":[31],"Poly(A)+RNA":[32],"from":[33,91],"breast":[34],"thigh":[36],"muscle":[37,93],"5-week-old":[39],"chicks":[40],"was":[41,65,108,125,151],"enriched":[42],"for":[43,77],"CK":[44,89],"by":[46,110,128],"novel":[48],"procedure":[49],"sucrose":[51],"gradient":[52],"centrifugation":[53],"presence":[56],"methylmercuric":[58],"hydroxide.":[59],"this":[63],"inserted":[66],"into":[67],"pBR322,":[68],"colonies":[70],"containing":[71],"recombinant":[73],"plasmids":[74],"were":[75],"screened":[76],"ability":[79],"plasmid":[82],"hybridize":[85],"with":[86],"rescue":[88,103],"mRNA.":[94,105],"Three":[95],"plasmids,":[96],"pCS195,":[97],"pCS192,":[98],"pM35-4,":[100],"could":[101],"specifically":[102],"CK-M":[104,106,146,157],"detected":[109],"vitro":[112,122],"translation":[113,123,154],"specific":[115],"immunoprecipitation.":[116],"The":[117,143],"identity":[118],"product":[124],"further":[126],"confirmed":[127],"its":[129],"migration":[130],"two-dimensional":[132],"gels":[133],"at":[134],"isoelectric":[136],"point":[137],"molecular":[139],"weight":[140],"CK-M.":[142],"heterogeneity":[144],"observed":[147],"vivo":[149],"also":[150],"found":[152],"upon":[153],"which":[159],"hybridizes":[160],"plasmid.":[163]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
