{"id":"https://openalex.org/W2008299229","doi":"https://doi.org/10.1016/j.semcancer.2013.12.006","title":"p53 orchestrates between normal differentiation and cancer","display_name":"p53 orchestrates between normal differentiation and cancer","publication_year":2014,"publication_date":"2014-01-07","ids":{"openalex":"https://openalex.org/W2008299229","doi":"https://doi.org/10.1016/j.semcancer.2013.12.006","mag":"2008299229","pmid":"https://pubmed.ncbi.nlm.nih.gov/24406212"},"language":"en","primary_location":{"id":"doi:10.1016/j.semcancer.2013.12.006","doi":"https://doi.org/10.1016/j.semcancer.2013.12.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.semcancer.2013.12.006","pdf_url":null,"source":{"id":"https://openalex.org/S154149207","display_name":"Seminars in Cancer Biology","issn_l":"1044-579X","issn":["1044-579X","1096-3650"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Cancer Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001776231","display_name":"Noa Rivlin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Noa Rivlin","raw_affiliation_strings":["Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. Electronic address: noa.rivlin@weizmann.ac.il","Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, , Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. Electronic address: noa.rivlin@weizmann.ac.il","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, , Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048004012","display_name":"Gabriela Koifman","orcid":"https://orcid.org/0000-0002-7728-5214","observed_orcids":["https://orcid.org/0000-0002-7728-5214"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Gabriela Koifman","raw_affiliation_strings":["Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113722992","display_name":"Varda Rotter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Varda Rotter","raw_affiliation_strings":["Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001776231"],"corresponding_institution_ids":["https://openalex.org/I53964585"],"apc_list":{"value":6060,"currency":"USD","value_usd":6060},"apc_paid":null,"fwci":0.9411,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.69904963,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"32","issue":null,"first_page":"10","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8199999928474426},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/stem-cells","display_name":"stem cells","score":0.968999981880188},{"id":"https://openalex.org/keywords/malignant-transformation","display_name":"malignant transformation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/tumor-initiation","display_name":"tumor initiation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.6439999938011169},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.843999981880188},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.843999981880188}],"concepts":[{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.605430006980896},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5925307273864746},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.572268545627594},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.5652099251747131},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.560943067073822},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5438604354858398},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5380935072898865},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5298765897750854},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5204337239265442},{"id":"https://openalex.org/C31033888","wikidata":"https://www.wikidata.org/wiki/Q752076","display_name":"Malignant transformation","level":2,"score":0.4865826368331909},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47174108028411865},{"id":"https://openalex.org/C2993273003","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Neoplastic transformation","level":4,"score":0.4285285770893097},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.2364213466644287},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17982211709022522},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12775075435638428}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.semcancer.2013.12.006","doi":"https://doi.org/10.1016/j.semcancer.2013.12.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.semcancer.2013.12.006","pdf_url":null,"source":{"id":"https://openalex.org/S154149207","display_name":"Seminars in Cancer Biology","issn_l":"1044-579X","issn":["1044-579X","1096-3650"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Cancer Biology","raw_type":"journal-article"},{"id":"pmid:24406212","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24406212","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in cancer biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":163,"referenced_works":["https://openalex.org/W142554537","https://openalex.org/W1486455950","https://openalex.org/W1591281137","https://openalex.org/W1645741024","https://openalex.org/W1869240171","https://openalex.org/W1881393103","https://openalex.org/W1940372773","https://openalex.org/W1964081206","https://openalex.org/W1964903539","https://openalex.org/W1965568527","https://openalex.org/W1966163762","https://openalex.org/W1966791160","https://openalex.org/W1967467247","https://openalex.org/W1967569975","https://openalex.org/W1967703106","https://openalex.org/W1968075505","https://openalex.org/W1969044026","https://openalex.org/W1969437200","https://openalex.org/W1970431885","https://openalex.org/W1970993216","https://openalex.org/W1976501240","https://openalex.org/W1976878409","https://openalex.org/W1979454030","https://openalex.org/W1981986780","https://openalex.org/W1982245016","https://openalex.org/W1983991097","https://openalex.org/W1984885474","https://openalex.org/W1986619013","https://openalex.org/W1992947462","https://openalex.org/W1993302385","https://openalex.org/W1993864973","https://openalex.org/W1994775779","https://openalex.org/W1996053472","https://openalex.org/W1999356404","https://openalex.org/W2001461804","https://openalex.org/W2002819368","https://openalex.org/W2004836344","https://openalex.org/W2004838336","https://openalex.org/W2004935845","https://openalex.org/W2005047548","https://openalex.org/W2005963190","https://openalex.org/W2010202464","https://openalex.org/W2010672807","https://openalex.org/W2011341080","https://openalex.org/W2011586304","https://openalex.org/W2012024423","https://openalex.org/W2012053348","https://openalex.org/W2012831165","https://openalex.org/W2014128254","https://openalex.org/W2014691022","https://openalex.org/W2015619266","https://openalex.org/W2018321310","https://openalex.org/W2018429029","https://openalex.org/W2018492629","https://openalex.org/W2019199359","https://openalex.org/W2019264784","https://openalex.org/W2021938834","https://openalex.org/W2023560061","https://openalex.org/W2023599593","https://openalex.org/W2024213079","https://openalex.org/W2024957578","https://openalex.org/W2024981991","https://openalex.org/W2026541878","https://openalex.org/W2028329963","https://openalex.org/W2029434473","https://openalex.org/W2029803778","https://openalex.org/W2030054341","https://openalex.org/W2031658244","https://openalex.org/W2038604992","https://openalex.org/W2041822919","https://openalex.org/W2043678696","https://openalex.org/W2045899482","https://openalex.org/W2048724204","https://openalex.org/W2050265341","https://openalex.org/W2051233997","https://openalex.org/W2054002500","https://openalex.org/W2055313461","https://openalex.org/W2056079046","https://openalex.org/W2056992430","https://openalex.org/W2057159461","https://openalex.org/W2059006768","https://openalex.org/W2059407064","https://openalex.org/W2060551076","https://openalex.org/W2060678499","https://openalex.org/W2061666056","https://openalex.org/W2061824613","https://openalex.org/W2062069198","https://openalex.org/W2062190575","https://openalex.org/W2062515127","https://openalex.org/W2063157236","https://openalex.org/W2065624759","https://openalex.org/W2065653704","https://openalex.org/W2066441178","https://openalex.org/W2069167711","https://openalex.org/W2069266255","https://openalex.org/W2070672434","https://openalex.org/W2073302269","https://openalex.org/W2073759231","https://openalex.org/W2075084906","https://openalex.org/W2076047032","https://openalex.org/W2076149108","https://openalex.org/W2076583198","https://openalex.org/W2077046530","https://openalex.org/W2079244250","https://openalex.org/W2080392221","https://openalex.org/W2081620485","https://openalex.org/W2082823320","https://openalex.org/W2082979850","https://openalex.org/W2083462941","https://openalex.org/W2083625284","https://openalex.org/W2084652820","https://openalex.org/W2085252210","https://openalex.org/W2086640720","https://openalex.org/W2088665606","https://openalex.org/W2088744498","https://openalex.org/W2092015913","https://openalex.org/W2092658747","https://openalex.org/W2096371557","https://openalex.org/W2096882254","https://openalex.org/W2097491758","https://openalex.org/W2097933346","https://openalex.org/W2100610935","https://openalex.org/W2102085111","https://openalex.org/W2102414780","https://openalex.org/W2107023512","https://openalex.org/W2109377963","https://openalex.org/W2109610561","https://openalex.org/W2111783800","https://openalex.org/W2111920812","https://openalex.org/W2114254430","https://openalex.org/W2117692326","https://openalex.org/W2122492394","https://openalex.org/W2124488916","https://openalex.org/W2124595934","https://openalex.org/W2125987139","https://openalex.org/W2126376889","https://openalex.org/W2127617517","https://openalex.org/W2128020963","https://openalex.org/W2128786355","https://openalex.org/W2137052967","https://openalex.org/W2138784667","https://openalex.org/W2140473883","https://openalex.org/W2141310245","https://openalex.org/W2150144117","https://openalex.org/W2150666626","https://openalex.org/W2153051750","https://openalex.org/W2158144966","https://openalex.org/W2158811885","https://openalex.org/W2159199900","https://openalex.org/W2159792406","https://openalex.org/W2159999899","https://openalex.org/W2166556978","https://openalex.org/W2166636120","https://openalex.org/W2167291962","https://openalex.org/W2168218774","https://openalex.org/W2168571184","https://openalex.org/W2170685293","https://openalex.org/W2332617654","https://openalex.org/W4231707378","https://openalex.org/W6605696246","https://openalex.org/W6636765354","https://openalex.org/W6645572762","https://openalex.org/W6655958293"],"related_works":["https://openalex.org/W2096371557","https://openalex.org/W2101624484","https://openalex.org/W3118787732","https://openalex.org/W2112849254","https://openalex.org/W2167679665","https://openalex.org/W2407075270","https://openalex.org/W2604266977","https://openalex.org/W2559531164","https://openalex.org/W2001393525","https://openalex.org/W2094102780"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}