{"id":"https://openalex.org/W2008287879","doi":"https://doi.org/10.1186/1756-0500-4-162","title":"Selection of reference genes for normalization of quantitative real-time PCR in organ culture of the rat and rabbit intervertebral disc","display_name":"Selection of reference genes for normalization of quantitative real-time PCR in organ culture of the rat and rabbit intervertebral disc","publication_year":2011,"publication_date":"2011-05-26","ids":{"openalex":"https://openalex.org/W2008287879","doi":"https://doi.org/10.1186/1756-0500-4-162","mag":"2008287879","pmid":"https://pubmed.ncbi.nlm.nih.gov/21615931","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3118343"},"language":"en","primary_location":{"id":"doi:10.1186/1756-0500-4-162","doi":"https://doi.org/10.1186/1756-0500-4-162","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-0500-4-162","pdf_url":"https://bmcresnotes.biomedcentral.com/counter/pdf/10.1186/1756-0500-4-162","source":{"id":"https://openalex.org/S100014455","display_name":"BMC Research Notes","issn_l":"1756-0500","issn":["1756-0500"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Research Notes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcresnotes.biomedcentral.com/counter/pdf/10.1186/1756-0500-4-162","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004515371","display_name":"Dongrim Seol","orcid":"https://orcid.org/0000-0003-0383-3756","observed_orcids":["https://orcid.org/0000-0003-0383-3756"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dongrim Seol","raw_affiliation_strings":["Department of Orthopedics and Rehabilitation, University of Iowa, 1182 ML, Iowa city, IA 52242, USA. prem-ramakrishnan@uiowa.edu","Department of Orthopedics and Rehabilitation, University of Iowa, 1182 ML, Iowa city, IA, 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics and Rehabilitation, University of Iowa, 1182 ML, Iowa city, IA 52242, USA. prem-ramakrishnan@uiowa.edu","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Department of Orthopedics and Rehabilitation, University of Iowa, 1182 ML, Iowa city, IA, 52242, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071633284","display_name":"Hyeonghun Choe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyeonghun Choe","raw_affiliation_strings":["Department of Biomedical Engineering, University of Iowa, 1402 SC, Iowa city, IA, 52242, USA","Department of Orthopedics and Rehabilitation, University of Iowa, 1182 ML, Iowa city, IA, 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Iowa, 1402 SC, Iowa city, IA, 52242, USA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Department of Orthopedics and Rehabilitation, University of Iowa, 1182 ML, Iowa city, IA, 52242, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110210111","display_name":"Hongjun Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongjun Zheng","raw_affiliation_strings":["Department of Orthopedics and Rehabilitation, University of Iowa, 1182 ML, Iowa city, IA, 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics and Rehabilitation, University of Iowa, 1182 ML, Iowa city, IA, 52242, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045813994","display_name":"Keewoong Jang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keewoong Jang","raw_affiliation_strings":["Department of Biomedical Engineering, University of Iowa, 1402 SC, Iowa city, IA, 52242, USA","Department of Orthopedics and Rehabilitation, University of Iowa, 1182 ML, Iowa city, IA, 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Iowa, 1402 SC, Iowa city, IA, 52242, USA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Department of Orthopedics and Rehabilitation, University of Iowa, 1182 ML, Iowa city, IA, 52242, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024259110","display_name":"Prem S. Ramakrishnan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Prem S Ramakrishnan","raw_affiliation_strings":["Department of Orthopedics and Rehabilitation, University of Iowa, 1182 ML, Iowa city, IA, 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics and Rehabilitation, University of Iowa, 1182 ML, Iowa city, IA, 52242, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110455596","display_name":"Tae Hong Lim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tae-Hong Lim","raw_affiliation_strings":["Department of Biomedical Engineering, University of Iowa, 1402 SC, Iowa city, IA, 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Iowa, 1402 SC, Iowa city, IA, 52242, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015592017","display_name":"James A. Martin","orcid":"https://orcid.org/0000-0001-5085-0108","observed_orcids":["https://orcid.org/0000-0001-5085-0108"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James A Martin","raw_affiliation_strings":["Department of Orthopedics and Rehabilitation, University of Iowa, 1182 ML, Iowa city, IA, 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics and Rehabilitation, University of Iowa, 1182 ML, Iowa city, IA, 52242, USA","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024259110"],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":{"value":1690,"currency":"USD","value_usd":1690},"apc_paid":{"value":1690,"currency":"USD","value_usd":1690},"fwci":2.4694,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.89382272,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"4","issue":"1","first_page":"162","last_page":"162"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reference-genes","display_name":"reference genes","score":0.8999999761581421},{"id":"https://openalex.org/keywords/rt-qpcr-normalization","display_name":"qRT-PCR normalization","score":0.8679999709129333},{"id":"https://openalex.org/keywords/intervertebral-disc","display_name":"intervertebral disc","score":0.9470000267028809},{"id":"https://openalex.org/keywords/organ-culture","display_name":"organ culture","score":0.7730000019073486},{"id":"https://openalex.org/keywords/gene-expression-stability","display_name":"gene expression stability","score":0.859000027179718},{"id":"https://openalex.org/keywords/hypoxanthine-guanine-phosphoribosyltransferase","display_name":"hypoxanthine-guanine phosphoribosyltransferase","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cycas","display_name":"Cycas","score":0.9409999847412109},{"id":"https://openalex.org/keywords/beta-actin","display_name":"beta-actin","score":0.8970000147819519},{"id":"https://openalex.org/keywords/glyceraldehyde-3-phosphate-dehydrogenase","display_name":"glyceraldehyde-3-phosphate dehydrogenase","score":0.8859999775886536},{"id":"https://openalex.org/keywords/18s-rrna","display_name":"18S rRNA","score":0.9150000214576721},{"id":"https://openalex.org/keywords/pgk1","display_name":"PGK1","score":0.906000018119812},{"id":"https://openalex.org/keywords/14-3-3","display_name":"14-3-3\u03b6","score":0.984000027179718},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.9319999814033508},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":1.0}],"concepts":[{"id":"https://openalex.org/C2779148672","wikidata":"https://www.wikidata.org/wiki/Q25326537","display_name":"Reference genes","level":4,"score":0.9508002996444702},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6268813610076904},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6232684850692749},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5477418899536133},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.4535934627056122},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4236748218536377},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40250909328460693},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3266713619232178},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3112477660179138}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/1756-0500-4-162","doi":"https://doi.org/10.1186/1756-0500-4-162","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-0500-4-162","pdf_url":"https://bmcresnotes.biomedcentral.com/counter/pdf/10.1186/1756-0500-4-162","source":{"id":"https://openalex.org/S100014455","display_name":"BMC Research Notes","issn_l":"1756-0500","issn":["1756-0500"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Research Notes","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3118343","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3118343","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Res Notes","raw_type":"Text"},{"id":"pmid:21615931","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21615931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC research notes","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f2c43d218656488b8e89f1ef1d575233","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f2c43d218656488b8e89f1ef1d575233","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Research Notes, Vol 4, Iss 1, p 162 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1756-0500-4-162","doi":"https://doi.org/10.1186/1756-0500-4-162","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-0500-4-162","pdf_url":"https://bmcresnotes.biomedcentral.com/counter/pdf/10.1186/1756-0500-4-162","source":{"id":"https://openalex.org/S100014455","display_name":"BMC Research Notes","issn_l":"1756-0500","issn":["1756-0500"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Research Notes","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2008287879.pdf","grobid_xml":"https://content.openalex.org/works/W2008287879.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W16422547","https://openalex.org/W32482760","https://openalex.org/W1577577364","https://openalex.org/W1965310616","https://openalex.org/W1968316058","https://openalex.org/W1979094033","https://openalex.org/W1982808092","https://openalex.org/W1983133093","https://openalex.org/W2001582636","https://openalex.org/W2009840300","https://openalex.org/W2016743817","https://openalex.org/W2030506483","https://openalex.org/W2043193936","https://openalex.org/W2048524426","https://openalex.org/W2060036312","https://openalex.org/W2081904449","https://openalex.org/W2085377206","https://openalex.org/W2087865533","https://openalex.org/W2092861873","https://openalex.org/W2099824652","https://openalex.org/W2105423509","https://openalex.org/W2112982595","https://openalex.org/W2113961735","https://openalex.org/W2127535576","https://openalex.org/W2137412331","https://openalex.org/W2140568669","https://openalex.org/W2142034162","https://openalex.org/W2143146123","https://openalex.org/W2154127252"],"related_works":["https://openalex.org/W2150040166","https://openalex.org/W7100661523","https://openalex.org/W4311802454","https://openalex.org/W2113017723","https://openalex.org/W2149432088","https://openalex.org/W2075029558","https://openalex.org/W7099244927","https://openalex.org/W2010824741","https://openalex.org/W2392990673","https://openalex.org/W4385984942"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,22,55],"accuracy":[2],"of":[3,19,24,42,48,57,65,144,153,209,221],"quantitative":[4],"real-time":[5],"RT-PCR":[6],"(qRT-PCR)":[7],"is":[8,47],"often":[9],"influenced":[10],"by":[11],"experimental":[12],"artifacts,":[13],"resulting":[14],"in":[15,86,109,122,136,148,158,202],"erroneous":[16],"expression":[17],"profiles":[18],"target":[20],"genes.":[21],"practice":[23],"employing":[25],"normalization":[26],"using":[27,90],"a":[28,216],"reference":[29,45,68,163,182,211],"gene":[30,164,183,200,212],"significantly":[31],"improves":[32],"reliability":[33],"and":[34,77,79,93,106,113,120,146,150,156,176,187,206],"its":[35],"applicability":[36],"to":[37,51,61,133],"molecular":[38],"biology.":[39],"However,":[40],"selection":[41],"an":[43,198],"ideal":[44],"gene(s)":[46,83],"critical":[49],"importance":[50],"discern":[52],"meaningful":[53],"results.":[54],"aim":[56],"this":[58],"study":[59],"was":[60],"evaluate":[62],"the":[63,91,151,179],"stability":[64],"seven":[66],"potential":[67],"genes":[69,102,115],"(Actb,":[70],"GAPDH,":[71,105],"18S":[72,107],"rRNA,":[73],"CycA,":[74,104,155],"Hprt1,":[75,117,154],"Ywhaz,":[76],"Pgk1)":[78],"identify":[80],"most":[81,129,161,180],"stable":[82,130,162,181],"for":[84,131,166,185,225],"application":[85],"tissue":[87,112,125,168],"culture":[88,190],"research":[89],"rat":[92,110,149,186],"rabbit":[94,123,159,188,193],"intervertebral":[95],"disc":[96],"(IVD).":[97],"FINDINGS:":[98],"In":[99,192],"vitro,":[100],"four":[101],"(Hprt1,":[103],"rRNA)":[108],"IVD":[111,124,167,189],"five":[114],"(CycA,":[116],"Actb,":[118],"Pgk1,":[119],"Ywhaz)":[121],"were":[126],"determined":[127],"as":[128],"up":[132],"14":[134],"days":[135],"culture.":[137,169],"Pair-wise":[138],"variation":[139],"analysis":[140],"indicated":[141],"that":[142,174],"combination":[143,152],"Hprt1":[145,175,205],"CycA":[147,177],"Actb":[157,195],"may":[160],"candidates":[165,184],"CONCLUSIONS:":[170],"Our":[171],"results":[172],"indicate":[173],"are":[178],"studies.":[191],"IVD,":[194],"could":[196],"be":[197,215],"additional":[199],"employed":[201],"conjunction":[203],"with":[204],"CycA.":[207],"Selection":[208],"optimal":[210],"candidate(s)":[213],"should":[214],"pertinent":[217],"exercise":[218],"before":[219],"employment":[220],"PCR":[222],"outcome":[223],"measures":[224],"biomedical":[226],"research.":[227]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
