{"id":"https://openalex.org/W2008286952","doi":"https://doi.org/10.1159/000339028","title":"Renal and Cardiac Effects of DPP-4 Inhibitors \u2013 from Preclinical Development to Clinical Research","display_name":"Renal and Cardiac Effects of DPP-4 Inhibitors \u2013 from Preclinical Development to Clinical Research","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2008286952","doi":"https://doi.org/10.1159/000339028","mag":"2008286952","pmid":"https://pubmed.ncbi.nlm.nih.gov/22947920"},"language":"en","primary_location":{"id":"doi:10.1159/000339028","doi":"https://doi.org/10.1159/000339028","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000339028","pdf_url":null,"source":{"id":"https://openalex.org/S167815962","display_name":"Kidney & Blood Pressure Research","issn_l":"1420-4096","issn":["1420-4096","1423-0143"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney and Blood Pressure Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022687335","display_name":"Berthold Hocher","orcid":"https://orcid.org/0000-0001-8143-0579","observed_orcids":["https://orcid.org/0000-0001-8143-0579"]},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Berthold Hocher","raw_affiliation_strings":["Institute of Nutritional Science, University of Potsdam, Potsdam, Germany. hocher@uni-potsdam.de","Center for Cardiovascular Research, Charit\u00e9, Berlin, Germany,","Institute of Nutritional Science, University of Potsdam, Potsdam, Germany,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Nutritional Science, University of Potsdam, Potsdam, Germany. hocher@uni-potsdam.de","institution_ids":["https://openalex.org/I176453806"]},{"raw_affiliation_string":"Center for Cardiovascular Research, Charit\u00e9, Berlin, Germany,","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Institute of Nutritional Science, University of Potsdam, Potsdam, Germany,","institution_ids":["https://openalex.org/I176453806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107051365","display_name":"Christoph Reichetzeder","orcid":"https://orcid.org/0000-0002-2219-5529","observed_orcids":["https://orcid.org/0000-0002-2219-5529"]},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Reichetzeder","raw_affiliation_strings":["Center for Cardiovascular Research, Charit\u00e9, Berlin, Germany,","Institute of Nutritional Science, University of Potsdam, Potsdam, Germany,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cardiovascular Research, Charit\u00e9, Berlin, Germany,","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Institute of Nutritional Science, University of Potsdam, Potsdam, Germany,","institution_ids":["https://openalex.org/I176453806"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026754112","display_name":"Markus Alter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]},{"id":"https://openalex.org/I4392738228","display_name":"Stiftung Charit\u00e9","ror":"https://ror.org/016rf0n60","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4392738228","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus L. Alter","raw_affiliation_strings":["Center for Cardiovascular Research, Charit\u00e9, Berlin, Germany,","Department of Nephrology, Campus Benjamin Franklin, Charit\u00e9, Berlin, Germany","Institute of Nutritional Science, University of Potsdam, Potsdam, Germany,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cardiovascular Research, Charit\u00e9, Berlin, Germany,","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Nephrology, Campus Benjamin Franklin, Charit\u00e9, Berlin, Germany","institution_ids":["https://openalex.org/I4392738228","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Institute of Nutritional Science, University of Potsdam, Potsdam, Germany,","institution_ids":["https://openalex.org/I176453806"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2530,"currency":"CHF","value_usd":2780},"apc_paid":null,"fwci":2.4805,"has_fulltext":false,"cited_by_count":146,"citation_normalized_percentile":{"value":0.92537313,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"36","issue":"1","first_page":"65","last_page":"84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dpp-4-inhibitors","display_name":"DPP-4 inhibitors","score":1.0},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8180000185966492},{"id":"https://openalex.org/keywords/glp-1-receptor","display_name":"GLP-1 receptor","score":0.8360000252723694},{"id":"https://openalex.org/keywords/glucagon-like-peptide-1","display_name":"glucagon-like peptide-1","score":0.7279999852180481},{"id":"https://openalex.org/keywords/glucose-dependent-insulinotropic-polypeptide","display_name":"glucose-dependent insulinotropic polypeptide","score":0.8289999961853027},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.7639999985694885},{"id":"https://openalex.org/keywords/cardiovascular-effects","display_name":"cardiovascular effects","score":0.6370000243186951},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.6850000023841858},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9599999785423279},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.8939999938011169},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9240000247955322},{"id":"https://openalex.org/keywords/urinary-albumin-excretion","display_name":"urinary albumin excretion","score":0.8629999756813049},{"id":"https://openalex.org/keywords/linagliptin","display_name":"linagliptin","score":0.9629999995231628},{"id":"https://openalex.org/keywords/renal-dose-adjustment","display_name":"renal dose adjustment","score":0.7670000195503235},{"id":"https://openalex.org/keywords/incretin-hormones","display_name":"incretins","score":0.5139999985694885},{"id":"https://openalex.org/keywords/natriuretic-peptides","display_name":"natriuretic peptides","score":0.6230000257492065},{"id":"https://openalex.org/keywords/neuropeptides","display_name":"neuropeptides","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C156490143","wikidata":"https://www.wikidata.org/wiki/Q412214","display_name":"Dipeptidyl peptidase-4","level":4,"score":0.7348847389221191},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7255781888961792},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6622591018676758},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5975863337516785},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5749189853668213},{"id":"https://openalex.org/C2781469919","wikidata":"https://www.wikidata.org/wiki/Q5279728","display_name":"Dipeptidyl peptidase","level":3,"score":0.4884845018386841},{"id":"https://openalex.org/C2776398474","wikidata":"https://www.wikidata.org/wiki/Q424611","display_name":"Glucagon-like peptide-1","level":4,"score":0.4796314835548401},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.47038355469703674},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.464313268661499},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3619391918182373},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.36177751421928406},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.17321649193763733},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07620906829833984},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017326","descriptor_name":"Clinical Trials, Phase III as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018819","descriptor_name":"Dipeptidyl Peptidase 4","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018819","descriptor_name":"Dipeptidyl Peptidase 4","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D035843","descriptor_name":"Biomedical Research","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1159/000339028","doi":"https://doi.org/10.1159/000339028","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000339028","pdf_url":null,"source":{"id":"https://openalex.org/S167815962","display_name":"Kidney & Blood Pressure Research","issn_l":"1420-4096","issn":["1420-4096","1423-0143"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney and Blood Pressure Research","raw_type":"journal-article"},{"id":"pmid:22947920","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22947920","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney & blood pressure research","raw_type":"Journal Article"},{"id":"pmh:oai:kobv.de-opus4-uni-potsdam:36221","doi":null,"is_oa":false,"landing_page_url":"https://publishup.uni-potsdam.de/frontdoor/index/index/docId/36221","pdf_url":null,"source":{"id":"https://openalex.org/S4306400594","display_name":"publish.UP (University of Potsdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I176453806","host_organization_name":"University of Potsdam","host_organization_lineage":["https://openalex.org/I176453806"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"review"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":103,"referenced_works":["https://openalex.org/W47644979","https://openalex.org/W54677887","https://openalex.org/W140610734","https://openalex.org/W172609984","https://openalex.org/W1526927233","https://openalex.org/W1557233532","https://openalex.org/W1589657989","https://openalex.org/W1605414982","https://openalex.org/W1783549145","https://openalex.org/W1968315455","https://openalex.org/W1971414511","https://openalex.org/W1976026431","https://openalex.org/W1976403777","https://openalex.org/W1977619586","https://openalex.org/W1980937864","https://openalex.org/W1982261608","https://openalex.org/W1982778753","https://openalex.org/W1984037141","https://openalex.org/W1985164695","https://openalex.org/W1985572091","https://openalex.org/W1986044732","https://openalex.org/W1991295934","https://openalex.org/W1993287695","https://openalex.org/W1994593037","https://openalex.org/W1994743271","https://openalex.org/W1997576345","https://openalex.org/W1999763887","https://openalex.org/W2000823223","https://openalex.org/W2000976083","https://openalex.org/W2007003907","https://openalex.org/W2007982994","https://openalex.org/W2011238752","https://openalex.org/W2011601530","https://openalex.org/W2015169646","https://openalex.org/W2017351479","https://openalex.org/W2023650360","https://openalex.org/W2028317115","https://openalex.org/W2028648326","https://openalex.org/W2031484324","https://openalex.org/W2042457844","https://openalex.org/W2042702624","https://openalex.org/W2043299715","https://openalex.org/W2043772514","https://openalex.org/W2045505493","https://openalex.org/W2047353065","https://openalex.org/W2047463598","https://openalex.org/W2048505222","https://openalex.org/W2051833527","https://openalex.org/W2053330911","https://openalex.org/W2053433479","https://openalex.org/W2054185381","https://openalex.org/W2054676771","https://openalex.org/W2055678371","https://openalex.org/W2056118072","https://openalex.org/W2063400466","https://openalex.org/W2065399019","https://openalex.org/W2066734164","https://openalex.org/W2070489366","https://openalex.org/W2079681415","https://openalex.org/W2082503109","https://openalex.org/W2083473802","https://openalex.org/W2084403835","https://openalex.org/W2089437374","https://openalex.org/W2090360729","https://openalex.org/W2090920461","https://openalex.org/W2093552577","https://openalex.org/W2102941723","https://openalex.org/W2104581780","https://openalex.org/W2107259575","https://openalex.org/W2107988751","https://openalex.org/W2108004712","https://openalex.org/W2108377130","https://openalex.org/W2109157463","https://openalex.org/W2109889741","https://openalex.org/W2111538581","https://openalex.org/W2112980868","https://openalex.org/W2117412164","https://openalex.org/W2118090274","https://openalex.org/W2118186702","https://openalex.org/W2120622647","https://openalex.org/W2124016563","https://openalex.org/W2125617388","https://openalex.org/W2127125241","https://openalex.org/W2128766821","https://openalex.org/W2132600168","https://openalex.org/W2134141467","https://openalex.org/W2138451589","https://openalex.org/W2140047096","https://openalex.org/W2147779427","https://openalex.org/W2150379125","https://openalex.org/W2150715270","https://openalex.org/W2150849997","https://openalex.org/W2152253892","https://openalex.org/W2154595662","https://openalex.org/W2158506982","https://openalex.org/W2158666727","https://openalex.org/W2165765596","https://openalex.org/W2166051277","https://openalex.org/W2167522349","https://openalex.org/W2167621077","https://openalex.org/W2341751247","https://openalex.org/W2412569636","https://openalex.org/W2781184586"],"related_works":["https://openalex.org/W2072898110","https://openalex.org/W3124767381","https://openalex.org/W2118812428","https://openalex.org/W2098558953","https://openalex.org/W1818704632","https://openalex.org/W4205184361","https://openalex.org/W1547911633","https://openalex.org/W4400045260","https://openalex.org/W2035274147","https://openalex.org/W4416105536"],"abstract_inverted_index":{"Inhibitors":[0],"of":[1,15,21,28,92,142,160,172,179,186,193,201,261,271,279],"type":[2,16,32,64,81],"4":[3,212],"dipeptidyl":[4,213],"peptidase":[5,214],"(DDP-4)":[6],"were":[7],"developed":[8],"and":[9,38,48,76,100,122,135,250,295],"approved":[10],"for":[11,227,275],"the":[12,26,62,73,80,154,231,247],"oral":[13],"treatment":[14],"2":[17],"diabetes.":[18],"Its":[19],"mode":[20],"action":[22,60],"is":[23],"to":[24,219,236,241],"inhibit":[25],"degradation":[27],"incretins,":[29],"such":[30,103,281],"as":[31,104,126,128,257,259,282,289,291],"1":[33,65,82],"glucagon":[34,50,66,83],"like":[35,67,84,132],"peptide":[36,68,85],"(GLP-1),":[37],"GIP.":[39],"GLP-1":[40],"stimulates":[41],"glucose-dependent":[42],"insulin":[43],"secretion":[44],"from":[45,52],"pancreatic":[46],"beta-cells":[47],"suppresses":[49],"release":[51],"alpha-cells,":[53],"thereby":[54],"improving":[55],"glucose":[56],"control.":[57],"Besides":[58],"its":[59,208],"on":[61,72],"pancreas":[63],"has":[69],"direct":[70,198,248],"effects":[71,102,200,252],"heart,":[74],"vessels":[75],"kidney":[77,232,284,287],"mainly":[78],"via":[79,230],"receptor":[86],"(GLP-1R).":[87],"Moreover,":[88],"there":[89],"are":[90,239],"substrates":[91],"DPP-4":[93,115,149,202],"beyond":[94,207,269],"incretins":[95],"that":[96,114,204],"have":[97,216],"proven":[98],"renal":[99,124,237,251],"cardiovascular":[101,140,161],"BNP/ANP,":[105],"NPY,":[106],"PYY":[107],"or":[108],"SDF-1":[109],"alpha.":[110],"Preclinical":[111],"evidence":[112],"suggests":[113,197],"inhibitors":[116,150,215],"may":[117,205,264],"be":[118,220],"effective":[119],"in":[120,129,153,163,224,254],"acute":[121,283,292],"chronic":[123,286],"failure":[125,288],"well":[127,222,258,290],"cardiac":[130,249],"diseases":[131],"myocardial":[133,293],"infarction":[134,294],"heart":[136,296],"failure.":[137,297],"Interestingly,":[138],"large":[139],"meta-analyses":[141],"combined":[143],"phase":[144,174],"II/III":[145],"clinical":[146,262],"trials":[147,263],"with":[148,166],"point":[151],"all":[152],"same":[155],"direction:":[156],"a":[157,183],"potential":[158],"reduction":[159,185],"events":[162],"patients":[164],"treated":[165],"these":[167],"agents.":[168],"A":[169],"pooled":[170],"analysis":[171],"pivotal":[173],"III,":[175],"placebo-controlled,":[176],"registration":[177],"studies":[178,256],"linagliptin":[180],"further":[181],"showed":[182],"significant":[184],"urinary":[187],"albumin":[188],"excretion":[189],"after":[190],"24":[191],"weeks":[192],"treatment.":[194],"The":[195],"observation":[196],"renoprotective":[199],"inhibition":[203],"go":[206],"glucose-lowering":[209],"potential.":[210],"Type":[211],"been":[217],"shown":[218],"very":[221],"tolerated":[223],"general,":[225],"but":[226],"those":[228],"excreted":[229],"dose":[233],"adjustments":[234],"according":[235],"function":[238],"needed":[240],"avoid":[242],"side":[243],"effects.":[244],"In":[245],"conclusion,":[246],"seen":[253],"preclinical":[255],"meta-analysis":[260],"offer":[265],"additional":[266],"potentials":[267],"-":[268,274],"improvement":[270],"glycemic":[272],"control":[273],"this":[276],"newer":[277],"class":[278],"drugs,":[280],"failure,":[285]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":27},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
