{"id":"https://openalex.org/W2008283141","doi":"https://doi.org/10.4236/ojanes.2013.37071","title":"The Volume Effect and Safety of 6% Hydroxyethyl Starch 130/0.4 in Patients Undergoing Major Elective Surgery: An Uncontrolled, Open-Labeled, Multi-Center Study","display_name":"The Volume Effect and Safety of 6% Hydroxyethyl Starch 130/0.4 in Patients Undergoing Major Elective Surgery: An Uncontrolled, Open-Labeled, Multi-Center Study","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2008283141","doi":"https://doi.org/10.4236/ojanes.2013.37071","mag":"2008283141"},"language":"en","primary_location":{"id":"doi:10.4236/ojanes.2013.37071","doi":"https://doi.org/10.4236/ojanes.2013.37071","is_oa":true,"landing_page_url":"https://doi.org/10.4236/ojanes.2013.37071","pdf_url":"http://www.scirp.org/journal/PaperDownload.aspx?paperID=36596","source":{"id":"https://openalex.org/S2764630504","display_name":"Open Journal of Anesthesiology","issn_l":"2164-5531","issn":["2164-5531","2164-5558"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Journal of Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.scirp.org/journal/PaperDownload.aspx?paperID=36596","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110100797","display_name":"Nobutada Morioka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobutada Morioka","raw_affiliation_strings":["Department of Anesthesiology, Tokyo Women's Medical University, Tokyo, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Tokyo Women's Medical University, Tokyo, Japan;","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028329455","display_name":"Makoto Ozaki","orcid":"https://orcid.org/0000-0001-7841-6661","observed_orcids":["https://orcid.org/0000-0001-7841-6661"]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Ozaki","raw_affiliation_strings":["Department of Anesthesiology, Tokyo Women's Medical University, Tokyo, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Tokyo Women's Medical University, Tokyo, Japan;","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017247892","display_name":"Michiaki Yamakage","orcid":"https://orcid.org/0000-0002-6226-2669","observed_orcids":["https://orcid.org/0000-0002-6226-2669"]},"institutions":[{"id":"https://openalex.org/I141882310","display_name":"Sapporo Medical University","ror":"https://ror.org/01h7cca57","country_code":"JP","type":"education","lineage":["https://openalex.org/I141882310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michiaki Yamakage","raw_affiliation_strings":["Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo, Japan;","institution_ids":["https://openalex.org/I141882310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079580258","display_name":"Hiroshi Morimatsu","orcid":"https://orcid.org/0000-0002-6744-0508","observed_orcids":["https://orcid.org/0000-0002-6744-0508"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Morimatsu","raw_affiliation_strings":["Department of Anesthesiology, Okayama University, Okayama, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Okayama University, Okayama, Japan;","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109493968","display_name":"Yasuyuki Suzuki","orcid":"https://orcid.org/0000-0001-8073-0633","observed_orcids":["https://orcid.org/0000-0001-8073-0633"]},"institutions":[{"id":"https://openalex.org/I4210132193","display_name":"National Center For Child Health and Development","ror":"https://ror.org/03fvwxc59","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210132193"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuyuki Suzuki","raw_affiliation_strings":["Department of Anesthesia and Intensive Care Medicine, National Center for Child Health and Development, Tokyo, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia and Intensive Care Medicine, National Center for Child Health and Development, Tokyo, Japan;","institution_ids":["https://openalex.org/I4210132193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083538866","display_name":"Frank Bepperling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108778","display_name":"Fresenius (Germany)","ror":"https://ror.org/01v376g59","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210108778"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Bepperling","raw_affiliation_strings":["Fresenius Kabi Deutschland GmbH, Bad Homburg, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fresenius Kabi Deutschland GmbH, Bad Homburg, Germany;","institution_ids":["https://openalex.org/I4210108778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070786968","display_name":"Hideki Miyao","orcid":"https://orcid.org/0000-0003-4911-4028","observed_orcids":["https://orcid.org/0000-0003-4911-4028"]},"institutions":[{"id":"https://openalex.org/I4405282892","display_name":"Saitama Medical Center, Saitama Medical University","ror":"https://ror.org/00ma6wk53","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405282892"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideki Miyao","raw_affiliation_strings":["Department of Anesthesiology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan;","institution_ids":["https://openalex.org/I4405282892"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109373043","display_name":"Akiyoshi Namiki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100788","display_name":"Otaru Municipal Hospital","ror":"https://ror.org/01d1kad18","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210100788"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akiyoshi Namiki","raw_affiliation_strings":["Otaru City Hospitals, Otaru-shi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Otaru City Hospitals, Otaru-shi, Japan","institution_ids":["https://openalex.org/I4210100788"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110498476","display_name":"Kiyoshi Morita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoshi Morita","raw_affiliation_strings":["Department of Anesthesiology, Okayama University, Okayama, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Okayama University, Okayama, Japan;","institution_ids":["https://openalex.org/I163770644"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2624,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.65799541,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"03","issue":"07","first_page":"326","last_page":"337"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.7768999934196472,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.7768999934196472,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.20640000700950623,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydroxyethyl-starch-130-0-4","display_name":"hydroxyethyl starch 130/0.4","score":0.9829999804496765},{"id":"https://openalex.org/keywords/voluven","display_name":"Voluven","score":0.8209999799728394},{"id":"https://openalex.org/keywords/volume-effect","display_name":"volume effect","score":0.5669999718666077},{"id":"https://openalex.org/keywords/major-elective-surgery","display_name":"elective major surgery","score":0.7210000157356262},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.4569999873638153},{"id":"https://openalex.org/keywords/hemodynamic-stability","display_name":"hemodynamic stability","score":0.8930000066757202},{"id":"https://openalex.org/keywords/fluid-balance","display_name":"fluid balance","score":0.7599999904632568},{"id":"https://openalex.org/keywords/plasma-expanders","display_name":"plasma expanders","score":0.5490000247955322},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.5210000276565552},{"id":"https://openalex.org/keywords/coagulation-parameters","display_name":"coagulation parameters","score":0.6399999856948853},{"id":"https://openalex.org/keywords/hematological-parameters","display_name":"hematological parameters","score":0.7059999704360962},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.5770000219345093},{"id":"https://openalex.org/keywords/japan","display_name":"Japan","score":0.3799999952316284},{"id":"https://openalex.org/keywords/japanese-red-cross-society","display_name":"Japan Red Cross Society","score":0.4189999997615814}],"concepts":[{"id":"https://openalex.org/C2779412105","wikidata":"https://www.wikidata.org/wiki/Q415775","display_name":"Hydroxyethyl starch","level":2,"score":0.9611116647720337},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.925067663192749},{"id":"https://openalex.org/C2781312054","wikidata":"https://www.wikidata.org/wiki/Q5354947","display_name":"Elective surgery","level":2,"score":0.6358544230461121},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6255759596824646},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5680124163627625},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.5660068392753601},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5136696696281433},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.4983212947845459},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.45679429173469543},{"id":"https://openalex.org/C3020062846","wikidata":"https://www.wikidata.org/wiki/Q7940891","display_name":"Volume expansion","level":2,"score":0.4544154107570648},{"id":"https://openalex.org/C195646399","wikidata":"https://www.wikidata.org/wiki/Q6058580","display_name":"Intravascular volume status","level":3,"score":0.42056265473365784},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.20389863848686218},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1623115837574005}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4236/ojanes.2013.37071","doi":"https://doi.org/10.4236/ojanes.2013.37071","is_oa":true,"landing_page_url":"https://doi.org/10.4236/ojanes.2013.37071","pdf_url":"http://www.scirp.org/journal/PaperDownload.aspx?paperID=36596","source":{"id":"https://openalex.org/S2764630504","display_name":"Open Journal of Anesthesiology","issn_l":"2164-5531","issn":["2164-5531","2164-5558"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Journal of Anesthesiology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4236/ojanes.2013.37071","doi":"https://doi.org/10.4236/ojanes.2013.37071","is_oa":true,"landing_page_url":"https://doi.org/10.4236/ojanes.2013.37071","pdf_url":"http://www.scirp.org/journal/PaperDownload.aspx?paperID=36596","source":{"id":"https://openalex.org/S2764630504","display_name":"Open Journal of Anesthesiology","issn_l":"2164-5531","issn":["2164-5531","2164-5558"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Journal of Anesthesiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2008283141.pdf","grobid_xml":"https://content.openalex.org/works/W2008283141.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W80115196","https://openalex.org/W105377228","https://openalex.org/W1596318799","https://openalex.org/W1963806248","https://openalex.org/W1996447886","https://openalex.org/W2005498036","https://openalex.org/W2006995562","https://openalex.org/W2012473865","https://openalex.org/W2040930971","https://openalex.org/W2054289237","https://openalex.org/W2068231640","https://openalex.org/W2076875735","https://openalex.org/W2125566349","https://openalex.org/W2129048121","https://openalex.org/W2139613326","https://openalex.org/W2143409784","https://openalex.org/W2149253228","https://openalex.org/W2165691241","https://openalex.org/W2170487286","https://openalex.org/W2466697993"],"related_works":["https://openalex.org/W2231737570","https://openalex.org/W2563817789","https://openalex.org/W2149253228","https://openalex.org/W2371809241","https://openalex.org/W2056747135","https://openalex.org/W2106735984","https://openalex.org/W3016180625","https://openalex.org/W1979651875","https://openalex.org/W2143409784","https://openalex.org/W2390075340"],"abstract_inverted_index":{"Purpose:":[0],"The":[1,34,58,106,190,230,247,290],"primary":[2,107],"aim":[3],"of":[4,14,85,91,99,114,122,133,164,167,174,181,202,212,221,232,250,277,284,321],"this":[5],"study":[6,59,291],"was":[7,60,110,311],"to":[8,16,36,102,274,282,305,317],"investigate":[9],"volume":[10,112,121,301],"effect":[11,113],"and":[12,27,68,129,138,147,152,155,235,257,310,313,328],"safety":[13,264,271],"up":[15,281,316],"50":[17,86,210,285,322],"mL/kg":[18,87,166,211,223,286,323],"BW":[19],"6%":[20,51,77,115,168,278,295],"hydroxyethyl":[21],"starch":[22],"(HES)":[23],"130/0.4":[24,53,79,117,280,297],"in":[25,45,136,261,326],"adult":[26,67,137,176,193,233,327],"pediatric":[28,70,139,206,237,329],"patients":[29,71,160,177,194,207,217,238,330],"undergoing":[30,72,331],"major":[31,73,332],"elective":[32,74,333],"surgery.":[33,334],"need":[35],"infuse":[37],"human":[38,307],"albumin":[39,124,186,226,308],"may":[40],"be":[41,55,188,228],"reduced":[42],"or":[43,260],"avoided":[44],"Japan":[46],"if":[47],"these":[48,216],"large":[49],"doses":[50,283],"HES":[52,78,116,169,203,213,279,296],"can":[54],"infused.":[56],"Methods:":[57],"an":[61,178,218],"uncontrolled,":[62],"open-labeled,":[63],"multi-center":[64],"trial.":[65],"Fifteen":[66],"5":[69],"surgery":[75,92,100],"received":[76,161,208],"(Voluven\u00ae)":[80],"with":[81],"a":[82,103,162,299,318],"maximum":[83,319],"dose":[84,320],"from":[88],"the":[89,97,111,120,126,130,251,275],"start":[90],"until":[93],"2":[94],"hours":[95],"after":[96],"end":[98],"according":[101],"treatment":[104],"algorithm.":[105],"efficacy":[108],"endpoint":[109],"determined":[118,266],"by":[119],"saved":[123],"during":[125],"investigational":[127],"period":[128],"time":[131,245],"course":[132],"hemodynamic":[134,146],"stability":[135],"patients.":[140],"Safety":[141],"parameters":[142,149,254,259],"were":[143,239],"fluid":[144],"balance,":[145],"laboratory":[148,253],"ECG,":[150],"local":[151],"systemic":[153],"tolerance":[154],"adverse":[156],"events.":[157],"Results:":[158],"Adult":[159],"mean":[163],"32.0":[165],"130/0.4.":[170,204],"For":[171],"12":[172],"out":[173],"15":[175],"average":[179,219],"amount":[180,220],"1033.8":[182],"mL":[183,201],"(18.6":[184],"mL/kg)":[185],"could":[187,227,303],"saved.":[189,229],"other":[191,263],"3":[192,244],"did":[195,267],"not":[196,268],"receive":[197],"more":[198],"than":[199],"1000":[200],"All":[205],"approximately":[209],"130/0.4;":[214],"for":[215],"39.9":[222],"body":[224,287,324],"weight":[225,325],"majority":[231],"patients,":[234],"all":[236,243],"hemodynamically":[240],"stable":[241],"at":[242],"points.":[246],"observed":[248],"changes":[249],"assessed":[252],"including":[255],"hematological":[256],"coagulation":[258],"any":[262,270],"parameter":[265],"reveal":[269],"concern":[272],"related":[273],"administration":[276],"weight.":[288],"Conclusion:":[289],"results":[292],"indicate":[293],"that":[294],"has":[298],"reliable":[300],"effect,":[302],"contribute":[304],"significant":[306],"savings":[309],"safe":[312],"well":[314],"tolerated":[315]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}