{"id":"https://openalex.org/W2008278566","doi":"https://doi.org/10.1002/jss.400040311","title":"The regulatory control of \u03b2\u2010receptor dependent adenylate cyclase","display_name":"The regulatory control of \u03b2\u2010receptor dependent adenylate cyclase","publication_year":1976,"publication_date":"1976-01-01","ids":{"openalex":"https://openalex.org/W2008278566","doi":"https://doi.org/10.1002/jss.400040311","mag":"2008278566","pmid":"https://pubmed.ncbi.nlm.nih.gov/1263515"},"language":"en","primary_location":{"id":"doi:10.1002/jss.400040311","doi":"https://doi.org/10.1002/jss.400040311","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jss.400040311","pdf_url":null,"source":{"id":"https://openalex.org/S122364590","display_name":"Journal of Supramolecular Structure","issn_l":"0091-7419","issn":["0091-7419","1547-9366"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Supramolecular Structure","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086404962","display_name":"Alexander Levitzki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Alexander Levitzki","raw_affiliation_strings":["Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001064846","display_name":"Nehama Sevilla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Nehama Sevilla","raw_affiliation_strings":["Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089990723","display_name":"Michael L. Steer","orcid":"https://orcid.org/0000-0002-5365-8215","observed_orcids":["https://orcid.org/0000-0002-5365-8215"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Michael L. Steer","raw_affiliation_strings":["Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I197251160"],"apc_list":null,"apc_paid":null,"fwci":2.988,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.91362571,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"3","first_page":"405","last_page":"418"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-adrenergic-receptors","display_name":"beta-adrenergic receptors","score":0.9089999794960022},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.9549999833106995},{"id":"https://openalex.org/keywords/turkey-erythrocytes","display_name":"turkey erythrocytes","score":0.8109999895095825},{"id":"https://openalex.org/keywords/gpp-nh-p","display_name":"Gpp(NH)p","score":0.8799999952316284},{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"allosteric regulation","score":0.7289999723434448},{"id":"https://openalex.org/keywords/enzyme-activation-kinetics","display_name":"enzyme activation kinetics","score":0.7940000295639038},{"id":"https://openalex.org/keywords/calcium-inhibition","display_name":"calcium inhibition","score":0.777999997138977},{"id":"https://openalex.org/keywords/negative-cooperativity","display_name":"negative cooperativity","score":0.878000020980835},{"id":"https://openalex.org/keywords/ligand-receptor-interactions","display_name":"ligand-receptor interactions","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.8398661613464355},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.7139267921447754},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6600790619850159},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6321552991867065},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5987595319747925},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5698344111442566},{"id":"https://openalex.org/C2780069284","wikidata":"https://www.wikidata.org/wiki/Q5198121","display_name":"Cyclase","level":3,"score":0.5471247434616089},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5281553268432617},{"id":"https://openalex.org/C125209161","wikidata":"https://www.wikidata.org/wiki/Q422816","display_name":"Enzyme activator","level":3,"score":0.5273523926734924},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.5099481344223022},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4418550431728363},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.4127141535282135},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.36117154359817505},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004837","descriptor_name":"Epinephrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004837","descriptor_name":"Epinephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006150","descriptor_name":"Guanine Nucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011941","descriptor_name":"Receptors, Adrenergic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014422","descriptor_name":"Turkeys","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jss.400040311","doi":"https://doi.org/10.1002/jss.400040311","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jss.400040311","pdf_url":null,"source":{"id":"https://openalex.org/S122364590","display_name":"Journal of Supramolecular Structure","issn_l":"0091-7419","issn":["0091-7419","1547-9366"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Supramolecular Structure","raw_type":"journal-article"},{"id":"pmid:1263515","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1263515","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of supramolecular structure","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1487187369","https://openalex.org/W1490796893","https://openalex.org/W1577436652","https://openalex.org/W1863678882","https://openalex.org/W1907944131","https://openalex.org/W1971836830","https://openalex.org/W2004376903","https://openalex.org/W2023634139","https://openalex.org/W2036199911","https://openalex.org/W2074581799","https://openalex.org/W2109389789"],"related_works":["https://openalex.org/W2036148683","https://openalex.org/W2089015327","https://openalex.org/W2075869274","https://openalex.org/W1624531326","https://openalex.org/W2469877610","https://openalex.org/W357281225","https://openalex.org/W1595057575","https://openalex.org/W2039374858","https://openalex.org/W2081963773","https://openalex.org/W1968785938"],"abstract_inverted_index":{"Abstract":[0],"The":[1,31,80,143,314],"characteristics":[2],"of":[3,16,23,64,73,92,97,105,109,140,153,170,185,193,210,225,234,244,254,284,293,311,317],"the":[4,24,29,44,48,52,62,65,71,74,77,90,95,98,103,110,116,123,126,129,133,137,141,151,154,168,171,175,183,186,191,198,208,211,223,232,264,291,297,322,329],"\u03b2\u2010receptor":[5,176],"in":[6,89,102,231],"turkey":[7],"erythrocyte":[8],"adenylate":[9,312],"cyclase":[10],"were":[11],"studied":[12],"using":[13,271],"both":[14,253],"kinetics":[15],"enzyme":[17,49,75,99,156,187,213,324],"activation":[18,72,96,184],"and":[19,26,35,135,148,177,250],"direct":[20,41,268],"binding":[21,144,269],"measurement":[22],"\u03b2\u2010agonists":[25],"antagonists":[27],"to":[28,69,85,158,206,214,227,305],"\u03b2\u2010receptor.":[30],"regulatory":[32,56,81,246,300],"ligands":[33],"Gpp(NH)p":[34,245,330],"Ca2+":[36,318],"do":[37],"not":[38,204,275],"have":[39,261],"any":[40],"effect":[42,316],"on":[43,321,328],"\u03b2\u2010receptor,":[45],"but":[46,94,150,203],"modulate":[47],"activity":[50],"through":[51],"interaction":[53],"with":[54,163],"specific":[55],"sites.":[57,301],"It":[58,273],"was":[59,303],"found":[60,304],"that":[61],"role":[63,108],"catecholamine":[66],"hormone":[67,111,235],"is":[68,100,122,188,201,274,319],"facilitate":[70],"by":[76,115,237,267],"guanyl":[78,82,130,195,298],"nucleotide.":[79],"nucleotide":[83,196,299],"binds":[84],"its":[86,159,215],"allosteric":[87,199,309],"site":[88,200],"absence":[91,104,169,233],"hormone,":[93,134],"slow":[101],"hormone.":[106],"This":[107],"can":[112,256],"be":[113,257,306],"described":[114],"scheme:":[117],"magnified":[118],"image":[119],"Where":[120],"R":[121],"receptor,":[124],"E":[125,157,226],"enzyme,":[127],"G":[128],"nucleotide,":[131],"H":[132],"E\u2032":[136,228],"activated":[138],"form":[139,161],"enzyme.":[142,332],"steps":[145],"are":[146,241,280],"fast":[147],"reversible":[149],"conversion":[152,209,224],"inactive":[155,212],"active":[160,216],"occurs":[162,229],"a":[164,194,307],"k\u223c1.0":[165],"min\u22121":[166],"In":[167],"\u03b2\u2010agonist":[172],"(l\u2010catecholamine)":[173],"at":[174,178,197],"physiological":[179],"free":[180],"Mg2+":[181,221],"concentrations,":[182],"insignificant.":[189],"Thus":[190],"presence":[192,292],"obligatory":[202],"sufficient":[205],"induce":[207],"form.":[217],"At":[218],"high":[219],"(nonphysiological)":[220],"concentration":[222],"slowly":[230],"probably":[236],"another":[238],"pathway.":[239],"There":[240],"two":[242,281],"classes":[243,283],"sites:":[247],"tight":[248,265],"sites":[249,266,285],"loose":[251],"sites,":[252],"which":[255],"identified":[258,263],"kinetically.":[259],"We":[260],"also":[262],"studies":[270],"3H\u2010Gpp(NH)p.":[272],"clear,":[276],"however,":[277],"whether":[278,287],"these":[279],"distinct":[282],"or":[286],"their":[288],"existence":[289],"reflects":[290],"negative":[294,308],"cooperativity":[295],"among":[296],"Calcium":[302],"inhibitor":[310],"cyclase.":[313],"inhibitory":[315],"exerted":[320],"nonactivated":[323],"as":[325,327],"well":[326],"preactivated":[331]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}