{"id":"https://openalex.org/W2008276173","doi":"https://doi.org/10.1016/j.str.2012.03.022","title":"A Unique Spatial Arrangement of the snRNPs within the Native Spliceosome Emerges from In Silico Studies","display_name":"A Unique Spatial Arrangement of the snRNPs within the Native Spliceosome Emerges from In Silico Studies","publication_year":2012,"publication_date":"2012-06-01","ids":{"openalex":"https://openalex.org/W2008276173","doi":"https://doi.org/10.1016/j.str.2012.03.022","mag":"2008276173","pmid":"https://pubmed.ncbi.nlm.nih.gov/22578543","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3372696"},"language":"en","primary_location":{"id":"doi:10.1016/j.str.2012.03.022","doi":"https://doi.org/10.1016/j.str.2012.03.022","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.str.2012.03.022","pdf_url":"http://www.cell.com/article/S0969212612001414/pdf","source":{"id":"https://openalex.org/S7112016","display_name":"Structure","issn_l":"0969-2126","issn":["0969-2126","1878-4186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0969212612001414/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029309088","display_name":"Ziv Frankenstein","orcid":"https://orcid.org/0009-0000-8563-7534","observed_orcids":["https://orcid.org/0009-0000-8563-7534"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ziv Frankenstein","raw_affiliation_strings":["Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047459030","display_name":"Joseph M. Sperling","orcid":"https://orcid.org/0000-0003-1916-5633","observed_orcids":["https://orcid.org/0000-0003-1916-5633"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Joseph Sperling","raw_affiliation_strings":["Department of Organic Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organic Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045761416","display_name":"Ruth Sperling","orcid":"https://orcid.org/0000-0002-8950-4584","observed_orcids":["https://orcid.org/0000-0002-8950-4584"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ruth Sperling","raw_affiliation_strings":["Department of Genetics, The Hebrew University of Jerusalem, Jerusalem 91904, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, The Hebrew University of Jerusalem, Jerusalem 91904, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028551465","display_name":"Miriam Eisenstein","orcid":"https://orcid.org/0000-0001-6401-2199","observed_orcids":["https://orcid.org/0000-0001-6401-2199"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Miriam Eisenstein","raw_affiliation_strings":["Department of Chemical Research Support, Weizmann Institute of Science, Rehovot 76100, Israel","Dept. of Chemical Research Support, Weizmann Institute of Science, Rehovot 76100 (Israel)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Research Support, Weizmann Institute of Science, Rehovot 76100, Israel","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"Dept. of Chemical Research Support, Weizmann Institute of Science, Rehovot 76100 (Israel)","institution_ids":["https://openalex.org/I53964585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5028551465"],"corresponding_institution_ids":["https://openalex.org/I53964585"],"apc_list":{"value":9350,"currency":"USD","value_usd":9350},"apc_paid":null,"fwci":0.3853,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.57525666,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"20","issue":"6","first_page":"1097","last_page":"1106"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spliceosome","display_name":"spliceosome","score":0.9929999709129333},{"id":"https://openalex.org/keywords/small-nuclear-ribonucleoproteins","display_name":"small nuclear ribonucleoproteins","score":0.9559999704360962},{"id":"https://openalex.org/keywords/spatial-layout","display_name":"spatial configuration","score":0.7940000295639038},{"id":"https://openalex.org/keywords/ribonucleoprotein-assembly","display_name":"ribonucleoprotein assembly","score":0.8289999961853027},{"id":"https://openalex.org/keywords/rna-splicing","display_name":"RNA splicing","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C40000846","wikidata":"https://www.wikidata.org/wiki/Q915868","display_name":"Spliceosome","level":5,"score":0.9809880256652832},{"id":"https://openalex.org/C68483431","wikidata":"https://www.wikidata.org/wiki/Q2076770","display_name":"snRNP","level":5,"score":0.8533347845077515},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.7716869115829468},{"id":"https://openalex.org/C2908584439","wikidata":"https://www.wikidata.org/wiki/Q2076770","display_name":"Small nuclear ribonucleoprotein","level":5,"score":0.7176687717437744},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5329825282096863},{"id":"https://openalex.org/C75934600","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Ribonucleoprotein","level":4,"score":0.4968438446521759},{"id":"https://openalex.org/C60542250","wikidata":"https://www.wikidata.org/wiki/Q21105762","display_name":"Minor spliceosome","level":5,"score":0.47176244854927063},{"id":"https://openalex.org/C100299639","wikidata":"https://www.wikidata.org/wiki/Q284578","display_name":"Small nuclear RNA","level":5,"score":0.45472633838653564},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.41618362069129944},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3748713731765747},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.36322128772735596},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3611326217651367},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11829209327697754},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.10364696383476257}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017381","descriptor_name":"Spliceosomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017411","descriptor_name":"Ribonucleoproteins, Small Nuclear","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.str.2012.03.022","doi":"https://doi.org/10.1016/j.str.2012.03.022","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.str.2012.03.022","pdf_url":"http://www.cell.com/article/S0969212612001414/pdf","source":{"id":"https://openalex.org/S7112016","display_name":"Structure","issn_l":"0969-2126","issn":["0969-2126","1878-4186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure","raw_type":"journal-article"},{"id":"pmid:22578543","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22578543","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure (London, England : 1993)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2671058","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3372696","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3372696","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3372696","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Structure","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.str.2012.03.022","doi":"https://doi.org/10.1016/j.str.2012.03.022","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.str.2012.03.022","pdf_url":"http://www.cell.com/article/S0969212612001414/pdf","source":{"id":"https://openalex.org/S7112016","display_name":"Structure","issn_l":"0969-2126","issn":["0969-2126","1878-4186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4512027191","display_name":null,"funder_award_id":"GM079549","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5084572106","display_name":"The Mammalian Cellular Splicing Machine - Structure and Function","funder_award_id":"R01GM079549","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2008276173.pdf"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W81403819","https://openalex.org/W1963672664","https://openalex.org/W1970302143","https://openalex.org/W1972801928","https://openalex.org/W1976247681","https://openalex.org/W1979907792","https://openalex.org/W1984116290","https://openalex.org/W1985880320","https://openalex.org/W1985991078","https://openalex.org/W1989547144","https://openalex.org/W1998790160","https://openalex.org/W2002337973","https://openalex.org/W2002965078","https://openalex.org/W2005049999","https://openalex.org/W2015315608","https://openalex.org/W2016093990","https://openalex.org/W2021293338","https://openalex.org/W2030193187","https://openalex.org/W2031061513","https://openalex.org/W2037726485","https://openalex.org/W2038182020","https://openalex.org/W2041519101","https://openalex.org/W2041562931","https://openalex.org/W2042811802","https://openalex.org/W2042820257","https://openalex.org/W2045936988","https://openalex.org/W2051631967","https://openalex.org/W2054591207","https://openalex.org/W2061434726","https://openalex.org/W2063206231","https://openalex.org/W2066040214","https://openalex.org/W2067709324","https://openalex.org/W2067763399","https://openalex.org/W2067838228","https://openalex.org/W2069777230","https://openalex.org/W2090774487","https://openalex.org/W2092801170","https://openalex.org/W2099244854","https://openalex.org/W2102322022","https://openalex.org/W2104686275","https://openalex.org/W2112315506","https://openalex.org/W2127650328","https://openalex.org/W2132505931","https://openalex.org/W2132686610","https://openalex.org/W2142747988","https://openalex.org/W2148393113","https://openalex.org/W2155103924","https://openalex.org/W2163206554","https://openalex.org/W2164448313","https://openalex.org/W2166437079","https://openalex.org/W2166992176","https://openalex.org/W2284602184","https://openalex.org/W6603271412","https://openalex.org/W6684254741","https://openalex.org/W6695958791"],"related_works":["https://openalex.org/W1972244447","https://openalex.org/W2148393113","https://openalex.org/W2316311476","https://openalex.org/W2061434726","https://openalex.org/W2467638363","https://openalex.org/W7037003179","https://openalex.org/W1988498926","https://openalex.org/W2115101918","https://openalex.org/W4241365179","https://openalex.org/W7055720601"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}