{"id":"https://openalex.org/W2008233240","doi":"https://doi.org/10.1371/journal.pone.0007839","title":"Gene Regulation and Epigenetic Remodeling in Murine Embryonic Stem Cells by c-Myc","display_name":"Gene Regulation and Epigenetic Remodeling in Murine Embryonic Stem Cells by c-Myc","publication_year":2009,"publication_date":"2009-11-12","ids":{"openalex":"https://openalex.org/W2008233240","doi":"https://doi.org/10.1371/journal.pone.0007839","mag":"2008233240","pmid":"https://pubmed.ncbi.nlm.nih.gov/19915707","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2773118"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0007839","doi":"https://doi.org/10.1371/journal.pone.0007839","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0007839","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0007839&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0007839&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111671563","display_name":"Chin-Hsing Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chin-Hsing Lin","raw_affiliation_strings":["Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA","Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109921773","display_name":"Chen Wei Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ChenWei Lin","raw_affiliation_strings":["Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA","Fred Hutchinson Cancer Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102852556","display_name":"Hisashi Tanaka","orcid":"https://orcid.org/0000-0001-9223-4186","observed_orcids":["https://orcid.org/0000-0001-9223-4186"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hisashi Tanaka","raw_affiliation_strings":["Department of Molecular Genetics, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022727340","display_name":"Matthew L. Fero","orcid":"https://orcid.org/0000-0002-9967-4659","observed_orcids":["https://orcid.org/0000-0002-9967-4659"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew L. Fero","raw_affiliation_strings":["Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","Fred Hutchinson Cancer Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082542184","display_name":"Robert N. Eisenman","orcid":"https://orcid.org/0000-0002-0274-9846","observed_orcids":["https://orcid.org/0000-0002-0274-9846"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert N. Eisenman","raw_affiliation_strings":["Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","Fred Hutchinson Cancer Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center","institution_ids":["https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5082542184"],"corresponding_institution_ids":["https://openalex.org/I4210089486"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.7358,"has_fulltext":true,"cited_by_count":82,"citation_normalized_percentile":{"value":0.94651198,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"4","issue":"11","first_page":"e7839","last_page":"e7839"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.5830000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.5830000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.3100999891757965,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.09109999984502792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9980000257492065},{"id":"https://openalex.org/keywords/myc-oncoprotein","display_name":"Myc oncoprotein","score":0.7570000290870667},{"id":"https://openalex.org/keywords/mouse-embryonic-stem-cells","display_name":"mouse embryonic stem cells","score":0.9010000228881836},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/epigenetic-remodeling","display_name":"epigenetic remodeling","score":0.8820000290870667},{"id":"https://openalex.org/keywords/histone-methylation","display_name":"histone methylation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/h3k4-trimethylation","display_name":"H3K4 trimethylation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/h3k27me3","display_name":"H3K27me3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/polycomb-group-genes","display_name":"Polycomb group genes","score":0.7829999923706055},{"id":"https://openalex.org/keywords/bivalent-chromatin","display_name":"bivalent chromatin","score":0.9150000214576721},{"id":"https://openalex.org/keywords/chromatin-remodeling","display_name":"chromatin remodeling","score":0.8529999852180481},{"id":"https://openalex.org/keywords/pluripotency","display_name":"pluripotency","score":0.9810000061988831},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.7935453653335571},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7678532600402832},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7439621090888977},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.706035852432251},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.6539045572280884},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.5469127893447876},{"id":"https://openalex.org/C2776745794","wikidata":"https://www.wikidata.org/wiki/Q24777451","display_name":"Histone H3","level":4,"score":0.531037449836731},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5268755555152893},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.45959246158599854},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4558001160621643},{"id":"https://openalex.org/C137338518","wikidata":"https://www.wikidata.org/wiki/Q4919210","display_name":"Bivalent chromatin","level":5,"score":0.4513664245605469},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42024779319763184},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.41099637746810913},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3923652768135071},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3274920582771301},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2592129707336426},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.1945539116859436}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0007839","doi":"https://doi.org/10.1371/journal.pone.0007839","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0007839","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0007839&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmid:19915707","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19915707","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2773118","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2773118/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:c627c88b584247ac9cbf94f931ddc5a7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c627c88b584247ac9cbf94f931ddc5a7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 4, Iss 11, p e7839 (2009)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/145736","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/Gene_Regulation_and_Epigenetic_Remodeling_in_Murine_Embryonic_Stem_Cells_by_c_Myc/145736","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0007839","doi":"https://doi.org/10.1371/journal.pone.0007839","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0007839","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0007839&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1707745320","display_name":null,"funder_award_id":"R.O.1 CA20525","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4042463571","display_name":"Regulation of cell growth and proliferation by Myc","funder_award_id":"R01CA020525","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2008233240.pdf","grobid_xml":"https://content.openalex.org/works/W2008233240.grobid-xml"},"referenced_works_count":82,"referenced_works":["https://openalex.org/W69965022","https://openalex.org/W192718590","https://openalex.org/W1543093074","https://openalex.org/W1577222190","https://openalex.org/W1965428318","https://openalex.org/W1968931043","https://openalex.org/W1971209629","https://openalex.org/W1972778166","https://openalex.org/W1975489321","https://openalex.org/W1976049735","https://openalex.org/W1978173381","https://openalex.org/W1979245454","https://openalex.org/W1980673831","https://openalex.org/W1981088384","https://openalex.org/W1987160935","https://openalex.org/W1988294855","https://openalex.org/W1993522288","https://openalex.org/W2002179012","https://openalex.org/W2005391235","https://openalex.org/W2010031978","https://openalex.org/W2010982295","https://openalex.org/W2014386433","https://openalex.org/W2014744254","https://openalex.org/W2017840637","https://openalex.org/W2020965347","https://openalex.org/W2030523067","https://openalex.org/W2032580087","https://openalex.org/W2038121225","https://openalex.org/W2039551265","https://openalex.org/W2042633640","https://openalex.org/W2043848225","https://openalex.org/W2048768497","https://openalex.org/W2049598074","https://openalex.org/W2054193017","https://openalex.org/W2056401732","https://openalex.org/W2059694060","https://openalex.org/W2067563155","https://openalex.org/W2069717852","https://openalex.org/W2070399051","https://openalex.org/W2071746976","https://openalex.org/W2079599988","https://openalex.org/W2093540365","https://openalex.org/W2103667298","https://openalex.org/W2106921118","https://openalex.org/W2107575419","https://openalex.org/W2108241558","https://openalex.org/W2110015307","https://openalex.org/W2110255526","https://openalex.org/W2116562692","https://openalex.org/W2117224259","https://openalex.org/W2119739306","https://openalex.org/W2120006551","https://openalex.org/W2120060263","https://openalex.org/W2122504027","https://openalex.org/W2122807692","https://openalex.org/W2123011109","https://openalex.org/W2123641599","https://openalex.org/W2124966133","https://openalex.org/W2125734502","https://openalex.org/W2125987139","https://openalex.org/W2126851387","https://openalex.org/W2137650223","https://openalex.org/W2137862639","https://openalex.org/W2138366746","https://openalex.org/W2138977668","https://openalex.org/W2139384923","https://openalex.org/W2140089324","https://openalex.org/W2142046859","https://openalex.org/W2142389206","https://openalex.org/W2150163104","https://openalex.org/W2153044421","https://openalex.org/W2153424791","https://openalex.org/W2158107632","https://openalex.org/W2158610627","https://openalex.org/W2160014402","https://openalex.org/W2169529166","https://openalex.org/W3213154483","https://openalex.org/W4236316592","https://openalex.org/W7027433782","https://openalex.org/W7074230359","https://openalex.org/W7096257995","https://openalex.org/W7098464179"],"related_works":["https://openalex.org/W2605551581","https://openalex.org/W2038121225","https://openalex.org/W7099656213","https://openalex.org/W2947900718","https://openalex.org/W2098057038","https://openalex.org/W2023677322","https://openalex.org/W2158668089","https://openalex.org/W2056782902","https://openalex.org/W2131888467","https://openalex.org/W2107280466"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"Myc":[2,40,102,174,206,220,241],"oncoprotein,":[3],"a":[4,190,257],"transcriptional":[5],"regulator":[6],"involved":[7,83,249,295],"in":[8,24,46,57,84,98,143,162,193,198,226,229,250,271,281,296],"the":[9,25,53,126,134,289],"etiology":[10],"of":[11,27,55,129,136,138,152,179,213,240,246,259,293],"many":[12],"different":[13],"tumor":[14],"types,":[15],"has":[16,41],"been":[17],"demonstrated":[18],"to":[19,38,76,173,201,209,273],"play":[20],"an":[21],"important":[22],"role":[23,54],"functions":[26,45],"embryonic":[28],"stem":[29],"(ES)":[30],"cells.":[31,48,101,231],"Nonetheless,":[32],"it":[33],"is":[34,207],"still":[35],"unclear":[36],"as":[37,110],"whether":[39,123],"unique":[42],"target":[43,247],"and":[44,88,94,105,141,149,158,164,171,223,269,287,300],"ES":[47,59,100,230],"METHODOLOGY/PRINCIPAL":[49],"FINDINGS:":[50],"To":[51,121],"elucidate":[52],"c-Myc":[56,97,124,275,284],"murine":[58,99],"cells,":[60],"we":[61,80,132],"mapped":[62],"its":[63,244],"genomic":[64],"binding":[65,175],"sites":[66],"by":[67,96,243],"chromatin-immunoprecipitation":[68],"combined":[69],"with":[70,195,262],"DNA":[71],"microarrays":[72],"(ChIP-chip).":[73],"In":[74],"addition":[75],"previously":[77,108],"identified":[78,81,109],"targets":[79],"genes":[82,115,248,261,294],"pluripotency,":[85,299],"early":[86],"development,":[87],"chromatin":[89,119,181,251,297],"modification/structure":[90],"that":[91,116,205,219,234,256,280],"are":[92,237,267],"bound":[93,268],"regulated":[95,270],"also":[103],"binds":[104],"regulates":[106],"loci":[107],"Polycomb":[111],"(PcG)":[112],"targets,":[113],"including":[114],"contain":[117],"bivalent":[118,263],"domains.":[120],"determine":[122],"influences":[125,288],"epigenetic":[127],"state":[128],"Myc-bound":[130],"genes,":[131],"assessed":[133],"patterns":[135,266,292],"trimethylation":[137],"histone":[139,166,214,227,264,290],"H3-K4":[140],"H3-K27":[142],"mES":[144,282],"cells":[145,283],"containing":[146],"normal,":[147],"increased,":[148],"reduced":[150],"levels":[151,212],"c-Myc.":[153],"Our":[154,277],"analysis":[155,178],"reveals":[156],"widespread":[157,222],"surprisingly":[159],"diverse":[160,224],"changes":[161,225,236],"repressive":[163],"activating":[165],"methylation":[167,228,265],"marks":[168],"both":[169],"proximal":[170],"distal":[172],"sites.":[176],"Furthermore,":[177],"bulk":[180],"from":[182],"phenotypically":[183],"normal":[184,211],"c-myc":[185],"null":[186],"E7":[187],"embryos":[188,203],"demonstrates":[189],"70-80%":[191],"decrease":[192],"H3-K4me3,":[194],"little":[196],"change":[197],"H3-K27me3,":[199],"compared":[200],"wild-type":[202],"indicating":[204],"required":[208],"maintain":[210],"methylation.":[215],"CONCLUSIONS/SIGNIFICANCE:":[216],"We":[217,232,253],"show":[218,255],"induces":[221],"postulate":[233],"these":[235],"indirect":[238],"effects":[239],"mediated":[242],"regulation":[245],"remodeling.":[252],"further":[254],"subset":[258],"PcG-bound":[260],"response":[272],"altered":[274],"levels.":[276],"data":[278],"indicate":[279],"binds,":[285],"regulates,":[286],"modification":[291],"remodeling,":[298],"differentiation.":[301]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
