{"id":"https://openalex.org/W2008199331","doi":"https://doi.org/10.1128/jvi.01573-14","title":"Host Genetic and Viral Determinants of HIV-1 RNA Set Point among HIV-1 Seroconverters from Sub-Saharan Africa","display_name":"Host Genetic and Viral Determinants of HIV-1 RNA Set Point among HIV-1 Seroconverters from Sub-Saharan Africa","publication_year":2014,"publication_date":"2014-12-04","ids":{"openalex":"https://openalex.org/W2008199331","doi":"https://doi.org/10.1128/jvi.01573-14","mag":"2008199331","pmid":"https://pubmed.ncbi.nlm.nih.gov/25473042","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4338863"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.01573-14","doi":"https://doi.org/10.1128/jvi.01573-14","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.01573-14","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4338863","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088589127","display_name":"Romel D. Mackelprang","orcid":"https://orcid.org/0000-0003-0308-4097","observed_orcids":["https://orcid.org/0000-0003-0308-4097"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Romel D. Mackelprang","raw_affiliation_strings":["Department of Global Health, University of Washington, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Global Health, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015541994","display_name":"Mary N Carrington","orcid":"https://orcid.org/0000-0002-2692-2180","observed_orcids":["https://orcid.org/0000-0002-2692-2180"]},"institutions":[{"id":"https://openalex.org/I2802422659","display_name":"Ragon Institute of MGH, MIT and Harvard","ror":"https://ror.org/053r20n13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I2802422659","https://openalex.org/I4210087915","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4396570585","display_name":"Leidos Biomedical Research Inc. (United States)","ror":"https://ror.org/00bardy64","country_code":"US","type":"company","lineage":["https://openalex.org/I114662689","https://openalex.org/I4396570585"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Carrington","raw_affiliation_strings":["Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Inc., Frederick National Laboratories for Cancer Research, Frederick, Maryland, USA","Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Inc., Frederick National Laboratories for Cancer Research, Frederick, Maryland, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4396570585"]},{"raw_affiliation_string":"Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I2802422659","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013103542","display_name":"Katherine K. Thomas","orcid":"https://orcid.org/0000-0002-7024-468X","observed_orcids":["https://orcid.org/0000-0002-7024-468X"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine K. Thomas","raw_affiliation_strings":["Department of Global Health, University of Washington, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Global Health, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111877761","display_name":"James P. Hughes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James P. Hughes","raw_affiliation_strings":["Department of Biostatistics, University of Washington, Seattle, Washington, USA","Fred Hutchinson Cancer Research Center, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, Washington, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064486492","display_name":"Jared M. Baeten","orcid":"https://orcid.org/0000-0001-8242-8438","observed_orcids":["https://orcid.org/0000-0001-8242-8438"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jared M. Baeten","raw_affiliation_strings":["Department of Epidemiology, University of Washington, Seattle, Washington, USA","Department of Global Health, University of Washington, Seattle, Washington, USA","Department of Medicine, University of Washington, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Global Health, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052928140","display_name":"Anna Wald","orcid":"https://orcid.org/0000-0003-3486-6438","observed_orcids":["https://orcid.org/0000-0003-3486-6438"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Wald","raw_affiliation_strings":["Department of Epidemiology, University of Washington, Seattle, Washington, USA","Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA","Department of Medicine, University of Washington, Seattle, Washington, USA","Fred Hutchinson Cancer Research Center, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, Washington, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019319282","display_name":"Carey Farquhar","orcid":"https://orcid.org/0000-0001-8575-3439","observed_orcids":["https://orcid.org/0000-0001-8575-3439"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carey Farquhar","raw_affiliation_strings":["Department of Epidemiology, University of Washington, Seattle, Washington, USA","Department of Global Health, University of Washington, Seattle, Washington, USA","Department of Medicine, University of Washington, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Global Health, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110721667","display_name":"Kenneth H. Fife","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth Fife","raw_affiliation_strings":["Department of Medicine, Indiana University, Indianapolis, Indiana, USA","Department of Microbiology and Immunology, Indiana University, Indianapolis, Indiana, USA","Department of Pathology, Indiana University, Indianapolis, Indiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Indiana University, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I4388446366"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Indiana University, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I4388446366"]},{"raw_affiliation_string":"Department of Pathology, Indiana University, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I4388446366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110409479","display_name":"Mary S. Campbell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary S. Campbell","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021019665","display_name":"Saidi Kapiga","orcid":"https://orcid.org/0000-0003-1753-4060","observed_orcids":["https://orcid.org/0000-0003-1753-4060"]},"institutions":[{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]},{"id":"https://openalex.org/I4210131399","display_name":"Mwanza Intervention Trials Unit","ror":"https://ror.org/03djmvy73","country_code":"TZ","type":"facility","lineage":["https://openalex.org/I4210131399"]},{"id":"https://openalex.org/I4210164902","display_name":"National Institute for Medical Research","ror":"https://ror.org/05fjs7w98","country_code":"TZ","type":"facility","lineage":["https://openalex.org/I2801810276","https://openalex.org/I4210164902"]}],"countries":["GB","TZ"],"is_corresponding":false,"raw_author_name":"Saida Kapiga","raw_affiliation_strings":["Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom","Mwanza Intervention Trials Unit, National Institute for Medical Research, Mwanza, Tanzania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom","institution_ids":["https://openalex.org/I4210089966"]},{"raw_affiliation_string":"Mwanza Intervention Trials Unit, National Institute for Medical Research, Mwanza, Tanzania","institution_ids":["https://openalex.org/I4210131399","https://openalex.org/I4210164902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111674930","display_name":"Xiaojiang Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4396570585","display_name":"Leidos Biomedical Research Inc. (United States)","ror":"https://ror.org/00bardy64","country_code":"US","type":"company","lineage":["https://openalex.org/I114662689","https://openalex.org/I4396570585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaojiang Gao","raw_affiliation_strings":["Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Inc., Frederick National Laboratories for Cancer Research, Frederick, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Inc., Frederick National Laboratories for Cancer Research, Frederick, Maryland, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4396570585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028336562","display_name":"James I. Mullins","orcid":"https://orcid.org/0000-0002-4461-8158","observed_orcids":["https://orcid.org/0000-0002-4461-8158"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James I. Mullins","raw_affiliation_strings":["Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA","Department of Medicine, University of Washington, Seattle, Washington, USA","Department of Microbiology, University of Washington, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Microbiology, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009104193","display_name":"Jairam R. Lingappa","orcid":"https://orcid.org/0000-0001-6191-9828","observed_orcids":["https://orcid.org/0000-0001-6191-9828"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jairam R. Lingappa","raw_affiliation_strings":["Department of Global Health, University of Washington, Seattle, Washington, USA","Department of Medicine, University of Washington, Seattle, Washington, USA","Department of Pediatrics, University of Washington, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Global Health, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Pediatrics, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3356,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.79315264,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"89","issue":"4","first_page":"2104","last_page":"2111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-viral-load","display_name":"HIV-1 viral load","score":0.7879999876022339},{"id":"https://openalex.org/keywords/hiv-1-seroconversion","display_name":"HIV-1 seroconversion","score":0.7960000038146973},{"id":"https://openalex.org/keywords/hla-alleles","display_name":"HLA alleles","score":0.875},{"id":"https://openalex.org/keywords/innate-immune-response","display_name":"innate immune response","score":0.7390000224113464},{"id":"https://openalex.org/keywords/adaptive-immune-response","display_name":"adaptive immune response","score":0.8019999861717224},{"id":"https://openalex.org/keywords/serodiscordant-couples","display_name":"serodiscordant couples","score":0.8460000157356262},{"id":"https://openalex.org/keywords/hiv-transmission","display_name":"HIV transmission","score":0.4189999997615814},{"id":"https://openalex.org/keywords/male-circumcision","display_name":"male circumcision","score":0.6629999876022339},{"id":"https://openalex.org/keywords/bacterial-vaginosis","display_name":"bacterial vaginosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/acyclovir","display_name":"acyclovir","score":0.9760000109672546},{"id":"https://openalex.org/keywords/sub-saharan-africa","display_name":"sub-Saharan Africa","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8519334197044373},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7108533978462219},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.6791626811027527},{"id":"https://openalex.org/C2993627981","wikidata":"https://www.wikidata.org/wiki/Q7456295","display_name":"Set point","level":2,"score":0.4610556364059448},{"id":"https://openalex.org/C2779690655","wikidata":"https://www.wikidata.org/wiki/Q374232","display_name":"Lentivirus","level":4,"score":0.4527103006839752},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.4463907778263092},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33659762144088745},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3311867117881775},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.27461177110671997},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D017954","descriptor_name":"Africa South of the Sahara","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017954","descriptor_name":"Africa South of the Sahara","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017954","descriptor_name":"Africa South of the Sahara","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017954","descriptor_name":"Africa South of the Sahara","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017954","descriptor_name":"Africa South of the Sahara","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.01573-14","doi":"https://doi.org/10.1128/jvi.01573-14","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.01573-14","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4338863","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4338863","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:25473042","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25473042","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:http://erepository.uonbi.ac.ke:11295/90384","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11295/90384","pdf_url":null,"source":{"id":"https://openalex.org/S4306402107","display_name":"University of Nairobi Research Archive (University of Nairobi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I12859529","host_organization_name":"University of Nairobi","host_organization_lineage":["https://openalex.org/I12859529"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4338863","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4338863","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8100000023841858}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1621430908","display_name":null,"funder_award_id":"AI 27757","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2168696107","display_name":"Host Genetic Factors in the HIV Virus Life-Cycle and HIV Disease Progression","funder_award_id":"R21AI073115","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2986588876","display_name":"Clinical Epidemiology and Pathogenesis of Asymptomatic HSV","funder_award_id":"P01AI030731","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G378552126","display_name":null,"funder_award_id":"P30 AI 027757","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G386607036","display_name":null,"funder_award_id":"HHSN261200800001E)","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5888954722","display_name":null,"funder_award_id":"HHSN261200800001C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G599564316","display_name":null,"funder_award_id":"AI073115","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7538259299","display_name":"IMMUNOLOGICAL AND VIROLOGICAL EVENTS IN EARLY HIV INFECTION","funder_award_id":"P01AI057005","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000858644","display_name":"STD and AIDS Research Training Grant","funder_award_id":"T32AI007140","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"},{"id":"https://openalex.org/F4320310094","display_name":"University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320332582","display_name":"Center for AIDS Research, University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W113574532","https://openalex.org/W1606271020","https://openalex.org/W1830847181","https://openalex.org/W1928100000","https://openalex.org/W1963813930","https://openalex.org/W1967714946","https://openalex.org/W1967791423","https://openalex.org/W1969072247","https://openalex.org/W1977328931","https://openalex.org/W1982416473","https://openalex.org/W1985816803","https://openalex.org/W1986152436","https://openalex.org/W1988933769","https://openalex.org/W1993754021","https://openalex.org/W1994391392","https://openalex.org/W1995453338","https://openalex.org/W1996464851","https://openalex.org/W2000693515","https://openalex.org/W2002572303","https://openalex.org/W2009082439","https://openalex.org/W2011560892","https://openalex.org/W2012139740","https://openalex.org/W2019559865","https://openalex.org/W2025590019","https://openalex.org/W2031754540","https://openalex.org/W2032099305","https://openalex.org/W2035555649","https://openalex.org/W2038542171","https://openalex.org/W2047325790","https://openalex.org/W2049146045","https://openalex.org/W2053002571","https://openalex.org/W2060731298","https://openalex.org/W2061474260","https://openalex.org/W2061765698","https://openalex.org/W2064163367","https://openalex.org/W2067115510","https://openalex.org/W2075906228","https://openalex.org/W2087484510","https://openalex.org/W2091932385","https://openalex.org/W2096015577","https://openalex.org/W2096614211","https://openalex.org/W2097135837","https://openalex.org/W2101208237","https://openalex.org/W2103938894","https://openalex.org/W2108178787","https://openalex.org/W2116296845","https://openalex.org/W2120229808","https://openalex.org/W2121634437","https://openalex.org/W2125001603","https://openalex.org/W2128528264","https://openalex.org/W2129174937","https://openalex.org/W2131940574","https://openalex.org/W2132705297","https://openalex.org/W2142405752","https://openalex.org/W2146366486","https://openalex.org/W2149759731","https://openalex.org/W2152534166","https://openalex.org/W2153134282","https://openalex.org/W2157222418","https://openalex.org/W2161035695","https://openalex.org/W2164299931","https://openalex.org/W2167876918","https://openalex.org/W2169629503","https://openalex.org/W2314461521","https://openalex.org/W2332421827","https://openalex.org/W2418168991","https://openalex.org/W2582743722","https://openalex.org/W2728415225","https://openalex.org/W3151856769","https://openalex.org/W4236933712","https://openalex.org/W4290291744"],"related_works":["https://openalex.org/W1982416473","https://openalex.org/W7100410281","https://openalex.org/W2032099305","https://openalex.org/W2077203965","https://openalex.org/W2318166998","https://openalex.org/W2109853326","https://openalex.org/W2102952290","https://openalex.org/W2091337695","https://openalex.org/W1645604036","https://openalex.org/W7098238965"],"abstract_inverted_index":{"UNLABELLED:":[0],"We":[1,142,258],"quantified":[2],"the":[3,26,77,114,124,157,164,220,296],"collective":[4],"impact":[5],"of":[6,62,76,85,113,123,133,137,156,163,228,295],"source":[7],"partner":[8],"HIV-1":[9,27,33,37,74,154,173,184,192,213,244,256,266,289,299],"RNA":[10],"levels,":[11],"human":[12],"leukocyte":[13],"antigen":[14],"(HLA)":[15],"alleles,":[16],"and":[17,51,70,72,83,95,100,111,120,131,147,197,222,225,232,238,261,279,291],"innate":[18,146,278],"responses":[19,189,224],"through":[20],"Toll-like":[21],"receptor":[22],"(TLR)":[23],"alleles":[24,67],"on":[25],"set":[28,49,63,88,107,140,169,214,245,267,300],"point.":[29,141,170,301],"Data":[30],"came":[31],"from":[32],"seroconverters":[34],"in":[35,87,139,166,183,269,298],"African":[36],"serodiscordant":[38],"couple":[39],"cohorts.":[40],"Linear":[41],"regression":[42],"was":[43],"used":[44],"to":[45,53,179,242],"determine":[46,243],"associations":[47],"with":[48,106,152,284],"point":[50,64,215,246,268],"R(2)":[52],"estimate":[54],"variation":[55,86,138,165,297],"explained":[56,81,135],"by":[57],"covariates.":[58],"The":[59],"strongest":[60],"predictors":[61],"were":[65,104],"HLA":[66],"(B*53:01,":[68],"B*14:01,":[69],"B*27:03)":[71],"plasma":[73,153],"levels":[75,155,193],"transmitting":[78,158],"partner,":[79,159],"which":[80],"13%":[82],"10%":[84],"point,":[89,108],"respectively.":[90,116],"HLA-A":[91],"concordance":[92],"between":[93,219],"partners":[94],"TLR":[96],"polymorphisms":[97],"(TLR2":[98],"rs3804100":[99],"TLR7":[101],"rs179012)":[102],"also":[103],"associated":[105],"explaining":[109],"6%":[110],"5%":[112],"variation,":[115],"Overall,":[117],"these":[118],"factors":[119,122,240,263,285],"genital":[121],"transmitter":[125],"(i.e.,":[126],"male":[127],"circumcision,":[128],"bacterial":[129],"vaginosis,":[130],"use":[132],"acyclovir)":[134],"46%":[136],"found":[143],"that":[144,206,264,276,286],"both":[145,277],"adaptive":[148,280],"immune":[149,188,281],"responses,":[150,282],"together":[151],"explain":[160,293],"almost":[161],"half":[162],"viral":[167],"load":[168],"IMPORTANCE:":[171],"After":[172],"infection,":[174],"uncontrolled":[175],"virus":[176,221,239,262],"replication":[177],"leads":[178],"a":[180,195,203],"rapid":[181],"increase":[182],"concentrations.":[185],"Once":[186],"host":[187,223,237,260],"develop,":[190],"however,":[191],"reach":[194,202],"peak":[196],"subsequently":[198],"decline":[199],"until":[200],"they":[201],"stable":[204,212],"level":[205],"may":[207,247],"persist":[208],"for":[209,254],"years.":[210],"This":[211],"represents":[216],"an":[217],"equilibrium":[218],"is":[226],"predictive":[227],"later":[229],"disease":[230],"progression":[231],"transmission":[233],"potential.":[234],"Understanding":[235],"how":[236],"interact":[241],"elucidate":[248],"novel":[249],"mechanisms":[250],"or":[251],"biological":[252],"pathways":[253],"treating":[255],"infection.":[257],"identified":[259],"predict":[265],"people":[270],"who":[271],"recently":[272],"acquired":[273],"HIV-1,":[274],"finding":[275],"along":[283],"likely":[287],"influence":[288],"virulence":[290],"inoculum,":[292],"\u223c46%":[294]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}