{"id":"https://openalex.org/W2008193236","doi":"https://doi.org/10.2165/00003088-198106060-00004","title":"Pharmacokinetics of Metildigoxin and Digoxin in Geriatric Patients with Normal and Elevated Serum Creatinine Levels","display_name":"Pharmacokinetics of Metildigoxin and Digoxin in Geriatric Patients with Normal and Elevated Serum Creatinine Levels","publication_year":1981,"publication_date":"1981-01-01","ids":{"openalex":"https://openalex.org/W2008193236","doi":"https://doi.org/10.2165/00003088-198106060-00004","mag":"2008193236","pmid":"https://pubmed.ncbi.nlm.nih.gov/7318305"},"language":"en","primary_location":{"id":"doi:10.2165/00003088-198106060-00004","doi":"https://doi.org/10.2165/00003088-198106060-00004","is_oa":false,"landing_page_url":"https://doi.org/10.2165/00003088-198106060-00004","pdf_url":null,"source":{"id":"https://openalex.org/S69290020","display_name":"Clinical Pharmacokinetics","issn_l":"0312-5963","issn":["0312-5963","1179-1926"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacokinetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086404853","display_name":"Burchard Kaufmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153150","display_name":"Klinikum Saarbr\u00fccken","ror":"https://ror.org/04wg18j80","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153150"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Burchard Kaufmann","raw_affiliation_strings":["Geriatrische Klinik I, Sonnenberg, Saarbr\u00fccken, Deutschland","Medizinische Forschung, Boehringer Mannheim GmbH, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geriatrische Klinik I, Sonnenberg, Saarbr\u00fccken, Deutschland","institution_ids":["https://openalex.org/I4210153150"]},{"raw_affiliation_string":"Medizinische Forschung, Boehringer Mannheim GmbH, Mannheim, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Olcay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153150","display_name":"Klinikum Saarbr\u00fccken","ror":"https://ror.org/04wg18j80","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153150"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Olcay","raw_affiliation_strings":["Geriatrische Klinik I, Sonnenberg, Saarbr\u00fccken, Deutschland","Medizinische Forschung, Boehringer Mannheim GmbH, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geriatrische Klinik I, Sonnenberg, Saarbr\u00fccken, Deutschland","institution_ids":["https://openalex.org/I4210153150"]},{"raw_affiliation_string":"Medizinische Forschung, Boehringer Mannheim GmbH, Mannheim, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034401100","display_name":"W. Schaumann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153150","display_name":"Klinikum Saarbr\u00fccken","ror":"https://ror.org/04wg18j80","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153150"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"W. Schaumann","raw_affiliation_strings":["Geriatrische Klinik I, Sonnenberg, Saarbr\u00fccken, Deutschland","Medizinische Forschung, Boehringer Mannheim GmbH, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geriatrische Klinik I, Sonnenberg, Saarbr\u00fccken, Deutschland","institution_ids":["https://openalex.org/I4210153150"]},{"raw_affiliation_string":"Medizinische Forschung, Boehringer Mannheim GmbH, Mannheim, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014794682","display_name":"W Teufel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153150","display_name":"Klinikum Saarbr\u00fccken","ror":"https://ror.org/04wg18j80","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153150"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"W. Teufel","raw_affiliation_strings":["Geriatrische Klinik I, Sonnenberg, Saarbr\u00fccken, Deutschland","Medizinische Forschung, Boehringer Mannheim GmbH, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geriatrische Klinik I, Sonnenberg, Saarbr\u00fccken, Deutschland","institution_ids":["https://openalex.org/I4210153150"]},{"raw_affiliation_string":"Medizinische Forschung, Boehringer Mannheim GmbH, Mannheim, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085417471","display_name":"WU Wei-b","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153150","display_name":"Klinikum Saarbr\u00fccken","ror":"https://ror.org/04wg18j80","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153150"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"W. Weib","raw_affiliation_strings":["Geriatrische Klinik I, Sonnenberg, Saarbr\u00fccken, Deutschland","Medizinische Forschung, Boehringer Mannheim GmbH, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geriatrische Klinik I, Sonnenberg, Saarbr\u00fccken, Deutschland","institution_ids":["https://openalex.org/I4210153150"]},{"raw_affiliation_string":"Medizinische Forschung, Boehringer Mannheim GmbH, Mannheim, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210153150"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":3.1025,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.90015387,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"6","issue":"6","first_page":"463","last_page":"468"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.23899999260902405,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.23899999260902405,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.17329999804496765,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.16599999368190765,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/digoxin","display_name":"digoxin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9279999732971191},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.8809999823570251},{"id":"https://openalex.org/keywords/serum-creatinine","display_name":"serum creatinine","score":0.8339999914169312},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.675000011920929},{"id":"https://openalex.org/keywords/creatinine-clearance","display_name":"creatinine clearance","score":0.906000018119812},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.6179999709129333},{"id":"https://openalex.org/keywords/elimination-rate","display_name":"elimination rate","score":0.7590000033378601},{"id":"https://openalex.org/keywords/volume-of-distribution","display_name":"volume of distribution","score":0.9729999899864197}],"concepts":[{"id":"https://openalex.org/C2777707475","wikidata":"https://www.wikidata.org/wiki/Q422222","display_name":"Digoxin","level":3,"score":0.923474907875061},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8456658124923706},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.8071894645690918},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.6826164722442627},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6377339363098145},{"id":"https://openalex.org/C139254425","wikidata":"https://www.wikidata.org/wiki/Q1332167","display_name":"Volume of distribution","level":3,"score":0.6177387237548828},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.46217578649520874},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4488157629966736},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4020002484321594},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3556367754936218},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.10930708050727844}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004077","descriptor_name":"Digoxin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D004077","descriptor_name":"Digoxin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004077","descriptor_name":"Digoxin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008520","descriptor_name":"Medigoxin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2165/00003088-198106060-00004","doi":"https://doi.org/10.2165/00003088-198106060-00004","is_oa":false,"landing_page_url":"https://doi.org/10.2165/00003088-198106060-00004","pdf_url":null,"source":{"id":"https://openalex.org/S69290020","display_name":"Clinical Pharmacokinetics","issn_l":"0312-5963","issn":["0312-5963","1179-1926"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacokinetics","raw_type":"journal-article"},{"id":"pmid:7318305","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7318305","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacokinetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W121320495","https://openalex.org/W176291163","https://openalex.org/W1550111394","https://openalex.org/W1969788137","https://openalex.org/W1998198153","https://openalex.org/W2011252221","https://openalex.org/W2025807122","https://openalex.org/W2033996723","https://openalex.org/W2058263078","https://openalex.org/W2068035230","https://openalex.org/W2077332541","https://openalex.org/W2078876868","https://openalex.org/W2089695199","https://openalex.org/W2098167340","https://openalex.org/W2100567333","https://openalex.org/W2125275645","https://openalex.org/W2344979205","https://openalex.org/W2412705142","https://openalex.org/W2418104551","https://openalex.org/W2429926177","https://openalex.org/W3000291807"],"related_works":["https://openalex.org/W2429926177","https://openalex.org/W1987956008","https://openalex.org/W1965789389","https://openalex.org/W2088467049","https://openalex.org/W2073566245","https://openalex.org/W2059122113","https://openalex.org/W2056396767","https://openalex.org/W2397075867","https://openalex.org/W6923471076","https://openalex.org/W7106663939"],"abstract_inverted_index":null,"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
