{"id":"https://openalex.org/W2008172959","doi":"https://doi.org/10.1016/j.bpj.2009.12.3082","title":"Mechanism of Glycan Receptor Recognition and Specificity Switch for Avian, Swine and Human Adapted Influenza Virus Hemagglutinins: A Molecular Dynamics Perspective","display_name":"Mechanism of Glycan Receptor Recognition and Specificity Switch for Avian, Swine and Human Adapted Influenza Virus Hemagglutinins: A Molecular Dynamics Perspective","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2008172959","doi":"https://doi.org/10.1016/j.bpj.2009.12.3082","mag":"2008172959"},"language":"en","primary_location":{"id":"doi:10.1016/j.bpj.2009.12.3082","doi":"https://doi.org/10.1016/j.bpj.2009.12.3082","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2009.12.3082","pdf_url":"http://www.cell.com/article/S0006349509048875/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0006349509048875/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079162665","display_name":"Dong Xu","orcid":"https://orcid.org/0000-0001-5800-7115","observed_orcids":["https://orcid.org/0000-0001-5800-7115"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong Xu","raw_affiliation_strings":["University of California, San Diego, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025893183","display_name":"E. Irene Newhouse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Irene Newhouse","raw_affiliation_strings":["University of California, San Diego, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057335177","display_name":"Phineus R. L. Markwick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phineus R.L Markwick","raw_affiliation_strings":["University of California, San Diego, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081468273","display_name":"Rommie E. Amaro","orcid":"https://orcid.org/0000-0002-9275-9553","observed_orcids":["https://orcid.org/0000-0002-9275-9553"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rommie E. Amaro","raw_affiliation_strings":["University of California, San Diego, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028984161","display_name":"Hsing C. Pao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hsing C. Pao","raw_affiliation_strings":["University of California, San Diego, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101844232","display_name":"Kevin J. Wu","orcid":"https://orcid.org/0000-0003-2787-7577","observed_orcids":["https://orcid.org/0000-0003-2787-7577"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin J. Wu","raw_affiliation_strings":["University of California, San Diego, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111535337","display_name":"M. Shahid Alam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maqsudul Alam","raw_affiliation_strings":["University of California, San Diego, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015837947","display_name":"James Andrew McCammon","orcid":"https://orcid.org/0000-0003-3065-1456","observed_orcids":["https://orcid.org/0000-0003-3065-1456"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Andrew McCammon","raw_affiliation_strings":["University of California, San Diego, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086731177","display_name":"Wilfred W. Li","orcid":"https://orcid.org/0009-0007-1702-7196","observed_orcids":["https://orcid.org/0009-0007-1702-7196"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wilfred W. Li","raw_affiliation_strings":["University of California, San Diego, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.4655,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.6959908,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"98","issue":"3","first_page":"568a","last_page":"568a"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/influenza-virus-hemagglutinin","display_name":"influenza virus hemagglutinin","score":0.9549999833106995},{"id":"https://openalex.org/keywords/receptor-binding-domain","display_name":"receptor binding domain","score":0.8659999966621399},{"id":"https://openalex.org/keywords/avian-influenza","display_name":"avian influenza","score":0.8320000171661377},{"id":"https://openalex.org/keywords/swine-influenza","display_name":"swine influenza","score":0.9589999914169312},{"id":"https://openalex.org/keywords/human-influenza","display_name":"human influenza","score":0.9309999942779541},{"id":"https://openalex.org/keywords/electrostatic-steering","display_name":"electrostatic steering","score":0.6880000233650208},{"id":"https://openalex.org/keywords/multivalent-interactions","display_name":"multivalent interactions","score":0.7390000224113464},{"id":"https://openalex.org/keywords/receptor-analogues","display_name":"receptor analogues","score":0.5509999990463257},{"id":"https://openalex.org/keywords/hemagglutination","display_name":"hemagglutination","score":0.5149999856948853},{"id":"https://openalex.org/keywords/drug-and-vaccine-development","display_name":"vaccine and drug development","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.8832719326019287},{"id":"https://openalex.org/C179223381","wikidata":"https://www.wikidata.org/wiki/Q419425","display_name":"Avidity","level":3,"score":0.7086307406425476},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4975004494190216},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45883411169052124},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.4501301646232605},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39256399869918823},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3377148509025574},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2948320508003235},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2834872603416443},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2789002060890198},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.27146703004837036},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.bpj.2009.12.3082","doi":"https://doi.org/10.1016/j.bpj.2009.12.3082","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2009.12.3082","pdf_url":"http://www.cell.com/article/S0006349509048875/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.bpj.2009.12.3082","doi":"https://doi.org/10.1016/j.bpj.2009.12.3082","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2009.12.3082","pdf_url":"http://www.cell.com/article/S0006349509048875/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2008172959.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2073630636","https://openalex.org/W2081686995","https://openalex.org/W2554933798","https://openalex.org/W2170695076","https://openalex.org/W1979649675","https://openalex.org/W4401930119","https://openalex.org/W1986056795","https://openalex.org/W2101165138","https://openalex.org/W2160834305","https://openalex.org/W2087948238"],"abstract_inverted_index":null,"counts_by_year":[{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}