{"id":"https://openalex.org/W2008172197","doi":"https://doi.org/10.1081/ddc-100101301","title":"Formulation and Release Behavior of Diclofenac Sodium in Compritol 888 Matrix Beads Encapsulated in Alginate","display_name":"Formulation and Release Behavior of Diclofenac Sodium in Compritol 888 Matrix Beads Encapsulated in Alginate","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2008172197","doi":"https://doi.org/10.1081/ddc-100101301","mag":"2008172197","pmid":"https://pubmed.ncbi.nlm.nih.gov/10872101"},"language":"en","primary_location":{"id":"doi:10.1081/ddc-100101301","doi":"https://doi.org/10.1081/ddc-100101301","is_oa":false,"landing_page_url":"https://doi.org/10.1081/ddc-100101301","pdf_url":null,"source":{"id":"https://openalex.org/S162444473","display_name":"Drug Development and Industrial Pharmacy","issn_l":"0363-9045","issn":["0363-9045","1520-5762"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Development and Industrial Pharmacy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111426977","display_name":"Amani Mirghani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156983542","display_name":"Jordan University of Science and Technology","ror":"https://ror.org/03y8mtb59","country_code":"JO","type":"education","lineage":["https://openalex.org/I156983542"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Amani Mirghani","raw_affiliation_strings":["Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan","institution_ids":["https://openalex.org/I156983542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005031221","display_name":"Nasir Idkaidek","orcid":"https://orcid.org/0000-0003-3115-4240","observed_orcids":["https://orcid.org/0000-0003-3115-4240"]},"institutions":[{"id":"https://openalex.org/I156983542","display_name":"Jordan University of Science and Technology","ror":"https://ror.org/03y8mtb59","country_code":"JO","type":"education","lineage":["https://openalex.org/I156983542"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Nasir M. Idkaidek","raw_affiliation_strings":["Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan","institution_ids":["https://openalex.org/I156983542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076808425","display_name":"Mutaz Sheikh-Salem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156983542","display_name":"Jordan University of Science and Technology","ror":"https://ror.org/03y8mtb59","country_code":"JO","type":"education","lineage":["https://openalex.org/I156983542"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Mu'taz S. Salem","raw_affiliation_strings":["Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan","institution_ids":["https://openalex.org/I156983542"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110038255","display_name":"Naji M. Najib","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156983542","display_name":"Jordan University of Science and Technology","ror":"https://ror.org/03y8mtb59","country_code":"JO","type":"education","lineage":["https://openalex.org/I156983542"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Naji M. Najib","raw_affiliation_strings":["Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan","institution_ids":["https://openalex.org/I156983542"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I156983542"],"apc_list":null,"apc_paid":null,"fwci":0.6353,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.5838537,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"26","issue":"7","first_page":"791","last_page":"795"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diclofenac-sodium","display_name":"diclofenac sodium","score":1.0},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.6669999957084656},{"id":"https://openalex.org/keywords/calcium-alginate-encapsulation","display_name":"calcium alginate encapsulation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/polymer-beads","display_name":"polymer beads","score":0.703000009059906},{"id":"https://openalex.org/keywords/drug-release-kinetics","display_name":"drug release kinetics","score":0.7609999775886536},{"id":"https://openalex.org/keywords/dissolution-time","display_name":"dissolution time","score":0.6510000228881836},{"id":"https://openalex.org/keywords/calcium-chloride-crosslinking","display_name":"calcium chloride crosslinking","score":0.6830000281333923},{"id":"https://openalex.org/keywords/sodium-alginate-concentration","display_name":"sodium alginate concentration","score":0.753000020980835},{"id":"https://openalex.org/keywords/factorial-design","display_name":"factorial design","score":0.5630000233650208},{"id":"https://openalex.org/keywords/ph-sensitive-release","display_name":"pH-dependent release","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C2908765736","wikidata":"https://www.wikidata.org/wiki/Q244408","display_name":"Diclofenac Sodium","level":2,"score":0.8939955830574036},{"id":"https://openalex.org/C169222746","wikidata":"https://www.wikidata.org/wiki/Q4116558","display_name":"Factorial experiment","level":2,"score":0.6988790035247803},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6880415678024292},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.661602258682251},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.4929542541503906},{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.4775579571723938},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.47354429960250854},{"id":"https://openalex.org/C2779826273","wikidata":"https://www.wikidata.org/wiki/Q244408","display_name":"Diclofenac","level":2,"score":0.4733861982822418},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.45040756464004517},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.4357059597969055},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.41486504673957825},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.30138373374938965},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1380734145641327},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11729872226715088},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05876988172531128},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.05208045244216919},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000464","descriptor_name":"Alginates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004008","descriptor_name":"Diclofenac","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005079","descriptor_name":"Excipients","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006603","descriptor_name":"Hexuronic Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020723","descriptor_name":"Glucuronic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1081/ddc-100101301","doi":"https://doi.org/10.1081/ddc-100101301","is_oa":false,"landing_page_url":"https://doi.org/10.1081/ddc-100101301","pdf_url":null,"source":{"id":"https://openalex.org/S162444473","display_name":"Drug Development and Industrial Pharmacy","issn_l":"0363-9045","issn":["0363-9045","1520-5762"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Development and Industrial Pharmacy","raw_type":"journal-article"},{"id":"pmid:10872101","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10872101","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug development and industrial pharmacy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W76221951","https://openalex.org/W87780399","https://openalex.org/W628468902","https://openalex.org/W1553138080","https://openalex.org/W1555994455","https://openalex.org/W1968226729","https://openalex.org/W2019394944","https://openalex.org/W2050803711","https://openalex.org/W2056174843","https://openalex.org/W2083906795"],"related_works":["https://openalex.org/W1988132263","https://openalex.org/W2033429835","https://openalex.org/W2090275401","https://openalex.org/W1983620590","https://openalex.org/W2085828332","https://openalex.org/W4406021946","https://openalex.org/W1986528315","https://openalex.org/W1997666717","https://openalex.org/W1529398234","https://openalex.org/W2109236100"],"abstract_inverted_index":{"Sustained-release":[0],"polymer":[1],"beads":[2],"containing":[3],"diclofenac":[4],"sodium":[5,26],"(DNa)":[6],"dispersed":[7],"in":[8,13,66,75],"Compritol":[9,30],"888":[10,31],"and":[11,34,44,52,78,81],"encapsulated":[12],"calcium":[14],"alginate":[15,27],"shell":[16],"were":[17,57,83],"prepared":[18],"utilizing":[19],"2(3)":[20],"factorial":[21],"design.":[22],"The":[23,85],"effect":[24],"of":[25,46,61,69,93],"concentration,":[28],"drug:":[29],"weight":[32],"ratio":[33],"CaCl2":[35],"concentration":[36],"on":[37,90],"drug":[38,48,86],"content":[39],"(%),":[40],"time":[41,55],"for":[42],"50%":[43],"80%":[45],"the":[47,67,76,91,94],"to":[49,104],"be":[50],"released,":[51],"mean":[53],"dissolution":[54],"(MDT)":[56],"evaluated":[58],"with":[59],"analysis":[60],"variance":[62],"(ANOVA).":[63],"An":[64],"increase":[65],"level":[68],"all":[70],"these":[71],"factors":[72],"caused":[73],"retardation":[74],"release,":[77],"t50%,":[79],"t80%,":[80],"MDT":[82],"increased.":[84],"release":[87,95,102],"was":[88,107],"dependent":[89],"pH":[92],"media.":[96],"A":[97],"formula":[98],"that":[99],"gives":[100],"a":[101],"comparable":[103],"commercial":[105],"products":[106],"prepared.":[108]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
