{"id":"https://openalex.org/W2008160052","doi":"https://doi.org/10.1038/308652a0","title":"Carboxy terminus of vasopressin required for activity but not binding","display_name":"Carboxy terminus of vasopressin required for activity but not binding","publication_year":1984,"publication_date":"1984-04-01","ids":{"openalex":"https://openalex.org/W2008160052","doi":"https://doi.org/10.1038/308652a0","mag":"2008160052","pmid":"https://pubmed.ncbi.nlm.nih.gov/6709073"},"language":"en","primary_location":{"id":"doi:10.1038/308652a0","doi":"https://doi.org/10.1038/308652a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/308652a0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110409708","display_name":"Maurice Manning","orcid":"https://orcid.org/0000-0002-0051-5149","observed_orcids":["https://orcid.org/0000-0002-0051-5149"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maurice Manning","raw_affiliation_strings":["Department of Biochemistry, Medical College of Ohio at Toledo, CS 10008, Toledo, Ohio, 43699, USA","Department of Biochemistry, Medical College of Ohio at Toledo, Toledo, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Medical College of Ohio at Toledo, CS 10008, Toledo, Ohio, 43699, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry, Medical College of Ohio at Toledo, Toledo, USA","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108494294","display_name":"Aleksandra Olma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aleksandra Olma","raw_affiliation_strings":["Department of Biochemistry, Medical College of Ohio at Toledo, CS 10008, Toledo, Ohio, 43699, USA","Department of Biochemistry, Medical College of Ohio at Toledo, Toledo, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Medical College of Ohio at Toledo, CS 10008, Toledo, Ohio, 43699, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry, Medical College of Ohio at Toledo, Toledo, USA","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052093356","display_name":"Wieslaw A. Kli\u015b","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wieslaw Klis","raw_affiliation_strings":["Department of Biochemistry, Medical College of Ohio at Toledo, CS 10008, Toledo, Ohio, 43699, USA","Department of Biochemistry, Medical College of Ohio at Toledo, Toledo, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Medical College of Ohio at Toledo, CS 10008, Toledo, Ohio, 43699, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry, Medical College of Ohio at Toledo, Toledo, USA","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102068984","display_name":"Aleksander M. Kolodziejczyk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aleksander Kolodziejczyk","raw_affiliation_strings":["Department of Biochemistry, Medical College of Ohio at Toledo, CS 10008, Toledo, Ohio, 43699, USA","Department of Biochemistry, Medical College of Ohio at Toledo, Toledo, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Medical College of Ohio at Toledo, CS 10008, Toledo, Ohio, 43699, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry, Medical College of Ohio at Toledo, Toledo, USA","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024212718","display_name":"Eleonora Nawrocka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eleonora Nawrocka","raw_affiliation_strings":["Department of Biochemistry, Medical College of Ohio at Toledo, CS 10008, Toledo, Ohio, 43699, USA","Department of Biochemistry, Medical College of Ohio at Toledo, Toledo, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Medical College of Ohio at Toledo, CS 10008, Toledo, Ohio, 43699, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry, Medical College of Ohio at Toledo, Toledo, USA","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037449952","display_name":"Aleksandra Misicka","orcid":"https://orcid.org/0000-0001-7446-2396","observed_orcids":["https://orcid.org/0000-0001-7446-2396"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aleksandra Misicka","raw_affiliation_strings":["Department of Biochemistry, Medical College of Ohio at Toledo, CS 10008, Toledo, Ohio, 43699, USA","Department of Biochemistry, Medical College of Ohio at Toledo, Toledo, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Medical College of Ohio at Toledo, CS 10008, Toledo, Ohio, 43699, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry, Medical College of Ohio at Toledo, Toledo, USA","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105211577","display_name":"Janny Seto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janny Seto","raw_affiliation_strings":["Department of Pharmacology, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, New York, New York, 10032, USA","Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York. USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, New York, New York, 10032, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York. USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109103296","display_name":"Wilbur H. Sawyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wilbur H. Sawyer","raw_affiliation_strings":["Department of Pharmacology, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, New York, New York, 10032, USA","Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York. USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, New York, New York, 10032, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York. USA","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":15.5555,"has_fulltext":false,"cited_by_count":91,"citation_normalized_percentile":{"value":0.99069903,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"308","issue":"5960","first_page":"652","last_page":"653"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.6425999999046326,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.6425999999046326,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.22050000727176666,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.06319999694824219,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vasopressin","display_name":"vasopressin","score":0.9380000233650208},{"id":"https://openalex.org/keywords/vasopressin-receptor-antagonists","display_name":"vasopressin receptor antagonists","score":0.9089999794960022},{"id":"https://openalex.org/keywords/vasopressor-activity","display_name":"vasopressor activity","score":0.7839999794960022},{"id":"https://openalex.org/keywords/antidiuretic-activity","display_name":"antidiuretic activity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/receptor-activation","display_name":"receptor activation","score":0.7070000171661377},{"id":"https://openalex.org/keywords/receptor-binding","display_name":"receptor binding","score":0.9200000166893005},{"id":"https://openalex.org/keywords/vasopressin-receptor","display_name":"vasopressin receptor","score":0.7210000157356262},{"id":"https://openalex.org/keywords/affinity-ligands","display_name":"affinity ligands","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C2776370428","wikidata":"https://www.wikidata.org/wiki/Q21124841","display_name":"Vasopressin","level":2,"score":0.9361212253570557},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.6992925405502319},{"id":"https://openalex.org/C2779420931","wikidata":"https://www.wikidata.org/wiki/Q4774696","display_name":"Antidiuretic","level":3,"score":0.6851573586463928},{"id":"https://openalex.org/C90474776","wikidata":"https://www.wikidata.org/wiki/Q24784390","display_name":"Vasopressin receptor","level":4,"score":0.6366399526596069},{"id":"https://openalex.org/C20352681","wikidata":"https://www.wikidata.org/wiki/Q14890035","display_name":"Arginine vasopressin receptor 2","level":4,"score":0.604590654373169},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5555772185325623},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5237029790878296},{"id":"https://openalex.org/C2777756961","wikidata":"https://www.wikidata.org/wiki/Q620730","display_name":"Glycine","level":3,"score":0.5232540369033813},{"id":"https://openalex.org/C90277851","wikidata":"https://www.wikidata.org/wiki/Q14890030","display_name":"Arginine vasopressin receptor 1B","level":5,"score":0.45868611335754395},{"id":"https://openalex.org/C2779881253","wikidata":"https://www.wikidata.org/wiki/Q1587028","display_name":"Vasopressin Antagonists","level":4,"score":0.45865532755851746},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45534783601760864},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4316480755805969},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.33599331974983215},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3171248733997345},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.29117274284362793},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2598331570625305},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21287992596626282}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001127","descriptor_name":"Arginine Vasopressin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D001127","descriptor_name":"Arginine Vasopressin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004231","descriptor_name":"Diuresis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/308652a0","doi":"https://doi.org/10.1038/308652a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/308652a0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:6709073","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6709073","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1968369855","https://openalex.org/W1991009311","https://openalex.org/W1991446640","https://openalex.org/W1991522711","https://openalex.org/W1996996770","https://openalex.org/W1998705738","https://openalex.org/W2001060581","https://openalex.org/W2011621580","https://openalex.org/W2025300532","https://openalex.org/W2046452564","https://openalex.org/W2057380338","https://openalex.org/W2070715552","https://openalex.org/W2080398954","https://openalex.org/W2089142602","https://openalex.org/W2089719236","https://openalex.org/W2327047986"],"related_works":["https://openalex.org/W2057068715","https://openalex.org/W1965916054","https://openalex.org/W2433513445","https://openalex.org/W154221056","https://openalex.org/W2051360140","https://openalex.org/W2023063483","https://openalex.org/W1998664058","https://openalex.org/W2083022501","https://openalex.org/W2019314934","https://openalex.org/W1969210555"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}