{"id":"https://openalex.org/W2008149648","doi":"https://doi.org/10.1073/pnas.78.9.5493","title":"Total synthesis of a RNA molecule with sequence identical to that of Escherichia coli formylmethionine tRNA.","display_name":"Total synthesis of a RNA molecule with sequence identical to that of Escherichia coli formylmethionine tRNA.","publication_year":1981,"publication_date":"1981-09-01","ids":{"openalex":"https://openalex.org/W2008149648","doi":"https://doi.org/10.1073/pnas.78.9.5493","mag":"2008149648","pmid":"https://pubmed.ncbi.nlm.nih.gov/7029537","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/348772"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.78.9.5493","doi":"https://doi.org/10.1073/pnas.78.9.5493","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.78.9.5493","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC348772","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111760550","display_name":"Eiko Ohtsuka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Ohtsuka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045630844","display_name":"Satoshi Tanaka","orcid":"https://orcid.org/0000-0002-3468-7694","observed_orcids":["https://orcid.org/0000-0002-3468-7694"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Tanaka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041636298","display_name":"Toshihiro Tanaka","orcid":"https://orcid.org/0000-0001-6201-9784","observed_orcids":["https://orcid.org/0000-0001-6201-9784"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Tanaka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"T Miyake","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Miyake","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112079404","display_name":"Alexander F. Markham","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A F Markham","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024343938","display_name":"Eiko Nakagawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Nakagawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"T Wakabayashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Wakabayashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082554675","display_name":"Yoshio Taniyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Taniyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058960117","display_name":"Satoshi Nishikawa","orcid":"https://orcid.org/0000-0003-0905-8615","observed_orcids":["https://orcid.org/0000-0003-0905-8615"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Nishikawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048669038","display_name":"Ryo Fukumoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Fukumoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018192888","display_name":"Haruki Uemura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Uemura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041382010","display_name":"Takefumi Doi","orcid":"https://orcid.org/0000-0003-1092-0700","observed_orcids":["https://orcid.org/0000-0003-1092-0700"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Doi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"T Tokunaga","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Tokunaga","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111648826","display_name":"Mono Ikehara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Ikehara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7773,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.83995437,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"78","issue":"9","first_page":"5493","last_page":"5497"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trnafmet","display_name":"tRNAfMet","score":0.7200000286102295},{"id":"https://openalex.org/keywords/enzymatic-ligation","display_name":"enzymatic ligation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/rna-ligase","display_name":"RNA ligase","score":0.9800000190734863},{"id":"https://openalex.org/keywords/phosphotriester-method","display_name":"phosphotriester method","score":0.7260000109672546},{"id":"https://openalex.org/keywords/polynucleotide-kinase","display_name":"polynucleotide kinase","score":0.7409999966621399},{"id":"https://openalex.org/keywords/phosphatase","display_name":"phosphatase","score":0.7680000066757202},{"id":"https://openalex.org/keywords/aminoacylation","display_name":"aminoacylation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/methionyl-trna-synthetase","display_name":"methionyl-tRNA synthetase","score":0.9769999980926514}],"concepts":[{"id":"https://openalex.org/C2909068217","wikidata":"https://www.wikidata.org/wiki/Q7277177","display_name":"RNA ligase","level":4,"score":0.9352034330368042},{"id":"https://openalex.org/C38441620","wikidata":"https://www.wikidata.org/wiki/Q863983","display_name":"Phosphodiester bond","level":4,"score":0.8063368201255798},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.7515698075294495},{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.749191164970398},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.6528567671775818},{"id":"https://openalex.org/C111921641","wikidata":"https://www.wikidata.org/wiki/Q80756","display_name":"Polynucleotide","level":2,"score":0.6098325848579407},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6042768955230713},{"id":"https://openalex.org/C151238385","wikidata":"https://www.wikidata.org/wiki/Q4746444","display_name":"Aminoacylation","level":5,"score":0.5949909687042236},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.513251543045044},{"id":"https://openalex.org/C175114707","wikidata":"https://www.wikidata.org/wiki/Q408483","display_name":"DNA ligase","level":3,"score":0.5079451203346252},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45860227942466736},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.423662006855011},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3836997151374817},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.37897789478302},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.335237592458725},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2231440544128418},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0835401713848114},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06628850102424622}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009239","descriptor_name":"N-Formylmethionine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010442","descriptor_name":"Peptide Chain Initiation, Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011130","descriptor_name":"RNA Ligase (ATP)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012343","descriptor_name":"RNA, Transfer","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.78.9.5493","doi":"https://doi.org/10.1073/pnas.78.9.5493","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.78.9.5493","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:240116","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC348772","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:7029537","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7029537","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:348772","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC348772/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:240116","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC348772","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W229794","https://openalex.org/W1965920068","https://openalex.org/W1970144391","https://openalex.org/W1970511608","https://openalex.org/W1996605502","https://openalex.org/W2006189853","https://openalex.org/W2008340551","https://openalex.org/W2012972361","https://openalex.org/W2014960849","https://openalex.org/W2024412145","https://openalex.org/W2034346811","https://openalex.org/W2038191381","https://openalex.org/W2046295974","https://openalex.org/W2056641750","https://openalex.org/W2060942798","https://openalex.org/W2062578054","https://openalex.org/W2064421540","https://openalex.org/W2072713437","https://openalex.org/W2080407833","https://openalex.org/W2086745635","https://openalex.org/W2107532401","https://openalex.org/W2143819593","https://openalex.org/W2325314501","https://openalex.org/W2330388051","https://openalex.org/W2331017116"],"related_works":["https://openalex.org/W2412444484","https://openalex.org/W1970511608","https://openalex.org/W2398249206","https://openalex.org/W2486312142","https://openalex.org/W2088025779","https://openalex.org/W2027288701","https://openalex.org/W2094677358","https://openalex.org/W2034346811","https://openalex.org/W2066070180","https://openalex.org/W2086549247"],"abstract_inverted_index":{"A":[0],"RNA":[1,66],"molecule":[2,70,84,89,101],"has":[3],"been":[4],"synthesized":[5,36,45,63],"that":[6,16],"is":[7],"identical":[8],"in":[9,23,77,136],"sequence":[10],"to":[11,98],"Escherichia":[12],"coli":[13,26,140],"tRNAfMet":[14],"except":[15],"it":[17],"lacks":[18],"the":[19,24,47,81,99,108],"base":[20],"modifications":[21],"present":[22],"E.":[25,139],"tRNA.":[27],"This":[28],"was":[29,92,103,127,133],"achieved":[30],"by":[31,46,59,105,119,129],"enzymatic":[32],"joining":[33,60,78],"of":[34,41,55,61,107],"chemically":[35,62],"oligonucleotides":[37],"with":[38,65,80,94,121,138],"chain":[39],"lengths":[40],"3-10":[42],"which":[43,102],"were":[44,57],"phosphodiester":[48],"or":[49],"phosphotriester":[50],"method.":[51],"First,":[52],"quarter":[53,110],"molecules":[54,111],"tRNA":[56,126],"constructed":[58],"fragments":[64],"ligase.":[67],"The":[68,87,124],"5'-quarter":[69],"(bases":[71,85,112],"1-20)":[72],"served":[73],"as":[74],"an":[75],"acceptor":[76],"reactions":[79],"3',5'-bisphosphorylated":[82],"donor":[83],"21-34).":[86],"5'-half":[88],"thus":[90],"obtained":[91],"treated":[93],"phosphatase":[95],"and":[96,132],"joined":[97],"3'-half":[100],"prepared":[104],"ligation":[106],"other":[109],"35-60,":[113],"acceptor;":[114],"bases":[115],"61-77,":[116],"donor)":[117],"followed":[118],"5'-phosphorylation":[120],"polynucleotide":[122],"kinase.":[123],"synthetic":[125],"characterized":[128],"oligonucleotide":[130],"pattern":[131],"partially":[134],"active":[135],"aminoacylation":[137],"methionyl-tRNA":[141],"synthetase.":[142]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
