{"id":"https://openalex.org/W2008149232","doi":"https://doi.org/10.1373/clinchem.2008.106427","title":"Reference Population and Marathon Runner Sera Assessed by Highly Sensitive Cardiac Troponin T and Commercial Cardiac Troponin T and I Assays","display_name":"Reference Population and Marathon Runner Sera Assessed by Highly Sensitive Cardiac Troponin T and Commercial Cardiac Troponin T and I Assays","publication_year":2008,"publication_date":"2008-11-07","ids":{"openalex":"https://openalex.org/W2008149232","doi":"https://doi.org/10.1373/clinchem.2008.106427","mag":"2008149232","pmid":"https://pubmed.ncbi.nlm.nih.gov/18988757"},"language":"en","primary_location":{"id":"doi:10.1373/clinchem.2008.106427","doi":"https://doi.org/10.1373/clinchem.2008.106427","is_oa":true,"landing_page_url":"https://doi.org/10.1373/clinchem.2008.106427","pdf_url":"https://academic.oup.com/clinchem/article-pdf/55/1/101/32872744/clinchem0101.pdf","source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/clinchem/article-pdf/55/1/101/32872744/clinchem0101.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033298453","display_name":"Alma M.A. Mingels","orcid":"https://orcid.org/0000-0002-4648-5053","observed_orcids":["https://orcid.org/0000-0002-4648-5053"]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800191616"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Alma Mingels","raw_affiliation_strings":["Department of Clinical Chemistry, University Hospital Maastricht, Maastricht, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, University Hospital Maastricht, Maastricht, the Netherlands","institution_ids":["https://openalex.org/I2800191616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101791039","display_name":"Leo H.J. Jacobs","orcid":"https://orcid.org/0000-0002-6635-5440","observed_orcids":["https://orcid.org/0000-0002-6635-5440"]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800191616"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Leo Jacobs","raw_affiliation_strings":["Department of Clinical Chemistry, University Hospital Maastricht, Maastricht, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, University Hospital Maastricht, Maastricht, the Netherlands","institution_ids":["https://openalex.org/I2800191616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023457086","display_name":"Etienne C. H. J. Michielsen","orcid":"https://orcid.org/0000-0001-6098-8872","observed_orcids":["https://orcid.org/0000-0001-6098-8872"]},"institutions":[{"id":"https://openalex.org/I4210116663","display_name":"VieCuri Medisch Centrum","ror":"https://ror.org/02kjpb485","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210116663"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Etienne Michielsen","raw_affiliation_strings":["Department of Clinical Chemistry and Haematology, VieCuri Medical Center, Venlo, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry and Haematology, VieCuri Medical Center, Venlo, the Netherlands","institution_ids":["https://openalex.org/I4210116663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060212774","display_name":"Joost C.J.M. Swaanenburg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116663","display_name":"VieCuri Medisch Centrum","ror":"https://ror.org/02kjpb485","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210116663"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Joost Swaanenburg","raw_affiliation_strings":["Department of Clinical Chemistry and Haematology, VieCuri Medical Center, Venlo, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry and Haematology, VieCuri Medical Center, Venlo, the Netherlands","institution_ids":["https://openalex.org/I4210116663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108644959","display_name":"Will K. W. H. Wodzig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800191616"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Will Wodzig","raw_affiliation_strings":["Department of Clinical Chemistry, University Hospital Maastricht, Maastricht, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, University Hospital Maastricht, Maastricht, the Netherlands","institution_ids":["https://openalex.org/I2800191616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080024907","display_name":"Marja P. van Dieijen\u2010Visser","orcid":"https://orcid.org/0000-0001-8327-0206","observed_orcids":["https://orcid.org/0000-0001-8327-0206"]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800191616"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Marja van Dieijen-Visser","raw_affiliation_strings":["Department of Clinical Chemistry, University Hospital Maastricht, Maastricht, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, University Hospital Maastricht, Maastricht, the Netherlands","institution_ids":["https://openalex.org/I2800191616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5080024907"],"corresponding_institution_ids":["https://openalex.org/I2800191616"],"apc_list":{"value":4636,"currency":"USD","value_usd":4636},"apc_paid":null,"fwci":16.9327,"has_fulltext":true,"cited_by_count":295,"citation_normalized_percentile":{"value":0.99381075,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"55","issue":"1","first_page":"101","last_page":"108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.8984000086784363,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.8984000086784363,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.08139999955892563,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-troponin-t","display_name":"cardiac troponin T","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cardiac-troponin-i","display_name":"cardiac troponin I","score":0.890999972820282},{"id":"https://openalex.org/keywords/high-sensitivity-cardiac-troponin","display_name":"high-sensitivity troponin","score":0.8939999938011169},{"id":"https://openalex.org/keywords/marathon-runners","display_name":"marathon runners","score":0.7760000228881836},{"id":"https://openalex.org/keywords/endurance-exercise","display_name":"endurance exercise","score":0.9819999933242798},{"id":"https://openalex.org/keywords/detection-limit","display_name":"detection limit","score":0.8209999799728394},{"id":"https://openalex.org/keywords/assay-performance-comparison","display_name":"assay performance comparison","score":0.5920000076293945},{"id":"https://openalex.org/keywords/reference-population","display_name":"reference population","score":0.7459999918937683},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C8880881","wikidata":"https://www.wikidata.org/wiki/Q7846262","display_name":"Troponin complex","level":4,"score":0.8576042652130127},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.6595616936683655},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6293942928314209},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5741124153137207},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5690892338752747},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5562119483947754},{"id":"https://openalex.org/C144469398","wikidata":"https://www.wikidata.org/wiki/Q24785650","display_name":"Troponin T","level":3,"score":0.5391547679901123},{"id":"https://openalex.org/C36036425","wikidata":"https://www.wikidata.org/wiki/Q7846262","display_name":"Troponin","level":3,"score":0.4664205014705658},{"id":"https://openalex.org/C2909597000","wikidata":"https://www.wikidata.org/wiki/Q212646","display_name":"Roche Diagnostics","level":2,"score":0.4542475640773773},{"id":"https://openalex.org/C122048520","wikidata":"https://www.wikidata.org/wiki/Q2913954","display_name":"Percentile","level":2,"score":0.41333839297294617},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006262","descriptor_name":"Health","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006262","descriptor_name":"Health","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006262","descriptor_name":"Health","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007118","descriptor_name":"Immunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007118","descriptor_name":"Immunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007118","descriptor_name":"Immunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012420","descriptor_name":"Running","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012420","descriptor_name":"Running","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012420","descriptor_name":"Running","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019210","descriptor_name":"Troponin I","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019210","descriptor_name":"Troponin I","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019210","descriptor_name":"Troponin I","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020107","descriptor_name":"Troponin T","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020107","descriptor_name":"Troponin T","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020107","descriptor_name":"Troponin T","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1373/clinchem.2008.106427","doi":"https://doi.org/10.1373/clinchem.2008.106427","is_oa":true,"landing_page_url":"https://doi.org/10.1373/clinchem.2008.106427","pdf_url":"https://academic.oup.com/clinchem/article-pdf/55/1/101/32872744/clinchem0101.pdf","source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},{"id":"pmid:18988757","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18988757","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1373/clinchem.2008.106427","doi":"https://doi.org/10.1373/clinchem.2008.106427","is_oa":true,"landing_page_url":"https://doi.org/10.1373/clinchem.2008.106427","pdf_url":"https://academic.oup.com/clinchem/article-pdf/55/1/101/32872744/clinchem0101.pdf","source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6600000262260437,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2008149232.pdf","grobid_xml":"https://content.openalex.org/works/W2008149232.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W132144188","https://openalex.org/W174286142","https://openalex.org/W1966329493","https://openalex.org/W1983613546","https://openalex.org/W1985704582","https://openalex.org/W1987044662","https://openalex.org/W1989864566","https://openalex.org/W1990134992","https://openalex.org/W1991461818","https://openalex.org/W2004476419","https://openalex.org/W2008891593","https://openalex.org/W2018213955","https://openalex.org/W2018465002","https://openalex.org/W2018588185","https://openalex.org/W2033699276","https://openalex.org/W2035712140","https://openalex.org/W2043233512","https://openalex.org/W2051495558","https://openalex.org/W2062615200","https://openalex.org/W2064991058","https://openalex.org/W2067665547","https://openalex.org/W2080385213","https://openalex.org/W2089325961","https://openalex.org/W2089586054","https://openalex.org/W2092028605","https://openalex.org/W2094872638","https://openalex.org/W2098655842","https://openalex.org/W2105629456","https://openalex.org/W2110511670","https://openalex.org/W2122563040","https://openalex.org/W2125352971","https://openalex.org/W2131110345","https://openalex.org/W2133869777","https://openalex.org/W2136109573","https://openalex.org/W2136578162","https://openalex.org/W2138210015","https://openalex.org/W2160278112","https://openalex.org/W2272962241","https://openalex.org/W2413535140","https://openalex.org/W2727252250","https://openalex.org/W3170020307"],"related_works":["https://openalex.org/W2013195452","https://openalex.org/W3152041689","https://openalex.org/W2082155590","https://openalex.org/W2402927453","https://openalex.org/W2334709023","https://openalex.org/W2157047587","https://openalex.org/W2058525629","https://openalex.org/W1993423515","https://openalex.org/W1863553834","https://openalex.org/W2069347095"],"abstract_inverted_index":{"BACKGROUND:":[0],"Endurance":[1],"exercise":[2],"can":[3],"increase":[4],"cardiac":[5,69,80],"troponin":[6,70,81],"(cTn)":[7],"concentrations":[8,33,130,133,169,187,194,219,240,251],"as":[9,11],"high":[10],"those":[12],"seen":[13],"in":[14,241],"cases":[15],"of":[16,22,43,50,95,101,127,143,149,157,164,182,216,246,261,285],"minor":[17],"myocardial":[18],"infarction.":[19],"The":[20,48,224,244,264,282],"inability":[21],"most":[23],"cTn":[24,29,55,129,193,218,239,250,280],"assays":[25,124],"to":[26,212,237],"reliably":[27],"quantify":[28],"at":[30,131,145],"very":[31],"low":[32,132],"complicates":[34],"a":[35,92,99,141,154,161,233,253],"thorough":[36],"data":[37],"analysis,":[38],"and":[39,77,98,122,153,210],"the":[40,65,78,108,111,120,137,146,150,158,165,172,176,183,189,198,201,228,267,270],"clinical":[41,283],"implications":[42,284],"such":[44],"increases":[45],"remain":[46],"unclear.":[47],"application":[49],"recently":[51],"developed":[52],"highly":[53,67,256],"sensitive":[54,68],"immunoassays":[56],"may":[57],"help":[58],"resolve":[59],"these":[60,286],"problems.":[61],"METHODS:":[62],"We":[63,105],"evaluated":[64],"precommercial":[66],"T":[71],"(hs-cTnT)":[72],"assay":[73,84,115,139,226,230,265],"from":[74,85,91],"Roche":[75],"Diagnostics":[76,87],"Architect":[79],"I":[82],"(cTnI-Architect)":[83],"Abbott":[86],"by":[88],"testing":[89],"samples":[90,109],"reference":[93,151],"population":[94,152],"546":[96],"individuals":[97],"cohort":[100],"85":[102],"marathon":[103,208,254],"runners.":[104],"also":[106],"measured":[107],"with":[110,175,188,232,248,266],"current":[112,190],"commercial":[113],"cTnT":[114,168,191],"for":[116],"comparison.":[117],"RESULTS:":[118],"Although":[119],"hs-cTnT":[121,138,177,225,271],"cTnI-Architect":[123],"were":[125],"capable":[126],"measuring":[128],"(<0.01":[134],"microg/L),":[135],"only":[136,180,229],"demonstrated":[140,207],"CV":[142],"<10%":[144],"99th":[147,173],"percentile":[148,174],"near-gaussian":[155],"distribution":[156],"measurements.":[159],"After":[160],"marathon,":[162],"86%":[163],"runners":[166,184,247,277],"had":[167,278],"greater":[170],"than":[171],"assay,":[178,272],"whereas":[179],"45%":[181],"showed":[185,273],"increased":[186,197,249,279],"assay.":[192],"remained":[195],"significantly":[196],"day":[199],"after":[200,252],"marathon.":[202],"A":[203],"multiple":[204],"regression":[205],"analysis":[206],"experience":[209],"age":[211],"be":[213],"significant":[214],"predictors":[215],"postmarathon":[217],"(P":[220],"<":[221],"0.05).":[222],"CONCLUSIONS:":[223],"was":[227],"tested":[231],"performance":[234],"capability":[235],"sufficient":[236],"detect":[238],"healthy":[242],"individuals.":[243],"number":[245],"depends":[255],"on":[257],"an":[258],"assay's":[259],"limit":[260],"detection":[262],"(LOD).":[263],"lowest":[268],"LOD,":[269],"that":[274],"almost":[275],"all":[276],"concentrations.":[281],"findings":[287],"require":[288],"further":[289],"investigation.":[290]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":22},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":25},{"year":2012,"cited_by_count":34}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}