{"id":"https://openalex.org/W2008129506","doi":"https://doi.org/10.1021/jm0308186","title":"Enantioselective Syntheses and Cytotoxicity of N,O-Nucleosides","display_name":"Enantioselective Syntheses and Cytotoxicity of N,O-Nucleosides","publication_year":2003,"publication_date":"2003-07-04","ids":{"openalex":"https://openalex.org/W2008129506","doi":"https://doi.org/10.1021/jm0308186","mag":"2008129506","pmid":"https://pubmed.ncbi.nlm.nih.gov/12904074"},"language":"he","primary_location":{"id":"doi:10.1021/jm0308186","doi":"https://doi.org/10.1021/jm0308186","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm0308186","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010395199","display_name":"Ugo Chiacchio","orcid":"https://orcid.org/0000-0002-3910-5999","observed_orcids":["https://orcid.org/0000-0002-3910-5999"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]},{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Ugo Chiacchio","raw_affiliation_strings":["Dipartimento di Scienze Chimiche, Universit\u00e0 di Catania, Viale Andrea Doria 6, Catania 95125, Italy, Dipartimento Farmaco-Chimico, Universit\u00e0 di Messina, Via SS. Annunziata, Messina 98168, Italy, and Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, Universit\u00e0 di Messina, Salita Sperone 31, Messina 98168, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Chimiche, Universit\u00e0 di Catania, Viale Andrea Doria 6, Catania 95125, Italy, Dipartimento Farmaco-Chimico, Universit\u00e0 di Messina, Via SS. Annunziata, Messina 98168, Italy, and Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, Universit\u00e0 di Messina, Salita Sperone 31, Messina 98168, Italy","institution_ids":["https://openalex.org/I112862951","https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052932521","display_name":"Antonino Corsaro","orcid":"https://orcid.org/0000-0002-0940-1172","observed_orcids":["https://orcid.org/0000-0002-0940-1172"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]},{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonino Corsaro","raw_affiliation_strings":["Dipartimento di Scienze Chimiche, Universit\u00e0 di Catania, Viale Andrea Doria 6, Catania 95125, Italy, Dipartimento Farmaco-Chimico, Universit\u00e0 di Messina, Via SS. Annunziata, Messina 98168, Italy, and Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, Universit\u00e0 di Messina, Salita Sperone 31, Messina 98168, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Chimiche, Universit\u00e0 di Catania, Viale Andrea Doria 6, Catania 95125, Italy, Dipartimento Farmaco-Chimico, Universit\u00e0 di Messina, Via SS. Annunziata, Messina 98168, Italy, and Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, Universit\u00e0 di Messina, Salita Sperone 31, Messina 98168, Italy","institution_ids":["https://openalex.org/I112862951","https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016970014","display_name":"Daniela Iannazzo","orcid":"https://orcid.org/0000-0003-2190-0035","observed_orcids":["https://orcid.org/0000-0003-2190-0035"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]},{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniela Iannazzo","raw_affiliation_strings":["Dipartimento di Scienze Chimiche, Universit\u00e0 di Catania, Viale Andrea Doria 6, Catania 95125, Italy, Dipartimento Farmaco-Chimico, Universit\u00e0 di Messina, Via SS. Annunziata, Messina 98168, Italy, and Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, Universit\u00e0 di Messina, Salita Sperone 31, Messina 98168, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Chimiche, Universit\u00e0 di Catania, Viale Andrea Doria 6, Catania 95125, Italy, Dipartimento Farmaco-Chimico, Universit\u00e0 di Messina, Via SS. Annunziata, Messina 98168, Italy, and Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, Universit\u00e0 di Messina, Salita Sperone 31, Messina 98168, Italy","institution_ids":["https://openalex.org/I112862951","https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047026747","display_name":"Anna Piperno","orcid":"https://orcid.org/0000-0001-6004-5196","observed_orcids":["https://orcid.org/0000-0001-6004-5196"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]},{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Piperno","raw_affiliation_strings":["Dipartimento di Scienze Chimiche, Universit\u00e0 di Catania, Viale Andrea Doria 6, Catania 95125, Italy, Dipartimento Farmaco-Chimico, Universit\u00e0 di Messina, Via SS. Annunziata, Messina 98168, Italy, and Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, Universit\u00e0 di Messina, Salita Sperone 31, Messina 98168, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Chimiche, Universit\u00e0 di Catania, Viale Andrea Doria 6, Catania 95125, Italy, Dipartimento Farmaco-Chimico, Universit\u00e0 di Messina, Via SS. Annunziata, Messina 98168, Italy, and Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, Universit\u00e0 di Messina, Salita Sperone 31, Messina 98168, Italy","institution_ids":["https://openalex.org/I112862951","https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062370914","display_name":"Venerando Pistar\u00e0","orcid":"https://orcid.org/0000-0003-2689-9272","observed_orcids":["https://orcid.org/0000-0003-2689-9272"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]},{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Venerando Pistar\u00e0","raw_affiliation_strings":["Dipartimento di Scienze Chimiche, Universit\u00e0 di Catania, Viale Andrea Doria 6, Catania 95125, Italy, Dipartimento Farmaco-Chimico, Universit\u00e0 di Messina, Via SS. Annunziata, Messina 98168, Italy, and Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, Universit\u00e0 di Messina, Salita Sperone 31, Messina 98168, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Chimiche, Universit\u00e0 di Catania, Viale Andrea Doria 6, Catania 95125, Italy, Dipartimento Farmaco-Chimico, Universit\u00e0 di Messina, Via SS. Annunziata, Messina 98168, Italy, and Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, Universit\u00e0 di Messina, Salita Sperone 31, Messina 98168, Italy","institution_ids":["https://openalex.org/I112862951","https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057685383","display_name":"Antonio Rescifina","orcid":"https://orcid.org/0000-0001-5039-2151","observed_orcids":["https://orcid.org/0000-0001-5039-2151"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]},{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Rescifina","raw_affiliation_strings":["Dipartimento di Scienze Chimiche, Universit\u00e0 di Catania, Viale Andrea Doria 6, Catania 95125, Italy, Dipartimento Farmaco-Chimico, Universit\u00e0 di Messina, Via SS. Annunziata, Messina 98168, Italy, and Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, Universit\u00e0 di Messina, Salita Sperone 31, Messina 98168, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Chimiche, Universit\u00e0 di Catania, Viale Andrea Doria 6, Catania 95125, Italy, Dipartimento Farmaco-Chimico, Universit\u00e0 di Messina, Via SS. Annunziata, Messina 98168, Italy, and Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, Universit\u00e0 di Messina, Salita Sperone 31, Messina 98168, Italy","institution_ids":["https://openalex.org/I112862951","https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020492506","display_name":"Roberto Romeo","orcid":"https://orcid.org/0000-0002-0745-0763","observed_orcids":["https://orcid.org/0000-0002-0745-0763"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]},{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Romeo","raw_affiliation_strings":["Dipartimento di Scienze Chimiche, Universit\u00e0 di Catania, Viale Andrea Doria 6, Catania 95125, Italy, Dipartimento Farmaco-Chimico, Universit\u00e0 di Messina, Via SS. Annunziata, Messina 98168, Italy, and Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, Universit\u00e0 di Messina, Salita Sperone 31, Messina 98168, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Chimiche, Universit\u00e0 di Catania, Viale Andrea Doria 6, Catania 95125, Italy, Dipartimento Farmaco-Chimico, Universit\u00e0 di Messina, Via SS. Annunziata, Messina 98168, Italy, and Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, Universit\u00e0 di Messina, Salita Sperone 31, Messina 98168, Italy","institution_ids":["https://openalex.org/I112862951","https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074088500","display_name":"Vincenza Valveri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]},{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vincenza Valveri","raw_affiliation_strings":["Dipartimento di Scienze Chimiche, Universit\u00e0 di Catania, Viale Andrea Doria 6, Catania 95125, Italy, Dipartimento Farmaco-Chimico, Universit\u00e0 di Messina, Via SS. Annunziata, Messina 98168, Italy, and Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, Universit\u00e0 di Messina, Salita Sperone 31, Messina 98168, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Chimiche, Universit\u00e0 di Catania, Viale Andrea Doria 6, Catania 95125, Italy, Dipartimento Farmaco-Chimico, Universit\u00e0 di Messina, Via SS. Annunziata, Messina 98168, Italy, and Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, Universit\u00e0 di Messina, Salita Sperone 31, Messina 98168, Italy","institution_ids":["https://openalex.org/I112862951","https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081390371","display_name":"Antonio Mastino","orcid":"https://orcid.org/0000-0002-0338-6450","observed_orcids":["https://orcid.org/0000-0002-0338-6450"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]},{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Mastino","raw_affiliation_strings":["Dipartimento di Scienze Chimiche, Universit\u00e0 di Catania, Viale Andrea Doria 6, Catania 95125, Italy, Dipartimento Farmaco-Chimico, Universit\u00e0 di Messina, Via SS. Annunziata, Messina 98168, Italy, and Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, Universit\u00e0 di Messina, Salita Sperone 31, Messina 98168, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Chimiche, Universit\u00e0 di Catania, Viale Andrea Doria 6, Catania 95125, Italy, Dipartimento Farmaco-Chimico, Universit\u00e0 di Messina, Via SS. Annunziata, Messina 98168, Italy, and Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, Universit\u00e0 di Messina, Salita Sperone 31, Messina 98168, Italy","institution_ids":["https://openalex.org/I112862951","https://openalex.org/I39063666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103853009","display_name":"Giovanni Romeo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]},{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Romeo","raw_affiliation_strings":["Dipartimento di Scienze Chimiche, Universit\u00e0 di Catania, Viale Andrea Doria 6, Catania 95125, Italy, Dipartimento Farmaco-Chimico, Universit\u00e0 di Messina, Via SS. Annunziata, Messina 98168, Italy, and Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, Universit\u00e0 di Messina, Salita Sperone 31, Messina 98168, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Chimiche, Universit\u00e0 di Catania, Viale Andrea Doria 6, Catania 95125, Italy, Dipartimento Farmaco-Chimico, Universit\u00e0 di Messina, Via SS. Annunziata, Messina 98168, Italy, and Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, Universit\u00e0 di Messina, Salita Sperone 31, Messina 98168, Italy","institution_ids":["https://openalex.org/I112862951","https://openalex.org/I39063666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010395199"],"corresponding_institution_ids":["https://openalex.org/I112862951","https://openalex.org/I39063666"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.3296,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.89145381,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"46","issue":"17","first_page":"3696","last_page":"3702"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.6547999978065491,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.6547999978065491,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.12890000641345978,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.05490000173449516,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asymmetric-synthesis","display_name":"asymmetric synthesis","score":0.9229999780654907},{"id":"https://openalex.org/keywords/1-3-dipolar-cycloaddition","display_name":"1,3-dipolar cycloaddition","score":0.9589999914169312},{"id":"https://openalex.org/keywords/chiral-nitrones","display_name":"chiral nitrones","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9010000228881836},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/lymphoid-cells","display_name":"lymphoid cells","score":0.6610000133514404},{"id":"https://openalex.org/keywords/monocytoid-cells","display_name":"monocytoid cells","score":0.9340000152587891},{"id":"https://openalex.org/keywords/antiviral-nucleoside-analogues","display_name":"antiviral nucleosides","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.9157642722129822},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8775857090950012},{"id":"https://openalex.org/C2779440280","wikidata":"https://www.wikidata.org/wiki/Q415778","display_name":"Nitrone","level":4,"score":0.6893100738525391},{"id":"https://openalex.org/C146686406","wikidata":"https://www.wikidata.org/wiki/Q898628","display_name":"Enantioselective synthesis","level":3,"score":0.6694243550300598},{"id":"https://openalex.org/C164718446","wikidata":"https://www.wikidata.org/wiki/Q7234839","display_name":"Potentiator","level":2,"score":0.6290674209594727},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6266494989395142},{"id":"https://openalex.org/C2779321679","wikidata":"https://www.wikidata.org/wiki/Q207722","display_name":"Pyrimidine","level":2,"score":0.5375691652297974},{"id":"https://openalex.org/C486523","wikidata":"https://www.wikidata.org/wiki/Q494483","display_name":"Enantiomer","level":2,"score":0.5240949988365173},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5136711001396179},{"id":"https://openalex.org/C2779664164","wikidata":"https://www.wikidata.org/wiki/Q898648","display_name":"Cycloaddition","level":3,"score":0.4589259922504425},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.322098970413208},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3028959035873413},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.13847440481185913},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D008221","descriptor_name":"Lymphoid Tissue","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011789","descriptor_name":"Quantum Theory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014529","descriptor_name":"Uridine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014529","descriptor_name":"Uridine","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D014529","descriptor_name":"Uridine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014529","descriptor_name":"Uridine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D015224","descriptor_name":"Dideoxynucleosides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D015224","descriptor_name":"Dideoxynucleosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015224","descriptor_name":"Dideoxynucleosides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053181","descriptor_name":"Caspase 8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053453","descriptor_name":"Caspase 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061945","descriptor_name":"Caspase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm0308186","doi":"https://doi.org/10.1021/jm0308186","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm0308186","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:12904074","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12904074","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1974893611","https://openalex.org/W2000010984","https://openalex.org/W2000947228","https://openalex.org/W2009939661","https://openalex.org/W2017436619","https://openalex.org/W2057941171","https://openalex.org/W2084592796","https://openalex.org/W2329146235","https://openalex.org/W2952922574","https://openalex.org/W2953375859","https://openalex.org/W4213183351"],"related_works":["https://openalex.org/W2517623451","https://openalex.org/W2156246573","https://openalex.org/W2024865008","https://openalex.org/W2080878916","https://openalex.org/W2014835401","https://openalex.org/W2059105063","https://openalex.org/W2176090539","https://openalex.org/W2953115897","https://openalex.org/W1997305621","https://openalex.org/W2949533701"],"abstract_inverted_index":{"Enantiomers":[0],"of":[1,14,17,34,40,52],"4'-aza-2',3'-dideoxynucleosides":[2],"have":[3,25],"been":[4,26],"prepared":[5],"by":[6],"two":[7],"different":[8],"synthetic":[9],"approaches,":[10],"on":[11,42],"the":[12],"basis":[13],"1,3-dipolar":[15],"cycloaddition":[16],"a":[18,37,49],"chiral":[19],"nitrone.":[20],"Cytotoxicity":[21],"and":[22,44],"apoptotic":[23],"activity":[24],"investigated.":[27],"(5'S)-5-Fluoro-1-isoxazolidin-5-yl-1H-pyrimidine-2,4-dione":[28],"[(-)-AdFU],":[29],"while":[30],"showing":[31],"low":[32],"level":[33],"cytotoxicity,":[35],"is":[36],"good":[38],"inductor":[39],"apoptosis":[41],"lymphoid":[43],"monocytoid":[45],"cells,":[46],"acting":[47],"as":[48],"strong":[50],"potentiator":[51],"Fas-induced":[53],"cell":[54],"death.":[55]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
