{"id":"https://openalex.org/W2008062018","doi":"https://doi.org/10.1111/j.1476-5381.1992.tb12752.x","title":"Nitric oxide synthase responsible for l \u2010arginine\u2010induced relaxation of rat aortic rings in vitro may be an inducible type","display_name":"Nitric oxide synthase responsible for l \u2010arginine\u2010induced relaxation of rat aortic rings in vitro may be an inducible type","publication_year":1992,"publication_date":"1992-10-01","ids":{"openalex":"https://openalex.org/W2008062018","doi":"https://doi.org/10.1111/j.1476-5381.1992.tb12752.x","mag":"2008062018","pmid":"https://pubmed.ncbi.nlm.nih.gov/1384911","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1907878"},"language":"en","primary_location":{"id":"doi:10.1111/j.1476-5381.1992.tb12752.x","doi":"https://doi.org/10.1111/j.1476-5381.1992.tb12752.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1992.tb12752.x","pdf_url":null,"source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1907878/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111655310","display_name":"Hideki Moritoki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideki Moritoki","raw_affiliation_strings":["Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokushima, Japan","Department of Chemical Pharmacology. Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi, Tokushima 770, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"Department of Chemical Pharmacology. Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi, Tokushima 770, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111642511","display_name":"Shougo Takeuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shougo Takeuchi","raw_affiliation_strings":["Department of Chemical Pharmacology. Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi, Tokushima 770, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Pharmacology. Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi, Tokushima 770, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008213951","display_name":"Tetsuhiro Hisayama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuhiro Hisayama","raw_affiliation_strings":["Department of Chemical Pharmacology. Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi, Tokushima 770, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Pharmacology. Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi, Tokushima 770, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065908512","display_name":"Wataru Kondoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Wataru Kondoh","raw_affiliation_strings":["Department of Chemical Pharmacology. Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi, Tokushima 770, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Pharmacology. Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi, Tokushima 770, Japan","institution_ids":["https://openalex.org/I922474255"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I922474255"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":2.3085,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.89568472,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"107","issue":"2","first_page":"361","last_page":"366"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9359999895095825},{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.9470000267028809},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.7889999747276306},{"id":"https://openalex.org/keywords/aortic-relaxation","display_name":"aortic relaxation","score":0.796999990940094},{"id":"https://openalex.org/keywords/thoracic-aorta","display_name":"thoracic aorta","score":0.7760000228881836},{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":0.9599999785423279},{"id":"https://openalex.org/keywords/endothelium-independent-relaxation","display_name":"endothelium-independent relaxation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.8240000009536743},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.9639999866485596},{"id":"https://openalex.org/keywords/dactinomycin","display_name":"actinomycin D","score":0.9919999837875366},{"id":"https://openalex.org/keywords/polymyxin-b","display_name":"polymyxin B","score":0.9940000176429749},{"id":"https://openalex.org/keywords/protein-synthesis-inhibition","display_name":"protein synthesis inhibition","score":0.640999972820282},{"id":"https://openalex.org/keywords/vascular-smooth-muscle","display_name":"vascular smooth muscle","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.8326427340507507},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.6946233510971069},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6662760376930237},{"id":"https://openalex.org/C2780994212","wikidata":"https://www.wikidata.org/wiki/Q422511","display_name":"Cyclic guanosine monophosphate","level":3,"score":0.5757403373718262},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5599913597106934},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.48672106862068176},{"id":"https://openalex.org/C2778010969","wikidata":"https://www.wikidata.org/wiki/Q7041453","display_name":"Nitroarginine","level":4,"score":0.4430539309978485},{"id":"https://openalex.org/C2780310817","wikidata":"https://www.wikidata.org/wiki/Q5376433","display_name":"Endothelium-derived relaxing factor","level":3,"score":0.42210283875465393},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.41749876737594604},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4056892395019531},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3939630091190338},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3252009153366089},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24898046255111694},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20433461666107178},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.13728183507919312}],"mesh":[{"descriptor_ui":"D000594","descriptor_name":"Amino Acid Oxidoreductases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001013","descriptor_name":"Aorta, Thoracic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001013","descriptor_name":"Aorta, Thoracic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003609","descriptor_name":"Dactinomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009126","descriptor_name":"Muscle Relaxation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010656","descriptor_name":"Phenylephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1476-5381.1992.tb12752.x","doi":"https://doi.org/10.1111/j.1476-5381.1992.tb12752.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1992.tb12752.x","pdf_url":null,"source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:1384911","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1384911","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1907878","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1907878/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1907878","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1907878/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.428600013256073}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309791","display_name":"Suzuken Memorial Foundation","ror":"https://ror.org/03yvcwz92"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1602113709","https://openalex.org/W1950953658","https://openalex.org/W1975644913","https://openalex.org/W1975982125","https://openalex.org/W1981046160","https://openalex.org/W1983925881","https://openalex.org/W1985839335","https://openalex.org/W1991143553","https://openalex.org/W1994410300","https://openalex.org/W2002019101","https://openalex.org/W2007737411","https://openalex.org/W2016880240","https://openalex.org/W2024862570","https://openalex.org/W2029726170","https://openalex.org/W2037768305","https://openalex.org/W2044263892","https://openalex.org/W2046514939","https://openalex.org/W2048635427","https://openalex.org/W2049048252","https://openalex.org/W2051031104","https://openalex.org/W2051116387","https://openalex.org/W2051927334","https://openalex.org/W2053289392","https://openalex.org/W2054442780","https://openalex.org/W2057025197","https://openalex.org/W2060243949","https://openalex.org/W2060352273","https://openalex.org/W2069298277","https://openalex.org/W2073030710","https://openalex.org/W2081045088","https://openalex.org/W2081759103","https://openalex.org/W2088355754","https://openalex.org/W2091637715","https://openalex.org/W2092145002","https://openalex.org/W2095104103","https://openalex.org/W2108771207","https://openalex.org/W2126215854","https://openalex.org/W2142975032","https://openalex.org/W2152390419","https://openalex.org/W2162455056","https://openalex.org/W2169182236","https://openalex.org/W3100575680","https://openalex.org/W4229841386"],"related_works":["https://openalex.org/W2054442780","https://openalex.org/W2424867661","https://openalex.org/W2088576621","https://openalex.org/W1967288671","https://openalex.org/W1932483871","https://openalex.org/W2083565776","https://openalex.org/W2054425467","https://openalex.org/W2086636212","https://openalex.org/W2021315250","https://openalex.org/W3139801036"],"abstract_inverted_index":{"1.":[0],"Characteristics":[1],"of":[2,24,45,94,137,146,157,165,179,192],"L-arginine-induced":[3,95,106],"non-endothelial":[4,148],"nitric":[5],"oxide":[6],"(NO)":[7],"formation":[8,121],"in":[9,20,53,73,100,118,132,141],"rat":[10],"isolated":[11,134],"thoracic":[12,135],"aorta":[13,136],"were":[14],"investigated.":[15],"2.":[16],"Relaxation":[17],"to":[18,55,75,79,122,162],"L-arginine":[19,35,77,161,196],"arterial":[21],"rings":[22],"devoid":[23],"endothelium":[25],"developed":[26],"about":[27],"2":[28],"h":[29,44],"after":[30,40],"the":[31,49,92,114,133,138,142,166,186,190],"first":[32],"challenge":[33],"with":[34],"and":[36,88,97,116,172],"reached":[37],"a":[38,41,147],"maximum":[39],"further":[42],"4":[43],"incubation.":[46],"3.":[47],"After":[48],"arteries":[50,67,167],"had":[51,69],"relaxed":[52,72],"response":[54,74],"L-arginine,":[56,76],"guanosine":[57],"3':5'-cyclic":[58],"monophosphate":[59],"(cyclic":[60],"GMP)":[61],"production":[62,156,191],"was":[63],"stimulated.":[64],"In":[65],"fresh":[66],"that":[68,131,185],"not":[70],"yet":[71],"failed":[78],"elevate":[80],"cyclic":[81,101,119,169],"GMP":[82,102,120],"levels.":[83],"4.":[84],"Glucocorticoids,":[85],"actinomycin":[86],"D":[87],"polymyxin":[89],"B":[90],"prevented":[91],"development":[93],"relaxation":[96,107,115,164],"L-arginine-stimulated":[98],"increase":[99,117],"formation.":[103],"5.":[104],"Once":[105],"developed,":[108],"these":[109,126],"agents":[110],"no":[111],"longer":[112],"suppressed":[113],"L-arginine.":[123],"6.":[124],"From":[125],"results,":[127],"it":[128],"is":[129,183,197],"suggested":[130,184],"rat,":[139],"endotoxin":[140],"medium":[143],"triggers":[144],"induction":[145,178],"NO":[149,158,180,187,194],"synthase":[150,188],"during":[151],"prolonged":[152],"incubation,":[153],"which":[154],"accelerates":[155],"from":[159,195],"added":[160],"cause":[163],"via":[168],"GMP.":[170],"Glucocorticoids":[171],"protein":[173],"synthesis":[174],"inhibitors":[175],"may":[176],"prevent":[177],"synthase.":[181],"It":[182],"mediating":[189],"muscle-derived":[193],"an":[198],"inducible":[199],"type.":[200]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
