{"id":"https://openalex.org/W2008050996","doi":"https://doi.org/10.1002/aja.1002030110","title":"Inhibitory effects of ouabain on early heart development and cardiomyogenesis in the chick embryo","display_name":"Inhibitory effects of ouabain on early heart development and cardiomyogenesis in the chick embryo","publication_year":1995,"publication_date":"1995-05-01","ids":{"openalex":"https://openalex.org/W2008050996","doi":"https://doi.org/10.1002/aja.1002030110","mag":"2008050996","pmid":"https://pubmed.ncbi.nlm.nih.gov/7647377"},"language":"en","primary_location":{"id":"doi:10.1002/aja.1002030110","doi":"https://doi.org/10.1002/aja.1002030110","is_oa":false,"landing_page_url":"https://doi.org/10.1002/aja.1002030110","pdf_url":null,"source":{"id":"https://openalex.org/S104993753","display_name":"Developmental Dynamics","issn_l":"1058-8388","issn":["1058-8388","1097-0177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Dynamics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073030423","display_name":"K\u00e9rsti K. Linask","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kersti K. Linask","raw_affiliation_strings":["Division of Cardiology, Children's Hospital of Philadelphia, Pennsylvania, USA","Division of Cardiology, The Children's Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104\u20134399"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Children's Hospital of Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Division of Cardiology, The Children's Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104\u20134399","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102008644","display_name":"Yonghao Gui","orcid":"https://orcid.org/0000-0002-4302-8375","observed_orcids":["https://orcid.org/0000-0002-4302-8375"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong\u2010Hao Gui","raw_affiliation_strings":["Division of Cardiology, The Children's Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104\u20134399"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, The Children's Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104\u20134399","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073030423"],"corresponding_institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":0.5196,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.56651157,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"203","issue":"1","first_page":"93","last_page":"105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ouabain","display_name":"ouabain","score":0.9990000128746033},{"id":"https://openalex.org/keywords/na-k-atpase","display_name":"Na+/K+-ATPase","score":0.8529999852180481},{"id":"https://openalex.org/keywords/sodium-pump-inhibition","display_name":"sodium pump inhibition","score":0.7799999713897705},{"id":"https://openalex.org/keywords/heart-development","display_name":"heart development","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cardiomyogenesis","display_name":"cardiomyogenesis","score":0.996999979019165},{"id":"https://openalex.org/keywords/cardiac-progenitor-cells","display_name":"cardiac progenitor cells","score":0.7350000143051147},{"id":"https://openalex.org/keywords/chick-embryo","display_name":"chick embryo","score":0.8640000224113464},{"id":"https://openalex.org/keywords/potassium-levels","display_name":"potassium concentration","score":0.4779999852180481},{"id":"https://openalex.org/keywords/rostrocaudal-gradient","display_name":"rostrocaudal gradient","score":0.777999997138977},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.41100001335144043}],"concepts":[{"id":"https://openalex.org/C2779133857","wikidata":"https://www.wikidata.org/wiki/Q285911","display_name":"Ouabain","level":3,"score":0.8903796672821045},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7077697515487671},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.6976088881492615},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.64728844165802},{"id":"https://openalex.org/C62425271","wikidata":"https://www.wikidata.org/wiki/Q14819288","display_name":"Heart development","level":4,"score":0.5050552487373352},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5020673274993896},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4887404441833496},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47488468885421753},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.3859061002731323},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3498092293739319},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20001435279846191},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.17244139313697815},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.13491743803024292},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05562853813171387},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000254","descriptor_name":"Sodium-Potassium-Exchanging ATPase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010042","descriptor_name":"Ouabain","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/aja.1002030110","doi":"https://doi.org/10.1002/aja.1002030110","is_oa":false,"landing_page_url":"https://doi.org/10.1002/aja.1002030110","pdf_url":null,"source":{"id":"https://openalex.org/S104993753","display_name":"Developmental Dynamics","issn_l":"1058-8388","issn":["1058-8388","1097-0177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Dynamics","raw_type":"journal-article"},{"id":"pmid:7647377","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7647377","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental dynamics : an official publication of the American Association of Anatomists","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7654813495","display_name":"N-CADHERIN IN EARLY HEART DEVELOPMENT","funder_award_id":"R29HL048746","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W19106316","https://openalex.org/W577335907","https://openalex.org/W1502488818","https://openalex.org/W1513205519","https://openalex.org/W1519072726","https://openalex.org/W1532893533","https://openalex.org/W1829700783","https://openalex.org/W1966805132","https://openalex.org/W1971927370","https://openalex.org/W1976094538","https://openalex.org/W1995187583","https://openalex.org/W1999730737","https://openalex.org/W2012208570","https://openalex.org/W2012928837","https://openalex.org/W2018640534","https://openalex.org/W2020597782","https://openalex.org/W2025453353","https://openalex.org/W2029172751","https://openalex.org/W2036530906","https://openalex.org/W2064729604","https://openalex.org/W2074404562","https://openalex.org/W2075115547","https://openalex.org/W2088591870","https://openalex.org/W2106000284","https://openalex.org/W2111072594","https://openalex.org/W2112055017","https://openalex.org/W2112431248","https://openalex.org/W2140034535","https://openalex.org/W2153339926","https://openalex.org/W2153713699","https://openalex.org/W2159999909","https://openalex.org/W2171854519","https://openalex.org/W2185613772","https://openalex.org/W2412420976"],"related_works":["https://openalex.org/W1571901793","https://openalex.org/W2471921560","https://openalex.org/W2053601630","https://openalex.org/W2004638168","https://openalex.org/W2077588479","https://openalex.org/W7100748248","https://openalex.org/W1966680761","https://openalex.org/W2070178580","https://openalex.org/W2049414505","https://openalex.org/W1905759801"],"abstract_inverted_index":{"Pericardial":[0],"cavity":[1,80],"formation":[2,81,87,223],"and":[3,22,29,59,131,178],"epithelialization":[4],"of":[5,37,72,110,118,148,211,221,224,232],"the":[6,27,34,44,70,108,111,146,158,187,194,200,219,222,225],"cardiac":[7,19,89],"precursor":[8,31],"cell":[9,20,90],"population":[10,32],"constitute":[11],"a":[12,151],"critical":[13],"developmental":[14,179],"period":[15],"that":[16,128,218],"precedes":[17],"stable":[18],"commitment":[21,91],"differentiation.":[23],"These":[24],"events":[25],"delineate":[26],"myocardial":[28],"endocardial":[30],"in":[33,57,60,83,100,107,193],"embryo.":[35],"Restriction":[36],"Na/K-ATPase":[38,52,114],"(the":[39],"sodium":[40,74],"pump)":[41],"expression":[42],"to":[43,67,105,121,160],"pre-cardiomyocyte":[45],"lateral":[46],"membranes":[47],"coincides":[48],"with":[49],"these":[50],"events.":[51],"has":[53],"been":[54],"implicated":[55],"developmentally":[56],"cavitation":[58],"maintaining":[61],"membrane":[62],"potential.":[63],"Experiments":[64],"were":[65],"undertaken":[66],"determine":[68],"if":[69],"effects":[71],"perturbing":[73],"pump":[75],"activity":[76],"will":[77,92],"affect":[78],"pericardial":[79],"and,":[82],"turn,":[84],"whether":[85],"heart":[86,129,170],"and/or":[88],"be":[93],"affected.":[94],"We":[95],"incubated":[96],"whole":[97,119],"chick":[98],"embryos":[99,120,201],"vitro":[101],"between":[102,137],"stages":[103],"5":[104,139],"8":[106,165],"presence":[109],"highly":[112],"specific":[113],"inhibitor":[115],"ouabain.":[116],"Exposure":[117],"10":[122],"microM":[123],"ouabain":[124,166,206,212],"(10(-5)":[125],"M)":[126],"demonstrated":[127],"development":[130,155,171],"precardiomyocyte":[132],"differentiation":[133],"are":[134],"inhibited":[135],"principally":[136],"stage":[138,141,145,164],"through":[140],"7.":[142],"In":[143],"each":[144],"degree":[147],"inhibition":[149,175,182],"follows":[150],"rostrocaudal":[152],"gradient":[153],"as":[154],"proceeds":[156],"along":[157],"anterior":[159],"posterior":[161],"axis.":[162],"After":[163],"no":[167],"longer":[168],"affects":[169],"or":[172,197],"cardiomyogenesis.":[173],"The":[174,181,214],"is":[176,183,228],"concentration-":[177],"stage-dependent.":[180],"reversible":[184],"by":[185,198],"elevating":[186],"outside":[188],"potassium":[189],"ion":[190],"concentration":[191],"[Ko]":[192],"culture":[195],"medium":[196,204],"transferring":[199],"into":[202],"normal":[203],"minus":[205],"even":[207],"after":[208],"20":[209],"hr":[210],"exposure.":[213],"results":[215],"also":[216],"suggest":[217],"regulation":[220,231],"three-dimensional":[226],"organ":[227],"independent":[229],"from":[230],"myogenesis.":[233]},"counts_by_year":[{"year":2018,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
