{"id":"https://openalex.org/W2008046763","doi":"https://doi.org/10.1158/1538-7445.am2012-2465","title":"Abstract 2465: Matrix metalloproteinase 9 promotes breast cancer through regulation of insulin-like growth factor-binding proteins","display_name":"Abstract 2465: Matrix metalloproteinase 9 promotes breast cancer through regulation of insulin-like growth factor-binding proteins","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W2008046763","doi":"https://doi.org/10.1158/1538-7445.am2012-2465","mag":"2008046763"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2012-2465","doi":"https://doi.org/10.1158/1538-7445.am2012-2465","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-2465","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jae-Hyun Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jae-Hyun Park","raw_affiliation_strings":["1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY","institution_ids":["https://openalex.org/I2750212522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050180369","display_name":"Morten Gr\u00f8nbech Rasch","orcid":"https://orcid.org/0000-0003-4319-4338","observed_orcids":["https://orcid.org/0000-0003-4319-4338"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Morten Gr\u00f8nbech Rasch","raw_affiliation_strings":["2The Finsen Laboratory, Copenhagen N., Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2The Finsen Laboratory, Copenhagen N., Denmark","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057638577","display_name":"Jing Qiu","orcid":"https://orcid.org/0000-0003-4202-7802","observed_orcids":["https://orcid.org/0000-0003-4202-7802","https://orcid.org/0000-0002-0697-9315"]},"institutions":[{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Qiu","raw_affiliation_strings":["1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY","institution_ids":["https://openalex.org/I2750212522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091115867","display_name":"Ida Katrine Lund","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ida Katrine Lund","raw_affiliation_strings":["2The Finsen Laboratory, Copenhagen N., Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2The Finsen Laboratory, Copenhagen N., Denmark","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048523154","display_name":"Zena Werb","orcid":"https://orcid.org/0000-0002-6525-3872","observed_orcids":["https://orcid.org/0000-0002-6525-3872"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zena Werb","raw_affiliation_strings":["3Department of Anatomy, University of California San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Anatomy, University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006671000","display_name":"Mikala Egeblad","orcid":"https://orcid.org/0000-0002-3371-1445","observed_orcids":["https://orcid.org/0000-0002-3371-1445"]},"institutions":[{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mikala Egeblad","raw_affiliation_strings":["1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY","institution_ids":["https://openalex.org/I2750212522"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"8_Supplement","first_page":"2465","last_page":"2465"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9559999704360962},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9789999723434448},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-binding-proteins","display_name":"IGF binding proteins","score":0.9890000224113464},{"id":"https://openalex.org/keywords/igfbp-1","display_name":"IGFBP-1","score":0.925000011920929},{"id":"https://openalex.org/keywords/igfbp-2","display_name":"IGFBP-2","score":0.7670000195503235},{"id":"https://openalex.org/keywords/igfbp-3","display_name":"IGFBP-3","score":0.9980000257492065},{"id":"https://openalex.org/keywords/igfbp-4","display_name":"IGFBP-4","score":1.0},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6589999794960022},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.7440000176429749},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8389999866485596},{"id":"https://openalex.org/keywords/proteolysis","display_name":"proteolysis","score":0.6610000133514404},{"id":"https://openalex.org/keywords/igf-signaling","display_name":"IGF signaling","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C2775997469","wikidata":"https://www.wikidata.org/wiki/Q18029196","display_name":"MMP9","level":4,"score":0.7583087682723999},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6515560150146484},{"id":"https://openalex.org/C2776187077","wikidata":"https://www.wikidata.org/wiki/Q1888235","display_name":"Mammary tumor","level":4,"score":0.5416799187660217},{"id":"https://openalex.org/C2780378035","wikidata":"https://www.wikidata.org/wiki/Q17143674","display_name":"Insulin-like growth factor-binding protein","level":5,"score":0.5218122005462646},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49925947189331055},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.48901471495628357},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.4635993540287018},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44717124104499817},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.442646861076355},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.39670708775520325},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3496105968952179},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.31952911615371704},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31090134382247925},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28791072964668274},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2473067343235016},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08104333281517029},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2012-2465","doi":"https://doi.org/10.1158/1538-7445.am2012-2465","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-2465","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2168842852","https://openalex.org/W7095347413","https://openalex.org/W3144746700","https://openalex.org/W3130917571","https://openalex.org/W3109379722","https://openalex.org/W2022518765","https://openalex.org/W2003432147","https://openalex.org/W2061601119","https://openalex.org/W2172172019","https://openalex.org/W7216597471"],"abstract_inverted_index":{"Abstract":[0],"The":[1,150],"matrix":[2],"metalloproteinase":[3],"(MMP)":[4],"family":[5,9,233],"is":[6,15,156],"a":[7,255,302],"large":[8,86],"of":[10,29,34,60,72,78,94,102,182,195,219,252,267,277,299,304,306,335,340],"extracellularly":[11],"acting":[12],"proteases.":[13],"MMP9":[14,38,103,126,161,185,220,244,253,290,311],"expressed":[16],"by":[17,76,98,184],"tumor":[18,24,68,292],"infiltrating":[19],"myeloid":[20],"cells":[21],"and":[22,81,96,176,237,270,285,312],"promotes":[23,291],"progression":[25,293],"in":[26,36,106,113,159,166,200,214,245,294],"animal":[27],"models":[28,284],"cancer.":[30,326],"Yet,":[31],"the":[32,35,58,64,82,114,167,189,192,201,215,231,268,278,336,341],"identities":[33],"vivo":[37],"substrates":[39,242],"are":[40,241],"not":[41,141,226,271],"well":[42],"established.":[43],"Furthermore,":[44,301],"clinical":[45,322],"trials":[46],"with":[47,119,136,146,262,274],"broad-spectrum":[48],"MMP":[49,318],"inhibitors":[50,319],"have":[51],"shown":[52],"no":[53,111,321],"therapeutic":[54],"benefit.":[55],"We":[56,247],"compared":[57,203],"effects":[59],"deleting":[61],"Mmp9":[62],"between":[63],"luminal":[65],"mouse":[66,283],"mammary":[67],"virus":[69],"(MMTV)-Neu":[70],"model":[71,217],"breast":[73,133,223,295,325],"cancer,":[74],"driven":[75,91],"expression":[77,127,265],"rodent":[79],"HER2/ErbB2,":[80],"basal-like":[83],"C3(1)":[84],"SV40":[85],"T":[87],"antigen":[88],"(Tag)":[89],"model,":[90],"through":[92],"inactivation":[93],"p53":[95],"Rb":[97],"Tag.":[99],"Interestingly,":[100,191],"absence":[101],"delayed":[104],"tumor-onset":[105],"C3(1)-Tag":[107],"mice,":[108],"but":[109,139,229],"had":[110],"effect":[112],"MMTV-Neu":[115,216],"mice.":[116],"In":[117,207],"line":[118],"these":[120],"data,":[121],"we":[122],"found":[123,248],"that":[124,249,289],"low":[125,213,250,275],"indeed":[128],"predicts":[129],"good":[130,256],"prognosis":[131,143],"for":[132,144,243,260,272,344],"cancer":[134,178,296],"patients":[135,145,261,273,287,307],"mutant":[137],"p53,":[138],"does":[140],"influence":[142],"wild":[147],"type":[148],"p53.":[149],"insulin-like":[151],"growth":[152],"factor-binding":[153],"protein-1":[154],"(IGFBP-1)":[155],"an":[157],"established":[158],"vitro":[160],"substrate.":[162],"IGFBP-1":[163,196,209,228],"sequesters":[164],"IGF":[165,173,187],"extracellular":[168],"matrix,":[169],"leading":[170],"to":[171,204],"reduced":[172],"receptor":[174],"activity":[175],"thereby":[177],"cell":[179],"proliferation.":[180],"Proteolysis":[181],"IGFBP":[183],"releases":[186],"from":[188,282],"matrix.":[190],"protein":[193,210],"levels":[194,211,251,266,276,314],"were":[197,212,254],"significantly":[198],"increased":[199],"C3(1)-Tag;Mmp9\u2212/\u2212":[202],"C3(1)-Tag;Mmp9+/+":[205],"tumors.":[206],"contrast,":[208],"regardless":[218],"status.":[221],"Human":[222],"tumors":[224],"did":[225],"express":[227],"instead":[230],"other":[232],"members,":[234],"IGFBP-2,":[235],"-3,":[236],"-4,":[238],"which":[239],"all":[240],"vitro.":[246],"prognostic":[257],"factor":[258],"only":[259],"high":[263],"mRNA":[264],"IGFBPs,":[269],"IGFBPs.":[279,300],"Our":[280],"findings":[281],"human":[286],"suggest":[288],"via":[297],"proteolysis":[298],"lack":[303],"stratification":[305],"based":[308],"on":[309],"both":[310],"IGFBPs":[313],"might":[315],"explain":[316],"why":[317],"showed":[320],"benefit":[323],"against":[324],"Citation":[327],"Format:":[328],"{Authors}.":[329],"{Abstract":[330],"title}":[331],"[abstract].":[332],"In:":[333],"Proceedings":[334],"103rd":[337],"Annual":[338],"Meeting":[339],"American":[342],"Association":[343],"Cancer":[345,356],"Research;":[346],"2012":[347],"Mar":[348],"31-Apr":[349],"4;":[350],"Chicago,":[351],"IL.":[352],"Philadelphia":[353],"(PA):":[354],"AACR;":[355],"Res":[357],"2012;72(8":[358],"Suppl):Abstract":[359],"nr":[360],"2465.":[361],"doi:1538-7445.AM2012-2465":[362]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
