{"id":"https://openalex.org/W2008026041","doi":"https://doi.org/10.1080/15287398209530249","title":"Teratogenic and reproductive effects of ethanol in Long\u2010Evans rats","display_name":"Teratogenic and reproductive effects of ethanol in Long\u2010Evans rats","publication_year":1982,"publication_date":"1982-08-01","ids":{"openalex":"https://openalex.org/W2008026041","doi":"https://doi.org/10.1080/15287398209530249","mag":"2008026041","pmid":"https://pubmed.ncbi.nlm.nih.gov/7143480"},"language":"en","primary_location":{"id":"doi:10.1080/15287398209530249","doi":"https://doi.org/10.1080/15287398209530249","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15287398209530249","pdf_url":null,"source":{"id":"https://openalex.org/S85071590","display_name":"Journal of Toxicology and Environmental Health","issn_l":"0098-4108","issn":["0098-4108","1087-2620"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicology and Environmental Health","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111830275","display_name":"Russell F. Mankes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. F. Mankes","raw_affiliation_strings":["Institute of Experimental Pathology and Toxicology, Albany Medical College, Union University, Albany, New York, 12208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Pathology and Toxicology, Albany Medical College, Union University, Albany, New York, 12208","institution_ids":["https://openalex.org/I4405260259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002434945","display_name":"Ira Rosenblum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I. Rosenblum","raw_affiliation_strings":["Institute of Experimental Pathology and Toxicology, The Albany Medical College, Union University, Albany, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Pathology and Toxicology, The Albany Medical College, Union University, Albany, New York","institution_ids":["https://openalex.org/I4405260259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110754102","display_name":"Karl F. Benitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K.\u2010F. Benitz","raw_affiliation_strings":["Institute of Experimental Pathology and Toxicology, The Albany Medical College, Union University, Albany, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Pathology and Toxicology, The Albany Medical College, Union University, Albany, New York","institution_ids":["https://openalex.org/I4405260259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014560751","display_name":"R. LeFevre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. LeFevre","raw_affiliation_strings":["Institute of Experimental Pathology and Toxicology, The Albany Medical College, Union University, Albany, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Pathology and Toxicology, The Albany Medical College, Union University, Albany, New York","institution_ids":["https://openalex.org/I4405260259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112871694","display_name":"R. Abraham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Abraham","raw_affiliation_strings":["Institute of Experimental Pathology and Toxicology, The Albany Medical College, Union University, Albany, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Pathology and Toxicology, The Albany Medical College, Union University, Albany, New York","institution_ids":["https://openalex.org/I4405260259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405260259"],"apc_list":null,"apc_paid":null,"fwci":3.0861,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.89514919,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"10","issue":"2","first_page":"267","last_page":"276"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.6797000169754028,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.6797000169754028,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.3163999915122986,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ethanol","display_name":"ethanol","score":0.9179999828338623},{"id":"https://openalex.org/keywords/teratogenicity","display_name":"teratogenicity","score":0.9549999833106995},{"id":"https://openalex.org/keywords/reproductive-toxicity","display_name":"reproductive toxicity","score":0.890999972820282},{"id":"https://openalex.org/keywords/dieldrin","display_name":"dieldrin","score":0.7490000128746033},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.9679999947547913},{"id":"https://openalex.org/keywords/fetal-alcohol-syndrome","display_name":"fetal alcohol syndrome","score":0.7580000162124634},{"id":"https://openalex.org/keywords/microphthalmia","display_name":"microphthalmia","score":0.7879999876022339},{"id":"https://openalex.org/keywords/hydronephrosis","display_name":"hydronephrosis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/embryonic-lethality","display_name":"embryonic lethality","score":0.9760000109672546},{"id":"https://openalex.org/keywords/postnatal-effects","display_name":"postnatal effects","score":0.7379999756813049},{"id":"https://openalex.org/keywords/maternal-toxicity","display_name":"maternal toxicity","score":0.718999981880188},{"id":"https://openalex.org/keywords/organochlorine-pesticides","display_name":"organochlorine pesticides","score":0.8579999804496765},{"id":"https://openalex.org/keywords/long-evans-rats","display_name":"Long-Evans rats","score":0.6959999799728394},{"id":"https://openalex.org/keywords/prenatal-exposure","display_name":"prenatal exposure","score":0.3889999985694885}],"concepts":[{"id":"https://openalex.org/C65290608","wikidata":"https://www.wikidata.org/wiki/Q631521","display_name":"Teratology","level":4,"score":0.7405351400375366},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.7206695675849915},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.6060295104980469},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.574746310710907},{"id":"https://openalex.org/C179335377","wikidata":"https://www.wikidata.org/wiki/Q5266825","display_name":"Developmental toxicity","level":4,"score":0.48384323716163635},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43320998549461365},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4300110638141632},{"id":"https://openalex.org/C195289149","wikidata":"https://www.wikidata.org/wiki/Q2256694","display_name":"Toxicokinetics","level":3,"score":0.41597995162010193},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.39712393283843994},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3869819641113281},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.371354341506958},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3564033508300781},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.3233581781387329},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17683812975883484},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13818922638893127},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004026","descriptor_name":"Dieldrin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007774","descriptor_name":"Lactation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012098","descriptor_name":"Reproduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013723","descriptor_name":"Teratogens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/15287398209530249","doi":"https://doi.org/10.1080/15287398209530249","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15287398209530249","pdf_url":null,"source":{"id":"https://openalex.org/S85071590","display_name":"Journal of Toxicology and Environmental Health","issn_l":"0098-4108","issn":["0098-4108","1087-2620"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicology and Environmental Health","raw_type":"journal-article"},{"id":"pmid:7143480","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7143480","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of toxicology and environmental health","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W28827516","https://openalex.org/W341850071","https://openalex.org/W1976913042","https://openalex.org/W1991942425","https://openalex.org/W2005337103","https://openalex.org/W2013942765","https://openalex.org/W2022144267","https://openalex.org/W2062121876","https://openalex.org/W2067776958","https://openalex.org/W2080785373","https://openalex.org/W2081096617","https://openalex.org/W2083419095","https://openalex.org/W2087917521","https://openalex.org/W2104788447","https://openalex.org/W2122487511","https://openalex.org/W2129504530","https://openalex.org/W2137462759","https://openalex.org/W2168635919","https://openalex.org/W2403029138","https://openalex.org/W2411899113","https://openalex.org/W2415758429","https://openalex.org/W2467408552","https://openalex.org/W4248002767"],"related_works":["https://openalex.org/W2019978032","https://openalex.org/W2013324082","https://openalex.org/W2030706292","https://openalex.org/W7220228479","https://openalex.org/W7028979530","https://openalex.org/W1991942425","https://openalex.org/W2074549457","https://openalex.org/W2434872207","https://openalex.org/W2804874239","https://openalex.org/W2059903895"],"abstract_inverted_index":{"The":[0,266],"effects":[1,25,33,38,125],"of":[2,17,109,172,221,250,270],"ethanol":[3,6,101,186,279],"alone":[4,135],"or":[5],"and":[7,31,36,66,87,92,115,179,206,223,278],"dieidrin":[8],"given":[9,218],"orally":[10],"were":[11,23,44,77,117,155],"investigated":[12],"on":[13,26],"the":[14,80,97,107,118,141,158,170,185,240,248],"reproductive":[15],"processes":[16],"female":[18],"Long\u2010Evans":[19,42,241],"rats.":[20],"Three":[21],"studies":[22],"undertaken:":[24],"reproduction":[27],"(phase":[28,34,39],"I),":[29],"perinatal":[30],"postnatal":[32],"III),":[35],"teratological":[37],"II).":[40],"Female":[41],"rats":[43],"divided":[45],"into":[46],"five":[47],"groups":[48,76],"for":[49,146,247],"all":[50],"studies:":[51],"group":[52,55,58,62,67,83,88],"I\u2010distilled":[53],"water;":[54],"II\u2014corn":[56],"oil;":[57],"III\u20144":[59],"mg":[60,64,90],"Dieldrin/kg;":[61],"IV\u2010500":[63],"aspirin/kg;":[65],"V\u20100.4":[68],"ml":[69,85,94,163,225],"ethanol/kg.":[70,95],"For":[71],"phase":[72,98,142,159],"II,":[73],"two":[74],"additional":[75],"added":[78],"to":[79,257,273],"experimental":[81],"design:":[82],"VI\u20104.0":[84],"ethanol/kg":[86,164,226],"VII\u20144":[89],"Dieldrin/kg":[91],"0.4":[93,162,224],"In":[96,140,157],"I":[99],"study,":[100,144,161],"produced":[102],"a":[103,166,219,244,253],"significant":[104,123,167],"increase":[105,168,183],"in":[106,169,184,210,263],"number":[108],"malformed":[110],"pups":[111],"at":[112,252],"birth:":[113],"micro\u2010phthalmia":[114],"paralysis":[116],"defects":[119,205],"noted.":[120,235],"Aspirin":[121,198],"caused":[122,136,190,201],"teratogenic":[124,232],"as":[126,128,177,192,194],"well":[127,193],"maternal":[129,147],"deaths":[130],"from":[131],"gastrointestinal":[132],"hemorrhage.":[133],"Dieidrin":[134,212,222,274],"no":[137,152,231],"adverse":[138,153],"effects.":[139,216],"III":[143],"except":[145],"toxicity":[148],"among":[149],"aspirin\u2010dosed":[150],"dams,":[151],"findings":[154],"elicited.":[156],"II":[160],"induced":[165],"frequency":[171],"soft":[173,195,207],"tissue":[174,196,208],"malformations":[175],"such":[176],"microphthalmia":[178],"hydronephrosis.":[180],"A":[181],"10\u2010fold":[182],"dosage":[187],"(4.0":[188],"ml/kg),":[189],"embryolethality":[191,229],"teratology.":[197],"(500":[199],"mg/kg)":[200],"skeletal":[202],"(cranial":[203],"bone)":[204],"anomalies":[209],"pups;":[211],"was":[213,234],"without":[214],"untoward":[215],"Dams":[217],"combination":[220],"displayed":[227],"increased":[228],"but":[230],"effect":[233,269],"These":[236],"results":[237],"suggest":[238],"that":[239],"rat":[242],"is":[243],"sensitive":[245],"model":[246],"induction":[249],"FAS":[251],"dose":[254],"level":[255],"equivalent":[256],"one":[258],"alcoholic":[259],"drink":[260],"per":[261],"day":[262],"human":[264],"females.":[265],"reported":[267],"embryolethal":[268],"concommitant":[271],"exposure":[272],"(an":[275],"organochlorine":[276],"pesticide)":[277],"deserves":[280],"further":[281],"evaluation.":[282]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}