{"id":"https://openalex.org/W2008022535","doi":"https://doi.org/10.1038/ki.1977.28","title":"Angiotensin II blockade in normal man: Interaction of renin and sodium in maintaining blood pressure","display_name":"Angiotensin II blockade in normal man: Interaction of renin and sodium in maintaining blood pressure","publication_year":1977,"publication_date":"1977-03-01","ids":{"openalex":"https://openalex.org/W2008022535","doi":"https://doi.org/10.1038/ki.1977.28","mag":"2008022535","pmid":"https://pubmed.ncbi.nlm.nih.gov/846071"},"language":"en","primary_location":{"id":"doi:10.1038/ki.1977.28","doi":"https://doi.org/10.1038/ki.1977.28","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ki.1977.28","pdf_url":null,"source":{"id":"https://openalex.org/S97303050","display_name":"Kidney International","issn_l":"0085-2538","issn":["0085-2538","1523-1755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1038/ki.1977.28","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080307652","display_name":"Laurence Posternak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"Laurence Posternak","raw_affiliation_strings":["Departments of Medicine, Centre Hospitalier Universitaire, Lausanne, Switzerland","Departments of Medicine, Centre Hospitalier Universitaire, Lausanne, Switzerland, and Boston University School of Medicine, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Centre Hospitalier Universitaire, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]},{"raw_affiliation_string":"Departments of Medicine, Centre Hospitalier Universitaire, Lausanne, Switzerland, and Boston University School of Medicine, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I2802229882"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105933648","display_name":"Hans Rudolf Brunner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH","US"],"is_corresponding":true,"raw_author_name":"Hans R. Brunner","raw_affiliation_strings":["Departments of Medicine, Centre Hospitalier Universitaire, Lausanne, Switzerland","Departments of Medicine, Centre Hospitalier Universitaire, Lausanne, Switzerland, and Boston University School of Medicine, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Centre Hospitalier Universitaire, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]},{"raw_affiliation_string":"Departments of Medicine, Centre Hospitalier Universitaire, Lausanne, Switzerland, and Boston University School of Medicine, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I2802229882"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060042484","display_name":"Haralambos P. Gavras","orcid":"https://orcid.org/0000-0001-9675-9983","observed_orcids":["https://orcid.org/0000-0001-9675-9983"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"Haralambos Gavras","raw_affiliation_strings":["Departments of Medicine, Centre Hospitalier Universitaire, Lausanne, Switzerland","Departments of Medicine, Centre Hospitalier Universitaire, Lausanne, Switzerland, and Boston University School of Medicine, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Centre Hospitalier Universitaire, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]},{"raw_affiliation_string":"Departments of Medicine, Centre Hospitalier Universitaire, Lausanne, Switzerland, and Boston University School of Medicine, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I2802229882"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108422788","display_name":"Dorette B. Brunner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"Dorette B. Brunner","raw_affiliation_strings":["Departments of Medicine, Centre Hospitalier Universitaire, Lausanne, Switzerland","Departments of Medicine, Centre Hospitalier Universitaire, Lausanne, Switzerland, and Boston University School of Medicine, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Centre Hospitalier Universitaire, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]},{"raw_affiliation_string":"Departments of Medicine, Centre Hospitalier Universitaire, Lausanne, Switzerland, and Boston University School of Medicine, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I2802229882"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5105933648"],"corresponding_institution_ids":["https://openalex.org/I111088046","https://openalex.org/I2802229882"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":7.814,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.97282174,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"11","issue":"3","first_page":"197","last_page":"203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12075","display_name":"Sodium Intake and Health","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.9739999771118164},{"id":"https://openalex.org/keywords/renin","display_name":"renin","score":0.6449999809265137},{"id":"https://openalex.org/keywords/sodium-balance","display_name":"sodium balance","score":0.8539999723434448},{"id":"https://openalex.org/keywords/blood-pressure-regulation","display_name":"blood pressure regulation","score":0.9190000295639038},{"id":"https://openalex.org/keywords/saralasin","display_name":"saralasin","score":0.8960000276565552},{"id":"https://openalex.org/keywords/sodium-depletion","display_name":"sodium depletion","score":0.890999972820282},{"id":"https://openalex.org/keywords/sodium-repletion","display_name":"sodium repletion","score":0.8069999814033508},{"id":"https://openalex.org/keywords/hypotension","display_name":"hypotension","score":0.8140000104904175},{"id":"https://openalex.org/keywords/catecholamine-excess","display_name":"catecholamine excess","score":0.6639999747276306},{"id":"https://openalex.org/keywords/upright-posture","display_name":"upright posture","score":0.5049999952316284},{"id":"https://openalex.org/keywords/normotensive-subjects","display_name":"normotensive subjects","score":0.7210000157356262},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.8119999766349792},{"id":"https://openalex.org/keywords/postural-blood-pressure-response","display_name":"postural blood pressure response","score":0.5600000023841858},{"id":"https://openalex.org/keywords/sodium-excretion","display_name":"sodium excretion","score":0.593999981880188},{"id":"https://openalex.org/keywords/plasma-renin-activity","display_name":"plasma renin activity","score":0.5329999923706055},{"id":"https://openalex.org/keywords/plasma-aldosterone-concentration","display_name":"plasma aldosterone","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C2776823063","wikidata":"https://www.wikidata.org/wiki/Q410298","display_name":"Saralasin","level":4,"score":0.9372527003288269},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.719693660736084},{"id":"https://openalex.org/C125567185","wikidata":"https://www.wikidata.org/wiki/Q3267428","display_name":"Supine position","level":2,"score":0.679203987121582},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.661583423614502},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.6556504368782043},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.613713264465332},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5757622718811035},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5711740851402283},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5229447484016418},{"id":"https://openalex.org/C138976137","wikidata":"https://www.wikidata.org/wiki/Q7201790","display_name":"Plasma renin activity","level":4,"score":0.44443291425704956},{"id":"https://openalex.org/C2779918671","wikidata":"https://www.wikidata.org/wiki/Q200656","display_name":"Diuretic","level":2,"score":0.424477219581604},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3078944683074951},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003864","descriptor_name":"Depression, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011187","descriptor_name":"Posture","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012504","descriptor_name":"Saralasin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/ki.1977.28","doi":"https://doi.org/10.1038/ki.1977.28","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ki.1977.28","pdf_url":null,"source":{"id":"https://openalex.org/S97303050","display_name":"Kidney International","issn_l":"0085-2538","issn":["0085-2538","1523-1755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International","raw_type":"journal-article"},{"id":"pmid:846071","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/846071","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney international","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/ki.1977.28","doi":"https://doi.org/10.1038/ki.1977.28","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ki.1977.28","pdf_url":null,"source":{"id":"https://openalex.org/S97303050","display_name":"Kidney International","issn_l":"0085-2538","issn":["0085-2538","1523-1755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1970512054","https://openalex.org/W1991192995","https://openalex.org/W1996552732","https://openalex.org/W1997169369","https://openalex.org/W2002365740","https://openalex.org/W2015101794","https://openalex.org/W2018401813","https://openalex.org/W2032497006","https://openalex.org/W2041015644","https://openalex.org/W2043108352","https://openalex.org/W2070982824","https://openalex.org/W2076455258","https://openalex.org/W2076789308","https://openalex.org/W2092885332","https://openalex.org/W2095125029","https://openalex.org/W2107645164","https://openalex.org/W2315504621","https://openalex.org/W2335787154","https://openalex.org/W2339423792","https://openalex.org/W2420739074","https://openalex.org/W2983611914"],"related_works":["https://openalex.org/W2417602511","https://openalex.org/W2128958202","https://openalex.org/W2304807917","https://openalex.org/W2084084951","https://openalex.org/W2091408807","https://openalex.org/W2394541377","https://openalex.org/W2338343217","https://openalex.org/W2126035050","https://openalex.org/W2076789308","https://openalex.org/W2159857400"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
